48 research outputs found
Measurement of the analyzing powers in pd elastic and pn quasi-elastic scattering at small angles
The analyzing powers in proton-deuteron elastic and proton-neutron
quasi-elastic scattering have been measured at small angles using a polarized
proton beam at the COSY storage ring incident on an unpolarized deuterium
target. The data were taken at 796MeV and five higher energies from 1600MeV to
2400MeV. The analyzing power in pd elastic scattering was studied by detecting
the low energy recoil deuteron in telescopes placed symmetrically in the COSY
plane to the left and right of the beam whereas for pn quasi-elastic scattering
a low energy proton was registered in one of the telescopes in coincidence with
a fast scattered proton measured in the ANKE magnetic spectrometer. Though the
experiment explores new domains, the results are consistent with the limited
published information.Comment: 10 pages with 8 figure
Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets
This document is the Technical Design Report covering the two large
spectrometer magnets of the PANDA detector set-up. It shows the conceptual
design of the magnets and their anticipated performance. It precedes the tender
and procurement of the magnets and, hence, is subject to possible modifications
arising during this process.Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti
Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski,
Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy),
Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy
Feasibility studies of the time-like proton electromagnetic form factor measurements with PANDA at FAIR
The possibility of measuring the proton electromagnetic form factors in the
time-like region at FAIR with the \PANDA detector is discussed. Detailed
simulations on signal efficiency for the annihilation of into a
lepton pair as well as for the most important background channels have been
performed. It is shown that precision measurements of the differential cross
section of the reaction can be obtained in a wide
angular and kinematical range. The individual determination of the moduli of
the electric and magnetic proton form factors will be possible up to a value of
momentum transfer squared of (GeV/c). The total cross section will be measured up to (GeV/c).
The results obtained from simulated events are compared to the existing data.
Sensitivity to the two photons exchange mechanism is also investigated.Comment: 12 pages, 4 tables, 8 figures Revised, added details on simulations,
4 tables, 9 figure
Measurement of the analyzing powers in (p)over-right-arrowd elastic and (p)over-right-arrown quasi-elastic scattering at small angles
The analyzing powers in proton-deuteron elastic and proton-neutron quasi-elastic scattering
have been measured at small angles using a polarized proton beam at the COSY storage ring incident on
an unpolarized deuterium target. The data were taken at 796 MeV and five higher energies from 1600 MeV
to 2400 MeV. The analyzing power in pd elastic scattering was studied by detecting the low energy recoil
deuteron in telescopes placed symmetrically in the COSY plane to the left and right of the beam whereas
for pn quasi-elastic scattering a low energy proton was registered in one of the telescopes in coincidence with
a fast scattered proton measured in the ANKE magnetic spectrometer. Though the experiment explores
new domains, the results are consistent with the limited published information
The influence of collaborative language learning on cognitive control in unbalanced multilingual migrant children
Physics Performance Report for PANDA: Strong Interaction Studies with Antiprotons
To study fundamental questions of hadron and nuclear physics in interactions
of antiprotons with nucleons and nuclei, the universal PANDA detector will be
built. Gluonic excitations, the physics of strange and charm quarks and nucleon
structure studies will be performed with unprecedented accuracy thereby
allowing high-precision tests of the strong interaction. The proposed PANDA
detector is a state-of-the art internal target detector at the HESR at FAIR
allowing the detection and identification of neutral and charged particles
generated within the relevant angular and energy range. This report presents a
summary of the physics accessible at PANDA and what performance can be
expected.Comment: 216 page
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline