Auf den Spuren von Jane Jacobs: Über Trottoir-Ballett, Bevölkerungsbeteiligung und Vielfalt

Am ersten Maiwochenende nehmen weltweit Tausende Menschen in verschiedenen Städten an einem Spaziergang zu Ehren von Jane Jacobs teil. Doch wer war eigentlich Jane Jacobs? Die Stadtkritikerin prägt bis heute den Diskurs über unsere Siedlungsräume und hilft uns, unsere Umgebung bewusster wahrzunehmen. Das Trottoir-Ballett ist eine Wortschöpfung von Jane Jacobs. Sie veranschaulicht damit die Vielfalt der alltäglichen Wege und Aktivitäten der Bevölkerung von dichten und nutzungsgemischten Quartieren. Das Ballett folgt einer spontanen Choreografie zwischenmenschlicher Interaktionen, wie einem Gespräch unter Nachbarn oder einem flüchtigen Winken. Jane Jacobs stellte die Menschen in den Mittelpunkt ihrer Arbeit. Sie plädiert für die Bedeutung der Vielfalt im öffentlichen Raum, um lebenswerte Städte mit gut funktionierenden Nachbarschaften zu verwirklichen. Dazu gehört auch die Sichtbarkeit unterschiedlicher Bevölkerungsgruppen wie Kinder, ältere Menschen oder Personen auf dem Weg zur Arbeit

Evaluation of a bacteriocin-producing strain of pediococcus acidilactici as a biopreservative for "alheira", a fermented meat sausage

This study was conducted to evaluate the ability of Pediococcus acidilactici HA-6111-2, a PA-1 bacteriocinproducing lactic acid bacterium (LAB), isolated from ‘‘Alheira” to inhibit a cocktail of Listeria innocua strains during production and shelf-life of these products. The bacteriocinogenic culture reduced the Listeria population below the detection limit (1.5log CFU/g) and had no effect on the growth of the natural LAB flora or on the pH. Pathogenic organisms were not detected in any sample. The presence of some virulence factors and antibiotic resistances of the strain to be used as a bioprotective culture were investigated. P. acidilactici HA-6111-2 did not produce any of the biogenic amines tested; no formation of biofilms was observed; more L(+)lactic acid was produced than its isomer D(-); no gelatinase, DNase or lipase activity was recorded; no structural genes for the haemolysin, enterococcal surface protein, hydrolytic compounds, aggregation protein and cell-wall adhesins were detected, no significant antibiotic resistances were found. P. acidilactici HA-6111-2 appears to have potential as a bioprotective culture during ‘‘Alheira” fermentation. Moreover, a trained panel considered the protected product to be sensorially acceptable

Polarização e construção da força discursiva em manifestos políticos: o caso das presidenciais portuguesas de 2016

O presente estudo analisa o manifesto político apresentado publicamente por um dos dez candidatos às eleições presidenciais portuguesas de janeiro de 2016. O objetivo do estudo é, através do quadro de análise proposto por Adam (2001) para a descrição dos gêneros textuais em oito componentes (semântica; composicional; enunciativa; pragmática; estilístico-fraseológica; metatextual; peritextual e material), proceder a uma análise completa e integrada do texto, que torne visíveis os princípios centrais da sua organização argumentativa enunciativa e pragmática e, logo, os princípios da sua força discursiva. Ao mesmo tempo, a análise contribuirá para a descrição deste gênero de texto, pertencente ao tipo de discurso político, situando o texto numa zona prototípica do gênero.The present study analyzes the political manifesto publicly presented by one of the ten candidates to the Portuguese presidential elections of January 2016. The objective of the study is, through the framework of analysis proposed by Adam (2001) for the description of the textual genres in eight components (semantic, compositional, enunciative, pragmatic, stylistic-phraseological, metatextual, peritextual and material), to carry out a complete and integrated analysis of the text that makes visible the main principles of its argumentative, enunciative and pragmatic organization and hence the principles of its discursive force. At the same time, the analysis will contribute to the description of this text genre belonging to the political discourse type, placing the text in aprototypical area of the genre

White Paper: Designing the perfect New European Bauhaus neighbourhood

The concept of Smart Healthy Age-Friendly Environments (SHAFE) emphasises the comprehensive person-centred experience as essential to promoting living environments. SHAFE takes an interdisciplinary approach, conceptualising complete and multidisciplinary solutions for an inclusive society. From this approach, we promote participation, health, and well-being experiences by finding the best possible combinations of social, physical, and digital solutions in the community. This initiative emerged bottom-up in Europe from the dream and conviction that innovation can improve health equity, foster caring communities, and sustainable development. Smart, adaptable, and inclusive solutions can promote and support independence and autonomy throughout the lifespan, regardless of age, gender, disabilities, cultural differences, and personal choices, as well as promote happier and fairer living places. The New European Bauhaus initiative gathers "beautiful, sustainable, and inclusive projects and ideas" to inspire a positive transformation around us. The New European Bauhaus 2024 Festival took place between 9-13 April. "Designing the perfect New European Bauhaus neighbourhood: New European Bauhaus meets SHAFE" was a Satellite Event of the Festival, held as an online workshop, organised by the SHAFE Foundation on April 9th, 2024. At the event, a group of 50 participants with a multidisciplinary background discussed how to meet the challenges of the European Garcia family to enable them to live in a perfect neighbourhood. The White Paper presents the findings of the participants with the New European Bauhaus inspiring projects and ideas to house the European Garcia family in their neighbourhood. The White Paper recommends developers, designers, planners, and policymakers to include person-centred design of social and physical environments and technologies. Although awareness of person-centred design is growing, many initiatives still hamper the inclusion of citizens or end-users throughout the development of products and services

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Écobilans des bâtiments

Die Ziele der nachhaltigen Entwicklung müssen bis 2030 erreicht werden. Noch dringlicher sieht es beim Pariser Klimaabkommen aus: Die Massnahmen müssen ab sofort umgesetzt werden. Die Baubranche steht bei der Reduktion der CO2-Emissionen im Fokus. Und sie hat grosses Potenzial, diese Herausforderung zu meistern.Les objectifs du développement durable doivent être atteints d’ici 2030. L’Accord de Paris sur le climat, lui, est encore plus urgent : les mesures doivent être appliquées dès à présent. Le domaine de la construction est en ligne de mire pour la réduction des émissions de CO2 et a un haut potentiel pour relever ce défi

l-proline supplementation improves nitric oxide bioavailability and counteracts the blood pressure rise induced by angiotensin II in rats

We evaluated whether l-proline (Pro) supplementation improves redox status and nitric oxide (NO) bioavailability and prevents or delays angiotensin II (AngII)-induced hypertension. Male Sprague-Dawley rats were distributed to four experimental groups: Pro + AngII (Pro-Ang), Pro + Saline (Pro-Sal), Vehicle + AngII (Veh-Ang) and Veh + Saline (Veh-Sal). Pro solution (2 g.kg-1·day-1) or water (vehicle) were orally administered, from day 0 to day 21. AngII (200 ng.kg-1.min-1) or saline were infused (s.c.) from day 7 to day 21. Systolic blood pressure (SBP) was measured by the tail-cuff method. From day 20-21, animals were kept on metabolic cages for 24h-urine collection. On day 21, urine and blood were collected for further quantification of redox status biomarkers, NO-related markers (urinary nitrates and nitrites, U-NOx; plasma asymmetric dimethylarginine, P-ADMA), metabolic and renal parameters. Pro prevented the AngII-induced SBP rise [mean (95% CI), Day 19: Pro-AngII, 137 (131; 143) vs. Veh-AngII, 157 (151; 163) mm Hg, P < 0.001]. Pro-AngII rats also had increased values of U-NOx, systemic and urinary total antioxidant status (TAS), urinary H2O2 and plasma urea, as well as reduced P-ADMA and unaltered urinary isoprostanes. Plasma Pro was inversely correlated with P-ADMA (r = -0.52, p = 0.0009) and positively correlated with urinary TAS (r = 0.55, p = 0.0005) which, in turn, was inversely correlated with P-ADMA (r = -0.56, p = 0.0004). Furthermore, urinary H2O2 values decreased across P-ADMA tertiles (p for linear trend = 0.023). These results suggest that Pro reduces P-ADMA levels and improves redox status, thereby increasing NO bioavailability and counteracting the AngII-induced SBP rise. H2O2 and TAS modulation by Pro may contribute to the reduced P-ADMA concentration.The authors acknowledge funding under project “NORTE-07-0124- FEDER-000001 – Neurodegenerative Disorders”, co-funded by North Portugal Regional Operational Programme (ON.2—O Novo Norte), under QREN (National Strategic Reference Framework) through FEDER (European Regional Development Fund), and by FCT (Fundação para a Ciência e a Tecnologia, Portugal). This study was also funded by the Program PT2020 (project 007265 -UID/QUI/50006/2013) supported by FCT and FEDER. Teresa Sousa and Sónia Fraga were funded by FCT and POPH/FSE (EC) (Human Potential Operational Programme/ European Social Fund (European Comission) (Ciência 2008 Contract). Teresa Sousa is currently funded by FCT (SFRH/BPD/112005/2015). Luísa Teixeira-Santos is funded by University of Porto/Faculty of Medicine and by ESF – European Social Fund, through NORTE2020 – North Portugal Regional Operational Programme (NORTE-08-5369- FSE-000011-Doctoral Programmes). Fig. 6. Mean (95% CI) plasma values of ADMA (A) and L-Arginine/ADMA ratio (B) for the different experimental groups (Veh-Sal, n=9; Pro-Sal, n=8; Veh-Ang, n=10; Pro-Ang, n=10) at the end of the experiment (day 21). Data were analysed with single measure parametric analysis (ANOVA), with 2 experimental factors (Pro and Ang) and a blocking factor. P-values obtained from the analysis for each factor and interaction of factors are presented in tables below the graphs. Results from multiple comparison procedures, performed as described in section 2.7, are indicated on the graph. J. Leal et al. Nitric Oxide 82 (2019) 1–11.info:eu-repo/semantics/publishedVersio

The Impact of Storage Conditions and Bottle Orientation on the Evolution of Phenolic and Volatile Compounds of Vintage Port Wine

This work evaluates the influence of the cellar conditions and bottle orientation, on the phenolic and volatile composition of a Vintage Port wine, sealed with natural cork stoppers, for 44 months post-bottling. The storage was performed in two different cellars, namely a cellar A with controlled temperature and humidity, and a cellar B, representing a traditional cellar, with uncontrolled temperature and humidity. The impact of bottle orientation was studied in cellar A, where the bottles were stored in horizontal and vertical positions. The phenolic and volatile composition of the bottled Vintage Port wine were analyzed after 6, 15 and 44 months. The results unveiled that the cellar conditions and bottle orientation had an impact in Port wine composition which was higher at 44 months post-bottling. The samples stored in the traditional cellar unveiled significantly higher yellow tones, lower tannin specific activity, and higher levels of furfural and 5-methylfurfural. Furthermore, the samples stored in the horizontal position revealed significant higher levels of total proanthocyanidins and higher tannin specific activity than the samples stored in the vertical position. Interestingly, for the first time to our knowledge, an ellagitannin-derived compound (Corklin) was detected in Vintage Port wines stored in the horizontal position, which results from the reaction of cork constituents with phenolic compounds present in wines

Cardio-respiratory health effects of exposure to traffic-related air pollutants while exercising outdoors: A systematic review

Despite physical exercise provides numerous health benefits, outdoor exercisers are frequently exposed to traffic-related air pollutants (TRAP) known to be associated with respiratory and cardiovascular diseases. The aim of this systematic review was to investigate the effects of TRAP exposure, specifically particulate matter and nitrogen dioxide (NO2), during outdoor exercise on cardio-respiratory health effects. Systematic database searches of PubMed, Web of Science, Scopus and Medline were performed by two researchers to identify peer-reviewed studies from 2000 to 2018. Combinations of keywords related to cardio-respiratory health effects, physical exercise and ambient air pollution were used. Thirteen studies were included, originating predominantly from European countries but also the American. They suggested that exercising in an environment with high TRAP exposure increases markers of respiratory and systemic inflammation, as well as, impairs the vascular function and increases artery pressure, when compared with an environment with low-TRAP exposure. In addition, the smaller particles appear to have the most severe health consequences compared with the larger coarse particles and NO2. This study also provides evidence that specific groups of the population have enhanced susceptibility to adverse effects from particulate matter exposure while exercising. There is a need for more studies focused on the relationship between air pollution, physical exercise and health, as large societal benefits can be obtained from healthy environments that can promote outdoor physical exercise.Highlights: High TRAP exposure increases markers of respiratory and systemic inflammation; Evidence of impairment of vascular function and increased artery pressure was noted; Severe health consequences were observed for PM2.5, compared with PM10 and NO2; The healthy population can be also affected by TRAP exposure.This study was supported by Fundação para a Ciência e a Tecnologia (FCT) through the scholarship SFRH/BPD/115112/2016 (Joana Madureira), FUMDES Fund for Support to the Maintenance and Development of Higher Education of the Santa Catarina State and Coordination for the Improvement of Higher Education Personnel- CAPES/Brazil.info:eu-repo/semantics/publishedVersio