11,828 research outputs found
Transonic CFD applications at Boeing
The use of computational methods for three dimensional transonic flow design and analysis at the Boeing Company is presented. A range of computational tools consisting of production tools for every day use by project engineers, expert user tools for special applications by computational researchers, and an emerging tool which may see considerable use in the near future are described. These methods include full potential and Euler solvers, some coupled to three dimensional boundary layer analysis methods, for transonic flow analysis about nacelle, wing-body, wing-body-strut-nacelle, and complete aircraft configurations. As the examples presented show, such a toolbox of codes is necessary for the variety of applications typical of an industrial environment. Such a toolbox of codes makes possible aerodynamic advances not previously achievable in a timely manner, if at all
Privacy-Protecting Energy Management Unit through Model-Distribution Predictive Control
The roll-out of smart meters in electricity networks introduces risks for
consumer privacy due to increased measurement frequency and granularity.
Through various Non-Intrusive Load Monitoring techniques, consumer behavior may
be inferred from their metering data. In this paper, we propose an energy
management method that reduces energy cost and protects privacy through the
minimization of information leakage. The method is based on a Model Predictive
Controller that utilizes energy storage and local generation, and that predicts
the effects of its actions on the statistics of the actual energy consumption
of a consumer and that seen by the grid. Computationally, the method requires
solving a Mixed-Integer Quadratic Program of manageable size whenever new meter
readings are available. We simulate the controller on generated residential
load profiles with different privacy costs in a two-tier time-of-use energy
pricing environment. Results show that information leakage is effectively
reduced at the expense of increased energy cost. The results also show that
with the proposed controller the consumer load profile seen by the grid
resembles a mixture between that obtained with Non-Intrusive Load Leveling and
Lazy Stepping.Comment: Accepted for publication in IEEE Transactions on Smart Grid 2017,
special issue on Distributed Control and Efficient Optimization Methods for
Smart Gri
Exploring Vanadium Chemical Transferrin Mimetic Compounds for Insulin Enhancement
Diabetes Mellitus (DM) is caused by a lack of insulin production (Type 1) or the body’s cells’ inability to properly receive it, also known as insulin resistance (Type 2), resulting in greatly elevated levels of blood glucose. Vanadium(IV) and vanadium(V) ions are believed to enhance insulin activity by inhibition of protein tyrosine phosphatase 1B (PTP1B). PTP1B is normally responsible for downregulating the insulin signaling, but in DM type 2, PTP1B activity is overexpressed leading to the insulin signaling blocking. The most promising V(IV) compounds are designed for oral delivery: they are absorbed into the gut and delivered into the bloodstream where they are bound by the iron transporting protein serum transferrin (sTf). STf delivers the compound into cells via endocytosis, where vanadium can bind PTP1B. A limitation of these compounds is their poor stability at the stomach acidic conditions in which they undergo a significant amount of dissociation, resulting in a very inefficient gut absorption. This study explores the use of a chemical transferrin mimetic (cTfm) ligand to create V(IV) and V(V) compounds featuring excellent acidic pH stability for improved gut absorption. The cTfm-V(IV,V) compounds are expected to be labile in the pH of the bloodstream and thus the vanadium species can be quickly ligand exchanged with sTF. The cTfm ligand N,N\u27-di(o-hydroxybenzyl)ethylenediamine-N,N\u27-diacetic acid (HBED) was used to synthesize VO(IV)HBED and VO(V)HBED which demonstrated great aqueous stability in the 1-4 pH range. The role of citrate as a vehicle for delivering vanadium to sTf to regulate the transport of vanadium is also examined
Cáncer de mama y de ovario: significados, dolor y sufrimiento en la cotidianidad de mujeres pacientes
El presente estudio tiene por objetivo conocer, explicar y comprender los significados, el dolor y sufrimiento en la cotidianidad de mujeres que padecen cáncer de mama y de ovario. Aborda la subjetividad e intersubjetividad de las pacientes en su realidad cotidiana y contexto sociocultural. La investigación encuentra sustento teórico en la Sociología de la salud, Antropología de la salud y en otras ciencias de frontera que abordan problemas de salud-enfermedad, dolor y sufrimiento; así como en los estudios sobre la vida cotidiana.El presente estudio tiene por objetivo conocer, explicar y comprender los significados, el dolor y sufrimiento en la cotidianidad de mujeres que padecen cáncer de mama y de ovario. Aborda la subjetividad e intersubjetividad de las pacientes en su realidad cotidiana y contexto sociocultural. La investigación encuentra sustento teórico en la Sociología de la salud, Antropología de la salud y en otras ciencias de frontera que abordan problemas de salud-enfermedad, dolor y sufrimiento; así como en los estudios sobre la vida cotidiana
An improved panel method for the solution of three-dimensional leading edge vortex flows Volume 2: User's guide and programmer's document
A computer program developed for solving the subsonic, three dimensional flow over wing-body configurations with leading edge vortex separation is presented. Instructions are given for the proper set up and input of a problem into the computer code. Program input formats and output are described, as well as the overlay structure of the program. The program is written in FORTRAN
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