Real-Space Approach for the Electronic Calculation of Twisted Bilayer Graphene Using the Orthogonal Polynomial Technique

We discuss technical issues involving the implementation of a computational method for the electronic structure of material systems of arbitrary atomic arrangement. The method is based on the analysis of time evolution of electron states in the real lattice space. The Chebyshev polynomials of the first kind are used to approximate the time evolution operator.  We demonstrate that the developed method is powerful and efficient since the computational scaling law is linear. We invoked the method to study the electronic properties of special twisted bilayer graphene whose atomic structure is quasi-crystalline. We show the density of states of an electron in this graphene system as well as the variation of the associated time auto-correlation function. We find the fluctuation of electron density on the lattice nodes forming a typical pattern closely related to the typical atomic pattern of the quasi-crystalline bilayer graphene configuration

The problems of foreign specialists education at UrFU for the nuclear energy of Rosatom partner countries

Сформулированы основные задачи по подготовке специалистов для АЭС российского дизайна, сооружаемых за рубежом, в УрФУ. Проведен анализ начального периода обучения студентов Республики Вьетнам на кафедре «Атомные станции и ВИЭ», выявлены основные проблемы. Сформулированы предложения по совершенствованию процесса обучения.Defined are the main tasks of the specialists training at UrFU for the NPPs of Russian design which are constructed abroad. The analysis of initial period of Vietnam students’ education at Nuclear Power Plants and RES department is made. Main problems are detected. The ways of educational process improvements are formulated

DEVELOPMENT OF VIETNAM ENERGY

In this work the history of Vietnam’s energy development is presented. Data on the structure of Vietnam’s energy production, energy development plans, including the construction of the “Ninh Thuan” NPP, are presented.В работе представлена история развития энергетики Вьетнама. Приведены данные по структуре энергопроизводства Вьетнама, планы развития энергетики, включая строительство атомной электростанции «Ниньтхуан»

THE DEVELOPMENT OF TRAINING MATERIALS IN THE VIETNAMESE LANGUAGE FOR TRAINING SPECIALISTS FOR THE ATOMIC ENERGY OF VIETNAM

В работе обоснована необходимость подготовки вьетнамских специалистов для атомной энергетики. Показана важность разработки учебно-методических материалов по вопросом использования атомной энергетики. Описаны разработанное учебное пособие и русско-вьетнамский словарь.The paper substantiates the need for training Vietnamese specialists for nuclear energy. The importance of developing teaching materials on the use of nuclear energy is shown. The developed manual and the Russian-Vietnamese dictionary are described

Estimation of the passive heat removing efficiency from a VVER NPP steam generator

Described are the computer models of several design variants of heat exchangers cooled by the natural convection of surrounding air. The results of thermohydraulic analysis are given.Описаны модели нескольких вариантов конструкции теплообменных аппаратов, охлаждаемых за счет естественной циркуляции воздуха. Приведены результаты теплогидравлического анализа

DEVELOPMENT OF GUIDANCE ON THE PREPARATION OF THE ENVIRONMENTAL IMPACT ASSESSMENT REPORT FOR THE CENTER FOR NUCLEAR SCIENCE AND TECHNOLOGY OF VIETNAM

The structure of the guidelines for the preparation of an environmental impact assessment (EIA) report for the Vietnam nuclear research reactor project is presented. The legal and tech-nical basis for the preparation of the report, the requirements for the reporting organization are described

EVALUATION OF ICE CONDENSER EFFICIENCY DEPENDING ON ITS GEOMETRIC CONFIGURATION

In this paper, we studied the influence of geometric characteristics of an ice condenser, modeled in the COMSOL Multiphysics computational package, on the heat flux intensity. The calculation of the necessary refrigeration unit to maintain the ice condenser in the state of readiness was carried out

Pichia pastoris versus Saccharomyces cerevisiae:a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor

BACKGROUND: Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is a glycoprotein that has been approved by the FDA for the treatment of neutropenia and leukemia in combination with chemotherapies. Recombinant hGM-CSF is produced industrially using the baker's yeast, Saccharomyces cerevisiae, by large-scale fermentation. The methylotrophic yeast, Pichia pastoris, has emerged as an alternative host cell system due to its shorter and less immunogenic glycosylation pattern together with higher cell density growth and higher secreted protein yield than S. cerevisiae. In this study, we compared the pipeline from gene to recombinant protein in these two yeasts. RESULTS: Codon optimization in silico for both yeast species showed no difference in frequent codon usage. However, rhGM-CSF expressed from S. cerevisiae BY4742 showed a significant discrepancy in molecular weight from those of P. pastoris X33. Analysis showed purified rhGM-CSF species with molecular weights ranging from 30 to more than 60 kDa. Fed-batch fermentation over 72 h showed that rhGM-CSF was more highly secreted from P. pastoris than S. cerevisiae (285 and 64 mg total secreted protein/L, respectively). Ion exchange chromatography gave higher purity and recovery than hydrophobic interaction chromatography. Purified rhGM-CSF from P. pastoris was 327 times more potent than rhGM-CSF from S. cerevisiae in terms of proliferative stimulating capacity on the hGM-CSF-dependent cell line, TF-1. CONCLUSION: Our data support a view that the methylotrophic yeast P. pastoris is an effective recombinant host for heterologous rhGM-CSF production

Estimated Estimation of the Residual Heat Release of SFAS in the Holding Pools

The paper presents a calculated estimate of the residual heat release of irradiated fuel assemblies (SFAS) in the holding pools, depending on the fuel parameters (burn-out depth, uranium-235 loading mass, etc.

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

Background: The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear. Methods: We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to the first-line antituberculosis drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents. For each isolate, mutations associated with drug resistance and drug susceptibility were identified across nine genes, and individual phenotypes were predicted unless mutations of unknown association were also present. To identify how whole-genome sequencing might direct first-line drug therapy, complete susceptibility profiles were predicted. These profiles were predicted to be susceptible to all four drugs (i.e., pansusceptible) if they were predicted to be susceptible to isoniazid and to the other drugs or if they contained mutations of unknown association in genes that affect susceptibility to the other drugs. We simulated the way in which the negative predictive value changed with the prevalence of drug resistance. Results: A total of 10,209 isolates were analyzed. The largest proportion of phenotypes was predicted for rifampin (9660 [95.4%] of 10,130) and the smallest was predicted for ethambutol (8794 [89.8%] of 9794). Resistance to isoniazid, rifampin, ethambutol, and pyrazinamide was correctly predicted with 97.1%, 97.5%, 94.6%, and 91.3% sensitivity, respectively, and susceptibility to these drugs was correctly predicted with 99.0%, 98.8%, 93.6%, and 96.8% specificity. Of the 7516 isolates with complete phenotypic drug-susceptibility profiles, 5865 (78.0%) had complete genotypic predictions, among which 5250 profiles (89.5%) were correctly predicted. Among the 4037 phenotypic profiles that were predicted to be pansusceptible, 3952 (97.9%) were correctly predicted. Conclusions: Genotypic predictions of the susceptibility of M. tuberculosis to first-line drugs were found to be correlated with phenotypic susceptibility to these drugs. (Funded by the Bill and Melinda Gates Foundation and others.