599 research outputs found
The HST Cosmos Project: Contribution from the Subaru Telescope
The Cosmic Evolution Survey (COSMOS) is a Hubble Space Telescope (HST)
treasury project.The COSMOS aims to perform a 2 square degree imaging survey of
an equatorial field in (F814W) band, using the Advanced Camera for Surveys
(ACS). Such a wide field survey, combined with ground-based photometric and
spectroscopic data, is essential to understand the interplay between large
scale structure, evolution and formation of galaxies and dark matter. In 2004,
we have obtained high-quality, broad band images of the COSMOS field ( and ) using Suprime-Cam on the Subaru
Telescope, and we have started our new optical multi-band program, COSMOS-21 in
2005. Here, we present a brief summary of the current status of the COSMOS
project together with contributions from the Subaru Telescope. Our future
Subaru program, COSMOS-21, is also discussed briefly.Comment: 4 pages, 3 figures, to appear in the Proceedings of the 6th East
Asian Meeting on Astronomy, JKAS, 39, in pres
Rosiglitazone RECORD study: glucose control outcomes at 18 months
AIMS: To compare glucose control over 18 months between rosiglitazone oral combination therapy and combination metformin and sulphonylurea in people with Type 2 diabetes. METHODS: RECORD, a multicentre, parallel-group study of cardiovascular outcomes, enrolled people with an HbA(1c) of 7.1-9.0% on maximum doses of metformin or sulphonylurea. If on metformin they were randomized to add-on rosiglitazone or sulphonylurea (open label) and if on sulphonylurea to rosiglitazone or metformin. HbA(1c) was managed to < or = 7.0% by dose titration. A prospectively defined analysis of glycaemic control on the first 1122 participants is reported here, with a primary outcome assessed against a non-inferiority margin for HbA(1c) of 0.4%. RESULTS: At 18 months, HbA(1c) reduction on background metformin was similar with rosiglitazone and sulphonylurea [difference 0.07 (95% CI -0.09, 0.23)%], as was the change when rosiglitazone or metformin was added to sulphonylurea [0.06 (-0.09, 0.20)%]. At 6 months, the effect on HbA(1c) was greater with add-on sulphonylurea, but was similar whether sulphonylurea was added to rosiglitazone or metformin. Differences in fasting plasma glucose were not statistically significant at 18 months [rosiglitazone vs. sulphonylurea -0.36 (-0.74, 0.02) mmol/l, rosiglitazone vs. metformin -0.34 (-0.73, 0.05) mmol/l]. Increased homeostasis model assessment insulin sensitivity and reduced C-reactive protein were greater with rosiglitazone than metformin or sulphonylurea (all P < or = 0.001). Body weight was significantly increased with rosiglitazone compared with sulphonylurea [difference 1.2 (0.4, 2.0) kg, P = 0.003] and metformin [difference 4.3 (3.6, 5.1) kg, P < 0.001]. CONCLUSIONS: In people with diabetes, rosiglitazone in combination with metformin or sulphonylurea was demonstrated to be non-inferior to the standard combination of metformin + sulphonylurea in lowering HbA(1c) over 18 months, and produces greater improvements in C-reactive protein and basal insulin sensitivity but is also associated with greater weight gain
Weighing the Giants - I. Weak-lensing masses for 51 massive galaxy clusters: project overview, data analysis methods and cluster images
This is the first in a series of papers in which we measure accurate
weak-lensing masses for 51 of the most X-ray luminous galaxy clusters known at
redshifts 0.15<z<0.7, in order to calibrate X-ray and other mass proxies for
cosmological cluster experiments. The primary aim is to improve the absolute
mass calibration of cluster observables, currently the dominant systematic
uncertainty for cluster count experiments. Key elements of this work are the
rigorous quantification of systematic uncertainties, high-quality data
reduction and photometric calibration, and the "blind" nature of the analysis
to avoid confirmation bias. Our target clusters are drawn from RASS X-ray
catalogs, and provide a versatile calibration sample for many aspects of
cluster cosmology. We have acquired wide-field, high-quality imaging using the
Subaru and CFHT telescopes for all 51 clusters, in at least three bands per
cluster. For a subset of 27 clusters, we have data in at least five bands,
allowing accurate photo-z estimates of lensed galaxies. In this paper, we
describe the cluster sample and observations, and detail the processing of the
SuprimeCam data to yield high-quality images suitable for robust weak-lensing
shape measurements and precision photometry. For each cluster, we present
wide-field color optical images and maps of the weak-lensing mass distribution,
the optical light distribution, and the X-ray emission, providing insights into
the large-scale structure in which the clusters are embedded. We measure the
offsets between X-ray centroids and Brightest Cluster Galaxies in the clusters,
finding these to be small in general, with a median of 20kpc. For offsets
<100kpc, weak-lensing mass measurements centered on the BCGs agree well with
values determined relative to the X-ray centroids; miscentering is therefore
not a significant source of systematic uncertainty for our mass measurements.
[abridged]Comment: 26 pages, 19 figures (Appendix C not included). Accepted after minor
revisio
Is There Evidence That Oral Hypoglycemic Agents Reduce Cardiovascular Morbidity/Mortality? Yes
Athough type 2 diabetes is a heterogeneous condition encompassing multiple metabolic and vascular alterations, it can be easily described as a disease characterized by chronic hyperglycemia and increased cardiovascular (CV) risk. Hyperglycemia is the diagnostic criterion for diabetes, the target for antidiabetic therapy, and, together with A1C, the marker of glycemic control. Progressive worsening of glycemic control has been described in type 2 diabetic patients irrespective of initial form of treatment, leading the U.K. Prospective Diabetes Study (UKPDS) investigators to describe such changes as the “natural history” of the disease ( 1). Still, maintaining good glycemic control is crucial, since it is associated with marked reduction in the risk of developing retinopathy, nephropathy, and neuropathy in both type 1 ( 2) and type 2 diabetic patients ( 1). But it is CV disease that worsens long-term prognosis in type 2 diabetes ( 3), to the point that diabetes has been proposed as a CV risk equivalent owed to the observation that 10-year risk for major coronary events approximates the risk in CHD in patients without diabetes with previous CV events ( 4), increased case fatality rate after myocardial infarction, and worse overall prognosis after CHD ( 5). In diabetic patients, even after correction for known CV risk factors, the incidence of myocardial infarction or stroke is two- to threefold higher than in the nondiabetic population, with a twofold increase in risk of death ( 6), suggesting that some feature of diabetes must confer excessive propensity toward CV disease.
Can this feature be hyperglycemia? No better issue can be chosen for debate. From an epidemiological point of view, there is evidence that the risk of CV mortality increases with the increase of plasma glucose concentrations ( 7) and A1C values ( 8). Moreover, multiple atherogenic mechanisms have been identified that can be activated by hyperglycemia ( 9)
Search for the decay followed by
We report a study of the decay followed by
, where indicates or . We
reconstruct the state in a phase space corresponding to . The CP-violating angle affects its decay rate via the
interference between and transitions. The
result is obtained from a 711 data sample that contains 772
pairs collected at the resonance with the
Belle detector at the KEKB asymmetric-energy collider. We measure the
ratio to be , and set an upper limit of at the 95% confidence level
Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter
Showers produced by positive hadrons in the highly granular CALICE
scintillator-steel analogue hadron calorimeter were studied. The experimental
data were collected at CERN and FNAL for single particles with initial momenta
from 10 to 80 GeV/c. The calorimeter response and resolution and spatial
characteristics of shower development for proton- and pion-induced showers for
test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos
corrected, new section added, figures regrouped. Accepted for publication in
JINS
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