364 research outputs found
PCN103 Reanalysis of Cost-Effectiveness of Abiraterone Acetate as Second Line Treatment for Metastatic Castration-Resistant Prostate Cancer in Japan Using a Japanese Claim Data Set
ClaimChain: Improving the Security and Privacy of In-band Key Distribution for Messaging
The social demand for email end-to-end encryption is barely supported by
mainstream service providers. Autocrypt is a new community-driven open
specification for e-mail encryption that attempts to respond to this demand. In
Autocrypt the encryption keys are attached directly to messages, and thus the
encryption can be implemented by email clients without any collaboration of the
providers. The decentralized nature of this in-band key distribution, however,
makes it prone to man-in-the-middle attacks and can leak the social graph of
users. To address this problem we introduce ClaimChain, a cryptographic
construction for privacy-preserving authentication of public keys. Users store
claims about their identities and keys, as well as their beliefs about others,
in ClaimChains. These chains form authenticated decentralized repositories that
enable users to prove the authenticity of both their keys and the keys of their
contacts. ClaimChains are encrypted, and therefore protect the stored
information, such as keys and contact identities, from prying eyes. At the same
time, ClaimChain implements mechanisms to provide strong non-equivocation
properties, discouraging malicious actors from distributing conflicting or
inauthentic claims. We implemented ClaimChain and we show that it offers
reasonable performance, low overhead, and authenticity guarantees.Comment: Appears in 2018 Workshop on Privacy in the Electronic Society
(WPES'18
Contribution of socioeconomic status, stature and birth weight to obesity in Sub-Saharan Africa: cross-sectional data from primary school-age children in Cameroon
Background: The pattern of obesity in relation to socioeconomic status is of public health concern. This study investigates whether the association between height and obesity in children is affected by their socioeconomic background. It also explores the relationship between high birth weight and obesity. Methods: School children, (N = 557; 5 to 12 years old) were recruited from randomly selected primary schools in a cross-sectional study including 173 rural and 384 urban children in the North West Region of Cameroon. Socioeconomic status (SES) and birth weight were obtained using a self administered questionnaire. Anthropometric measures included height, weight, BMI, waist circumference and percentage body fat. These measures were transformed into age and sex-standardized variables. Then participants were divided according to quartiles of height SDS. Results: The highest frequencies of overweight/obesity (18.8%), abdominal overweight/obesity (10.9%) and high body fat/obesity (12.3%) were observed among the tallest children from a high socioeconomic background. Univariate analyses indicate that children of high SES (39.9%), fourth height quartile (33.1%) and of high birth weight (54.8%) were significantly (p<0.001) more likely to be overweight/obese. Multivariate analyses showed high SES (OR 8.3, 95% CI 3.9 - 15.4), fourth height quartile (OR 9.1, 95% CI 3.4 - 16.7) and high birth weight (OR 0.1, 95% CI 0.06 - 0.2) as independent predictors of overweight/obesity. Conclusions: This study confirms that children coming from a high socioeconomic background and being tall are at particular risk of becoming obese
High-precision CTE measurement of hybrid C/SiC composite for cryogenic space telescopes
This paper presents highly precise measurements of thermal expansion of a
"hybrid" carbon-fiber reinforced silicon carbide composite,
HB-Cesic\textregistered - a trademark of ECM, in the temperature region of
\sim310-10K. Whilst C/SiC composites have been considered to be promising for
the mirrors and other structures of space-borne cryogenic telescopes, the
anisotropic thermal expansion has been a potential disadvantage of this
material. HB-Cesic\textregistered is a newly developed composite using a
mixture of different types of chopped, short carbon-fiber, in which one of the
important aims of the development was to reduce the anisotropy. The
measurements indicate that the anisotropy was much reduced down to 4% as a
result of hybridization. The thermal expansion data obtained are presented as
functions of temperature using eighth-order polynomials separately for the
horizontal (XY-) and vertical (Z-) directions of the fabrication process. The
average CTEs and their dispersion (1{\sigma}) in the range 293-10K derived from
the data for the XY- and Z-directions were 0.8050.003\times10
K and 0.837\pm0.001\times10 K, respectively. The absolute
accuracy and the reproducibility of the present measurements are suggested to
be better than 0.01\times10 K and 0.001\times(10)^{-6} K^{-1},
respectively. The residual anisotropy of the thermal expansion was consistent
with our previous speculation regarding carbon-fiber, in which the residual
anisotropy tended to lie mainly in the horizontal plane.Comment: Accepted by Cryogeincs. 12 pages, 3 figures, 1 tabll
Multi-wavelength analysis of 18um-selected galaxies in the AKARI/IRC monitor field towards the North Ecliptic Pole
We present an initial analysis of AKARI 18um-selected galaxies using all 9
photometric bands at 2-24um available in the InfraRed Camera (IRC), in order to
demonstrate new capabilities of AKARI cosmological surveys. We detected 72
sources at 18um in an area of 50.2 arcmin^2 in the AKARI/IRC monitor field
towards the North Ecliptic Pole (NEP). From this sample, 25 galaxies with
probable redshifts z>~ 0.5 are selected with a single colour cut (N2-N3>0.1)
for a detailed SED analysis with ground-based BVRi'z'JK data. Using an SED
radiative transfer model of starbursts covering the wavelength range UV --
submm, we derive photometric redshifts from the optical-MIR SEDs of
18um-selected galaxies. From the best-fit SED models, we show that the IRC
all-band photometry is capable of tracing the steep rise in flux at the blue
side of the PAH 6.2um emission feature. This indicates that the IRC all-band
photometry is useful to constrain the redshift of infrared galaxies,
specifically for dusty galaxies with a less prominent 4000A break. Also, we
find that the flux dip between the PAH 7.7 and 11.2um emission feature is
recognizable in the observed SEDs of galaxies at z~1. By using such a colour
anomaly due to the PAH and silicate absorption features, unique samples of
ULIRGs at z~1, `silicate-break' galaxies, can be constructed from large
cosmological surveys of AKARI towards the NEP, i.e. the NEP-Deep and NEP-Wide
survey. This pilot study suggests the possibility of detecting many interesting
galaxy properties in the NEP-Deep and Wide surveys, such as a systematic
difference in SEDs between high- and low-z ULIRGs, and a large variation of the
PAH inter-band strength ratio in galaxies at high redshifts. [abridged]Comment: Accepted for publication in PASJ, AKARI special issu
Planar shock wave generated by uniform irradiation from two overlapped partially coherent laser beams
Copyright 2001 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Journal of Applied Physics, 89(5), 2571-2575, 2001 and may be found at http://dx.doi.org/10.1063/1.134218
Electrons in High-Tc Compounds: Ab-Initio Correlation Results
Electronic correlations in the ground state of an idealized infinite-layer
high-Tc compound are computed using the ab-initio method of local ansatz.
Comparisons are made with the local-density approximation (LDA) results, and
the correlation functions are analyzed in detail. These correlation functions
are used to determine the effective atomic-interaction parameters for model
Hamiltonians. On the resulting model, doping dependencies of the relevant
correlations are investigated. Aside from the expected strong atomic
correlations, particular spin correlations arise. The dominating contribution
is a strong nearest neighbor correlation that is Stoner-enhanced due to the
closeness of the ground state to the magnetic phase. This feature depends
moderately on doping, and is absent in a single-band Hubbard model. Our
calculated spin correlation function is in good qualitative agreement with that
determined from the neutron scattering experiments for a metal.Comment: 21pp, 5fig, Phys. Rev. B (Oct. 98
Appetite and falls: Old age and lived experiences
Falling among older adults is a well-known public health problem but the association between falling and appetite is seldom studied although poor nutritional status is accepted as a risk factor for falls. On this background the aim of this study was to understand how older adults, who have fallen several times within a year, related their experiences of appetite as a phenomenon in everyday life. In narrative in-depth interviews, eight women and four men contributed with their stories. Using interpretative phenomenology the thematic analysis resulted in three main themes: appetite for food; appetite for social relations and appetite for influence. Eating was not trivial everyday routine and required self-regimentation. Meals were not an object of desire, but of discipline out of the wish to survive. Feelings, reflections and ambivalence were bound to the lack of appetite on food. The participants were oriented towards the forbidden, the delicious and to everyday food as a strengthener and as medicine. In their dependency on help, home was the framework for establishing social relations as means of social support. As well as family and neighbours, the significant others were persons on whom the participants were dependent. Personal relationships and mutual dependencies may ensure social security in lives characterised by contingency and maintain influence in daily life. Falling is both a dramatic and a trivial incident where life and death could be at stake. From this perspective, connectedness was prominent in all fall stories. The quest for influence and a sense of social connectedness was the incentive to re-enter local community arenas and to express solidarity. In health-care practice multi-factorial fall-prevention should be complemented with a multi-dimensional approach in order to balance the medical approach with humanistic and societal approaches towards fall-prevention
Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation
Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments. These adaptations are a valuable source of genetic material for efforts to improve commercial breeds. As a step toward this goal we identified candidate regions to be under selection in genomes of nine Russian native cattle breeds adapted to survive in harsh climates. After comparing our data to other breeds of European and Asian origins we found known and novel candidate genes that could potentially be related to domestication, economically important traits and environmental adaptations in cattle. The Russian cattle breed genomes contained regions under putative selection with genes that may be related to adaptations to harsh environments (e.g., AQP5, RAD50, and RETREG1). We found genomic signatures of selective sweeps near key genes related to economically important traits, such as the milk production (e.g., DGAT1, ABCG2), growth (e.g., XKR4), and reproduction (e.g., CSF2). Our data point to candidate genes which should be included in future studies attempting to identify genes to improve the extant breeds and facilitate generation of commercial breeds that fit better into the environments of Russia and other countries with similar climates
- …