H-alpha and Free-Free Emission from the WIM

Recent observations have found the ratio of H-alpha to free-free radio continuum to be surprisingly high in the diffuse ionized ISM (the so-called WIM), corresponding to an electron temperature of only ~3000K. Such low temperatures were unexpected in gas that was presumed to be photoionized. We consider a 3-component model for the observed diffuse emission, consisting of a mix of (1) photoionized gas, (2) gas that is recombining and cooling, and (3) cool H I gas. This model can successfully reproduce the observed intensities of free-free continuum, H-alpha, and collisionally-excited lines such as NII 6583. To reproduce the low observed value of free-free to H-alpha, the PAH abundance in the photoionized regions must be lowered by a factor ~3, and ~20% of the diffuse H-alpha must be reflected from dust grains, as suggested by Wood & Reynolds (1999).Comment: 25 pages, 7 figures, 4 tables, single column, details of the calculation and atomic physics added, accepted by Ap

Formation of iron nitride thin films with Al and Ti additives

In this work we investigate the process of iron nitride (Fe-N) phase formation using 2 at.% Al or 2 at.% Ti as additives. The samples were prepared with a magnetron sputtering technique using different amount of nitrogen during the deposition process. The nitrogen partial pressure (\pn) was varied between 0-50% (rest Argon) and the targets of pure Fe, [Fe+Ti] and [Fe+Al] were sputtered. The addition of small amount of Ti or Al results in improved soft-magnetic properties when sputtered using \pn $\leq$ 10\p. When \pn is increased to 50\p non-magnetic Fe-N phases are formed. We found that iron mononitride (FeN) phases (N at% $\sim$50) are formed with Al or Ti addition at \pn =50% whereas in absence of such addition \eFeN phases (N\pat$\sim$30) are formed. It was found that the overall nitrogen content can be increased significantly with Al or Ti additions. On the basis of obtained result we propose a mechanism describing formation of Fe-N phases Al and Ti additives.Comment: 9 Pages, 7 Figure

Cavitation: a technology on the horizon

An overview of the application of cavitation phenomenon for the intensification of chemical/physical processing applications has been presented here, discussing the causes for the observed enhancement and highlighting some of the typical examples. The important considerations required for efficient scale-up of the cavitational reactors and subsequent industrial applications have been depicted based on the work carried out as a result of sponsored projects at the Institute of Chemical Technology, Mumbai. Overall, it appears that the combined efforts of physicists, chemists and chemical engineers are required to effectively use cavitational reactors for industrial applications. Some recommendations for further work to be carried out in this area have also been mentioned, which should allow the exploitation of this technology on an industrial scale

“Pure” severe aortic stenosis without concomitant valvular heart diseases:echocardiographic and pathophysiological features

Purpose!#!In echocardiography the severity of aortic stenosis (AS) is defined by effective orifice area (EOA), mean pressure gradient (mPG!##!Methods and results!#!Patients (n = 306) with asymptomatic (n = 133) and symptomatic (n = 173) 'pure' severe AS (mean age 78 ± 9.5 years) defined by indexed EOA < 0.6 cm!##!Conclusion!#!In patients with 'pure' AS according to current guidelines the presence of combined LVH, DD and PAH as accepted pathophysiological sequelae of severe AS cannot be confirmed. Probably, the detection of these secondary cardiac alterations might improve the diagnostic algorithm to avoid overestimation of AS severity

Two Extrasolar Asteroids with Low Volatile-Element Mass Fractions

Using ultraviolet spectra obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope, we extend our previous ground-based optical determinations of the composition of the extrasolar asteroids accreted onto two white dwarfs, GD 40 and G241-6. Combining optical and ultraviolet spectra of these stars with He-dominated atmospheres, 13 and 12 polluting elements are confidently detected in GD 40 and G241-6, respectively. For the material accreted onto GD 40, the volatile elements C and S are deficient by more than a factor of 10 and N by at least a factor of 5 compared to their mass fractions in primitive CI chondrites and approach what is inferred for bulk Earth. A similar pattern is found for G241-6 except that S is undepleted. We have also newly detected or placed meaningful upper limits for the amount of Cl, Al, P, Ni and Cu in the accreted matter. Extending results from optical studies, the mass fractions of refractory elements in the accreted parent bodies are similar to what is measured for bulk Earth and chondrites. Thermal processing, perhaps interior to a snow line, appears to be of central importance in determining the elemental compositions of these particular extrasolar asteroids.Comment: 37 pages, 13 figures, 5 tables, ApJ, accepte

Risk factors for early mortality in patients with pulmonary tuberculosis admitted to the emergency room.

Abstract Background and objectives Mortality of patients with pulmonary tuberculosis (TB) admitted to emergency departments is high. This study was aimed at analysing the risk factors associated with early mortality and designing a risk score based on simple parameters. Methods This prospective case-control study enrolled patients admitted to the emergency department of a referral TB hospital. Clinical, radiological, biochemical and microbiological risk factors associated with death were compared among patients dying within one week from admission (cases) and those surviving (controls). Results Forty-nine of 250 patients (19.6%) experienced early mortality. Multiple logistic regression analysis showed that oxygen saturation (SaO2) ≤90%, severe malnutrition, tachypnoea, tachycardia, hypotension, advanced disease at chest radiography, severe anaemia, hyponatremia, hypoproteinemia and hypercapnia were independently and significantly associated with early mortality. A clinical scoring system was further designed to stratify the risk of death by selecting five simple parameters (SpO2 ≤ 90%, tachypnoea, hypotension, advanced disease at chest radiography and tachycardia). This model predicted early mortality with a positive predictive value of 94.88% and a negative predictive value of 19.90%. Conclusions The scoring system based on simple parameters may help to refer severely ill patients early to a higher level to reduce mortality, improve success rates, minimise the need for pulmonary rehabilitation and prevent post-treatment sequelae

Deposition of light-absorbing particles in glacier snow of the Sunderdhunga Valley, the southern forefront of the central Himalayas

Anthropogenic activities on the Indo-Gangetic Plain emit vast amounts of light-absorbing particles (LAPs) into the atmosphere, modifying the atmospheric radiation state. With transport to the nearby Himalayas and deposition to its surfaces the particles contribute to glacier melt and snowmelt via darkening of the highly reflective snow. The central Himalayas have been identified as a region where LAPs are especially pronounced in glacier snow but still remain a region where measurements of LAPs in the snow are scarce. Here we study the deposition of LAPs in five snow pits sampled in 2016 (and one from 2015) within 1 km from each other from two glaciers in the Sunderdhunga Valley, in the state of Uttarakhand, India, in the central Himalayas. The snow pits display a distinct enriched LAP layer interleaved by younger snow above and older snow below. The LAPs exhibit a distinct vertical distribution in these different snow layers. For the analyzed elemental carbon (EC), the younger snow layers in the different pits show similarities, which can be characterized by a deposition constant of about 50 mu g m(-2) mm(-1) snow water equivalent (SWE), while the old-snow layers also indicate similar values, described by a deposition constant of roughly 150 mu g m(-2) mm(-1) SWE. The enriched LAP layer, contrarily, displays no similar trends between the pits. Instead, it is characterized by very high amounts of LAPs and differ in orders of magnitude for concentration between the pits. The enriched LAP layer is likely a result of strong melting that took place during the summers of 2015 and 2016, as well as possible lateral transport of LAPs. The mineral dust fractional absorption is slightly below 50% for the young- and old-snow layers, whereas it is the dominating light-absorbing constituent in the enriched LAP layer, thus, highlighting the importance of dust in the region. Our results indicate the problems with complex topography in the Himalayas but, nonetheless, can be useful in large-scale assessments of LAPs in Himalayan snow.Peer reviewe

The addition of genetic testing and cardiovascular magnetic resonance to routine clinical data for stratification of aetiology in dilated cardiomyopathy

Background: Guidelines recommend genetic testing and cardiovascular magnetic resonance (CMR) for the investigation of dilated cardiomyopathy (DCM). However, the incremental value is unclear. We assessed the impact of these investigations in determining etiology. Methods: Sixty consecutive patients referred with DCM and recruited to our hospital biobank were selected. Six independent experts determined the etiology of each phenotype in a step-wise manner based on (1) routine clinical data, (2) clinical and genetic data and (3) clinical, genetic and CMR data. They indicated their confidence (1-3) in the classification and any changes to management at each step. Results: Six physicians adjudicated 60 cases. The addition of genetics and CMR resulted in 57 (15.8%) and 26 (7.2%) changes in the classification of etiology, including an increased number of genetic diagnoses and a reduction in idiopathic diagnoses. Diagnostic confidence improved at each step (p < 0.0005). The number of diagnoses made with low confidence reduced from 105 (29.2%) with routine clinical data to 71 (19.7%) following the addition of genetics and 37 (10.3%) with the addition of CMR. The addition of genetics and CMR led to 101 (28.1%) and 112 (31.1%) proposed changes to management, respectively. Interobserver variability showed moderate agreement with clinical data (κ = 0.44) which improved following the addition of genetics (κ = 0.65) and CMR (κ = 0.68). Conclusion: We demonstrate that genetics and CMR, frequently changed the classification of etiology in DCM, improved confidence and interobserver variability in determining the diagnosis and had an impact on proposed management

Snow albedo and its sensitivity to changes in deposited light-absorbing particles estimated from ambient temperature and snow depth observations at a high-altitude site in the Himalaya

Snow darkening by deposited light-absorbing particles (LAP) accelerates snowmelt and shifts the snow meltout date (MOD). Here, we present a simple approach to estimate the snow albedo variability due to LAP deposition and test this method with data for 2 seasons (February-May 2016 and December 2016-June 2017) at a high-altitude valley site in the Central Himalayas, India. We derive a parameterization for the snow albedo that only depends on the daily observations of average ambient temperature and change in snow depth, as well as an assumed average concentration of LAP in snow precipitation. Linear regression between observed and parameterized albedo for the base case assuming an equivalent elemental carbon concentration [ECeq] of 100 ng g(-1) in snow precipitation yields a slope of 0.75 and a Pearson correlation coefficient r(2) of 0.76. However, comparing the integrated amount of shortwave radiation absorbed during the winter season using observed albedo versus base case albedo resulted in rather small differences of 11% and 4% at the end of Seasons 1 and 2, respectively. The enhanced energy absorbed due to LAP at the end of the 2 seasons for the base case scenario (assuming an [ECeq] of 100 ng g(-1) in snow precipitation) was 40% and 36% compared to pristine snow. A numerical evaluation with different assumed [ECeq] in snow precipitation suggests that the relative sensitivity of snow albedo to changes in [ECeq] remains rather constant for the 2 seasons. Doubling [ECeq] augments the absorption by less than 20%, highlighting that the impact on a MOD is small even for a doubling of average LAP in snow precipitation.Peer reviewe