Fluid effects in model granular flows

Pore fluid plays a crucial role in many granular flows, especially those in geophysical settings. However, the transition in behaviour between dry flows and fully saturated flows and the underlying physics that relate to this are poorly understood. In this paper, we report the results of small-scale flume experiments using monodisperse granular particles with varying water content and volume in which the basal pore pressure, total pressure, flow height and velocity profile were measured at a section. We compare the results with theoretical profiles for granular flow and with flow regimes based on dimensional analysis. The runout and the centre of mass were also calculated from the deposit surface profiles. As the initial water content by mass was increased from zero to around 10%, we first observed a drop in mobility by approximately 50%, as surface tension caused cohesive behaviour due to matric suction. As the water content was further increased up to 45%, the mobility also increased dramatically, with increased flow velocity up to 50%, increased runout distance up to 240% and reduced travel angle by up to 10° compared to the dry case. These effects can be directly related to the basal pore pressure, with both negative pressures and positive pore pressures being measured relative to atmospheric during the unsteady flow. We find that the initial flow volume plays a role in the development of relative pore pressure, such that, at a fixed relative water content, larger flows exhibit greater positive pore pressures, greater velocities and greater relative runout distances. This aligns with many other granular experiments and field observations. Our findings suggest that the fundamental role of the pore fluid is to reduce frictional contact forces between grains thus increasing flow velocity and bulk mobility. While this can occur by the development of excess pore pressure, it can also occur where the positive pore pressure is not in excess of hydrostatic, as shown here, since buoyancy and lubrication alone will reduce frictional forces

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Soil deformation measurement using particle image velocimetry (PIV) and photogrammetry

A deformation measurement system based on particle image velocimetry (PIV) and close-range photogrammetry has been developed for use in geotechnical testing. In this paper, the theory underlying this system is described, and the performance is validated. Digital photography is used to capture images of planar soil deformation. Using PIV, the movement of a fine mesh of soil patches is measured to a high precision. Since PIV operates on the image texture, intrusive target markers need not be installed in the observed soil. The resulting displacement vectors are converted from image space to object space using a photogrammetric transformation. A series of validation experiments are reported. These demonstrate that the precision, accuracy and resolution of the system are an order of magnitude higher than previous image-based deformation methods, and are comparable to local instrumentation used in element testing. This performance is achieved concurrent with an order of magnitude increase in the number of measurement points that can be fitted in an image. The performance of the system is illustrated with two example applications.</p

General report for TC104 physical modelling in geotechnics

The session of the 18th ICSMGE on physical modelling in geotechnics, held by Technical Committee 104, provides an opportunity to reflect on the varied contributions that physical modelling makes to our profession - in both research and practice. The 27 papers contributed within this theme span many different applications of physical modelling. These range from simple small-scale laboratory tests to reveal mechanisms of soil-structure interaction - particularly where simulation by numerical methods is problematic -Through to scaled-down versions of field constructions, performed outdoors, to validate the performance of new monitoring technology. These examples show physical modelling in action across the entire spectrum of geotechnics, from the validation of fundamental analysis principles, to the assurance of construction technology. In all cases, physical models - defined here as physical idealisations of all or part of an envisioned geotechnical system - provide a more convenient method of gaining knowledge than observing or simulating the full geotechnical system.</p