Raiders of the Lost Mud : The geology behind drilling incidents within the Balder Formation around the Corona Ridge, West of Shetland

This work forms part of the lead author’s PhD research, which is funded by a University of Aberdeen College of Physical Sciences Scholarship. This study originally formed part of a talk delivered to the 2017 Schlumberger SIS Forum. Well log and drilling data interpretation was performed using Schlumberger Techlog* wellbore software platform. We would like to thank numerous staff at Schlumberger SIS in Aberdeen for useful discussions. DW would also like to thank staff at Chevron’s Aberdeen office for important insights on the Rosebank Field, particularly the presence of image logs. Andrew Hurst is thanked for informative discussions regarding smectite clays and their origins. Finally, DW would like to thank members of the VMRC Consortium for helpful feedback on a presentation related to the study, particularly staff at Siccar Point Energy. Two anonymous reviewers are thanked for their detailed reviews which greatly improved the paper.Peer reviewedPostprin

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Objective: The HOME BP (Home and Online Management and Evaluation of Blood Pressure) trial aimed to test a digital intervention for hypertension management in primary care by combining self-monitoring of blood pressure with guided self-management. Design: Unmasked randomised controlled trial with automated ascertainment of primary endpoint. Setting: 76 general practices in the United Kingdom. Participants: 622 people with treated but poorly controlled hypertension (>140/90 mm Hg) and access to the internet. Interventions: Participants were randomised by using a minimisation algorithm to self-monitoring of blood pressure with a digital intervention (305 participants) or usual care (routine hypertension care, with appointments and drug changes made at the discretion of the general practitioner; 317 participants). The digital intervention provided feedback of blood pressure results to patients and professionals with optional lifestyle advice and motivational support. Target blood pressure for hypertension, diabetes, and people aged 80 or older followed UK national guidelines. Main outcome measures: The primary outcome was the difference in systolic blood pressure (mean of second and third readings) after one year, adjusted for baseline blood pressure, blood pressure target, age, and practice, with multiple imputation for missing values. Results: After one year, data were available from 552 participants (88.6%) with imputation for the remaining 70 participants (11.4%). Mean blood pressure dropped from 151.7/86.4 to 138.4/80.2 mm Hg in the intervention group and from 151.6/85.3 to 141.8/79.8 mm Hg in the usual care group, giving a mean difference in systolic blood pressure of −3.4 mm Hg (95% confidence interval −6.1 to −0.8 mm Hg) and a mean difference in diastolic blood pressure of −0.5 mm Hg (−1.9 to 0.9 mm Hg). Results were comparable in the complete case analysis and adverse effects were similar between groups. Within trial costs showed an incremental cost effectiveness ratio of £11 ($15, €12; 95% confidence interval £6 to £29) per mm Hg reduction. Conclusions: The HOME BP digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs. Implementation in primary care will require integration into clinical workflows and consideration of people who are digitally excluded. Trial registration: ISRCTN13790648

The use of crowdfunding by environmental entrepreneurs: is it all about cash?

This chapter explores why environmental ventures engage in crowdfunding and the benefits of engagement with this form of financing. Insight from a single revelatory case study suggests that intangible benefits such as community support, awareness building and marketing may be of greater importance to environmental ventures than simply raising finance. The findings contribute to the nascent crowdfunding literature and raise a number of issues that would benefit from further research. The literature, and our understanding of crowdfunding, would also benefit from further quantitative and qualitative research examining environmental ventures in order to identify issues relating to tangible and intangible benefits across a wider range of organisations

A British Society for Haematology good practice paper: Recommendations for laboratory testing of <scp>UK</scp> patients with acute myeloid leukaemia

No abstract available

Dynamics of North Atlantic deep water masses during the Holocene

High resolution flow speed reconstructions of two core sites located on Gardar Drift in the North East Atlantic Basin and Orphan Knoll in the North West Atlantic Basin reveal a long-term decrease in flow speed of North East Atlantic Deep Water (NEADW) after 6,500 years. Benthic foraminiferal oxygen isotopes of sites currently bathed in NEADW show a 0.2‰ depletion after 6,500 years, shortly after the start of the development of a carbon isotope gradient between NEADW and Norwegian Sea Deep Water. We consider these changes in near-bottom flow vigour and benthic foraminiferal isotopic records to mark a significant reorganization of the Holocene deep ocean circulation, and attribute the changes to a weakening of NEADW flow during the mid to late Holocene that allowed the shoaling of Lower Deep Water and deeper eastward advection of Labrador Sea Water into the North East Atlantic Basin