Cambrian-Eocene pre-rift, pulsed rift, passive margin and emplacement processes along the northern margin of the Southern Neotethys: evidence from the Antalya Complex in the Alanya Window (S Turkey)

Sedimentary rocks in the Alanya Window document pulsed Permian-Triassic rifting in a proximal basin setting, adjacent to the Tauride continental unit (Geyik Dağ). Late Cambrian-Early Ordovician clastic sediments accumulated along the north margin of Gondwana on a variable shallow-marine shelf. Above an unconformity related to rift-shoulder uplift, Late Permian facies document shallow-marine to evaporitic environments during regional tectonic subsidence (first main rift pulse). Above a second unconformity (both extension and sea-level controlled), Early Triassic carbonates and mudrocks accumulated on an unstable, gently subsiding shelf. Mudrocks, sandstones and lithoclastic debris-flows, derived from the underlying succession, accumulated during the Middle Triassic (Anisian-early Ladinian), implying strong tectonic subsidence and flank uplift (second main rift pulse). Radiolarian mudstones accumulated during late Middle Triassic-early Late Triassic in a well-oxidised, organically productive, but relatively quiescent, deep-water basin above the carbonate compensation depth (CCD). Thick (100s m) lithoclastic sandstone turbidites (commonly plant-rich) and localised debris-flows accumulated during the Late Triassic (Carnian), together with detached blocks of underlying lithologies (third main rift pulse, with regional uplift). Alkaline basaltic sills were intruded locally. Final continental break-up to create the Southern Neotethys took place regionally during the Late Triassic (Carnian). Latest Triassic-Late Cretaceous deposition records passive margin subsidence. Variable low-grade metamorphism and two-stage tectonic emplacement (southwards(?) then northwards) took place during latest Cretaceous and Eocene, respectively. The tectonic-sedimentary development of the Antalya Complex provides insights into rift/continental break-up processes that differ from the recently well-documented Alpine-North Atlantic region.Publisher PDFPeer reviewe

Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes

This research was originally published in Blood Online. Tummala, H., et al. (2018). "Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes." Blood 132(12): 1349-1353. Title. Blood. Prepublished Sept 20 2018; DOI https://doi.org/10.1182/blood-2018-03-837799Dyskeratosis congenita (DC) and its severe form, Hoyeraal-Hreidarsson syndrome (HHS), are rare and have life-threatening failure of hematopoiesis. Typically, DC patients present with disease features such as nail dystrophy, oral leukoplakia, and abnormal skin pigmentation along with peripheral pancytopenia and marrow hypoplasia with strong predisposition to cancer.1 In DC, hematopoietic failure occurs due to critical shortening of telomeres,2,3 which enhances the DNA damage response4,5 and leads to premature senescence of hematopoietic stem cellsMedical Research Council (grant MR/P018440/1), Bloodwise (grant 14032), and Children with Cancer UK (grant 2013/144)

Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications—a review

Item does not contain fulltextBACKGROUND: The objective of this review is to evaluate the efficacy of Pulsed Radiofrequency (PRF) treatment in chronic pain management in randomized clinical trials (RCTs) and well-designed observational studies. The physics, mechanisms of action, and biological effects are discussed to provide the scientific basis for this promising modality. METHODS: We systematically searched for clinical studies on PRF. We searched the MEDLINE (PubMed) and EMBASE database, using the free text terms: pulsed radiofrequency, radio frequency, radiation, isothermal radiofrequency, and combination of these. We classified the information in two tables, one focusing only on RCTs, and another, containing prospective studies. Date of last electronic search was 30 May 2010. The methodological quality of the presented reports was scored using the original criteria proposed by Jadad et al. FINDINGS: We found six RCTs that evaluated the efficacy of PRF, one against corticosteroid injection, one against sham intervention, and the rest against conventional RF thermocoagulation. Two trials were conducted in patients with lower back pain due to lumbar zygapophyseal joint pain, one in cervical radicular pain, one in lumbosacral radicular pain, one in trigeminal neuralgia, and another in chronic shoulder pain. CONCLUSION: From the available evidence, the use of PRF to the dorsal root ganglion in cervical radicular pain is compelling. With regards to its lumbosacral counterpart, the use of PRF cannot be similarly advocated in view of the methodological quality of the included study. PRF application to the supracapular nerve was found to be as efficacious as intra-articular corticosteroid in patients with chronic shoulder pain. The use of PRF in lumbar facet arthropathy and trigeminal neuralgia was found to be less effective than conventional RF thermocoagulation techniques

The effects of turbulence and combustion models on supersonic combustion using computational fluid dynamics

Scramjet, süpersonik koşullarda yanmanın gerçekleştiği motorlara verilen isimdir. Turbomakine parçalara sahip olmadan itki sağlar. Bu tez kapsamında iki farklı Scramjet yanma odasının, hesaplamalı akışkanlar dinamiği kullanılarak analizleri gerçekleştirilmiştir. İlk süpersonik yanma odası alev tutucu içeren hidrojen yakıtlı DLR (Deutsches Zentrum für Luft- und Raumfahrt) Scramjet yanma odasının ve ikinci olarak Virginia Üniversitesi çift modlu Scramjet yanma odası: configuration A'nın hesaplamalı akış analizleri gerçekleştirilmiştir. Birinci kısımda, Reynolds-averaged Navier Stokes (RANS) yaklaşımı kullanılmıştır. Türbülanslı yanma bölgesini çözümlemek adına DLR Scramjet yanma odası farklı hidrojen-hava reaksiyon mekanizmaları, RANS temelli türbülans modelleri ve yanma modelleri kullanılarak analizler gerçekleştirilmiştir. Çalışma sonucunda analizler çözüm ağından başarılı bir şekilde bağımsızlaştırılmış, türbülans modeli, yanma modeli ve reaksiyon mekanizması çalışmaları çözüm ağı II kullanılarak gerçekleştirilmiştir. Yanma modeli çalışması Flamelet Generated Manifold (FGM), Standart Flamelet Model (SLF) ve Arrhenius yaklaşımı (FRC) yanma modelleri kullanarak yapılmıştır. Türbülans modeli ve yanma modeli çalışmaları için tüm reaksiyonlar, Burke hidrojen-hava reaksiyon mekanizması kullanılarak gerçekleştirilmiştir. Buna ek olarak FGM yanma modeli ile üç farklı hidrojen hava reaksiyon mekanizmasının etkileri incelenmiştir. Realizable k-? türbülans modeli FGM yanma modeli ve Burke hidrojen hava mekanizması analiz sonuçları, deney sonuçları ile karşılaştırdığında maksimum sapma %5'tir. Ayrıca farklı ilerleme değişkenleri kullanılarak parametrik bir çalışma gerçekleştirilmiştir. İkinci kısımda, Virginia Üniversitesi çift modlu Scramjet yanma odası: configuration A analizleri mevcut CARS deney sonuçları üzerinden sıcaklık ve diğer türlerin dağılımı ile analiz sonuçlarını karşılaştırmak adına gerçekleştirilmiştir. Standart Flamelet (SLF) yanma modeli ve Large Eddy Simulation (LES) kullanılarak yapılan analizlerde Wall Adapting Local Eddy Viscosity (WALE) subgrid scale modeli kullanılmıştır. Analiz sonuçları Coherant anti-Stokes Raman scattering (CARS) ölçümleri, hidrojen oranı, oksijen oranı, azot oranı ve sıcaklık, ve duvar basınç ölçümleri ile kıyaslandığında SLF yanma modelinin ortalama alev sıcaklıkları ve karışım hızını deneyden %15 daha yüksek tahmin ettiği görülmektedir. Buna karşın sıcaklık dağılımları ölçüm sonuçları ile uyum göstermektedir.Supersonic Ramjet (Scramjet) engines generate thrust without any turbomachinery parts. In Scramjet engines, combustion occurs in supersonic speeds. In this work, computational fluid dynamics (CFD) simulations are carried out on two different supersonic combustion ramjet (Scramjet) combustors. Present study is performed in two parts on two different combustors: first combustor is, wedge shaped, hydrogen fueled DLR Scramjet combustor. Second combustor is dual-mode, single ramp injected, hydrogen fueled Scramjet combustor, which is located at University of Virginia (UVa). In Part I, Reynolds-averaged Navier Stokes (RANS) simulation technique is used on DLR Scramjet combustor. In order to predict turbulent reacting flow field on DLR Scramjet combustor, different hydrogen-air reaction mechanisms, RANS-based turbulence models and combustion models are compared. Grid independence is proven with three different hex-dominant computational grids. All studies are conducted with medium computational grid. Combustion model study is conducted with flamelet generated manifold (FGM), standard flamelet model (SLF) and laminar chemistry (Arrhenius) combustion models. For both FGM and SLF flamelet tables are generated using Burke hydrogen-air reaction mechanism. Three different hydrogen-air reaction mechanisms are compared with FGM combustion model. Comparison with experimental data indicates, realizable k-? turbulence model predicts axial velocity better and FGM combustion model shows maximum %5 deviation with experimental data. Additionally, parametric progress variable study is performed. Different combination of species is defined as progress variable. It is seen that different progress variables are affect the temperature field. In Part II, in order to examine simulation results on species distribution, CFD simulations of UVa dual-mode Scramjet combustor: configuration A is carried out using SLF combustion model with LES. WALE subgrid scale model is used for LES. Simulation results are compared with experimental data that include distributions of H2, N2, O2 and temperature with Coherant anti-Stokes Raman scattering (CARS) and wall pressure distributions. SLF with LES over predicts average flame temperatures and mixing rate. Nonetheless, temperature distribution shows fair agreement with CARS data

The effect of atropine and fentanyl on QT interval [Atropin ve fentanilin QT araligi uzerine etkileri]

Prolongation of the QT interval is a good prognostic criteria for cardiac arrhythmias. In our study, the effects of the atropine and fentanyl on the QT interval has been assessed and their probable role on the cardiac arrhythmias has been researched. The EKG was recorded before and after IV administration of the 0.015 mg/kg atropine and 2 µg/kg fentanyl to 15, ASA I adult patients undergoing elective surgery. QT intervals were corrected according to Bazett's formula. Heart rate and QT increased significantly after atropine but decreased after fentanyl. Atropine should be used carefully in diabetic patients who may have vagal denervation and in patients with a congenital or required prolonged QT interval syndrome who are predisposed premature beats. In clinical dosages, opioids can have protective effects on the prolongation of the QT interval caused vagal blockage

Acute Promyelocytic Leukemia in a Child with Reticulin Fibrosis

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FIELD TRIALS OF ESTRUS SYNCHRONIZATION AND AL-RESULTS IN AN ARAB BROODMARE HERD IN THE NATIONAL STUD HASIRCI ESKISEHIR (TURKEY)

An Arab broodmare herd of 30 mares age ranging from 4 to 12 years was grouped into 3 groups (group A, B, C) with 1 0 mares each and exposed to three different methods of cycle synchronisation

Hb H Disease Diagnosed During Adolescent Pregnancy

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DOCUMENTATION OF SEXUAL CYCLE FEATURES, MATING AND AL-RESULTS IN ARAB HORSE AND HAFLINGER HERDS IN STUDS AND PRIVATE STUDFARMS IN WEST AND MIDDLE ANATOLIA

Within a german-turkish university partnership documentation of reproductive data of brood-mares was performed as a part project of the cooperation contract. In the study Arab, Haflinger and cross-breed mares were included. The mares mainly were housed in big studfarms and a smaller part was kept under small private farms. Almost three quarters of both the Arab and Haflinger mares exhibited an estrous length of 1-4 days, whereas the others showed a heat duration of a period of 5-10 days. In the same group of probands a mean length of sexual cycle of 18-24 days could be observed in 38.2 % of the Haflinger. The majority of the other mares in both races documented a cycle duration of more than 25 days. The remarkable short duration of heat is discussed as caused by the sharp change from winter to spring environment conditions in that area. An explanation of the marked long mean cycle interval is difficult and might be caused by inadequate documentation of the data. Conception results and foaling data as 83.4 % resp. 78.8 % in the Arabs and 76.6 % resp. 74.8 % in the Haflinger mares are within the international standard