Differential Expression of Telomere DNA in Blood content for Cancer Diagnostics

poster abstractHuman blood typically contains a very small amount of cell free DNA (cfDNA) of uncertain origin. The amount and makeup of this circulating DNA been shown to change with the presence of cancer in the body. These alterations are used currently in some countries as very rudimentary tests for specific cancers and their mutations, which is reflected in the cfDNA. Little is known about the extent of the changes as the field is very young, though very promising. Telomeres are repetitive DNA elements that function as chromosomal caps, and are essential to cancer survival. Their function in cell life limitation mandates that all cancer find a method by which to bring about telomere dysfunction, making telomere a uniquely universal cancer element. It is possible, therefore, that telomere presence in cfDNA would be altered in many cancers, providing a powerful biomarker for cancer diagnostics and prognostics. This study shows a direct link between cancer presence and an augmented telomeric DNA ration in the blood. This idea could pave the way for a powerful early warning test for difficult cancers

Individual Stellar Halos of Massive Galaxies Measured to 100 kpc at 0.3<z<0.50.3<z<0.5 using Hyper Suprime-Cam

Massive galaxies display extended light profiles that can reach several hundreds of kilo parsecs. These stellar halos provide a fossil record of galaxy assembly histories. Using data that is both wide (~100 square degree) and deep (i>28.5 mag/arcsec^2 in i-band), we present a systematic study of the stellar halos of a sample of more than 3000 galaxies at 0.3 < z < 0.5 with $\log M_{\star}/M_{\odot} > 11.4$. Our study is based on high-quality (0.6 arcsec seeing) imaging data from the Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP), which enables us to individually estimate surface mass density profiles to 100 kpc without stacking. As in previous work, we find that more massive galaxies exhibit more extended outer profiles. When this extended light is not properly accounted for as a result of shallow imaging or inadequate profile modeling, the derived stellar mass function can be significantly underestimated at the highest masses. Across our sample, the ellipticity of outer light profiles increases substantially as we probe larger radii. We show for the first time that these ellipticity gradients steepen dramatically as a function of galaxy mass, but we detect no mass-dependence in outer color gradients. Our results support the two-phase formation scenario for massive galaxies in which outer envelopes are built up at late times from a series of merging events. We provide surface mass surface mass density profiles in a convenient tabulated format to facilitate comparisons with predictions from numerical simulations of galaxy formation.Comment: Submitted to MNRAS; 23 pages, 8 figures, 2 appendix; Data will be made available here: http://massivegalaxies.com/ once the paper is publishe

Contrasting patterns in the occurrence and biomass centers of gravity among fish and macroinvertebrates in a continental shelf ecosystem

The distribution of a group of fish and macroinvertebrates (n = 52) resident in the US Northeast Shelf large marine ecosystem were characterized with species distribution models (SDM), which in turn were used to estimate occurrence and biomass center of gravity (COG). The SDMs were fit using random forest machine learning and were informed with a range of physical and biological variables. The estimated probability of occurrence and biomass from the models provided the weightings to determine depth, distance to the coast, and along-shelf distance COG. The COGs of occupancy and biomass habitat tended to be separated by distances averaging 50 km, which approximates half of the minor axis of the subject ecosystem. During the study period (1978–2018), the biomass COG has tended to shift to further offshore positions whereas occupancy habitat has stayed at a regular spacing from the coastline. Both habitat types have shifted their along-shelf distances, indicating a general movement to higher latitude or to the Northeast for this ecosystem. However, biomass tended to occur at lower latitudes in the spring and higher latitude in the fall in a response to seasonal conditions. Distribution of habitat in relation to depth reveals a divergence in response with occupancy habitat shallowing over time and biomass habitat distributing in progressively deeper water. These results suggest that climate forced change in distribution will differentially affect occurrence and biomass of marine taxa, which will likely affect the organization of ecosystems and the manner in which human populations utilize marine resources.publishedVersio

Enantioselective Synthesis of (+)-Cephalostatin 1

This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C−H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.Chemistry and Chemical Biolog

A branch and bound approach for large pre-marshalling problems

[EN] The container pre-marshalling problem involves the sorting of containers in stacks so that there are no blocking containers and retrieval is carried out without additional movements. This sorting process should be carried out in as few container moves as possible. Despite recent advancements in solving real world sized problems to optimality, several classes of pre-marshalling problems remain difficult for exact approaches. We propose a branch and bound algorithm with new components for solving such difficult instances. We strengthen existing lower bounds and introduce two new lower bounds that use a relaxation of the pre-marshalling problem to provide tight bounds in specific situations. We introduce generalized dominance rules that help reduce the search space, and a memoization heuristic that finds feasible solutions quickly. We evaluate our approach on standard benchmarks of pre-marshalling instances, as well as on a new dataset to avoid overfitting to the available data. Overall, our approach optimally solves many more instances than previous work, and finds feasible solutions on nearly every problem it encounters in limited CPU times.The authors thank the Paderborn Center for Parallel Computation (PC2) for the use of the Arminius cluster for the computational study in this work. This work has been partially supported by the Spanish Ministry of Science, Innovation, and Universities FPU Grant A-2015-12849 and by the Spanish Ministry of Economy and Competitiveness, under projects DPI2014-53665-P and DPI2015-65895-R, partially financed with FEDER funds.Tanaka, S.; Tierney, K.; Parreño-Torres, C.; Alvarez-Valdes, R.; Ruiz García, R. (2019). A branch and bound approach for large pre-marshalling problems. European Journal of Operational Research. 278(1):211-225. https://doi.org/10.1016/j.ejor.2019.04.005S211225278

Laterally Propagating Detonations in Thin Helium Layers on Accreting White Dwarfs

Theoretical work has shown that intermediate mass (0.01Msun<M_He<0.1Msun) Helium shells will unstably ignite on the accreting white dwarf (WD) in an AM CVn binary. For more massive (M>0.8Msun) WDs, these helium shells can be dense enough (5x10^5 g/cc) that the convectively burning region runs away on a timescale comparable to the sound travel time across the shell; raising the possibility for an explosive outcome. The nature of the explosion (i.e. deflagration or detonation) remains ambiguous. In the case of detonation, this causes a laterally propagating front whose properties in these geometrically thin and low density shells we begin to study here. Our calculations show that the radial expansion time of <0.1 s leads to incomplete helium burning, in agreement with recent work by Sim and collaborators, but that the nuclear energy released is still adequate to realize a self-sustaining detonation propagating laterally at slower than the Chapman-Jouguet speed. Our simulations resolve the subsonic region behind the front and are consistent with a direct computation of the reaction structure from the shock strength. The ashes are typically He rich, and consist of predominantly Ti-44, Cr-48, along with a small amount of Fe-52, with very little Ni-56 and with significant Ca-40 in carbon-enriched layers. If this helium detonation results in a Type Ia Supernova, its spectral signatures would appear for the first few days after explosion. (abridged)Comment: 7 pages, 5 figure, accepted to the Astrophysical Journa

Omnidirectional Stereo

Omnidirectional stereo (ODS) is a type of multi-perspective projection that captures horizontal parallax tangential to a viewing circle. This data allows the creation of stereo panoramas that provide plausible stereo views in all viewing directions on the equatorial plane

Analysis of the elemental composition of marine litter by field-portable-XRF

publisher: Elsevier articletitle: Analysis of the elemental composition of marine litter by field-portable-XRF journaltitle: Talanta articlelink: http://dx.doi.org/10.1016/j.talanta.2016.06.026 content_type: article copyright: © 2016 Elsevier B.V. All rights reserved