Constraining the black hole mass and accretion rate in the narrow-line Seyfert 1 RE J1034+396

We present a comprehensive study of the spectrum of the narrow-line Seyfert 1 galaxy RE J1034+396, summarizing the information obtained from the optical to X-rays with observations from the William Herschel 4.2m Telescope (WHT), the Hubble Space Telescope, the Extreme UltraViolet Explorer, ROSAT, ASCA and BeppoSAX. The BeppoSAX spectra reveal a soft component which is well-represented by two blackbodies with kT of about 60 eV and 160 eV, mimicking that expected from a hot, optically-thick accretion disc around a low-mass black hole. This is borne out by our modeling of the optical to X-ray nuclear continuum, which constrains the physical parameters of a NLS1 for the first time. The models demonstrate that RE J1034+396 is likely to be a system with a nearly edge-on accretion disk (60 to 75 degrees from the disk axis), accreting at nearly Eddington rates (0.3 to 0.7 L_edd) onto a low mass (about 2 million solar masses) black hole (abridged).Comment: ApJ accepte

Requirement of JNK1 for endothelial cell injury in atherogenesis

AbstractObjectiveThe c-Jun N-terminal kinase (JNK) family regulates fundamental physiological processes including apoptosis and metabolism. Although JNK2 is known to promote foam cell formation during atherosclerosis, the potential role of JNK1 is uncertain. We examined the potential influence of JNK1 and its negative regulator, MAP kinase phosphatase-1 (MKP-1), on endothelial cell (EC) injury and early lesion formation using hypercholesterolemic LDLR−/− mice.Methods and resultsTo assess the function of JNK1 in early atherogenesis, we measured EC apoptosis and lesion formation in LDLR−/− or LDLR−/−/JNK1−/− mice exposed to a high fat diet for 6 weeks. En face staining using antibodies that recognise active, cleaved caspase-3 (apoptosis) or using Sudan IV (lipid deposition) revealed that genetic deletion of JNK1 reduced EC apoptosis and lesion formation in hypercholesterolemic mice. By contrast, although EC apoptosis was enhanced in LDLR−/−/MKP-1−/− mice compared to LDLR−/− mice, lesion formation was unaltered.ConclusionWe conclude that JNK1 is required for EC apoptosis and lipid deposition during early atherogenesis. Thus pharmacological inhibitors of JNK may reduce atherosclerosis by preventing EC injury as well as by influencing foam cell formation

Can the quality of social research on ethnicity be improved through the introduction of guidance? Findings from a research commissioning pilot exercise

As the volume of UK social research addressing ethnicity grows, so too do concerns regarding the ethical and scientific rigour of this research domain and its potential to do more harm than good. The establishment of standards and principles and the introduction of guidance documents at critical points within the research cycle might be one way to enhance the quality of such research. This article reports the findings from the piloting of a guidance document within the research commissioning process of a major funder of UK social research. The guidance document was positively received by researchers, the majority of whom reported it to be comprehensible, relevant and potentially useful in improving the quality of research proposals. However, a review of the submitted proposals suggested the guidance had had little impact on practice. While guidance may have a role to play, it will need to be strongly promoted by commissioners and other gatekeepers. Findings also suggest the possibility that guidance may discourage some researchers from engaging with ethnicity if it raises problems without solutions; highlighting the need for complementary investments in research capacity development in this area

The narrow-line quasar NAB 0205+024 observed with XMM-Newton

The XMM-Newton observation of the narrow-line quasar NAB 0205+024 reveals three striking differences since it was last observed in the X-rays with ASCA. Firstly, the 2-10 keV power-law is notably steeper. Secondly, a hard X-ray flare is detected, very similar to that seen in I Zw 1. Thirdly, a strong and broad emission feature is detected with the bulk of its emission redward of 6.4 keV, and extending down to ~5 keV in the rest frame. The most likely explanation for the broad feature is neutral iron emission emitted from a narrow annulus of an accretion disc close to the black hole. The hard X-ray flare could be the mechanism which illuminates this region of the disc, allowing for the emission line to be detected. The combination of effects can be understood in terms of the `thundercloud' model proposed by Merloni & Fabian.Comment: 7 pages. Accepted for publication in MNRA

Evaluation of surface contamination with cyclophosphamide following simulated hazardous drug preparation activities using two closed-system products

Purpose. A preliminary investigation was conducted to evaluate and compare the effectiveness of two closed-system products in preventing contamination of typical pharmacy workplace surfaces with cyclophosphamide during simulated hazardous drug preparation activities in a controlled laboratory setting

XMM-Newton observation of Mrk 110

We report on the first XMM-Newton observation of the bright Narrow-Line Seyfert 1 galaxy Mrk 110. We find a narrow Fe K fluorescent line, a broad component FWHM ~ 16500 km/s of the OVII triplet, either due to infall motions or gravitational redshift effects in the vicinity of the central black hole, a Comptonized accretion disc layer, and a strong starburst component. If the broad redshifted soft X-ray components are due to gravitational redshift effects, the distance of the line emitting regions ranges between about 0.2 and 1 light day with respect to the central black hole.Comment: 8 pages, 9 figures, accepted by A&

The Onfp Class in the Magellanic Clouds

The Onfp class of rotationally broadened, hot spectra was defined some time ago in the Galaxy, where its membership to date numbers only eight. The principal defining characteristic is a broad, centrally reversed He II $\lambda$4686 emission profile; other emission and absorption lines are also rotationally broadened. Recent surveys in the Magellanic Clouds (MCs) have brought the class membership there, including some related spectra, to 28. We present a survey of the spectral morphology and rotational velocities, as a first step toward elucidating the nature of this class. Evolved, rapidly rotating hot stars are not expected theoretically, because the stellar winds should brake the rotation. Luminosity classification of these spectra is not possible, because the principal criterion (He II $\lambda$4686) is peculiar; however, the MCs provide reliable absolute magnitudes, which show that they span the entire range from dwarfs to supergiants. The Onfp line-broadening distribution is distinct and shifted toward larger values from those of normal O dwarfs and supergiants with >99.99% confidence. All cases with multiple observations show line-profile variations, which even remove some objects from the class temporarily. Some of them are spectroscopic binaries; it is possible that the peculiar profiles may have multiple causes among different objects. The origin and future of these stars are intriguing; for instance, they could be stellar mergers and/or gamma-ray-burst progenitors.Comment: 27 pages, 8 figures, 2 tables; AJ accepte

Optical spectroscopy of EX Lupi during quiescence and outburst: Infall, wind, and dynamics in the accretion flow

We explore the accretion mechanisms in EX Lupi, prototype of EXor variables, during its quiescence and outburst phases. We analyse high-resolution optical spectra taken before, during, and after its 2008 outburst. In quiescence and outburst, the star presents many permitted emission lines, including typical CTTS lines and numerous neutral and ionized metallic lines. During the outburst, the number of emission lines increases to over a thousand, with narrow plus broad component structure (NC+BC). The BC profile is highly variable on short timescales (24-72h). An active chromosphere can explain the metallic lines in quiescence and the outburst NC. The dynamics of the BC line profiles suggest an origin in a hot, dense, non-axisymmetric, and non-uniform accretion column that suffers velocity variations along the line-of-sight on timescales of days. Assuming Keplerian rotation, the emitting region would be located at ~0.1-0.2 AU, consistent with the inner disk rim, but the velocity profiles of the lines reveal a combination of rotation and infall. Line ratios of ions and neutrals can be reproduced with a temperature of T~6500 K for electron densities of a few times 10$^{12}$cm$^{-3}$ in the line-emitting region. The data confirm that the 2008 outburst was an episode of increased accretion, albeit much stronger than previous EX Lupi and typical EXors outbursts. The line profiles are consistent with the infall/rotation of a non-axisymmetric structure that could be produced by clumpy accretion during the outburst phase. A strong inner disk wind appears in the epochs of higher accretion. The rapid recovery of the system after the outburst and the similarity between the pre-outburst and post-outburst states suggest that the accretion channels are similar during the whole period, and only the accretion rate varies, providing a superb environment for studying the accretion processes.Comment: 15 pages plus 26 pages online material, accepted by A&

Tunable few-electron double quantum dots and Klein tunnelling in ultra-clean carbon nanotubes

Quantum dots defined in carbon nanotubes are a platform for both basic scientific studies and research into new device applications. In particular, they have unique properties that make them attractive for studying the coherent properties of single electron spins. To perform such experiments it is necessary to confine a single electron in a quantum dot with highly tunable barriers, but disorder has until now prevented tunable nanotube-based quantum-dot devices from reaching the single-electron regime. Here, we use local gate voltages applied to an ultra-clean suspended nanotube to confine a single electron in both a single quantum dot and, for the first time, in a tunable double quantum dot. This tunability is limited by a novel type of tunnelling that is analogous to that in the Klein paradox of relativistic quantum mechanics.Comment: 21 pages including supplementary informatio

Periodic Anderson model with degenerate orbitals: linearized dynamical mean field theory approach

We investigate a multi-orbital extension of the periodic Anderson model with particular emphasis on electron correlations including orbital fluctuations. By means of a linearized version of the dynamical mean-field theory, we compute the renormalization factor, the density of states, the spectral gap and the local correlation functions for a given set of the intra- and inter-orbital Coulomb interactions as well as the Hund coupling. It is found that when a certain condition is met for the intra- and inter-orbital interactions for $f$ electrons, orbital fluctuations are enhanced, thereby enlarging the Kondo insulating gap. This effect is suppressed in the presence of the Hund coupling. We also clarify how the Kondo insulator is continuously changed to the Mott insulator when electron correlations among conduction electrons are increased.Comment: 7 pages, 10 figure