La Importància de la competències emocionals en la gent gran

Curs 2010-2011Aquesta Memòria recull les pràctiques realitzades dins del marc del Màster en Envelliment Actiu a dues institucions: al Casal de Gent Gran Mn. Guiteras de Vic i a l’Hospital sociosanitari Sant Jaume de Manlleu. A la primera institució, es va dissenyar, elaborar, aplicar i avaluar, de forma conjunta amb la M. Teresa Lladó (una altra psicòloga companya del Màster) una intervenció en l’àmbit de la gent gran. L’actuació consistia en un taller de deu sessions de competències socioemocionals adreçat a la gent gran. A la segona institució, l’Hospital de Manlleu, les pràctiques van ser de caràcter individual i van consistir en el seguiment de la figura del psicòleg del centre sociosanitari per copsar les diverses funcions que realitza.Director/a: Anna Maria Damin

The interpretation of plural mass nouns in Greek

Altres ajuts: Acord transformatiu CRUE-CSICThis paper focuses on the interpretation of what has been considered an expletive marker in the grammar of the Greek nominal domain: the plural number of mass nouns. We present the results of an experimental investigation on the interpretation of plural mass nouns by native speakers of this language, and we propose a speech act analysis according to which at the time of producing utterances that contain plural mass nouns the speaker performs two speech acts: an assertion and an expressive speech act by which (s)he publicly commits to an emotive stance of dislike towards the expressed proposition φ. This stance is analyzed as an emotive judgment with respect to φ, the expression of which directly transfers the speaker's emotion from the conversation into the speaker and addressee's common ground

How speakers interpret the negative markers no and no … pas in Catalan

This paper reports the results of an experimental investigation designed to test the interpretation of the optional doubling of the negative markers no and pas in Expletive Negation (EN) contexts and in preverbal Negative Concord Items (NCI) contexts in Catalan. We show that in EN contexts a negative interpretation of no is preferred to anexpletive one, with non-negative readings being less widespread than expected from what is described in traditional grammars. In NCI contexts the overt presence of no basically contributes to a single negation interpretation, thus confirming the status of Catalan as aNegative Concord language. We also show that, in the absence of discourse environments, pas in both EN and NCI contexts shows a variable interpretation, a characteristic of negative polarity items. Our results indicate that pas does not increase the amount of negative interpretation of no in EN contexts, or of Double Negation in NCI contexts, but is an item dependent on the interpretation of no. We conclude that the strengthening role of Catalan pas (at stage two of Jespersen's cycle), while associated with the expression of metalinguistic negation, does not reverse the truth or falsity of a proposition

Plasma assisted deposition of single and multistacked TiO2 hierarchical nanotubes photoanodes

We present herein an evolved methodology for the growth of nanocrystalline hierarchical nanotubes combining physical vapor deposition of organic nanowires (ONWs) and plasma enhanced chemical vacuum deposition of anatase TiO2 layers. The ONWs act as vacuum removable 1D and 3D templates, with the whole process occurring at temperatures ranging from RT to 250 °C. As a result, a high density of hierarchical nanotubes with tunable diameter, length and tailored wall microstructures are formed on a variety of processable substrates as metal and metal oxide films or nanoparticles including transparent conductive oxides. The reiteration of the process leads to the development of an unprecedented 3D nanoarchitecture formed by stacking the layers of hierarchical TiO2 nanotubes. As a proof of concept, we present the superior performance of the 3D nanoarchitecture as a photoanode within an excitonic solar cell with efficiencies as high as 4.69% for a nominal thickness of the anatase layer below 2.75 ¿m. Mechanical stability and straightforward implementation in devices are demonstrated at the same time. The process is extendable to other functional oxides fabricated by plasma-assisted methods with readily available applications in energy harvesting and storage, catalysis and nanosensingJunta de Andalucia(FQM 1851 and FQM-2310)España Mineco 201560E055 MAT2016-79866-R MAT2013-40852-R MAT2013-4MAT2013-47192-C3-3-R2900-

The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.

Regulation of cellular volume is an essential process to balance volume changes during cell proliferation and migration or when intracellular osmolality increases due to transepithelial transport. We previously characterized the key role of volume-regulated anion channels (VRAC) in the modulation of the volume of trabecular meshwork (TM) cells and, in turn, the aqueous humour (AH) outflow from the eye. The balance between the secretion and the drainage of AH determines the intraocular pressure (IOP) that is the major casual risk factor for glaucoma. Glaucoma is an ocular disease that causes irreversible blindness due to the degeneration of retinal ganglion cells. The recent identification of Leucine-Rich Repeat-Containing 8 (LRRC8A-E) proteins as the molecular components of VRAC opens the field to elucidate their function in the physiology of TM and glaucoma. Human TM cells derived from non-glaucomatous donors and from open-angle glaucoma patients were used to determine the expression and the functional activity of LRRC8-mediated channels. Expression levels of LRRC8A-E subunits were decreased in HTM glaucomatous cells compared to normotensive HTM cells. Consequently, the activity of VRAC currents and volume regulation of TM cells were significantly affected. Impaired cell volume regulation will likely contribute to altered aqueous outflow and intraocular pressure

Conformal TiO2_2 aerogel-like films by plasma deposition: from omniphobic antireflective coatings to perovskite solar cells photoelectrodes

The ability to control porosity in oxide thin films is one of the key factors that determine their properties. Despite the abundance of dry processes for the synthesis of oxide porous layers, the high porosity range is typically achieved by spin-coating-based wet chemical methods. Besides, special techniques such as supercritical drying are required to replace the pore liquid with air while maintaining the porous network. In this study, we propose a new method for the fabrication of ultra-porous titanium dioxide thin films at room or mild temperatures (T lower or equal to 120 degrees Celsius) by the sequential process involving plasma deposition and etching. These films are conformal to the substrate topography even for high-aspect-ratio substrates and show percolated porosity values above 85 percent that are comparable to advanced aerogels. The films deposited at room temperature are amorphous. However, they become partly crystalline at slightly higher temperatures presenting a distribution of anatase clusters embedded in the sponge-like structure. Surprisingly, the porous structure remains after annealing the films at 450 degrees Celsius in air, which increases the fraction of the embedded anatase nanocrystals. The films are antireflective, omniphobic, and photoactive becoming super-hydrophilic subjected to UV light irradiation The supported percolated nanoporous structure can be used as an electron-conducting electrode in perovskite solar cells. The properties of the cells depend on the aerogel film thickness reaching efficiencies close to those of commercial mesoporous anatase electrodes. This generic solvent-free synthesis is scalable and is applicable to ultra-high porous conformal oxides of different compositions with potential applications in photonics, optoelectronics, energy storage, and controlled wetting.Comment: 31 pages, 10 Figs. plus Supporting Information 7 pags, 6 figs. Full Pape

A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo

The development of tools for efficient targeting of antigens to antigen presenting cells is of great importance for vaccine development. We have previously shown that fusion proteins containing antigens fused to the extra domain A from fibronectin (EDA), an endogenous TLR4 ligand, which targets antigens to TLR4-expressing dendritic cells (DC), are highly immunogenic. To facilitate the procedure of joining EDA to any antigen of choice, we have prepared the fusion protein EDAvidin by linking EDA to the N terminus of streptavidin, allowing its conjugation with biotinylated antigens. We found that EDAvidin, as streptavidin, forms tetramers and binds biotin or biotinylated proteins with a ~ 2.6 × 10−14 mol/L. EDAvidin favours the uptake of biotinylated green fluorescent protein by DC. Moreover, EDAvidin retains the proinflammatory properties of EDA, inducing NF-κβ by TLR4-expressing cells, as well as the production of TNF-α by the human monocyte cell line THP1 and IL-12 by DC. More importantly, immunization of mice with EDAvidin conjugated with the biotinylated nonstructural NS3 protein from hepatitis C virus induces a strong anti-NS3 T cell immune response. These results open a new way to use the EDA-based delivery tool to target any antigen of choice to DC for vaccination against infectious diseases and cancer

I Biomaratón de Flora Española: ciencia ciudadana para visibilizar la biodiversidad vegetal

[ES] Con objeto de fomentar el interés por la botánica, surgió la idea de organizar el I Biomaratón de Flora Española: un evento de ciencia ciudadana en el que personas de todo el país salieron a fotografiar el mayor número posible de plantas. Se realizó utilizando la plataforma de ciencia ciudadana iNaturalist, y se vertebró por medio de coordinadores en todas las comunidades autónomas y de alrededor de 100 instituciones, que dieron apoyo y divulgación al evento. Del 21 al 23 de mayo de 2021, más de 1.000 participantes registraron unas 25.000 observaciones de más de 2.500 especies, aproximadamente el 25% de las especies documentadas en España. Además, se organizaron actividades asociadas, como charlas, paseos botánicos, talleres de manejo de la plataforma, etc. Posteriormente se realizó un datablitz, centrado en la identificación de grupos de plantas poco conocidos, complicados y/o atractivos, y en compartir las experiencias de las actividades realizadas, fomentando así la interacción entre botánicos y ciudadanos. Este ha sido el mayor evento de ciencia ciudadana centrado en la botánica organizado en España. Queda demostrado que la acción conjunta de aficionados y profesionales puede ayudar a fomentar la pasión por la biodiversidad.[EN] With the intention of fostering the interest in botany in the society, the idea of organizing the 1st Bioblitz of Spanish Flora arose: a citizen science event in which people from all over the country went out to register as many species of plants as possible through photographs. The event was organized throughout the iNaturalist citizen science platform, and later supported by coordinators in all the Spanish Autonomous Communities and around 100 institutions that gave support and dissemination of the event. From May 21st to 23rd of 2021, more than 1,000 participants recorded about 25,000 observations of more than 2,500 species, approximately 25% of the species documented in Spain. In addition, numerous associated activities were organized, such as talks, botanical walks, workshops, etc. Subsequently, a datablitz was held, focused on the identification of little-known, complicated and/or attractive plant groups, and to share the experiences of the activities carried out, thus promoting interaction between botanists and citizens. To conclude, some of the experiences of the Bioblitz were presented. This is the largest botanical-focused citizen science event ever organized in Spain. It has been proven that the cooperative action of amateurs and professionals might help foster the passion for biodiversity.Motivación y objetivos Resultados del I Biomaratón Evento datablitz para comunicar a científicos y ciudadanos Ciencia ciudadana como motor de interés botánico II Biomaratón de Flora Española Agradecimiento

A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America

Background: Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. Methods: Eleven LS hereditary cancer registries and 34 published LS databases were used to identify unrelated families that fulfilled the Amsterdam II (AMSII) criteria and/or the Bethesda guidelines or suggestive of a dominant colorectal (CRC) inheritance syndrome. Results: We performed a thorough investigation of 15 countries and identified 6 countries where germline genetic testing for LS is available and 3 countries where tumor testing is used in the LS diagnosis. The spectrum of pathogenic MMR variants included MLH1 up to 54%, MSH2 up to 43%, MSH6 up to 10%, PMS2 up to 3% and EPCAM up to 0.8%. The Latin America MMR spectrum is broad with a total of 220 different variants which 80% were private and 20% were recurrent. Frequent regions included exons 11 of MLH1 (15%), exon 3 and 7 of MSH2 (17 and 15%, respectively), exon 4 of MSH6 (65%), exons 11 and 13 of PMS2 (31% and 23%, respectively). Sixteen international founder variants in MLH1, MSH2 and MSH6 were identified and 41 (19%) variants have not previously been reported, thus representing novel genetic variants in the MMR genes. The AMSII criteria was the most used clinical criteria to identify pathogenic MMR carriers although microsatellite instability, immunohistochemistry and family history are still the primary methods in several countries where no genetic testing for LS is available yet. Conclusion: The Latin America LS pathogenic MMR variants spectrum included new variants, frequently altered genetic regions and potential founder effects, emphasizing the relevance implementing Lynch syndrome genetic testing and counseling in all of Latin America countries.Radium Hospital Foundation (Oslo, Norway) in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript, Helse Sør-Øst (Norway) in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript, the French Association Recherche contre le Cancer (ARC) in the analysis, and interpretation of data, the Groupement des Entreprises Françaises dans la Lutte contre le Cancer (Gefluc) in the analysis, and interpretation of data, the Association Nationale de la Recherche et de la Technologie (ANRT, CIFRE PhD fellowship to H.T.) in the analysis, and interpretation of data and by the OpenHealth Institute in the analysis, and interpretation of data. Barretos Cancer Hospital received financial support by FINEP-CT-INFRA (02/2010)info:eu-repo/semantics/publishedVersio