Les grilles de calcul au service de la physique médicale

présenté par C.O. Thiam, proceedings sous forme de CDLes Simulations Monte Carlo GATE en radiothérapie nécessitent plusieurs heures de calculs. En effet, un résultat précis ne peut être obtenu qu'en générant beaucoup d'événements. Nous étudions donc les capacités des grilles de calcul notamment en terme de réduction des temps de calculs, et les services qu'elles offrent pour une utilisation future en milieu médical. Cette infrastructure, s'inscrit dans le cadre du projet européen EGEE. Ce projet consiste à mutualiser des ressources réparties sur différentes sites afin de pouvoir accéder à de la puissance de calcul, à des données partagées et de bénéficier d'une continuité de service

Profile of patients with HPV infection at the regional hospital of Saint-Louis, Senegal

Background: Objectives of current study was to define the sociodemographic characteristics of patients, to determine the frequency of HPV infection at the CHRSL and to describe factors associated with HPV infection. Methods: This was a prospective cross-sectional study conducted in the gynecology-obstetrics department of the Saint Louis Regional Hospital Center from November 11, 2019 to November 11, 2021, a period of 24 months. We studied sociodemographic, clinical and test results characteristics. Samples were taken from patients in the gynaecological position using a dedicated kit (cytobrush and tube). Viral research was carried out using the Atila Biosystems device for amplification and detection of viral DNA. This test genotypes HPV 16, 18 and 45, and detects 12 other HR HPVs (31, 33, 35, 39, 51, 52, 56, 58, 59, 66 and 68) simultaneously using three probes labelled with different fluorophores. Analysis was performed using Epi-Info software and Excel 2010. Results: The study population comprised 128 patients. The mean age of the patients was 41.95 years, with extremes of 23 and 70 years. They were married (92.97%) and housewives (46.88%). Almost all patients (77.34%) were genitally active. The average age at marriage was 21.78 years, and polygamous households predominated (53.91%). The average age at first intercourse was 20.05 years. The average age at first pregnancy was 21.78. Over (57.81%) of patients had at least two partners. Incense was used in 97.66% of cases. The viral HPV test was positive in (38.28%) of patients. High-risk papillomaviruses were the most common, at 63.27%. Colposcopy was performed in 17.19%; normal and satisfactory in (63.64%) of patients, with 22.27% of cervical biopsies, and histology showed one CIN2 and two CIN3. Therapeutically, one thermoablation and two hysterectomies were performed. Conclusions: HPV viral typing in primary screening for cervical cancer offers opportunities and remains realistic and feasible in less developed countries such as Senegal, despite modest resources

Imperforate hymen complicated by obstructive acute renal failure

Imperforate hymen is a rare malformation (1/ 1000 female births). It is diagnosed most often during puberty. Early diagnosis of hematocolpos and evacuation is necessary to avoid any consequences. We report a rare case of an imperforate hymen complicated with acute urinary retention,  hydronephrosis and renal failure in a 14-year-old girl to emphasize thepossible misdiagnosis and its possible consequences. This is the firstcase we encounter in our unit

La gigantomastie gravidique à l’Institut du Cancer de Dakar: à propos de 2 cas

La gigantomastie gravidique est une augmentation exagérée et invalidante de la taille des seins survenant pendant la grossesse chez une patiente aux seins préalablement normaux. Sa physiopathologie est mal cernée. Elle pose localement des problèmes trophiques et rend difficile la grossesse. Le traitement est médical anti hormonal et chirurgical sur la base d'une réduction mammaire. Il est difficile et peut compromettre l'avenir esthétique et fonctionnel de la glande mammaire. Nous rapportons 2 cas de gigantomasties gravidiques suivies et traitées à l'Institut Joliot Curie de Dakar.Pan African Medical Journal 2015; 2

Asphyxie Perinatale Au Service De Neonatologie De L’hopital De La Paix De Ziguinchor (Senegal)

Introduction: Perinatal asphyxia (PA) is one of the reasons for the transfer of the newborn to neonatal resuscitation services. The objective of this work was to study the epidemiological, obstetrical, clinical and evolutionary aspects of PA at the Ziguinchor Peace Hospital. Materials and methods: This was a retrospective study of cases of hospitalized HAs during the period 1 December 2015 to 31 May 2017. The diagnosis of PA was based on an anomaly of the rhythm Fetal heart rate and / or amniotic fluid abnormality; A score of Apgar <7 at the 5th minute and / or the absence of an immediate cry at birth. We collected epidemiological, obstetric, clinical and evolutionary data. Results: We collected 153 cases of PA (90 boys and 63 girls) among 742 newborns, an incidence of 20.6% of neonatal hospitalizations. The mean age of mothers was 17.2 years; 82.0% of mothers were between 18 and 35 years of age and half (50.3%) had four or more NPCs. Anemia (37.0%), maternal infection (36.4%), hypertension (30.9%), premature rupture of membranes (RPM) (28.6%), eclampsia and Preeclampsia (9.9%) were the main obstetric complications. The delivery was performed by Caesarean section in 52.3% of cases and by low procedure in 47.7% of cases. The term of birth was between 37 and 41 SA in 53.3% of the cases. The amniotic fluid (LA) was tinted in 55.7% of the cases and meconium in 12.3%. At the 5th minute, 42.6% of the infants had an Apgar score <7. One hundred percent of the children (n = 153) had been aspirated at birth and 24.8% (n = 38) had been ventilated To the mask. One hundred and twenty-three patients (80.3%) had anoxo-ischemic encephalopathy, of which 95 (77.2%) were in stage 1; 27 (22.0%) were in stage 2 and 1 (0.8%) was in stage 3 of the Sarnat classification. The main neurological signs were the anomalies of archaic reflexes (64.2%); Tone disorders (57.7%); Disorders of consciousness (22.8%); Convulsions (21.9%). The case fatality rate was 10.4% (16 deaths). Deaths were significantly associated with low birth, MMP, mask ventilation, respiratory distress, and convulsion. Conclusion: PA accounts for 20.6% of neonatal hospitalizations at the Ziguinchor Peace Hospital. Its lethality is 10.4%. It is associated with high morbidity

Preparation, characterization, and performance evaluation of polysulfone hollow fiber membrane with PEBAX or PDMS coating for oxygen enhancement process

Air pollution is a widely discussed topic amongst the academic and industrial spheres as it can bring adverse effects to human health and economic loss. As humans spend most of their time at the office and at home, good indoor air quality with enriched oxygen concentration is particularly important. In this study, polysulfone (PSF) hollow fiber membranes fabricated by dry-jet wet phase inversion method were coated by a layer of polydimethylsiloxane (PDMS) or poly(ether block amide) (PEBAX) at different concentrations and used to evaluate their performance in gas separation for oxygen enrichment. The surface-coated membranes were characterized using SEM and EDX to determine the coating layer thickness and surface chemical properties, respectively. Results from the gas permeation study revealed that the PSF membrane coated with PDMS offered higher permeance and selectivity compared to the membrane coated with PEBAX. The best performing PDMS-coated membrane demonstrated oxygen and nitrogen gas permeance of 18.31 and 4.01 GPU, respectively with oxygen/nitrogen selectivity of 4.56. Meanwhile, the PEBAX-coated membrane only showed 12.23 and 3.11 GPU for oxygen and nitrogen gas, respectively with a selectivity of 3.94. It can be concluded the PDMS coating is more promising for PSF hollow fiber membrane compared to the PEBAX coating for the oxygen enrichment process

Preparation and characterization of chromium metal organic framework for carbon dioxide adsorption

Greenhouse gases (GHGs) have greatly changed the global climate in the recent year. Metal organic frameworks (MOFs) is one of the solutions which can be utilized as gas adsorbents to capture carbon dioxide (CO2), the main contributor of greenhouse effect. MOF possesses good CO2 adsorption ability attributed to its high surface area to volume ratio and pore size. Nevertheless, the success of the MOF is greatly depend on the fabrication parameter such as fabrication methods, type of metal oxide, type of organic linkers used and the molar ratio of the reactant. In this study, chromium (VI) oxide, trimesic acid and terephthalic acid were used to fabricate MOFs by solvothermal method to investigate the performance of CO2 adsorption. The characterization tests by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) shows that Cr-TMA-1:5 amongst the rest of the fabricated MOF possess the shape of small irregular diagonal with highest surface area to volume ratio which was ideal in CO2 adsorption. Furthers, the result CO2 adsorption test carried by thermogravimetric analyser (TGA) suggested the MOF Cr-TMA-1:5 possesses the highest the CO2 adsorption capacity recorded at 0.099 mmol/g. This had revealed that MOFs composed of chromium (VI) oxide and trimesic acid possess the potential to be applied in CO2 adsorption

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence

Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns

Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact.

BACKGROUND NlmCategory: BACKGROUND content: Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and evidence from different transmission settings is needed. - Label: METHODS NlmCategory: METHODS content: "A pilot quasi-experimental study to evaluate a package of population-wide test and treat interventions was conducted in six health facility catchment areas (HFCA) in the districts of Kanel, Lingu\xC3\xA8re, and Ran\xC3\xA9rou (Senegal). Seven adjacent HFCAs were selected as comparison. Villages within the intervention HFCAs were stratified according to the 2013 incidences of passively detected malaria cases, and those with an incidence\xE2\x80\x89\xE2\x89\xA5\xE2\x80\x8915 cases/1000/year were targeted for a mass test and treat (MTAT) in September 2014. All households were visited, all consenting individuals were tested with a rapid diagnostic test (RDT), and, if positive, treated with dihydroartemisinin-piperaquine. This was followed by weekly screening, testing and treatment of fever cases (PECADOM++) until the end of the transmission season in January 2015. Villages with lower incidence received only PECADOM++ or case investigation. To evaluate the impact of the interventions over that transmission season, the incidence of passively detected, RDT-confirmed malaria cases was compared between the intervention and comparison groups with a difference-in-difference analysis using negative binomial regression with random effects on HFCA." - Label: RESULTS NlmCategory: RESULTS content: "During MTAT, 89% (2225/2503) of households were visited and 86% (18,992/22,170) of individuals were tested, for a combined 77% effective coverage. Among those tested, 291 (1.5%) were RDT positive (range 0-10.8 by village), of whom 82% were\xE2\x80\x89<\xE2\x80\x8920\xC2\xA0years old and 70% were afebrile. During the PECADOM++ 40,002 visits were conducted to find 2784 individuals reporting fever, with an RDT positivity of 6.5% (170/2612). The combination of interventions resulted in an estimated 38% larger decrease in malaria case incidence in the intervention compared to the comparison group (adjusted incidence risk ratio\xE2\x80\x89=\xE2\x80\x890.62, 95% CI 0.45-0.84, p\xE2\x80\x89=\xE2\x80\x890.002). The cost of the MTAT was $14.3 per person." - Label: CONCLUSIONS NlmCategory: CONCLUSIONS content: It was operationally feasible to conduct MTAT and PECADOM++ with high coverage, although PECADOM++ was not an efficient strategy to complement MTAT. The modest impact of the intervention package suggests a need for alternative or complementary strategies