Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study

Background: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. Objectives: To identify early-life risk factors for eczema, and to explore how early-life risk factors explain any differences in eczema. Methods: We estimated odds ratios (ORs) for ever having had eczema by age 5 years in 14 499 children from the U.K. Millennium Cohort Study (MCS), with a focus on maternal, antenatal and early-life risk factors and socioeconomic circumstances (SECs). Risk factors were explored to assess whether they attenuated associations between SECs and eczema. Results: Overall 35·1% of children had ever had eczema by age 5 years. Children of mothers with degree-level qualifications vs. no educational qualifications were more likely to have eczema (OR 1·52, 95% confidence interval 1·31–1·76), and there was a gradient across the socioeconomic spectrum. Maternal atopy, breastfeeding (1–6 weeks and ≥ 6 months), introduction of solids under 4 months or cow's milk under 9 months, antibiotic exposure in the first year of life and grime exposure were associated with an increased odds of having eczema. Female sex, Pakistani and Bangladeshi ethnicity, smoking during pregnancy, exposure to environmental tobacco smoke and having more siblings were associated with reduced odds for eczema. Controlling for maternal, antenatal and early-life characteristics (particularly maternal smoking during pregnancy, breastfeeding and number of siblings) reduced the OR for eczema to 1·26 (95% confidence interval 1·03–1·50) in the group with the highest educational qualifications compared with the least. Conclusions: In a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early-life factors including not smoking during pregnancy, breastfeeding and having fewer siblings

Exploring the development of team identification.

The article discusses a study investigating the development of identification with sports teams, with particular focus given to the application of social identity theory and the psychological continuum model (PCM). The development of internal meaning attached to the team and external actions such as searching for team-related information and promoting the team to others is examined, and the influence of media on attitude formation is commented on. A review of previous literature on the topic is also provided

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography

Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine (18FLT) has allowed PET to image cellular proliferation by utilising the salvage pathway of DNA synthesis. In this study, we have compared uptake of 18FLT and 18FDG with MIB-1 immunohistochemistry to evaluate the role of PET in quantifying in vivo cellular proliferation in colorectal cancer (CRC). Patients and methods: Patients with resectable, primary, or recurrent CRC were prospectively studied. Thirteen lesions from 10 patients (five males, five females), median age 68 years (range 54–87), were evaluated. Patients underwent 18FDG and 18FLT PET scanning. Tracer uptake within lesions was quantified using standardised uptake values (SUVs). Histopathological examination and MIB-1 immunohistochemistry were performed on all lesions, and proliferation quantified by calculating a labelling index (% of MIB-1 positively stained nuclei within 1500 tumour cells). Results: Histology confirmed adenocarcinoma in 12 of 13 lesions; the remaining lesion was reactive. All eight extrahepatic lesions were visualised using both 18FLT and 18FDG. Three of the five resected liver metastases were also avid for 18FLT and showed high proliferation, while the remaining two lesions which demonstrated no uptake of 18FLT had correspondingly very low proliferation. There was a statistically significant positive correlation (r =0.8, p<0.01) between SUVs of the tumours visualised with 18FLT and the corresponding MIB-1 labelling indices. No such correlation was demonstrated with 18FDG avid lesions (r =0.4). Conclusions: 18FLT PET correlates with cellular proliferation markers in both primary and metastatic CRC. This technique could provide a mechanism for in vivo grading of malignancy and early prediction of response to adjuvant chemotherapy

Cardinal characteristics at in a small u (κ) model

We provide a model where u(κ)<2κu(κ)<2κ for a supercompact cardinal κ. [10] provides a sketch of how to obtain such a model by modifying the construction in [6]. We provide here a complete proof using a different modification of [6] and further study the values of other natural generalizations of classical cardinal characteristics in our model. For this purpose we generalize some standard facts that hold in the countable case as well as some classical forcing notions and their properties

Electron correlation energy in confined two-electron systems

Radial, angular and total correlation energies are calculated for four two-electron systems with atomic numbers Z=0-3 confined within an impenetrable sphere of radius R. We report accurate results for the non-relativistic, restricted Hartree-Fock and radial limit energies over a range of confinement radii from 0.05 - 10 a0. At small R, the correlation energies approach limiting values that are independent of Z while at intermediate R, systems with Z > 1 exhibit a characteristic maximum in the correlation energy resulting from an increase in the angular correlation energy which is offset by a decrease in the radial correlation energy

Multiplicative renormalizability of gluon and ghost propagators in QCD

We reformulate the coupled set of continuum equations for the renormalized gluon and ghost propagators in QCD, such that the multiplicative renormalizability of the solutions is manifest, independently of the specific form of full vertices and renormalization constants. In the Landau gauge, the equations are free of renormalization constants, and the renormalization point dependence enters only through the renormalized coupling and the renormalized propagator functions. The structure of the equations enables us to devise novel truncations with solutions that are multiplicatively renormalizable and agree with the leading order perturbative results. We show that, for infrared power law behaved propagators, the leading infrared behavior of the gluon equation is not solely determined by the ghost loop, as concluded in previous studies, but that the gluon loop, the three-gluon loop, the four-gluon loop, and even massless quarks also contribute to the infrared analysis. In our new Landau gauge truncation, the combination of gluon and ghost loop contributions seems to reject infrared power law solutions, but massless quark loops illustrate how additional contributions to the gluon vacuum polarization could reinstate these solutions. Moreover, a schematic study of the three-gluon and four-gluon loops shows that they too need to be considered in more detail before a definite conclusion about the existence of infrared power behaved gluon and ghost propagators can be reached.Comment: 13 pages, 1 figure, submitted to Phys. Rev.

Changes in the trajectory of the radio jet in 0735+178?

We present multi-epoch 8.4 and 43 GHz Very Long Baseline Array images of the BL Lac object 0735+178. The images confirm the presence of a twisted jet with two sharp apparent bends of 90$^{\circ}$ within two milliarcseconds of the core, resembling a helix in projection. The observed twisted geometry could be the result of precession of the jet inlet, but is more likely produced by pressure gradients in the external medium through which the jet propagates. Quasi-stationary components are observed at the locations of the 90$^{\circ}$ bends, possibly produced by differential Doppler boosting. Identification of components across epochs, since the earliest VLBI observations of this source in 1979.2, proves difficult due to the sometimes large time gaps between observations. One possible identification suggests the existence of superluminal components following non--ballistic trajectories with velocities up to $11.6\pm 0.6 h_{65}^{-1} c$. However, in images obtained after mid-1995, components show a remarkable tendency to cluster near several jet positions, suggesting a different scenario in which components have remained nearly stationary in time at least since mid-1995. Comparison with the earlier published data, covering more than 19 years of observations, suggests a striking qualitative change in the jet trajectory sometime between mid-1992 and mid-1995, with the twisted jet structure with stationary components becoming apparent only at the later epochs. This would require a re-evaluation of the physical parameters estimated for 0735+178, such as the observing viewing angle, the plasma bulk Lorentz factor, and those deduced from these.Comment: 18 pages, 5 figures, accepted for publication in MNRA

Precision Timing Measurements of PSR J1012+5307

We present results and applications of high precision timing measurements of the millisecond pulsar J1012+5307. Combining our radio observations with results based on optical observations, we derive complete 3-D velocity information for this system. Correcting for Doppler effects, we derive the intrinsic spin parameters of this pulsar and a characteristic age of 8.6 +/- 1.9 Gyr. Our upper limit for the orbital eccentricity of only 8 * 10^-7 (68% C.L.) is the smallest ever measured for a binary system. We demonstrate that this makes the pulsar an ideal laboratory to test certain aspects of alternative theories of gravitation. Our precise measurements suggest deviations from a simple pulsar spin-down timing model, which are consistent with timing noise and the extrapolation of the known behaviour of slowly rotating pulsars.Comment: 9 pages, 6 figure

On the spherical-axial transition in supernova remnants

A new law of motion for supernova remnant (SNR) which introduces the quantity of swept matter in the thin layer approximation is introduced. This new law of motion is tested on 10 years observations of SN1993J. The introduction of an exponential gradient in the surrounding medium allows to model an aspherical expansion. A weakly asymmetric SNR, SN1006, and a strongly asymmetric SNR, SN1987a, are modeled. In the case of SN1987a the three observed rings are simulated.Comment: 19 figures and 14 pages Accepted for publication in Astrophysics & Space Science in the year 201

Multiplicative renormalizability and quark propagator

The renormalized Dyson-Schwinger equation for the quark propagator is studied, in Landau gauge, in a novel truncation which preserves multiplicative renormalizability. The renormalization constants are formally eliminated from the integral equations, and the running coupling explicitly enters the kernels of the new equations. To construct a truncation which preserves multiplicative renormalizability, and reproduces the correct leading order perturbative behavior, non-trivial cancellations involving the full quark-gluon vertex are assumed in the quark self-energy loop. A model for the running coupling is introduced, with infrared fixed point in agreement with previous Dyson-Schwinger studies of the gauge sector, and with correct logarithmic tail. Dynamical chiral symmetry breaking is investigated, and the generated quark mass is of the order of the extension of the infrared plateau of the coupling, and about three times larger than in the Abelian approximation, which violates multiplicative renormalizability. The generated scale is of the right size for hadronic phenomenology, without requiring an infrared enhancement of the running coupling.Comment: 17 pages; minor corrections, comparison to lattice results added; accepted for publication in Phys. Rev.