Economics of environmental policy in Turkey: A general equilibrium investigation of the economic evaluation of sectoral emission reduction policies for climate change

Cataloged from PDF version of article.Research on climate change has intensified on a global scale as evidence on the costs of global warming continues to accumulate. Confronted with such evidence, the European Union set in late 2006 an ambitious target to reduce its greenhouse gas emissions, by 2020, to 20% below the level of 1990; and invited the rest of the developed economies and the developing world to take part with the Kyoto Protocol. Turkey is the only country that appears in the Annex-I list of the United Nations' Rio Summit and yet an official target for CO2 emission reductions has still not been established. Thus, as part of its accession negotiations with the EU, Turkey will likely to face significant pressures to introduce its national plan on climate change along with specific emission targets and the associated abatement policies. Given this motivation, we utilize a computable general equilibrium model for Turkey to study the economic impacts of the intended policy scenarios of compliance with the Kyoto Protocol and we report on the general equilibrium effects of various possible environmental abatement policies in Turkey over the period 2006-2020. The model is in the Walrasian tradition with 10 production sectors and a government operating within an open macroeconomy environment. It accommodates flexible production functions, imperfect substitution in trade and open unemployment. We focus on CO2 emissions and distinguish various basic sources of gaseous pollution in the model. Our results suggest that the burden of imposing emission control targets and the implied abatement costs could be quite high, and that there is a need to finance the expanded abatement investments from scarce domestic resources. Policies for environmental abatement via carbon and/or increased energy taxes further suffer from very adverse employment effects. This suggests that a first-best policy would necessarily call for a simultaneous reduction on the existing tax burden on producers elsewhere together with introduction of environmental taxes. (C) 2007 Society for Policy Modeling. Published by Elsevier Inc. All rights reserved

SMALL ENGINE-GENERATOR SET OPERATING ON DUAL-FUEL MODE WITH ETHANOL – CASTOR OIL BLENDS

The increase in greenhouse gas emissions and our dependence on fossil fuels have motivated researchers to seek the use of renewable fuels in internal combustion engines, which can be produced locally and have clean combustion. The blending method in diesel engines has been recognized as an effective alternative to partially or totally replace the use of diesel fuel. In this regard, this paper studied the operation of a small engine-generator set in mono-fuel mode (diesel fuel - DO) and in dual-fuel mode using hydrous ethanol (HET) and castor oil (OM) blends, indicating a total replacement of diesel fuel. Efficiency, power, specific fuel consumption and gaseous emissions were assessed in a single cylinder diesel cycle engine. The percentages in volume of the HET-OM samples were: 75% - 25%, 70% - 30%, 60% - 40%, and 50% - 50%. The exhaust gas temperature decreased with the mixtures. Carbon monoxide emission decreased 57%, carbon dioxide decreased 9.8%, and nitrogen oxides reduced 19%. It was also observed that the percentage of smoke opacity tends to decrease close to zero with addition of ethanol. Hydrocarbon emissions increased with rising of the OM concentration and the same for the specific fuel consumptions, which was 25.4% higher than diesel fuel. The best fuel conversion efficiency was achieved with the blend HET75-OM25, being 9% higher compared to diesel fuel operation. Power on diesel fuel operation showed a better result keeping stable, with the increase of the compression ratio and the delay of the start of injection. In general, the results confirmed that the performance is comparable to that of diesel fuel, indicating that renewable fuels appear as an alternative for the reduction of the environmental impacts and the reduction of fossil fuels consumption

A general equilibrium assessment of twin-targeting in Turkey

[No abstract available

DNA adducts in fish following an oil spill exposure

On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast. This oil contained polycyclic aromatic compounds (PAC) that are known to be genotoxic. Genotoxic effects induce DNA adducts formation, which can thus be used as pollution biomarkers. Here, we assessed the genotoxic impact of the “Erika” oil spill by DNA adducts detection in the liver of immature fishes (Solea solea) from four locations of the French Brittany coasts. Two months after the spill, a high amount of DNA adducts was found in samples from all locations, amounting to 92–290 DNA adduct per 109 nucleotides. Then total DNA adduct levels decreased to reach about 50 adducts per 109 nucleotides nine months after the spill. In vitro experiments using human cell cultures and fish liver microsomes evidence the genotoxicity of the Erika fuel. They also prove the formation of reactive species able to create DNA adducts. Furthermore, in vitro and in vivo DNA adducts fingerprints are similar, thus confirming that DNA adducts are a result of the oil spill

Ongoing under-reporting of clinically relevant safety data in phase II studies of tyrosine kinase inhibitors

status: publishe

Ethanol production from xylose by pichia stipitis NRRL Y-7124 in a stirred tank bioreactor

The ethanol production by Pichia stipitis was evaluated in a stirred tank bioreactor using semidefined medium containing xylose (90.0 g/l) as the main carbon source. Experimental assays were performed according to a 22 full factorial design to evaluate the influence of aeration (0.25 to 0.75 vvm) and agitation (150 to 250 rpm) conditions on ethanol production. In the studied range of values, the agitation increase and aeration decrease favored ethanol production, which was maximum (26.7 g/l) using 250 rpm and 0.25 vvm, conditions that gave a volumetric oxygen transfer coefficient (kLa value) of 4.9 h-1. Under these conditions, the ethanol yield factor, ethanol productivity, and the process efficiency were 0.32 g/g, 0.32 g/l.h, and 63%, respectively. These results are promising and contribute to the development of a suitable process for ethanol production from xylose by Pichia stipitis.The authors gratefully acknowledge Santander, Fapesp, Capes, and CNPq (Brazil)

The influence of initial xylose concentration, agitation, and aeration on ethanol production by Pichia stipitis from rice straw hemicellulosic hydrolysate

Rice straw hemicellulosic hydrolysate was used as fermentation medium for ethanol production by Pichia stipitis NRRL Y-7124. Shaking bath experiments were initially performed aiming to establish the best initial xylose concentration to be used in this bioconversion process. In the sequence, assays were carried out under different agitation (100 to 200 rpm) and aeration (V flask/V medium ratio varying from 2.5 to 5.0) conditions, and the influence of these variables on the fermentative parameters values (ethanol yield factor, Y P/S; cell yield factor, Y X/S; and ethanol volumetric productivity, Q P) was investigated through a 22 full-factorial design. Initial xylose concentration of about 50 g/l was the most suitable for the development of this process, since the yeast was able to convert substrate in product with high efficiency. The factorial design assays showed a strong influence of both process variables in all the evaluated responses. The agitation and aeration increase caused a deviation in the yeast metabolism from ethanol to biomass production. The best results (Y P/S = 0.37 g/g and Q P = 0.39 g/l.h) were found when the lowest aeration (2.5 V flask/V medium ratio) and highest agitation (200 rpm) levels were employed. Under this condition, a process efficiency of 72.5% was achieved. These results demonstrated that the establishment of adequate conditions of aeration is of great relevance to improve the ethanol production from xylose by Pichia stipitis, using rice straw hemicellulosic hydrolysate as fermentation medium.The financial support from Fapesp (Brazil) is gratefully acknowledged

A Phase II Study of Talazoparib after Platinum or Cytotoxic Nonplatinum Regimens in Patients with Advanced Breast Cancer and Germline BRCA1/2 Mutations (ABRAZO).

PURPOSE:To assess talazoparib activity in germline BRCA1/2 mutation carriers with advanced breast cancer. PATIENTS AND METHODS:ABRAZO (NCT02034916) was a two-cohort, two-stage, phase II study of talazoparib (1 mg/day) in germline BRCA mutation carriers with a response to prior platinum with no progression on or within 8 weeks of the last platinum dose (cohort 1) or ≥3 platinum-free cytotoxic regimens (cohort 2) for advanced breast cancer. Primary endpoint was confirmed objective response rate (ORR) by independent radiological assessment. RESULTS:We enrolled 84 patients (cohort 1, n = 49; cohort 2, n = 35) from May 2014 to February 2016. Median age was 50 (range, 31-75) years. Triple-negative breast cancer (TNBC) incidence was 59% (cohort 1) and 17% (cohort 2). Median number of prior cytotoxic regimens for advanced breast cancer was two and four, respectively. Confirmed ORR was 21% [95% confidence interval (CI), 10-35; cohort 1] and 37% [95% CI, 22-55; cohort 2]. Median duration of response was 5.8 and 3.8 months, respectively. Confirmed ORR was 23% (BRCA1), 33% (BRCA2), 26% (TNBC), and 29% (hormone receptor-positive). The most common all-grade adverse events (AE) included anemia (52%), fatigue (45%), and nausea (42%). Talazoparib-related AEs led to drug discontinuation in 3 (4%) patients. In an exploratory analysis, longer platinum-free interval was associated with higher response rate in cohort 1 (0% ORR with interval 6 months). CONCLUSIONS:Talazoparib exhibited promising antitumor activity in patients with advanced breast cancer and germline BRCA mutation

I progetti gestiti dai Coordinatori: analisi del loro profilo e successo

Obiettivo. Descrivere la storia dei progetti affidati/ gestiti dai Coordinatori infermieristici ospedalieri. Metodi. \uc8 stato incluso un campione di 56 Coordinatori in ruolo da almeno un anno nei reparti di 13 Ospedali del nord Italia, contattati con criterio di convenienza. Tramite un\u2019intervista strutturata sono stati raccolti dati sui progetti gestiti nel 2009, tipologia, origine (bottom up; top down), il numero di operatori coinvolti e stato del progetto al momento dell\u2019intervista (concluso, incompleto, abbandonato). Risultati. Nel 2009 i Coordinatori hanno gestito 114 progetti, in media 1.8/ciascuno (\ub11.2): 94 (82.5%) erano progetti di miglioramento, 17 (14.9%) di accreditamento, e 3 (2.6%) di ricerca. I progetti avevano coinvolto complessivamente 2.732 persone (73.7% dei team) con un impegno medio di 84 ore ciascuno; 55 (48.2%) progetti erano ancora in corso, 52 (45.6%) conclusi, 5 (4.4%) incompleti (ovvero mancavano di valutazione) mentre 2 (1.8%) erano stati abbandonati. Conclusioni. Gli infermieri sono coinvolti in numerosi progetti nelle aziende sanitarie. La fase pi\uf9 trascurata \ue8 il monitoraggio dei risultati e il loro consolidamento: i progetti assorbono molte risorse e per questo \ue8 fondamentale che siano correttamente gestiti e partano da reali problemi ed esigenze dei pazienti