Erstellung und Anwendung eines spezifischen Scores zur Erfassung der abdominellen Symptome bei Patienten mit zystischer Fibrose (CF) und Relation der Untersuchungsbefunde zu klinischen, laborchemischen und sonographischen Parametern

Obwohl abdominelle Symptome kennzeichnend für die gastrointestinale Manifestation bei Mukoviszidose (zystische Fibrose, engl.: cystic fibrosis, CF) sind, wurden sie bisher im klinischen Alltag kaum strukturiert erfasst und im Vergleich zur Lungenpathologie liegen wenig Studiendaten vor. Ziel der zweigliedrigen Studie ist es, die abdominellen Symptome bei CF qualitativ und quantitativ zu erfassen und die Ergebnisse mit klinischen, laborchemischen und sonographischen Parametern zu korrelieren. In diesem Rahmen soll ein standardisierter neuer Fragebogen für die klinische und wissenschaftliche Arbeit mit CF entwickelt werden. Initial wurde ein 5-seitiger Fragebogen (CFAbd-Score 1.0/Anfangs JenAbdomen-CF Score 1.0 genannt) mit 17 Items zu qualitativ beurteilten abdominellen Beschwerden erstellt. Hiermit wurden im ersten Studienteil 131 im Jenaer CF-Zentrum betreute Patienten aller Altersgruppen bezugnehmend auf die letzten 3 Monate befragt. Ergebnisse wurden mit anamnestisch erfassten abdominellen Manifestationen, Voroperationen, dem Ernährungszustand, der Lungenfunktion, dem CFTR-Genotyp und Laborbefunden, einschließlich Befunden zur Besiedlung der Atemwege mit Pseudomonas aeruginosa (PsA) und Staphylokokkus aureus (SA) und der resultierenden antibiotischen Therapie korreliert. Im anschließenden zweiten Studienteil wurden im Jenaer CF-Zentrum bei 114 CF-Patienten die Ergebnisse des auf eine 2-seitige Version weiterentwickelten Fragebogens (CFAbd-Score 2.0) mit 17 sonographischen Parametern (US-17 Score) korreliert. Alle CF-Patienten wiesen in den vorhergehenden drei Monaten Symptome auf, die im Zusammenhang mit der abdominellen Beteiligung stehen können. Am häufigsten waren Appetitlosigkeit (130/131), Geschmacksminderung (119/131), Bauchschmerzen (104/131), Blähungen (102/131) und Völlegefühl (83/131). ..

Brecht on Brecht

An interpretation of Bertold Brecht, Don\u27t write that you admire me! Write that I was an uncomfortable person, and that I intend to remain so after my death. Even then there are certain possibilities. April, 1971.https://collected.jcu.edu/plays/1052/thumbnail.jp

Cancer stem cells in prostate cancer: implications for targeted therapy

Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most common cause of cancer-related mortality among men in the developed world. Conventional anti-PCa therapies include surgery, radiation, hormonal ablation, and chemotherapy. Despite increasing efforts, these therapies are not effective for patients with advanced and/or metastatic disease. In most cases, cancer therapies fail due to an incomplete depletion of tumor cells, resulting in tumor relapse. The cancer stem cell (CSC) hypothesis is an emerging model that explains many of the molecular characteristics of oncological disease as well as the tendency of cancers to relapse, metastasize, and develop resistance to conventional therapies. CSCs are a reservoir of cancer cells that exhibit properties of self-renewal and the ability to reestablish the heterogeneous tumor cell population. The existence of PCa stem cells offers a theoretical explanation for many uncertainties regarding PCa and also for treatment resistance and disease progression once clinical cure is achieved. Therapies targeting CSCs might therefore lead to more effective cancer treatments, divergent from a traditional anti-proliferative approach, based on tumor bulk reduction accompanied by CSC-specific inhibition. Here, we focus on reviewing the historical perspective as well as concepts regarding stem cells and CSCs in PCa. In addition, we will report possible strategies and new clinical approaches that address the CSC-based concept of tumorigenesis in PCa. (C) 2017 S. Karger AG, Base

Investigating the Relationship between Age of Acquisition of a Second Language and Lexical Retrieval Ability in Bilinguals

The current study investigated the relationship between age of acquisition (AOA) of a second language and lexical retrieval ability in bilinguals. This study compared the lexical retrieval ability of 30 English monolinguals, 25 early Spanish-English bilinguals (AOA birth to three years), and 17 late Spanish-English bilinguals (AOA four to nine years). Participants completed a picture-naming task in English, a measure of non-verbal intelligence (Cattell Culture Fair Test), and a standardized measure of vocabulary size (PPVT-III). We predicted that both bilingual groups would experience more lexical retrieval difficulty on the picture naming tasks relative to monolinguals but that early bilinguals would experience less difficulty than late bilinguals

Reintroduction of the Building Code for Canton Sarajevo as a Prerequisite of Urban Planning and Urban Management in the Cantonal Transformation Process

The City of Sarajevo, since its establishment in the 15th century, was facing a constant population growth and enlargement process of the city area. Due to the topographical conditions of Sarajevo's location in the valley, the potential expanding city area is very limited and the future expanding zones should be carefully selected (Arhiv Zavoda za planiranje razvoja Kantona Sarajevo, 1984a). Different phases and epochs of city's development history are readable along the valley from east towards west, from Ottoman, through Austro–Hungarian, Modern and Post–Modern period. As a part of former Austro-Hungarian Monarchy, Sarajevo got its first Building Code in 1880. This planning document should have helped to regulate the upcoming development of the city and its settlement area in an integrative way. In 1893 Sarajevo got its second Building Code, an "update" of the first one, and ever since then, this kind of spatial planning instrument was and is missing in Sarajevo's development and planning regulative (Biblioteka Zemaljskog muzeja BiH, 1884). This paper explains why it is important to reintroduce the planning tool of the “Building Code for Canton Sarajevo” as an instrument of the integrative, balanced and smart trans-sectoral development of Canton Sarajevo

Why Roma Children Need Testing in Romani

In this paper we make one major point: that Roma children in Europe need to be tested in their mother tongue before school placement. Roma children are in a particularly perilous position with respect to their education. We describe the problematic linguistic situation of Roma children, who are bilingual and often bidialectal, but are frequently evaluated in the language of the state for educational placement, a process that has been shown to significantly compromise their chance of success. We then review the considerable empirical evidence that bilingual children must be evaluated in both languages to give a fair assessment of their knowledge and skills. Furthermore, strength in the mother tongue has demonstrable transfer to skills in the second language. We provide a brief summary of a new assessment for Romani that has been used successfully to evaluate children aged 3 to 6 years, and present the results of a new study using it in Slovakia on 29 children aged 3 to 6 years

03/19/1992 - Steve Petrowski Accepted into Sigma Pi

In this paper we make one major point: that Roma children in Europe need to be tested in their mother tongue before school placement. Roma children are in a particularly perilous position with respect to their education. We describe the problematic linguistic situation of Roma children, who are bilingual and often bidialectal, but are frequently evaluated in the language of the state for educational placement, a process that has been shown to significantly compromise their chance of success. We then review the considerable empirical evidence that bilingual children must be evaluated in both languages to give a fair assessment of their knowledge and skills. Furthermore, strength in the mother tongue has demonstrable transfer to skills in the second language. We provide a brief summary of a new assessment for Romani that has been used successfully to evaluate children aged 3 to 6 years, and present the results of a new study using it in Slovakia on 29 children aged 3 to 6 years

In Caelo et In Terra: Konsepsi Peran Takhta Suci Vatikan dalam Nonproliferasi Nuklir

Proliferasi senjata nuklir merupakan isu perdamaian yang terus beredar selama beberapa dekade terakhir. Terutama setelah penggunaan senjata pemusnah massal pada tahun 1945 yang mengakhiri Perang Dunia II sekaligus mengawali era ketegangan yang baru. Amerika Serikat dan Uni Soviet adalah dua kekuatan nuklir tradisional yang pertama mengembangkan teknologi tersebut untuk kepentingan militer. Dalam perkembangannya, terdapat total 9 kekuatan nuklir dunia. Takhta Suci sebagai aktor internasional turut terlibat dalam usahanya mewujudkan nonproliferasi nuklir. Melalui kerangka moral yang dipegang, Gereja melalui Paus-paus berbicara kepada dunia. Riset ini menggunakan Teori Peran sebagai metode penelitian dan alat analisis. Data yang dihimpun berupa dokumentasi teks-teks resmi pejabat senior Takhta Suci maupun negara lainnya. Dengan demikian, tulisan ini bertujuan untuk menjawab Konsepsi Peran Takhta Suci atas isu nuklir

In Caelo et In Terra: Konsepsi Peran Takhta Suci Vatikan dalam Nonproliferasi Nuklir

Proliferasi senjata nuklir merupakan isu perdamaian yang terus beredar selama beberapa dekade terakhir. Terutama setelah penggunaan senjata pemusnah massal pada tahun 1945 yang mengakhiri Perang Dunia II sekaligus mengawali era ketegangan yang baru. Amerika Serikat dan Uni Soviet adalah dua kekuatan nuklir tradisional yang pertama mengembangkan teknologi tersebut untuk kepentingan militer. Dalam perkembangannya, terdapat total 9 kekuatan nuklir dunia. Takhta Suci sebagai aktor internasional turut terlibat dalam usahanya mewujudkan nonproliferasi nuklir. Melalui kerangka moral yang dipegang, Gereja melalui Paus-paus berbicara kepada dunia. Riset ini menggunakan Teori Peran sebagai metode penelitian dan alat analisis. Data yang dihimpun berupa dokumentasi teks-teks resmi pejabat senior Takhta Suci maupun negara lainnya. Dengan demikian, tulisan ini bertujuan untuk menjawab Konsepsi Peran Takhta Suci atas isu nuklir