Industry needs and tertiary journalism education: Views from news editors

This research paper discusses the findings from a 2012 Australian Learning and Teaching Council (ALTC) sponsored project that canvassed the views of news editors around Australia about the job readiness of tertiary educated journalism graduates. The focus of this paper is limited to responses from news editors in Western Australia. Data was collected via face to face interviews with eleven news editors in Perth, Western Australia. The editors work in print, online, broadcast and television and all of them employ journalism graduates. The aim was to assess whether the five university based journalism programs in Perth provide graduates with the skillset prospective employers were seeking. Editors are uniquely placed as they employ journalism graduates as interns, or as full time employees when they complete their studies, and they know which attributes and skills will help journalism graduates to succeed. The editors, for the most part, agreed that there was a key role for universities in Perth to provide both an educational background and skills based training for people contemplating a career in journalism and early career journalists. There was, however, some disagreement as to what the ideal university based journalism program should consist of

Atubular glomeruli in a rat model of polycystic kidney disease

Atubular glomeruli in a rat model of polycystic kidney disease.BackgroundAutosomal-dominant polycystic kidney disease (ADPKD) is associated with a progressive decline in glomerular filtration rate (GFR) that often leads to end-stage renal disease. The basis for this decline in GFR is poorly understood.MethodsGlomeruli in heterozygous Han:SPRD rats with ADPKD and their normal litter mates were studied by light microscopy, using serial sectioning techniques. The connections of the renal corpuscles to proximal tubules were classified as normal, atrophied, or absent (atubular glomerulus). Renal corpuscles also were examined by scanning electron microscopy. Single nephron glomerular blood flows were determined using microspheres.ResultsIn the kidneys of six-month-old rats with ADPKD, 50% of the glomeruli were atubular and another 26% were associated with atrophied neck segments; these glomeruli were most often smaller in size than normal. About 16% of the glomeruli were hypertrophied and had normal connections to proximal tubules. Sclerotic changes in cystic kidney glomeruli were usually mild or moderate, and belied the failure of glomerular function. Glomerular blood flow in the cystic kidneys averaged half of normal and was markedly heterogeneous; the majority of small glomeruli displayed very low blood flows and a few showed relatively high blood flows. Fewer glomerular abnormalities were found in rats treated for five months with potassium citrate in their drinking water.ConclusionsThe diminished GFR in the rat with ADPKD can be accounted for largely by the formation of atubular glomeruli. Compensatory glomerular hypertrophy also is present and may contribute to the progression of the renal disease

Challenges for resilience policy and practice

Resilience is interpreted in multiple, often conflicting ways, which prompts critiques but is also viewed by others as a strength, bringing together otherwise disparate groups, institutions, disciplines and scales. The absence of explicit values within resilience concepts has caused some authors to caution its use as a guiding narrative or framework. A major challenge for practitioners lies in how to explicitly inject values and to navigate tradeoffs in resilience between groups, locations and timescales. This working paper sets out the multiple ways in which resilience is interpreted. It highlights the broad dichotomy between functional and dynamic interpretations of resilience, which lead to different operational approaches. A functional perspective tends to fit with existing institutional approaches and a projectised approach, while dynamic interpretations perhaps represent the complexities and chaos evident across the world. The inconsistent treatment of system transformations is also a major challenge; while some see transformation as occurring incrementally within a system, others see it as when resilience fails and systems collapse

Beyond technical fixes: climate solutions and the great derangement

Climate change research is at an impasse. The transformation of economies and everyday practices is more urgent, and yet appears ever more daunting as attempts at behaviour change, regulations, and global agreements confront material and social-political infrastructures that support the status quo. Effective action requires new ways of conceptualizing society, climate and environment and yet current research struggles to break free of established categories. In response, this contribution revisits important insights from the social sciences and humanities on the co-production of political economies, cultures, societies and biophysical relations and shows the possibilities for ontological pluralism to open up for new imaginations. Its intention is to help generate a different framing of socionatural change that goes beyond the current science-policy-behavioural change pathway. It puts forward several moments of inadvertent concealment in contemporary debates that stem directly from the way issues are framed and imagined in contemporary discourses. By placing values, normative commitments, and experiential and plural ways of knowing from around the world at the centre of climate knowledge, we confront climate change with contested politics and the everyday foundations of action rather than just data

Isoperimetric Inequalities in Simplicial Complexes

In graph theory there are intimate connections between the expansion properties of a graph and the spectrum of its Laplacian. In this paper we define a notion of combinatorial expansion for simplicial complexes of general dimension, and prove that similar connections exist between the combinatorial expansion of a complex, and the spectrum of the high dimensional Laplacian defined by Eckmann. In particular, we present a Cheeger-type inequality, and a high-dimensional Expander Mixing Lemma. As a corollary, using the work of Pach, we obtain a connection between spectral properties of complexes and Gromov's notion of geometric overlap. Using the work of Gunder and Wagner, we give an estimate for the combinatorial expansion and geometric overlap of random Linial-Meshulam complexes

Quantum Graphs: A simple model for Chaotic Scattering

We connect quantum graphs with infinite leads, and turn them to scattering systems. We show that they display all the features which characterize quantum scattering systems with an underlying classical chaotic dynamics: typical poles, delay time and conductance distributions, Ericson fluctuations, and when considered statistically, the ensemble of scattering matrices reproduce quite well the predictions of appropriately defined Random Matrix ensembles. The underlying classical dynamics can be defined, and it provides important parameters which are needed for the quantum theory. In particular, we derive exact expressions for the scattering matrix, and an exact trace formula for the density of resonances, in terms of classical orbits, analogous to the semiclassical theory of chaotic scattering. We use this in order to investigate the origin of the connection between Random Matrix Theory and the underlying classical chaotic dynamics. Being an exact theory, and due to its relative simplicity, it offers new insights into this problem which is at the fore-front of the research in chaotic scattering and related fields.Comment: 28 pages, 13 figures, submitted to J. Phys. A Special Issue -- Random Matrix Theor

Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis

Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH(+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Additionally, platinum-tolerant cells and tumors exhibited expression of the Wnt receptor Frizzled 7 (FZD7). Knockdown of FZD7 improved sensitivity to platinum, decreased spheroid formation, and delayed tumor initiation. The molecular signature distinguishing FZD7(+) from FZD7(−) cells included epithelial-to-mesenchymal (EMT), stemness, and oxidative phosphorylation-enriched gene sets. Overexpression of FZD7 activated the oncogenic factor Tp63, driving upregulation of glutathione metabolism pathways, including glutathione peroxidase 4 (GPX4), which protected cells from chemotherapy-induced oxidative stress. FZD7(+) platinum-tolerant OC cells were more sensitive and underwent ferroptosis after treatment with GPX4 inhibitors. FZD7, Tp63, and glutathione metabolism gene sets were strongly correlated in the OC Tumor Cancer Genome Atlas (TCGA) database and in residual human OC specimens after chemotherapy. These results support the existence of a platinum-tolerant cell population with partial cancer stem cell features, characterized by FZD7 expression and dependent on FZD7-β-catenin-Tp63-GPX4 pathway for survival. The findings reveal a novel therapeutic vulnerability of platinum-tolerant cancer cells and provide new insight into a potential “persister cancer cell” phenotype

Climate Change Adaptation, Disaster Risk Reduction and Social Protection: Complementary Roles in Agriculture and Rural Growth?

Reliance on subsistence agriculture means the impact of stresses and shocks (such as droughts or floods) are felt keenly by rural poor people, who depend directly on food system outcomes for their survival, with profound implications for the security of their livelihoods and welfare. However, such stresses and shocks will not necessarily lead to negative impacts, as risks and uncertainties, often associated with seasonality, are embedded in the practice of agriculture and there is considerable experience of coping and risk management strategies among people working in this sector. With climate change, the magnitude and frequency of stresses and shocks is changing and approaches such as social protection, disaster risk reduction (DRR) and climate change adaptation (CCA) will be needed to bolster local resilience and supplement people's experience. This study examines the opportunities for linking social protection, CCA and DRR in the context of agriculture and rural growth, exploring whether linking these three approaches together will help enhance resilience to shocks and stresses in agriculture‐dependent rural communities. The study does this by (i) reviewing conceptual and policy‐related similarities and differences between the three disciplines, by (ii) collecting evidence from case studies where climate change‐resilient social protection approaches have been trialled and by (iii) developing an adaptive social protection framework that highlight opportunities better coordination. This paper suggests social protection and DRR measures designed to limit damages from shocks and stresses may not be sufficient in the longer term. For social protection to be resilient to climate change impacts, it will need to consider how reducing dependence on climate sensitive livelihood activities can be part of adaptive strategies. Similarly, CCA and DRR cannot effectively address the root causes of poverty and vulnerability without taking a differentiated view of poverty, something that further integration with social protection can help with