Síntesis de cetonas policíclicas : I, síntesis, resolución y propiedades quirópticas de cetonas tricíclicas referible a esqueletos esteroidicos, II, síntesis biomimética de cetonas esteroidicas

Tesis - Universidad Complutense de Madrid, 1980.Fac. de Ciencias QuímicasTRUEProQuestpu

Síntesis de cetonas policíclicas : I, síntesis, resolución y propiedades quirópticas de cetonas tricíclicas referible a esqueletos esteroidicos, II, síntesis biomimética de cetonas esteroidicas

Tesis - Universidad Complutense de Madrid, 1980.Fac. de Ciencias QuímicasTRUEProQuestpu

New insights on the self-organization of PEG/alpha-cyclodextrin- based Polyrotaxanes in solution: an experimental and theoretical study

Size exclusion chromatography coupled with light scattering (SEC/MALS), dynamic light scattering (DLS), steady-state and time-resolved fluorescence, as well as molecular dynamics (MD) simulations are used to study the behavior of several poly(ethylene glycol) (PEG)/α-cyclodextrins (αCDs) polyrotaxanes (PRs) in solution. The number of CD units in any of the PRs studied is always smaller than that required to saturate the PEG chains. These PRs seem to aggregate in dimethyl sulfoxide (DMSO) solution. The presence of hairpins in the non-saturated PRs contributes to diminishing their expected large dimensions. Intra- and inter­molecular interactions and forces responsible for hairpins and aggregation are investigated.This work was supported by the University of Alcalá (GC2011–002 and UAH2011/EXP-036) and Nanomod (MAT2010–17091) from the Spanish Ministerio de Ciencia e Innovación. The authors acknowledge the assistance of M. L. Heijnen with the preparation of the manuscript

Optimización del proceso logístico para la adquisición de Equipos De Protección Personal (EPP) en el área de servicios de la empresa “NEWM s.a.”

El presente trabajo de investigación se enfoca en el planteamiento de una propuesta para la optimización del proceso de abastecimiento de equipos de protección personal (EPP), requeridos por el área de Servicios de la empresa NEWM S.A. para brindar los servicios de mantenimiento preventivo para sus clientes del sector minero. Dado los altos estándares de seguridad y regulaciones requeridos en el sector minero, los EPP son considerados como productos críticos, cuya falta de disponibilidad conlleva a la no realización de los servicios. Esto implica impactos negativos para la empresa, relacionados a la disminución de las ventas (por aplicación de penalidades) y el incremento de los costos de traslado, ya que se hace necesaria la programación de envíos adicionales a los puntos de trabajo. Por otro lado, el uso de EPP asegura que los servicios se realicen de forma segura, de modo de salvaguardar la integridad del personal técnico, que constituye el principal activo de la compañía. Con respecto a la metodología, se recogió información sobre el proceso de abastecimiento mediante entrevistas con los responsables de los procesos de Compras, Servicios y Almacén, y el análisis del flujo de proceso actual. Mediante la aplicación de las herramientas Teoría de los 5 Ceros y Diagrama de Ishikawa, se detectaron las principales causas que generan la falta de disponibilidad de EPP, logrando plantear una propuesta de mejora que aborda las necesidades de la empresa, basada en el ordenamiento de los procesos y la aplicación de tecnología para lograr la eficiencia operativa.The present research is focused in the approach of a proposal for the optimization of the supply process of personal protective equipment (PPE), required by the Service area of ​​the company NEWM S.A. in order to provide preventive maintenance services for its clients in the mining sector. Due to the high safety standards and regulations required in the mining sector, PPE are considered critical products, which lack of availability leads to the non-performance of services. It implies negative impacts for the company, related to the decrease in sales (due to penalties) and the increase in transportation costs, since it is necessary to program additional forwardings to the work points. On the other hand, the use of PPE ensures that the services are carried out safely, in order to safeguard the integrity of the technical staff, which is the main asset of the company. Regarding methodology, the information about supply process was collected making interviews with the responsible of Purchasing, Services and Warehouse processes, and making the analysis of the current process flow. By applying the Theory of 5 Zeros and Ishikawa Diagram tools, the main causes that generate the lack of availability of PPE were detected, and an improvement proposal was raised according to the needs of the company, based on the processes ordering and the application of technology to achieve operational efficiency.Trabajo de investigació

Planeamiento estratégico de recursos humanos para una empresa de servicios marítimos, periodo 2021-2023

El presente trabajo tiene como finalidad desarrollar el Plan Estratégico de Recursos Humanos para una empresa de servicios marítimos para el período 2021 – 2023. Como parte de este proceso, se ha definido la importancia de gestionar la implementación de programas de capacitación y desempeño con el fin de brindar el soporte que se requiere para potenciar la competitividad de los colaboradores y de la empresa. Para la elaboración del diagnóstico, la investigación fue de carácter exploratorio- descriptivo; empleando para ello entrevistas a profundidad y focus group a los trabajadores, además se utilizaron instrumentos de análisis estratégicos tales como FODA, PESTEL, fuerzas de PORTER, Análisis VRIO, entre otros, los cuales nos permitieron identificar una línea base y establecer los procesos críticos del área de Gestión Humana, promoviendo el alineamiento de esta con la estrategia del negocio. Finalmente, se establecieron mejoras y propuestas ad hoc a las necesidades de la empresa para lograr contrarrestar la problemática existente y focalizarla hacia la mejora continua

Representaciones sociales de estudiantes universitarios acerca de la palabra “perdón” en el contexto del conflicto y postconflicto colombiano

In a contextof internal warfare of more than fifty years in Colombia and with a signed peace process that seeks to end part of the conflict, forgiveness is spoken of daily, a fundamental term for the solution of conflicts. However, due to political-historical situations and the misinformation that has existed, this word has acquired multiple meanings. The present article pretends to show what are the social representations that the university students of Bucaramanga have in front of the word "forgiveness" in the context of the conflict and the Colombian post-conflict. A qualitative methodology linked to the grounded theory was implemented and different qualitative data collection techniques were used. Based on the general and emerging categories, an analysis of the speeches issued by students from two universities, one public and one private, was made. Here, it was evidenced that forgiveness is constantly related as a significant and necessary entity for the termination of a conflict. . In conclusion, the conception of forgiveness is directly related to forgetting, so it becomes an important factor in the construction of peace, a premise that becomes relevant because of the implications of having to forgive for societ

Spanish National Hip Fracture Registry (RNFC) : First-year results and comparison with other registries and prospective multi-centric studies from Spain

Fundamentos: El Registro Nacional de Fracturas de Cadera (RNFC) es un registro español multicéntrico, prospectivo y continuo, que comenzó en 2017. El objetivo de este artículo fue presentar los datos del primer informe anual y compararlos con los registros autonómicos y los estudios multicéntricos realizados recientemente en España. Métodos: Se incluyeron las personas de 75 años o más atendidas con el diagnóstico de fractura de cadera por fragilidad en alguno de los hospitales participantes en el RNFC, entre enero y octubre de 2017. En el análisis estadístico se utilizó la media y desviación estándar o mediana y rangos intercuartílicos para las variables numéricas y los porcentajes para las variables categóricas. Se realizó un análisis descriptivo global de la casuística y se comparó con los datos disponibles de los estudios previos mencionados. Resultados: Se registraron 7.208 personas de 54 hospitales, con una edad media de 86,7 años (DE 5,6). El 75,4% fueron mujeres y el 36,4% presentaron deterioro cognitivo previo. La demora quirúrgica media fue de 75,7 horas (DE 63,6) y la estancia media fue de 10,9 días (DE 6,7). De las personas que vivían en un domicilio antes de la fractura (75,4%), menos de la mitad (37,0%) volvieron a él tras el alta hospitalaria. Al mes, había fallecido el 7,1%. La comparación con los otros estudios mostró algunas diferencias importantes, sobre todo en la ubicación previa, en el porcentaje de pacientes institucionalizados de novo (7,7-29,4%) y en el porcentaje con tratamiento antiosteoporótico al alta (14,5-36,7%). Conclusiones: El RNFC es la mayor base de datos prospectiva que aporta datos sobre el perfil de los pacientes hospitalizados por fractura de cadera en España. La comparación con otros estudios recientes muestra algunas diferencias importantes.OBJECTIVE: The Spanish National Hip Fracture Registry (Registro Nacional de Fracturas de Cadera or RNFC) is a Spanish, prospective, multi- centric registry, commenced in 2017. The goal of this paper is to present the data from the first annual report and to compare them with autonomic registries and recent prospective multi-centric studies performed in Spain. METHODS: We included persons 75 years or older treated for fragility hip fractures in any of the centers participating in the RNFC between January and October 2017. The descriptive statistics of each variable used the mean (and standard deviation) or the median (and interquartile ranges) for the ordinal variables and the percentage for the categoric variables. A descriptive analysis of the casemix was performed and compared with available data from the aforementioned studies. RESULTS: The RNFC included 7.208 patients from 54 hospitals, with a mean age of 86.7 (SD 5.6) years; 75.4% were women, and 36.4% showed cognitive decline. Mean surgical delay was 75.7 (SD 63.6) hours, and length of stay averaged 10.9 (SD 6.7) days. Of the patients who lived at home (75.4%), less than half (37.0%) returned home at discharge. One-month mortality was 7.1%. Comparison with other studies showed important differences, especially regarding patients newly sent to nursing homes (7.7-29.4%) and with antiosteoporotic treatment at discharge (14.5-36.7%). CONCLUSIONS: The RNFC is the largest prospective database to date that offers data regarding the characteristics of patients hospitalized for hip fractures in Spain. Comparison with recent studies showed some important differences

Registro Nacional de Fracturas de Cadera (RNFC): Resultados del primer año y comparación con otros registros y estudios multicéntricos españoles

Background: The Spanish National Hip Fracture Registry (Registro Nacional de Fracturas de Cadera or RNFC) is a Spanish, prospective, multi- centric registry, commenced in 2017. The goal of this paper is to present the data from the first annual report and to compare them with autonomic registries and recent prospective multi-centric studies performed in Spain. Methods: We included persons 75 years of age or older treated for fragility hip fractures in any of the centers participating in the RNFC between January and October 2017. The descriptive statistics of each variable used the mean (and standard deviation) or the median (and interquartile ranges) for the ordinal variables and the percentage for the categoric variables. A descriptive analysis of the casemix was performed and compared with available data from the aforementioned studies. Results: The RNFC included 7.208 patients from 54 hospitals, with a mean age of 86.7 (SD 5.6) years; 75.4% were women, and 36.4% showed cognitive decline. Mean surgical delay was 75.7 (SD 63.6) hours, and length of stay averaged 10.9 (SD 6.7) days. Of the patients who lived at home (75.4%), less than half (37.0%) returned home at discharge. One-month mortality was 7.1%. Comparison with other studies showed important differences, especially regarding patients newly sent to nursing homes (7.7-29.4%) and with antiosteoporotic treatment at discharge (14.5-36.7%). Conclusions: The RNFC is the largest prospective database to date that offers data regarding the characteristics of patients hospitalized for hip fractures in Spain. Comparison with recent studies showed some important differencesFundamentos: El Registro Nacional de Fracturas de Cadera (RNFC) es un registro español multicéntrico, prospectivo y continuo, que comenzó en 2017. El objetivo de este artículo fue presentar los datos del primer informe anual y compararlos con los registros autonómicos y los estudios multicéntricos realizados recientemente en España. Métodos: Se incluyeron las personas de 75 años o más atendidas con el diagnóstico de fractura de cadera por fragilidad en alguno de los hospitales participantes en el RNFC, entre enero y octubre de 2017. En el análisis estadístico se utilizó la media y desviación estándar o mediana y rangos intercuartílicos para las variables numéricas y los porcentajes para las variables categóricas. Se realizó un análisis descriptivo global de la casuística y se comparó con los datos disponibles de los estudios previos mencionados. Resultados: Se registraron 7.208 personas de 54 hospitales, con una edad media de 86,7 años (DE 5,6). El 75,4% fueron mujeres y el 36,4% presentaron deterioro cognitivo previo. La demora quirúrgica media fue de 75,7 horas (DE 63,6) y la estancia media fue de 10,9 días (DE 6,7). De las personas que vivían en un domicilio antes de la fractura (75,4%), menos de la mitad (37,0%) volvieron a él tras el alta hospitalaria. Al mes, había fallecido el 7,1%. La comparación con los otros estudios mostró algunas diferencias importantes, sobre todo en la ubicación previa, en el porcentaje de pacientes institucionalizados de novo (7,7-29,4%) y en el porcentaje con tratamiento antiosteoporótico al alta (14,5-36,7%). Conclusiones: El RNFC es la mayor base de datos prospectiva que aporta datos sobre el perfil de los pacientes hospitalizados por fractura de cadera en España. La comparación con otros estudios recientes muestra algunas diferencias importantesThe RNFC has been financed through donations by AMGEN SA, UCB Pharma, Abbott Laboratories and FAES Farma, as well as a Research Grant from the Fundación Mutua Madrileña (AP169672018)

CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

ObjectivesCARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.MethodsIn total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis.ResultsIn total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5).ConclusionThis study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3

Teacher competencies in situations of harassment and Aggression due to sexual and gender diversities in classrooms. State the issue in the US and Canada

Bibliografía: • Aragón, S. R., Poteat, V. P., Espelage, D. L. y Koenig, B. W. (2014). The influence of peer victimization on educational outcomes for LGBTQ and non-LGBTQ high school students. Journal of LGBT Youth, 11(1), 1-19. https://doi.org/10.1080/19361653.2014.840761 • Bellini, C. (2012). The Pink Lesson Plan: Addressing the Emotional Needs of Gay and Lesbian Students in Canadian Teacher Education Programs. Journal of LGBT Youth, 9, 373-396. https://doi.org/10.108 0/19361653.2012.714178 • Callaghan, T. D. y van Leent, L. (2019). Homophobia in Catholic schools: An exploration of teachers’ rights and experiences in Canada and Australia. Journal of Catholic Education, 22(3). http://dx.doi. org/10.15365/joce.2203032019 • Fantus, S. y Newman, P. A. (2021). Promoting a positive school climate for sexual and gender minority youth through a systems approach: A theory-informed qualitative study. 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School connectedness and student-teacher relationships: a comparison of sexual minority youths and their peers. Children & Schools, 37, 3. https://doi.org/10.1093/cs/cdv012 • Kosciw, J. G., Clark, C. M. y Menard, L. (2022). The 2021 National School Climate Survey: The experiences of LGBTQ+ youth in our nation’s schools. Washington: GLSEN. https://www.glsen.org/research/2021- national-school-climate-survey • Kosciw, J. G., Palmer, N. A. y Kull, R. M. (2015). Reflecting resiliency: openness about sexual orientation and/or gender identity and its relationship to well-being and educational outcomes for LGBT students. Am J Community Psychol, 55(1-2), 167-178. https://doi.org/ 10.1007/s10464-014-9642-6 • Milburn, W. y Palladino, P. (2012). Preservice Teachers’ Knowledge, Skills, and Dispositions of LGBTQ Bullying Intervention. The American Association of Behavioral and Social Sciences Journal, 16, 86-100. • Moore, M. J. y Rienzo, B. A. (2000). Utilizing the SIECUS Guidelines to Assess Sexuality Education in One State: Content Scope and Importance. Journal of School Health, 70(2), 56-60. https://doi.org/10.11 11/j.1746-1561.2000.tb07243.x • O’Connell, L. M, Atlas, J. G, Saunders, A. L y Philbrick, R. (2010). Perceptions of Rural School Staff Regarding Sexual Minority Students. Journal of LGBT Youth, 7(4), 293-309. https://doi.org/10.1080/1936 1653.2010.518534 • Ortega-Leal, M. P. (2023). Las competencias del profesorado en diversidades sexo-genéricas en las etapas de Educación Infantil, Primaria y Secundaria obligatoria. Una investigación desde la metodología comunicativa [tesis doctoral, Universitat de València]. • Peter, T., Taylor, C. y Campbell, C. (2016). «You can’t break... when you’re already broken»: The importance of school climate to suicidality among LGBTQ youth. Journal of Gay & Lesbian Mental Health, 20(3), 195-213. https://doi.org/10.1080/19359705.2016.1171188 • Peter, T., Campbell, C. P. y Taylor, C. (2021). Still in every class in every school: Final report on the second climate survey on homophobia, biphobia, and transphobia in Canadian schools. Egale Canada Human Rights Trust. https://egale.ca/awareness/still-in-every-class • Potvin, L. (2021). It’s not all rainbows and unicorns: Straight teacher allies reflect on privilege. Journal of LGBT Youth, 18(3), 273-286. https://doi.org/10.1080/19361653.2020.1719952 • Price, J. H., Dake, J. A., Kirchofer, G. y Telljohann, S. K. (2003). Elementary school teachers’ techniques of responding to student questions regarding sexuality Issues. Journal of School Health, 73(1), 9-14. https://doi.org/10.1111/j.1746-1561.2003.tb06552.x • Richard, G. (2015). The pedagogical practices of Québec high school teachers relative to sexual diversity. Journal of LGBT Youth, 12(2), 113-143. https://doi.org/10.1080/19361653.2014.969866 • Schneider, M. S. y Dimito, A. (2008). Educators’ Beliefs about Raising Lesbian, Gay, Bisexual, and Transgender Issues in the Schools: The Experience in Ontario, Canada. Journal of LGBT Youth, 5(4), 49-71. http://dx.doi.org/10.1080/19361650802223003 • Steck, A. K. y Perry, D. (2018). Challenging heteronormativity: Creating a safe and inclusive environment for LGBTQ students. Journal of School Violence, 17(2), 227-243. http://doi.org/10.1080/1538822 0.2017.1308255 • Taylor, C. y Peter, T. (2011). Every class in every school: final report on the first national climate survey on homophobia, biphobia and transphobia in Canadian schools. Egale Canada Human Rights Trust. https://egale. ca/every-class/ • Toomey, R. B., Ryan, C., Diaz, R. M., Card, N. A., Russell, S. T. (2010). Gender-nonconforming lesbian, gay, bisexual, and transgender youth: school victimization and young adult psychosocial adjustment. Dev Psychol, 46(6), 1580-1589. https://doi.org/10.1037/ a0020705 • Van Der Toorn, J., Jost, J. T., Packer, D. J., Noorbaloochi, A. y Van Bavel, J. J. (2017). In Defense of Tradition: Religiosity, Conservatism, and Opposition to Same-Sex Marriage in North America. Personality & Social Psychology Bulletin, 43(10), 1455-1468. • Waters, E., Jindasurat, C. y Wolfe, C. (2016). Lesbian, gay, bisexual, transgender, queer and HIV-affected hate violence in 2015. National Coalition of Anti-Violence Programs. Nueva York.Estudios relativos a diversidades sexo-genéricas ganan espacio progresivamente en el campo académico educativo. Las conductas abusivas, agresiones físicas, pero también simbólicas, hacia alumnado LGBTIQ+ requieren profundizar sobre género y diversidad sexo-genérica y familiar en los centros de enseñanza. Este capítulo aborda el análisis de la LGBTIQ+fobia del profesorado en investigaciones de EE. UU. y Canadá. Países con abundantes investigaciones relativas al papel del profesorado como garante de escuelas seguras. Los resultados evidencian la relevancia de introducir competencias dirigidas al tratamiento de las diversidades sexo-genéricas en el currículo universitario del profesorado en formaciónDepto. de Estudios EducativosFac. de EducaciónTRUEpu