38 research outputs found
PERFORMANCE ASSESSMENT OF GAS TURBINE DRIVEN CENTRIFUGAL COMPRESSOR TRAINS DERIVED FROM FIELD TESTING
- Publication venue
- Turbomachinery Laboratory, Texas A&M Engineering Experiment Station
- Publication date
- 01/01/2013
- Field of study
LectureField testing of gas turbine driven centrifugal compressor
units at operational production facilities can provide valuable
information about the condition of the equipment. In this
paper, a case study is presented based on field testing
performed on the compressors and gas turbine drivers of six
units at a gas compression station. Since the compression units
at this station are two sets of three identical machines, this case
provides a unique opportunity to study both the advantages and
some of the challenges inherent in this type of testing. For the
compressors, comparisons are presented of the measured values
of head rise, required power, and thermodynamic efficiency.
For the gas turbines, performance comparisons are presented in
terms of delivered power and heat rate. Calculations of the
effects of ambient temperature on power and heat rate of the
gas turbines are also presented. Some of the challenges of field
testing are addressed, with the effects of fluctuations in gas
composition on the experimental uncertainty in the measured
performance treated in some detail. The topic of how field
testing can help to identify degradation of the capability of
compressors and gas turbines is also addressed. It is also
shown how models derived from the performance tests can be
used to forecast when factors such as high ambient
temperatures and changes in the composition of the process gas
can create situations where the compression units may not be
able to deliver the gas flow rates and pressure levels required
by the process
PERFORMANCE ASSESSMENT OF GAS TURBINE DRIVEN CENTRIFUGAL COMPRESSOR TRAINS DERIVED FROM FIELD TESTING
- Publication venue
- Turbomachinery Laboratory, Texas A&M Engineering Experiment Station
- Publication date
- 01/01/2013
- Field of study
LectureField testing of gas turbine driven centrifugal compressor
units at operational production facilities can provide valuable
information about the condition of the equipment. In this
paper, a case study is presented based on field testing
performed on the compressors and gas turbine drivers of six
units at a gas compression station. Since the compression units
at this station are two sets of three identical machines, this case
provides a unique opportunity to study both the advantages and
some of the challenges inherent in this type of testing. For the
compressors, comparisons are presented of the measured values
of head rise, required power, and thermodynamic efficiency.
For the gas turbines, performance comparisons are presented in
terms of delivered power and heat rate. Calculations of the
effects of ambient temperature on power and heat rate of the
gas turbines are also presented. Some of the challenges of field
testing are addressed, with the effects of fluctuations in gas
composition on the experimental uncertainty in the measured
performance treated in some detail. The topic of how field
testing can help to identify degradation of the capability of
compressors and gas turbines is also addressed. It is also
shown how models derived from the performance tests can be
used to forecast when factors such as high ambient
temperatures and changes in the composition of the process gas
can create situations where the compression units may not be
able to deliver the gas flow rates and pressure levels required
by the process
Prefacing unexplored archives from Central Andean surface-to-bedrock ice cores through a multifaceted investigation of regional firn and ice core glaciochemistry.
- Author
- Bernardo Ronaldo T.
- Birkel Sean
- BustĂnza Urviola Victor
- Carlos Franciéle Schwanck
- Casassa Gino
- Clifford Heather M.
- Dixon Daniel A.
- Gomez Oscar Vilca
- Handley Michael
- Introne Douglas
- Jara-Infantes Harrison
- Korotkikh Elena
- Lindau Filipe Gaudie Ley
- Maurer Jonathan
- Perry L. Baker
- Potocki Mariusz
- Rodda Charles
- Schwikowski Margit
- Seimon Anton
- Tavares Flavia Alves
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Shallow firn cores, in addition to a near-basal ice core, were recovered in 2018 from the Quelccaya ice cap (5470 m a.s.l) in the Cordillera Vilcanota, Peru, and in 2017 from the Nevado Illimani glacier (6350 m a.s.l) in the Cordillera Real, Bolivia. The two sites are ~450 km apart. Despite meltwater percolation resulting from warming, particle-based trace element records (e.g. Fe, Mg, K) in the Quelccaya and Illimani shallow cores retain well-preserved signals. The firn core chronologies, established independently by annual layer counting, show a convincing overlap indicating the two records contain comparable signals and therefore capture similar regional scale climatology. Trace element records at a ~1?4 cm resolution provide past records of anthropogenic emissions, dust sources, volcanic emissions, evaporite salts and marine-sourced air masses. Using novel ultra-high-resolution (120 ?m) laser technology, we identify annual layer thicknesses ranging from 0.3 to 0.8 cm in a section of 2000-year-old radiocarbon-dated near-basal ice which compared to the previous annual layer estimates suggests that Quelccaya ice cores drilled to bedrock may be older than previously suggested by depth-age models. With the information collected from this study in combination with past studies, we emphasize the importance of collecting new surface-to-bedrock ice cores from at least the Quelccaya ice cap, in particular, due to its projected disappearance as soon as the 2050s
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
- Author
- Aengus Stewart
- Aiman Alzetani
- Alex Bowman
- Alexandra Rice
- Alexandrov
- Alison Edwards
- Allah Dino Keerio
- Allan Hackshaw
- Amy Kerr
- Amy Smith
- Anand Devaraj
- Andreatta
- Andrew Furness
- Andrew G. Nicholson
- Andrew J. Rowan
- Andrew Rowan
- Andy Georgiou
- Angela Kwayie
- Angela Leek
- Anita Amadi
- Anne Marie Quinn
- Anshuman Chaturved
- Apostolos Nakas
- Asia Ahmed
- Assma Ben Aissa
- Azmina Verjee
- Babikir Ismail
- Babu Naidu
- Ben Phillimore
- Benjamin Johnson
- Brastianos
- Brown
- Campbell
- Campoli
- Caroline Dive
- Carter
- Celia Simeon
- Charles Swanton
- Charles Swanton
- Chiara Proli
- Christian Ottensmeier
- Christophe Dessimoz
- Christopher Abbosh
- Cibulskis
- Crispin Hiley
- Crispin T. Hiley
- Dahmane Oukrif
- David Lawrence
- David Moore
- Davoli
- Dawn Carnell
- Dean Fennell
- del Campo
- Diana Johnson
- Dionysis Papadatos-Pastos
- Dominic G. Rothwell
- Elaine Borg
- Elaine Smith
- Emily Shaw
- Emma Nye
- Eric Lim
- Eustace Fontaine
- Faiza Idries
- Favero
- Fiona Blackhall
- Fiona Morgan
- Francesca Chemi
- Gareth A. Wilson
- Gareth Wilson
- Gary Middleton
- Ged Brady
- Gemma Hector
- Gerald Langman
- Girija Anand
- Greg Elgar
- Ha
- Hanahan
- Hang Xu
- Hardy Remmen
- Harriet Bell
- Harshil Bhayani
- Haydn Adams
- Helen Davies
- Helen Doran
- Helen L. Lowe
- Hema Chavan
- Herbst
- Hicklin
- Hilary Marshall
- Hilgardt Raubenheimer
- Hillaria Mashinga
- Hiraki
- Hollie Bancroft
- Hoof
- Hugo J.W.L. Aerts
- Jacki Goldman
- Jackie Pierce
- Jacqui A. Shaw
- Jamal-Hanjani
- Jane Rogan
- Jason Lester
- Javier Herrero
- Javier Herrero
- Jennifer Hill
- Jeremy George
- Joan Riley
- Joanne Laycock
- Joanne Webb
- John A. Hartley
- John Carlo Ronquillo
- John Conibear
- John Edwards
- John Gosney
- John Le Quesne
- Jonathan Bennett
- Jonathan Bury
- Jonathan Finch
- Jonathan Tugwood
- Joy Miller
- Juliette Novasio
- Julius Asante-Siaw
- Junaid Choudhary
- Justyna Czyzewska-Khan
- Katrina Moore
- Keith Buchan
- Keith Kerr
- Kelvin Lau
- Kendadai Rammohan
- Kim Suvarna
- Koboldt
- Kroopa Joshi
- Lawrence
- Leena Joseph
- Leire Azcarate
- Lesley Gomersall
- Leticia Bosshard-Carter
- Li
- Li
- Lindsay Primrose
- Louise Nelson
- Luke Martinson
- Lyn Ambrose
- Madava Djearaman
- Magali Taylor
- Maggie Wilcox
- Mahendran Chetty
- Mairead MacKenzie
- Maise Al Bakir
- Malgorzata Kornaszewska
- Marco Novelli
- Maria Elena Cufari
- Mariam Jamal-Hanjani
- Marianne Nicolson
- Marie Aranda
- Marta Costa
- Martin
- Martin Forster
- Martin Hayward
- Mary Bellamy
- Mary Falzon
- Matthew Evison
- McGranahan
- McKenna
- Mehta
- Melanie Irvin-sellers
- Michael Shackcloth
- Michael Sheaff
- Mickael Escudero
- Monica Tavares Barbosa
- Morag Hamilton
- Moretta
- Natalie Mensah
- Neal Navani
- Nicholas McGranahan
- Nicholas McGranahan
- Nicolai J. Birkbak
- Nicolai J. Birkbak
- Nicole Gower
- Nielsen
- Nik Matthews
- Nikolaos Panagiotopoulos
- Ott
- Pat Gorman
- Patricia Fisher
- Paul Bishop
- Paul Taylor
- Paulo De Sousa
- Peter Russell
- Peter Schmid
- Peter Van Loo
- Peter Van Loo
- Phil Crosbie
- Phil Harrison
- Pieter Postmus
- Piha-Paul
- Piotr Krysiak
- Rachael Waddington
- Rachel Rosenthal
- Rachel Rosenthal
- Raffaele Califano
- Rajesh Shah
- Ribas
- Richard Attanoos
- Richard Booton
- Richard Kevin Stone
- Richard Mitter
- Ricky Thakrar
- Rimmer
- Rizvi
- Robert E. Hynds
- Rooney
- Rosenthal
- Roth
- Ruheena Mendes
- Sahin
- Sajid Khan
- Sakshi Gulati
- Salma Kadiri
- Sam M. Janes
- Samra Turajlic
- Sara Lock
- Sarah Danson
- Sarah Feeney
- Schumacher
- Sean Smith
- Seema Shafi
- Selvaraju Veeriah
- Selvaraju Veeriah
- Serena Chee
- Sergio Quezada
- Sharmin Begum
- Shen
- Shirley Palmer
- Shukla
- Shyam Kolvekar
- Silviu Buderi
- Simon Jordan
- Simon Trotter
- Siow Ming Lee
- Snyder
- Sofia Graca
- Sophia Ward
- Sophie Green
- Spranger
- Sridhar Rathinam
- Stefan Dentro
- Stuart Horswell
- Stuart Moss
- Sue Matthews
- Szolek
- Tamara Denner
- Tanya Ahmad
- Teresa Light
- Teresa Marafioti
- Thomas B.K. Watkins
- Thomas B.K. Watkins
- Tim Chambers
- Tracey Horey
- Tran
- Tumeh
- Van Allen
- Van Loo
- Veni Ezhil
- Vineet Prakash
- William Monteiro
- Yenting Ngai
- Yien Ning Sophia Wong
- Yoshihama
- Yota Kitsanta
- Yusura Bakar
- Yvonne Summers
- Zaretsky
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (LOHHLA), a computational tool to determine HLA allele-specific copy number from sequencing data. Using LOHHLA, we find that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity. The focal nature of HLA LOH alterations, their subclonal frequencies, enrichment in metastatic sites, and occurrence as parallel events suggests that HLA LOH is an immune escape mechanism that is subject to strong microenvironmental selection pressures later in tumor evolution. Characterizing HLA LOH with LOHHLA refines neoantigen prediction and may have implications for our understanding of resistance mechanisms and immunotherapeutic approaches targeting neoantigens. Video Abstract [Figure presented] Development of the bioinformatics tool LOHHLA allows precise measurement of allele-specific HLA copy number, improves the accuracy in neoantigen prediction, and uncovers insights into how immune escape contributes to tumor evolution in non-small-cell lung cancer
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
- Domingues J
- Donati D
- dos Santos Martins G
- Doudakmanis C
- Dowdy Sean
- Doyle A
- Drake Thomas M
- Drane A
- Droghetti M
- Duchalais E
- Dudi-Venkata NN
- Dumitra Sinziana
- Duran Sosa EE
- Earley H
- Eastmond A
- Ebbehoj AL
- Ebben L
- Economopoulou P
- Edwards John
- Edwards John G
- Efthimiou M
- Egoroff N
- El Ahmadi B
- El Amrani M
- El Arbi N
- El Bouazizi Y
- El Kassas M
- Elazzazy E
- Eldaly A
- Elghazaly MS
- Elhadi Muhammed
- Elliott JA
- Ellojli I
- Elmorsi R
- Emile Sameh
- Emmanuel K
- Enoch E
- Esene Ignatius
- Eskinazi DG
- Esposito G
- Esquide Ruiz M
- Essam E
- Evans Jonathan P
- Evans Richard PT
- Eveno C
- Ewedah M
- Ezanno AC
- Fabbri N
- Facundo H
- Fagotti Anna
- Fahey BA
- Fahmawee T
- Farik Shebani
- Farnesi F
- Farooka MW
- Fathi NQ
- Faustino A
- Fayed Y
- Federico P
- Federico Pipitone NS
- Feo C
- Feo CF
- Fernandes Sousa M
- Fernandes U
- Fernandes V
- Ferrari M
- Ferrario L
- Ferraz I
- Ferreira C
- Ferreira Peralta M
- Ferro Carvalho C
- Ferro Rey M
- Finnegan L
- Fiore M
- Fiore Marco
- Fiori E
- Fiorini A
- Fitzgerald J Edward
- Flamey N
- Fleming CA
- Fleres F
- Fonsi GB
- Foo CC
- Foppa C
- Ford Samuel
- Fortuna L
- Fotopoulou Christina
- Fountain Daniel M
- Fowler A
- Frade S
- Fragoso M
- Francone E
- Franken J
- Frantzeskou K
- Franzini M
- Frattaruolo C
- Frazao J
- Fredon F
- Freitas A
- Frena A
- Freyschlag Christian
- Fritzmann J
- Frongia F
- Frountzas M
- Fujiwar Keiichi
- Fuks D
- Furbetta N
- Futaba K
- Gahwagi M
- Gallo G
- Gallo Gaetano
- Galvao D
- Gani J
- Ganly Ian
- Garba S
- Garberini De Manzoni A
- Garcia JS
- Garfinkle R
- Garg PK
- Garino M
- Garmanova Tatiana
- Garrido R
- Gattolin A
- Gauri N
- Gaziants V
- Gelarda E
- Gennari S
- Gentilli S
- George G
- Gerns N
- Geroukalis A
- Ghaly G
- Ghamgh R
- Ghannam A
- Ghebre Rahel
- Ghitulescu G
- Ghosh Dhruva
- Giacometti M
- Giaglaras A
- Gianardi D
- Gill R
- Gillis AE
- Giraudo G
- Giuffrida M
- Giuffrida MC
- Giunta A
- Gklavas A
- Glasbey James C
- Glehen O
- Gold-Deutch R
- Gomes GMA
- Gomes Gustavo Mendonca Ataide
- Gomes J
- Gomez-Mayorga JL
- Gori A
- Gouvas N
- Grasset E
- Grasso M
- Grechenig M
- Grechi A
- Grecinos Gustavo
- Gribnev P
- Griffiths Ewen A
- Grilo J
- Grimaldi Di Maria S
- Gronchi Alessandro
- Groot G
- Grossi U
- Grotenhuis BA
- Gruber R
- Gruendl Magdalena
- Guadagni S
- Guaglio M
- Guerci C
- Guerra GR
- Guevara O
- Guglielmi A
- Guidi G
- Gujjuri Rohan R
- Gundara J
- Gupta S
- Gutelkin Murat
- Hakami I
- Halkias Constantine
- Hamdan KH
- Hamdy R
- Hamza HM
- Hanly A
- Haque PD
- Harald M
- Harbjerg JL
- Hardy NP
- Harris Benjamin
- Harrison Ewen M
- Hartveld L
- Hasan Aboharp Z
- Hassan E
- Hayati F
- Helminen O
- Heneghan H
- Henriques P
- Henriques S
- Heritage Emily
- Hernandez R
- Herzberg J
- Hisham Intisar
- Hmedat A
- Ho D
- Ho MF
- Ho Michael
- Hoffmann P
- Hogan A
- Hompes R
- Hon S
- Honarpisheh H
- Huhta H
- Hussain AH
- Hutchinson Peter
- Hutchinson Peter J
- Hwang Shelley
- Iannone I
- Ibrahim AF
- Ijichi TR
- Impellizzeri H
- Inama M
- Incollingo P
- Inzunza M
- Ioannidis O
- Ipponi P
- Isaac John
- Isik Arda
- Islam AA
- Isolani SM
- Isoton JC
- Iversen LH
- Izbicki J
- Izzo F
- Jacome F
- Jager T
- Jain A
- Jain D
- Jain M
- Jamal A
- Jang S
- Janik M
- Jayasilan J
- Jenkinson Michael D
- Jesudason MR
- Jeyaraj P
- Jeyarajan E
- Ji Almeida
- Jia F
- Jo Bello
- Joao Alagoa A
- Jobran F
- Jocson R
- Jones Conor S
- Jonescheit J
- Jonker Pascal
- Jordan P
- Jordan S
- Jouffret L
- Jovine E
- Jusoh Che A
- Jw Mall
- Kaafarani Haytham MA
- Kalayarasan R
- Kalfountzos C
- Kamal N
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- Wullschleger M
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- Zambon M
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- Zografos C
- Zonta S
- Zourntou S
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, Pâ<â0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, PÂ =Â 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, PÂ =Â 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
- Cao Yixin
- Cao Yuze
- Carrillo Leo
- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
- Chang Kevin
- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
- Clark Brittany
- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
- Coates Ryan
- Cohen Katherine
- Colant Noelle
- Coleman Sarah
- Colgan Cian
- Cone Eli
- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
- Crispim Larissa de Souza
- Crone Michael Andrew
- Crooijmans Marjolein
- Crosby Laurel Constanti
- Crowley Peter
- Cruz Frida
- Cubukcu Hande
- Culfogienis Dylan
- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
- DeKloe Jackson
- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
- Demchuk Aubrey
- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
- Dhaliwal Gurpreet
- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
- Dingyue Tang
- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
- Eidloth Franziska
- Eijkens Bruno
- Eilers Keno
- El Moubayed Yorgo
- Elcin Evrim
- Elias Noel
- Elikan Max
- Ellermeier Craig
- Elliott Hannah
- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
- Fan Catherine
- Fang Chengzhu
- Fang Choco
- Fang Xiangyi
- Farhi Einan
- Farias Sebastian
- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
- Faurdal David
- Faustova Ilona
- Feng Xinhua
- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
- Fu Wenhan
- Fu Yousi
- Fuentes Ernie
- Fulton Leah
- Fung Ip Ning
- Fung Yam Shing
- Gabrielli Jacopo
- Gahagan Maddison
- Gaitt Tobias
- Gaizauskaite Aukse
- Gallegos Isabella
- Gamoneda Diego
- Gandhi Rishi
- Gao Cecily
- Garavito Paula
- Garcia Chrismar
- Garcia David
- Garrido Delia
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- Zhao Peng
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- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
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- Zhou Hanmi
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- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Decifra-me ou te devoro! As finanças e a sociedade brasileira
- Author
- ADAY Kimberly Gross Sean Aday
- AGLIETTA Michel
- ARMSTRONG Peter
- BALASZ Gabrielle
- BAUTZER Tatiana
- BECKER Gary S
- BERNSTEIN Peter
- BIRNBAUM Pierre
- BOLTANSKI Luc
- BOLTANSKI Luc
- BOURDIEU JerĂŽme. J. H.
- BOURDIEU Pierre
- BOURDIEU Pierre
- BOURDIEU Pierre
- BOURDIEU Pierre
- BOURDIEU Pierre
- BOURDIEU Pierre
- BOYER Robert
- BRANDĂO F
- CAMBA Daniela
- CARVALHO M. C
- CASTELLS Manuel
- CASTELLS Manuel
- CASTELLS Manuel
- CASTELLS Manuel
- Charle Christophe
- COLEMAN J. W
- COLWYN JONES T. D
- CRUZ N. H. D
- D'AMBROSIO C. V. E. D.
- D'AMBROSIO C. V. E. D.
- DIAS L
- DIMAGGIO Paul
- DIMAGGIO Paul
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DUAILIBI J
- DUARTE F
- DUBY Georges
- DURAND José Carlos
- DĂVILA S
- EVANS Peter
- FAMA Eugene. F
- FAUCONNIER Gilles
- FERREIRA Aurélio. B. Hollanda
- FLIGSTEIN Neil
- GALBRAITH John Kenneth
- GARCIA Marie-France
- GIANNETTI Eduardo
- GRĂN Roberto
- GRĂN Roberto
- GRĂN Roberto
- GRĂN Roberto
- GRĂN Roberto
- GRĂN Roberto
- GRĂN Roberto
- GRĂN Roberto
- GUEX Sebastien
- HADDAD Claudio
- HIRSCH PAUL M. D.
- HOUAISS Antonio
- JOSEPH W. O. A. J
- KOTCHO Ricardo
- KOTCHO Ricardo
- LAKOFF G
- LAKOFF G
- LANGONI Carlos Geraldo
- LEITE P. D
- LEONEL Rita Tavares
- LOPES José Sergio Leite
- LORDON Federic
- MACKENZIE Donald
- MACKENZIE Donald
- MACKENZIE Donald
- MCGERR Michael. E
- MICHAEL Andréa
- MURPHY P
- NETTO Antonio Delfim
- OLIVEIRA R
- PAVINI Angelo
- PENSO DE LA VEGA José
- PEREIRA Luis Carlos Bresser
- PEĂA Bernardo de la
- POLANYI Karl
- POWELL Walter W
- RIPARDO SĂ©rgio
- Roberto GrĂŒn
- ROMERO Cristiano
- SALOMĂO Marta
- SCHORSKE Carl
- SILVA Luiz IgnĂĄcio Lula da
- SOUZA J. D
- SOUZA L
- STERNHELL Zeev
- THOMPSON Edward P
- THOMPSON Edward P
- THOMPSON Edward P
- TILLY Charles
- TROSTER Roberto L
- WEBER M
- WOODS Jr. M
- ZELIZER Viviana
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
- Author
- Adlard Julian
- Ahmed Munaza
- Aich Anshul
- Aitman Tim
- Alachkar Hana
- Alle Hana Lango
- Allsup David
- Almeida-King Jeff
- Ambrose J. C.
- Amin Aliya S.
- Ancliff Philip
- Antrobus Richard
- Armstrong Ruth
- Arno Gavin
- Arumugam P.
- Ashford Sofie
- Astle William
- Attwood Anthony
- Babbs Chris
- Bakchoul Tamam
- Bariana Tadbir
- Barwell Julian
- Bennett David
- Bentley David
- Bevers R.
- Bierzynska Agnieszka
- Biss Tina
- Bleda M.
- Bleda Marta
- Boardman-Pretty F.
- Bogaard Harm
- Bourne Christian
- Boustred C. R.
- Boyce Sara
- Bradley John
- Breen Gerome
- Brennan Paul
- Brewer Carole
- Brittain H.
- Brod Naomi Clements
- Brown M. A.
- Brown Matthew
- Browning Michael
- Buchan Rachel
- Buckland Matthew
- Bueser Teofila
- Burns Siobhan
- Burren Oliver
- Calleja Paul
- Carr-White Gerald
- Carss Keren
- Casey Ruth
- Caulfield M. J.
- Caulfield Mark
- Cebola InĂȘs
- Chambers Jennifer
- Chambers Jenny
- Chambers John
- Chan G. C.
- Chan Melanie M. Y.
- Cheng Floria
- Chinnery Patrick F.
- Christian Martin
- Church Colin
- Coghlan Gerry
- Colby Elizabeth
- Cole Trevor
- Collins Janine
- Collins Peter
- Colombo Camilla
- Condliffe Robin
- Cook Stuart
- Cook Terry
- Cooley Sharon
- Cooper Nichola
- Corris Paul
- Crisp-Hihn Abigail
- Curry Nicola
- Danesino Cesare
- Daniels Matthew
- Daugherty Louise
- Davis John
- Deevi Sri V. V.
- Dent Timothy
- Dewhurst Eleanor
- Dixon Peter
- Dixon Peter H.
- Donnelly Jennifer
- Downes Kate
- Drazyk Anna
- Drewe Elizabeth
- Dutt Tina
- Edgar David
- Edwards Karen
- Egner William
- Erber Wendy
- Erwood Marie
- Estiu Maria C.
- Estiu Maria Cecilia
- Evans Dafydd Gareth
- Evans Gillian
- Everington Tamara
- Eyries MĂ©lanie
- Favier Remi
- Fletcher Debra
- Fowler T.
- Fox James
- Frary Amy
- French Courtney
- Freson Kathleen
- Frontini Mattia
- Gale Daniel
- Gale Daniel P.
- Gall Henning
- Geary Michael
- Geoghegan Claire
- Gerighty Terry
- Ghio Stefano
- Ghofrani Hossein-Ardeschir
- Gibbs Simon
- Giess A.
- Gilmour Kimberley
- Girerd Barbara
- Goddard Sarah
- Gomez Keith
- Gordins Pavels
- Gosal David
- Grassi Luigi
- Greene Daniel
- Greenhalgh Lynn
- Greinacher Andreas
- Gresele Paolo
- Griffiths Philip
- Grigoriadou Sofia
- Grocock Russell
- Grozeva Detelina
- GrÀf Stefan
- Hackett Scott
- Hadinnapola Charaka
- Hague William
- Hague William M.
- Haimel Matthias
- Hall Matthew
- Hamblin A.
- Hanson Helen
- Harkness Kirsty
- Harper Andrew
- Harris Claire
- Hart Daniel
- Hassan Ahamad
- Hayman Grant
- Henderson Alex
- Henderson S.
- Hoffmann Jonathan
- Horvath Rita
- Houweling Arjan
- Howard Luke
- Hu Fengyuan
- Hubbard T. J. P.
- Hudson Gavin
- Hughes Joseph
- Huissoon Aarnoud
- Humbert Marc
- Humphray Sean
- Hunter Sarah
- Hurles Matthew
- Izatt Louise
- Jackson R.
- James Roger
- Johnson Sally
- Jolles Stephen
- Jolley Jennifer
- Jones L. J.
- Jurkute Neringa
- Kasanicki Mary
- Kasperaviciute D.
- Kayikci M.
- Kazkaz Hanadi
- Kazmi Rashid
- Kelleher Peter
- Kiely David
- Kingston Nathalie
- Klima Robert
- Kostadima Myrto
- Kousathanas A.
- Kovacs Gabor
- Koziell Ania
- Kreuzhuber Roman
- Kuijpers Taco
- Kumar Ajith
- Kumararatne Dinakantha
- Kuria Manju
- Laffa Michael
- Lahnstein L.
- Lalloo Fiona
- Lamber Michele
- Lawrie Allan
- Layton Mark
- Leigh S. E. A.
- Lentaigne Claire
- Leong I. U. S.
- Levine Adam
- Levine Adam P.
- Linger Rachel
- Longhurst Hilary
- Lopez F. J.
- Louka Eleni
- Madan Bella
- Maher Eamonn
- Maimaris Jesmeen
- Maleady-Crowe F.
- Mangles Sarah
- Mapeta Rutendo
- Marchbank Kevin
- Marks Stephen
- Markus Hugh S.
- Marschall Hanns-Ulrich
- Marshall Andrew
- Martin Jennifer
- Mathias Mary
- Matthews Emma
- Maude Hannah
- Maxwell Heather
- McAlinden Paul
- McCarthy Mark
- McEntagart M.
- Meacham Stuart
- Mead Adam
- Megy Karyn
- Mehta Sarju
- Michaelides Michel
- Millar Carolyn
- Minneci F.
- Mitchell Alice L.
- Moledina Shahin
- Montani David
- Moor Tony
- Morrell Nicholas
- Moutsianas L.
- Mozere Monika
- Mueller M.
- Muir Keith
- Mumford Andrew
- Murugaesu N.
- Need A. C.
- Newnham Michael
- Nicolaides Kypros
- Noordegraaf Anton Vonk
- O'Donovan P.
- O'Sullivan Jennifer
- Obaji Samya
- Odhams C. A.
- Okoli Steven
- Olschewski Andrea
- Olschewski Horst
- Ong Kai Ren
- Ormondroy Elizabeth
- Ouwehan Willem
- Papadi Sofia
- Park Soo-Mi
- Parry David
- Patch C.
- Paterson Joan
- Peacock Andrew
- Peden John
- Peerlinck Kathelijne
- Penkett Christopher
- Pepke-Zaba Joanna
- Pereira M. B.
- Perez-Gil D.
- Petersen Romina
- Pullinger J.
- Pyle Angela
- Rahim T.
- Rankin Stuart
- Rao Anupama
- Raymond F. Lucy
- Rayner-Matthew Paula
- Rees Christine
- Rendon A.
- Rendon Augusto
- Renton Tara
- Rice Andrew
- Richardson Sylvia
- Richter Alex
- Roberts Irene
- Rogers T.
- Ross Robert MacKenzie
- Roughley Catherine
- Roy Noemi
- Sadeghi-Alavijeh Omid
- Saleem Moin
- Samani Nilesh
- Sanchis-Juan Alba
- Sargur Ravishankar
- Satchell Simon
- Savage K.
- Savic Sinisa
- Sawant K.
- Scelsi Laura
- Schulman Sol
- Scott R. H.
- Scully Marie
- Searle Claire
- Seeger Werner
- Sewell Carrock
- Seyres Denis
- Shapiro Susie
- Sharmardina Olga
- Shtoyerman Rakefet
- Sibson Keith
- Siddiq A.
- Side Lucy
- Sieghart A.
- Simeoni Ilenia
- Simpson Michael
- Sivapalaratnam Suthesh
- Skytte Anne-Bine
- Smith Katherine
- Smith Kenneth G. C.
- Smith S. C.
- Snape Katie
- Sosinsky A.
- Soubrier Florent
- Staines Simon
- Staples Emily
- Stark Hannah
- Stephens Jonathan
- Stirrups Kathleen
- Stock Sophie
- Stuckey A.
- Suntharalingam Jay
- Swietlik Emilia
- Syngelaki Argyro
- Tait R. Campbell
- Talks Kate
- Tan Rhea
- Tanguy M.
- Taylor Tavares A. L.
- Thaventhiran James
- Themistocleous Andreas
- Thomas E. R. A.
- Thomas Moira
- Thompson S. R.
- Thomson Kate
- Thorsell Malin
- Thrasher Adrian
- Thys Chantal
- Tischkowitz Marc
- Titterton Catherine
- Toh Cheng-Hock
- Toshner Mark
- Traylor Matthew
- Treacy Carmen
- Trembath Richard
- Tucci A.
- Tuna Salih
- Turek Wojciech
- Turro Ernest
- Vale Tom
- Van Geet Chris
- Van Zuydam Natalie
- Vazquez-Lopez Marta
- von Ziegenweidt Julie
- Waisfisz Quintin
- Walker Suellen
- Ware James
- Watkins Hugh
- Watt Christopher
- Webster Andrew
- Wei Wei
- Welch Steven
- Welland M. J.
- Wessels Julie
- Westbury Sarah
- Westwood John-Paul
- Wharton John
- Whitehorn Deborah
- Whitworth James
- Wilkins Martin R.
- Williams E.
- Williamson Catherine
- Witkowska K.
- Wong Edwin
- Wood Nicholas
- Wood S. M.
- Wood Yvette
- Woods Geoff
- Woodward Emma
- Wort Stephen
- Worth Austen
- Yates Katherine
- Yong Patrick
- Young Tim
- Yu Ping
- Yu-Wai-Man Patrick
- Zhang Jun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/08/2022
- Field of study
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5â2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- AgnĂšs Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de JesĂșs Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Ć uput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali KaÄnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana AlĂcia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sånchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana MarĂa De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell FernĂĄndez
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas StĂŒbner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita VukoviÄ
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton TurÄan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- AvĆar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça GĂŒmĂŒĆ
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu TaĆdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
- BaĆar Erdivanli
- BaĆar Erdivanli
- Beatrice Pastore
- Begoña Zalba-Etayo
- Belen Burgos Conde
- Belinda Guadi-Gosh
- Ben Attwood
- Benjamin Bongiorno
- Benjamin Gerretsen
- BenoĂźt Chinardet
- Berenice Navarro
- Bernardo Panka
- Bernardo Panka
- Bernd Oliver Rose
- Bert Loef
- Betty Star Kampayana
- Beverley Thomas
- Beysim Ăzcan
- Beysim Ăzcan
- Bhagyesh Shah
- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
- Binny Tuinstra
- Birgitte Fosser Johansen
- Birthe Husted
- Biyan Li
- Bjoern Monsen
- Bjorn Bratsberg
- Bodin Khwannimit
- Bogdan Raitsiou
- Bojan Jovanovic
- Bonnie Bowes
- BoÄaç Ăzserezli
- Bram Kilapong
- Bram Kilapong
- Branislava Stefanovic
- Brian Marsh
- Brigitte Tejeda-Huezo
- Brita Fosser Olsen
- Britt Galaaen
- Britt Sjobo
- Britta Jepsen
- Bronagh Blackwood
- Bruno Miguel Bispo
- Bruno Sousa
- Bruno Sousa
- Brynja Rygvadottir
- Burhan Hadri
- Burhan Hadri
- Byung Ju Kang
- Caihong Hui
- Caiju Song
- Caitriona Cody
- Can Turan
- Carita Löfqvist
- Carlo Alberto Volta
- Carlos Alejandro Bascary
- Carlos Castro Delgado
- Carmel Chapman
- Carmel Georgiev
- Carmen Partera Luque
- Carmen Velasco Guillén
- Carole Boulanger
- Carole Boulanger
- Carole Brett
- Carolina GarzĂłn-Tovar
- Carolina Palaez
- Caroline LagerhÀll
- Caroline O'Donnell
- Caroline Paillet
- Carrie Sona
- Casiano Barrera Groba
- Catalin Traian Guran
- Catarina Nunes
- Catarina Tingsvik
- Catherine Motherway
- Catherine O'Brien
- Catherine Smith
- Cathy Becker
- Catia Quagliotto
- Cecilia Inés Loudet
- Cecilia Loudet
- Celia Tirado
- Ceri Lynch
- Cesar Aponte
- Cesar Rodriguez Nuñez
- Chaiwut Sawawiboon
- Chaoqun Ma
- Charalampos Martinos
- Charalice Ramiro
- Charikleia Nikolaou
- Charlotte Carter
- Charlotte Young
- Charlotte Young
- Chen Yumei
- Cheng
- Chenghau Mu
- Chengxia Sun
- Cheryl Bealer
- Cheryl Davidson
- Chiara Gatti
- Chiara Megna
- Chiara Megna
- Cho Young-Jae
- Chris Gerome Ellazar
- Chris Smith
- Chrisi Diakaki
- Christian Ferretti
- Christian Frey
- Christian Theisen
- Christiana Chime
- Christine Fiedler
- Christine Sheehan
- Christophe Borin
- Christophe Giacardi
- Christopher Barnes
- Christopher Barnes
- Christopher Palfreeman
- Christopher Potestio
- Christos Christofis
- Christos Dragoumanis
- Chrysanthos Markoulias
- Chrysostomos Katsenos
- Chun Jie Xia
- Chunxia Li
- Cindy Barefield
- Cindy Pillard
- Cintia Valencia Hurtado
- Cinzia Borgognoni
- Claire Derbyshire
- Claire Randell
- Claire Reynolds
- Clara Hurtado
- Clara Santa Rita
- Clare Fielding
- Clare Howcroft
- Claude Sertznig
- Claudia Lizbeth Lopez Nava
- Claudia Martins
- Congcong Liu
- Constantina Constantinou
- Cristal April Jane Aperocho
- Cristian Quiroga
- Cristiana Mota Pinheiro
- Cristina Paños Espinosa
- Cristina Petrisor
- Cui Yuan
- Cynthia Xing
- Cyril Thix
- Cyril Thix
- CĂ©dric Bruel
- CĂ©dric Daubin
- Dagmar Holmquist
- Daira Gonzalez
- Daisy Mehay
- Dale Ventour
- Damei Wang
- Damien O'Connell Rosemary Finn
- Dana Tomescu
- Dana Tomescu
- Danca LanÄariÄovĂĄ
- Daniel Blanco
- Daniel Horner
- Daniel Owens
- Daniel Sancho Muriel
- Daniela Alampi
- Daniela Carmen Filipescu
- Danielle Hacking
- Danil Baskakov
- Daria Rabarova
- Dassy Levy
- David De Bels
- David Higgins
- David Perez-Torres
- David Shaw
- Davide Massimo Ghioldi
- Dea Mahanes
- Debbie Noblezada-Uy
- Deborah Jibrin
- DeHong Lei
- Deirdre Doyle
- Dejan VeliÄkoviÄ
- Delmiro Becker
- Delphine Ngo
- Demet Tok Aydin
- Detlef Kindgen-Milles
- Devrim AkdaÄ
- Deyan Cao
- Diana Alvarez
- Diane Barkas
- Dianne Figaro-Barclay
- Dick Nahar
- Diego Rolando Morocho Tutillo
- Dimitra Lepida
- Dimitrios Papadopoulos
- Dinko Tonkovic
- Dirk von Lewinski
- Dmitriy Galishevskiy
- Dmitry Sergeev
- Dolly Mabel Bordon Cabral
- Dominic Carney
- Donaldo S Arteta Arteta
- Dongfang Wei
- Dongliang Lin
- Dongmei Bai
- Dongshu Ni
- Donna Cummings
- Dorel Sandesc
- Dorothee Mueller
- Dorothy Terry
- Drammen Sykehus
- Dritan Muzha
- Dritan Muzha
- Duygu Kayar Calili
- Dylan De Lange
- Dylan De Lange
- Edda Johansen
- Edwin Chapeta
- Egide Buregeya
- Egidija Bielskute
- Eileen Gilder
- Eirini Pantiora
- Eirini Papageorgiou
- Eirini-Chysovalanto Patsiou
- Ekaterina Tokareva
- Elaine Barros
- Elaine Thorpe
- Eleanor Santiago
- Elena Molinos
- Eleni Achilleos
- Eliane Mazocoli
- Elie Gharios
- Elif Erdogan
- Elif Erdogan
- Elin Kristoffersen
- Elin Mari Skorstad
- Elin Steffenak
- Elina Karjula
- Elisabet Gallart
- Elisabeth Wiborg
- Elisabetta Brizio
- Elizabeth Campbell
- Elizabeth Maidana
- Elizabeth Stones
- Ella Rokosh
- Elsa Afonso
- Elsa Afonso
- Emanuel Valgolio
- Emiliano Dean
- Emilio Maseda
- Emma Aves
- Emma Moreno Barreiro
- Emma Parkin
- Enas Soula
- Eneli Anvelt
- Enora Atchade
- Epaminontas Farmakis
- Erik Roman-Pognuz
- Erika Backlund Jansson
- Eryun Tian
- Esben Straede
- Esteban Milioto
- Estefania Orozco
- EstefanĂa Prol-Silva
- EstevĂŁo Lafuente
- Etienne De Montmollin
- Eugenio Garofalo
- Eugenio Martinez-Hurtado
- Eugeniya Larina
- EulĂĄlia Luis
- Eumorfia Kondili
- Eunice Tole
- Eva Joelsson-Alm
- Eva Joelsson-Alm
- Eva Ă kerman
- Eva Ă kerman
- Evangelia Michailidou
- Evdokia Sourla
- Evellyn Oliveira
- Evgeniy Zuev
- Evren ĆentĂŒrk
- Ewa Wahlbom
- Ewa Wallin
- Fabienne Etourneau
- Fabio Capuzzi
- Fabio Guarracino
- Fan Yang
- Fanglan Wang
- Farid Zand
- Farshad Heidari
- Fatema Salman
- Fateme Jafaraghaee
- Fatemeh Zarei
- Fatiha Essardy
- Fatima Fernandes
- Fatima Ferreira
- Fatima Kasem El Ahmad
- Fatime Hawchar
- Faustina Excel Adipa
- Fausto Guerrero
- Faye Morren
- Fayez François Abillama
- Fayez François Abillama
- Federica Dellafiore
- Federica Mancini
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- Silvio A Ăamendys-Silva
- Simant Jha
- Simeon Olanipekun
- Simeon Olanipekun
- Simon Dolenc
- Simon Mandaroux
- Simon Whiteley
- Simona Casaioli
- Sini John
- Siobhan O'Nuallain
- Siri Hansen
- Sirley Gill
- Siti Rohayah Sulaiman
- Siv Karin Malmin
- Siw Trudvang
- Slobodan Mihaljevic
- So Young Park
- Soad Imhmed R Alkhumsi
- Sofia Dias
- Sofia Kanakaki
- Sofia Putruele
- Sofia Zepoy
- Solenne Ory
- Sonia O Labeau
- Sonia Stiban
- Sonika Agarwal
- Sophie Liu
- Souheil Elatrous
- Souzana Anisoglou
- SrÄan Gavrilovic
- Stacey Watts
- Stanislas Ledochowski
- Stefan Goller
- Stefan Schaller
- Stefano Coremans
- Stella Soundoulounaki
- Stella Uba
- Stephan Graeser
- Stephanie Harris
- Stephen Brett
- Stephen J Brett
- Stephen M Pastores
- Stijn I Blot
- Stijn Van de Velde
- Styliani Bastani
- Styliani Kourelea
- Suha Bozbay
- Sun Lijuan
- Sun Zhiping
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sung Wai Ho
- Sunghoon Park
- Sunthiti Morakul
- Susana Ferreira
- Susana Pinto
- Susanna Hojden
- Susanne Fischer
- Suzana Bianchini
- Suzana PeÄenkoviÄ
- Suzanne Barrowcliffe
- Suzanne Bench
- Swagata Tripathy
- Swagotika Salo
- Sylvi Vullum
- Syragoula Tsikriki
- SĂ©bastien Jochmans
- SĂ©bastien Pili-Floury
- Taha Khaled
- Tai Sun Park
- Takoua Merhabene
- Talia Ben-Jacob
- Tamas Szakmany
- Tamas Vymazal
- Tanja Depuydt
- Tanja Goranovic
- Tao Zan
- Tara Clesi
- Tarek Dendane
- Tarja Tervo-Heikkinen
- Tatiana Patrichi
- Tatjana Beker
- TaĂs Pantaleao
- Teena Maguire
- Theogene Twagirumugabe
- Theogene Twagirumugabe
- Theonymfi Papavasilopoulou
- Thierry Dugernier
- Thomai Tholioti
- Thomas Dimski
- Thomas Leong
- Thomas Llewellym
- Tianfei Chen
- Ticiane Campanili
- Tien Meng Khoo
- Tim Chimunda
- Timothy Eng
- Tina Charlotte Bitsch Hansen
- Tina Damgaar Thomsen
- Tine Melgaard Frandsen
- Ting Han
- Tingting Li
- Tingting Yu
- Tobias Heinicke
- Tobias Odenthal
- Tobias Schulze
- Tom Dormans
- Tomas Jovaisa
- Tomas Jovaisa
- Tomas Vymazal
- Tomasz Torlinski
- Tomislav Mirkovic
- Tonia Onyeka
- Touraj Rastegar
- Treiza Trueman-Dawkins
- Trina Zhivotneva
- Troy Browne
- Turkay Akbas
- Ulf Guenther
- Ulla Kesti
- Ulla Sandberg
- Ulrica Mickelsson
- Ulrich Jaschinski
- Umeda Aya
- Una Gunter
- Uri Gorokhovatsky
- Uta Kolussi
- V Gusarov
- Vaarisan Ganeshalingam
- Vaibhav Bhargava
- Valentina Bendelari
- Valentina Di Gravio
- Vanda Seromenho
- Vanesa Mercado Telleria
- Vanesa Mercado Telleria
- Vanja Gievski
- Vanja Misic
- Vasileios Bekos
- Vasiliki Chantziara
- Vasilios Koulouras
- Vasilios Koulouras
- Veronica Curilen
- Veronika Kotanidi
- Vesna Bumbasirevic
- Vicent SalvĂ -Costa
- Victor Gonzalez
- Victoria Houghton
- Victoria Khoronenko
- Victoria Marriott
- Vilas Kushare
- Vincent Castelain
- Vincent Fraipont
- Vincianne Pleitinckx
- Virginie Souppart
- Virpi Lusenius
- Vishnu Das Sasidharan Nair
- Vitaly Gusarev
- Vitaly Gusarov
- Vitor Gomes
- Vitor Manuel Vaz Pinto
- Viveca Hamback Hellkvist
- ViĆĄnja Nesek Adam
- Vladimir Gurevich
- Vladimir Kulakov
- Vladislav Belskiy
- Volkan Inal
- Volodymyr Babych
- Vongayi Ogbeide
- W Nazaruddin W Hassan
- Walid Naija
- Walid Sellami
- Walter Swinnen
- Wan Nasrudin Wan Ismail
- Wang Zhijuan
- Wangari Waweru-Siika
- Wangari Waweru-Siika
- Wangyan Jin
- Wei Sun
- Wei Wang
- Wei Wei
- Wei Zhang
- Wei Zhang
- Weilian Yuan
- Weiwei Li
- Wenche Arntsen
- Wendy Brown
- Wendy Chaboyer
- Wendy Chaboyer
- Wendy Milner
- Wenjie Ju
- Wenmei Wang
- Wenmin Chen
- Wenwen Zhao
- Wenzhen Cao
- Wesal Ali Belkhair
- Willem Dieperink
- Windu Baskoro
- Won-Yeon Lee
- Wu Yuchen
- Xia Cui
- Xia Huang
- Xianhong Zheng
- Xianping Luo
- Xiao Fang Tian
- Xiao Xu
- XiaoChun Hu
- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ăgoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ăngela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Ellis Yvette
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazla Fathima
- Featherstone Peter
- Felton Tim
- Fennessy Gerard
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernandes Edna
- Fernandez Maria
- Fernando Gloria
- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
- Finn André
- Finn Stephanie
- Finnis Mackenzie
- Fiouni Sofia
- Fischer Roy
- Fitzgerald Mark
- Fitzpatrick Meghan
- Fletcher Simon
- Flint Neil
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- Florescu Simin
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- Flynn Gordon
- FocĂ Emanuele
- Folci Marco
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- Forster Elliot
- Foster Tracy
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- Foulds Angela
- Fowler Rob
- Fowler Robert
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- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
- Francois Bruno
- Frankfurter Claudia
- Franz Christopher
- François Bourgerol
- Fraser Catherine
- Frater Alasdair
- French Craig
- Frey Anna
- Frey Christian
- Frise Matthew
- Frost Victoria
- Fuchs Ralph
- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
- Ganguly Saibal
- Garcia Sara
- Gardiner-Hill Caroline
- Garot Denis
- Garrard Hywel
- Garrard William
- Garrett Peter
- Garrier Ludivine
- Garrod Esther
- Garton Mark
- Garvey James
- Gascoyne Rachel
- Gattas David
- Gauli Basanta
- Gay Alexandra
- Gaylard Jane
- Gellamucho Minerva
- Gemmell Lisa
- Gendall Emma
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- Simpson Benjamin
- Simpson Joanna
- Simpson Scott
- Simpson Tom
- Sinclair Julie-Ann
- Singh Jayaprakash
- Singh Rajeev
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- Singler Karen
- Singleton Jo
- Sinha Pratik
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- Skinner Tabitha
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- Stanworth Simon
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- Wood Hannah
- Wood Tracy
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- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570