4 research outputs found
The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis
In this review, the role of NF-κB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined. The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-κB in the livers of rats and mice. On the other hand, peroxisome proliferator activated receptor-α (PPARα) activation in non-hepatic tissues can lead to the inhibition of NF-κB activation. Several lines of evidence support the hypothesis that the activation of NF-κB by peroxisome proliferators in the liver is mediated by oxidative stress. The role of NF-κB in peroxisome proliferator-induced hepatocarcinogenesis has been examined using NF-κB knockout models. Specifically, the induction of cell proliferation and the promotion of liver carcinogenesis are inhibited in mice lacking the p50 subunit of NF-κB. Overall, the activation of NF-κB appears to be important in the carcinogenic activity of peroxisome proliferators
Polychlorinated Biphenyl-Induced Effects on Metabolic Enzymes, AP-1 Binding, Vitamin E, and Oxidative Stress in the Rat Liver
Joint FAO/WHO Expert Meeting to Review Toxicological and Health Aspects of Bisphenol A - Summary Report
This FAO/WHO summary report contains a review of the toxicological and health aspects of bisphenol A. It reflects the collective views of an international group of experts that met in Ottawa during 1-5 November 2010.JRC.I.2-Chemical assessment and testin