Screening of Sunflower Genotypes for Reaction to Alternaria Leaf Blight Disease across Multi-environments using Pooled Analysis

Sunflower (Helianthus annuus L.) is an oilseed crop with potential health benefits as a source of oil and dietary fiber. The productivity of sunflower is hampered by both biotic and abiotic stresses caused due to climate changes. So far, the available gene pool is having moderately resistant lines. In the present study, we evaluated two screening methods by artificially challenging the plants with the causative agent A. helianthi. Significant changes in disease severity have been observed across 160 pre-breeding lines of sunflower, including the susceptible check, Morden in three different seasons. Among the160 pre-breeding lines derived from a mutant population of sunflower cv. Morden, 6.25 and 5.63 % of lines showed less leaf blight disease incidence under in vivo and in vitro environments respectively. Moreover, 44.38 % of the sunflower pre breeding lines demonstrated field tolerance with disease severity in the scale of 5. The promising accessions evaluated in our studies by whole plant assay method and detached leaf technique includes KSFI 19, KSFI 24, KSFI 147, KSFI 56, KSFI 120, KSFI 88, KSFI 152, KSFI 51 and KSFI 115. Therefore, these sunflower lines, could be employed for introgression of resistance genes against leaf blight disease in sunflower cultivars through marker assisted breeding strategies

Energy bands, conductance and thermoelectric power for ballistic electrons in a nanowire with spin-orbit interaction

We calculated the effects of spin-orbit interaction (SOI) on the energy bands, ballistic conductance and the electron-diffusion thermoelectric power of a nanowire by varying the temperature, electron density and width of the wire. The potential barriers at the edges of the wire are assumed to be very high. A consequence of the boundary conditions used in this model is determined by the energy band structure, resulting in wider plateaus when the electron density is increased due to larger energy-level separation as the higher subbands are occupied by electrons. The nonlinear dependence of the transverse confinement on position with respect to the well center excludes the "pole-like feature" in the conductance which is obtained when a harmonic potential is employed for confinement. At low temperature, the electron diffusion thermoelectric power increases linearly with T but deviates from the linear behavior for large values of T.Comment: Updated corrected version of the original submissio

Central Odontogenic Fibroma of Simple Type

Central odontogenic fibroma (COF) is an extremely rare benign tumor that accounts for 0.1% of all odontogenic tumors. It is a lesion associated with the crown of an unerupted tooth resembling dentigerous cyst. In this report, a 10-year-old male patient is presented, who was diagnosed with central odontogenic fibroma of simple type from clinical, radiological, and histopathological findings

An account of hexactinellid sponge, Hyalonema (Cyliconema) apertum apertum collected from Andaman waters

The hexactinellid sponge collected aboard FORV Sagar Sampada from the eastern side of North Andaman waters at 13o06’ N lat. and 93o11’E long. was identified as Hyalonema (Cyliconema) apertum apertum. This species, collected at a depth of 402 m, belonged to the Class Hexactinellida, Order Amphidiscosida and Family Hyalonematidae. The body is spindle-like, followed by basalia in the form of long twisted spicules. Identical specimens collected from 12o57’ N lat. & 93o07’ E long. and 12o45’ N lat. & 93o09’ E long. confirmed the presence of H. (Cyliconema) apertum apertum in the Central Andaman waters too. The present communication describes the characteristic features of H. (Cyliconema) apertum apertum along with a detailed account of the types and dimensions of spicules

Place-Based Solutions for Transport Decarbonisation, Submission to the Department for Transport’s Consultation on the Transport Decarbonisation Plan

Place-based decarbonisation is a recognition that, whilst the decarbonisation of transport has to happen everywhere, it is enacted in places. Defining place-based solutions as a strategic priority, as DfT’s Decarbonising Transport: Setting the Challenge does, will have value if it enables the faster and more cost-effective achievement of the prime objective: early and rapid progress to meet the nationwide necessary emissions descent pathway. In this submission we set out some key elements of place-based decarbonisation and set out what we think the full Transport Decarbonisation Plan needs to address to unlock the potential that a place-based approach holds

Structure of DNA-Functionalized Dendrimer Nanoparticles

Atomistic molecular dynamics simulations have been carried out to reveal the characteristic features of ethylenediamine (EDA) cored protonated poly amido amine (PAMAM) dendrimers of generation 3 (G3) and 4 (G4) that are functionalized with single stranded DNAs (ssDNAs). The four ssDNA strands that are attached via alkythiolate [-S (CH2)6-] linker molecule to the free amine groups on the surface of the PAMAM dendrimers observed to undergo a rapid conformational change during the 25 ns long simulation period. From the RMSD values of ssDNAs, we find relative stability in the case of purine rich ssDNA strands than pyrimidine rich ssDNA strands. The degree of wrapping of ssDNA strands on the dendrimer molecule was found to be influenced by the charge ratio of DNA and the dendrimer. As G4 dendrimer contains relatively more positive charge than G3 dendrimer, we observe extensive wrapping of ssDNAs on the G4 dendrimer. The ssDNA strands along with the linkers are seen to penetrate the surface of the dendrimer molecule and approach closer to the center of the dendrimer indicating the soft sphere nature of the dendrimer molecule. The effective radius of DNA-functionalized dendrimer nanoparticle was found to be independent of base composition of ssDNAs and was observed to be around 19.5 {\AA} and 22.4 {\AA} when we used G3 and G4 PAMAM dendrimer as the core of the nanoparticle respectively. The observed effective radius of DNA-functionalized dendrimer molecule apparently indicates the significant shrinkage in the structure that has taken place in dendrimer, linker and DNA strands. As a whole our results describe the characteristic features of DNA-functionalized dendrimer nanoparticle and can be used as strong inputs to design effectively the DNA-dendrimer nanoparticle self-assembly for their active biological applications.Comment: 13 pages, 10 figures, 3 Table

Effect of the spin-orbit interaction on the band structure and conductance of quasi-one-dimensional systems

We discuss the effect of the spin-orbit interaction on the band structure, wave functions and low temperature conductance of long quasi-one-dimensional electron systems patterned in two-dimensional electron gases (2DEG). Our model for these systems consists of a linear (Rashba) potential confinement in the direction perpendicular to the 2DEG and a parabolic confinement transverse to the 2DEG. We find that these two terms can significantly affect the band structure introducing a wave vector dependence to subband energies, producing additional subband minima and inducing anticrossings between subbands. We discuss the origin of these effects in the symmetries of the subband wave functions.Comment: 15 pages including 14 figures; RevTeX; to appear in Phys.Rev.B (15 Nov 1999

Effectiveness of a scalable group-based education and monitoring program, delivered by health workers, to improve control of hypertension in rural India: A cluster randomised controlled trial

New methods are required to manage hypertension in resource-poor settings. We hypothesised that a community health worker (CHW)-led group-based education and monitoring intervention would improve control of blood pressure (BP). We conducted a baseline community-based survey followed by a cluster randomised controlled trial of people with hypertension in 3 rural regions of South India, each at differing stages of epidemiological transition. Participants with hypertension, defined as BP ≥ 140/90 mm Hg or taking antihypertensive medication, were advised to visit a doctor. In each region, villages were randomly assigned to intervention or usual care (UC) in a 1:2 ratio. In intervention clusters, trained CHWs delivered a group-based intervention to people with hypertension. The program, conducted fortnightly for 3 months, included monitoring of BP, education about hypertension, and support for healthy lifestyle change. Outcomes were assessed approximately 2 months after completion of the intervention. The primary outcome was control of BP (BP < 140/90 mm Hg), analysed using mixed effects regression, clustered by village within region and adjusted for baseline control of hypertension (using intention-to-treat principles). Of 2,382 potentially eligible people, 637 from 5 intervention clusters and 1,097 from 10 UC clusters were recruited between November 2015 and April 2016, with follow-up occurring in 459 in the intervention group and 1,012 in UC. Mean age was 56.9 years (SD 13.7). Baseline BP was similar between groups. Control of BP improved from baseline to follow-up more in the intervention group (from 227 [49.5%] to 320 [69.7%] individuals) than in the UC group (from 528 [52.2%] to 624 [61.7%] individuals) (odds ratio [OR] 1.6, 95% CI 1.2-2.1; P = 0.001). In secondary outcome analyses, there was a greater decline in systolic BP in the intervention than UC group (-5.0 mm Hg, 95% CI -7.1 to -3.0; P < 0.001) and a greater decline in diastolic BP (-2.1 mm Hg, 95% CI -3.6 to -0.6; P < 0.006), but no detectable difference in the use of BP-lowering medications between groups (OR 1.2, 95% CI 0.8-1.9; P = 0.34). Similar results were found when using imputation analyses that included those lost to follow-up. Limitations include a relatively short follow-up period and use of outcome assessors who were not blinded to the group allocation. While the durability of the effect is uncertain, this trial provides evidence that a low-cost program using CHWs to deliver an education and monitoring intervention is effective in controlling BP and is potentially scalable in resource-poor settings globally. The trial was registered with the Clinical Trials Registry-India (CTRI/2016/02/006678)

Lifestyle change in Kerala, India: needs assessment and planning for a community-based diabetes prevention trial

Abstract Background Type 2 Diabetes Mellitus (T2DM) has become a major public health challenge in India. Factors relevant to the development and implementation of diabetes prevention programmes in resource-constrained countries, such as India, have been under-studied. The purpose of this study is to describe the findings from research aimed at informing the development and evaluation of a Diabetes Prevention Programme in Kerala, India (K-DPP). Methods Data were collected from three main sources: (1) a systematic review of key research literature; (2) a review of relevant policy documents; and (3) focus groups conducted among individuals with a high risk of progressing to diabetes. The key findings were then triangulated and synthesised. Results Prevalence of risk factors for diabetes is very high and increasing in Kerala. This situation is largely attributable to rapid changes in the lifestyle of people living in this state of India. The findings from the systematic review and focus groups identified many environmental and personal determinants of these unhealthy lifestyle changes, including: less than ideal accessibility to and availability of health services; cultural values and norms; optimistic bias and other misconceptions related to risk; and low expectations regarding one’s ability to make lifestyle changes in order to influence health and disease outcomes. On the other hand, there are existing intervention trials conducted in India which suggests that risk reduction is possible. These programmes utilize multi-level strategies including mass media, as well as strategies to enhance community and individual empowerment. India’s national programme for the prevention and control of major non-communicable diseases (NCD) also provide a supportive environment for further community-based efforts to prevent diabetes. Conclusion These findings provide strong support for undertaking more research into the conduct of community-based diabetes prevention in the rural areas of Kerala. We aim to develop, implement and evaluate a group-based peer support programme that will address cultural and family determinants of lifestyle risks, including family decision-making regarding adoption of healthy dietary and physical activity patterns. Furthermore, we believe that this approach will be feasible, acceptable and effective in these communities; with the potential for scale-up in other parts of India