Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study

Background: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. Objectives: To identify early-life risk factors for eczema, and to explore how early-life risk factors explain any differences in eczema. Methods: We estimated odds ratios (ORs) for ever having had eczema by age 5 years in 14 499 children from the U.K. Millennium Cohort Study (MCS), with a focus on maternal, antenatal and early-life risk factors and socioeconomic circumstances (SECs). Risk factors were explored to assess whether they attenuated associations between SECs and eczema. Results: Overall 35·1% of children had ever had eczema by age 5 years. Children of mothers with degree-level qualifications vs. no educational qualifications were more likely to have eczema (OR 1·52, 95% confidence interval 1·31–1·76), and there was a gradient across the socioeconomic spectrum. Maternal atopy, breastfeeding (1–6 weeks and ≥ 6 months), introduction of solids under 4 months or cow's milk under 9 months, antibiotic exposure in the first year of life and grime exposure were associated with an increased odds of having eczema. Female sex, Pakistani and Bangladeshi ethnicity, smoking during pregnancy, exposure to environmental tobacco smoke and having more siblings were associated with reduced odds for eczema. Controlling for maternal, antenatal and early-life characteristics (particularly maternal smoking during pregnancy, breastfeeding and number of siblings) reduced the OR for eczema to 1·26 (95% confidence interval 1·03–1·50) in the group with the highest educational qualifications compared with the least. Conclusions: In a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early-life factors including not smoking during pregnancy, breastfeeding and having fewer siblings

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography

Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine (18FLT) has allowed PET to image cellular proliferation by utilising the salvage pathway of DNA synthesis. In this study, we have compared uptake of 18FLT and 18FDG with MIB-1 immunohistochemistry to evaluate the role of PET in quantifying in vivo cellular proliferation in colorectal cancer (CRC). Patients and methods: Patients with resectable, primary, or recurrent CRC were prospectively studied. Thirteen lesions from 10 patients (five males, five females), median age 68 years (range 54–87), were evaluated. Patients underwent 18FDG and 18FLT PET scanning. Tracer uptake within lesions was quantified using standardised uptake values (SUVs). Histopathological examination and MIB-1 immunohistochemistry were performed on all lesions, and proliferation quantified by calculating a labelling index (% of MIB-1 positively stained nuclei within 1500 tumour cells). Results: Histology confirmed adenocarcinoma in 12 of 13 lesions; the remaining lesion was reactive. All eight extrahepatic lesions were visualised using both 18FLT and 18FDG. Three of the five resected liver metastases were also avid for 18FLT and showed high proliferation, while the remaining two lesions which demonstrated no uptake of 18FLT had correspondingly very low proliferation. There was a statistically significant positive correlation (r =0.8, p<0.01) between SUVs of the tumours visualised with 18FLT and the corresponding MIB-1 labelling indices. No such correlation was demonstrated with 18FDG avid lesions (r =0.4). Conclusions: 18FLT PET correlates with cellular proliferation markers in both primary and metastatic CRC. This technique could provide a mechanism for in vivo grading of malignancy and early prediction of response to adjuvant chemotherapy

Exploring the development of team identification.

The article discusses a study investigating the development of identification with sports teams, with particular focus given to the application of social identity theory and the psychological continuum model (PCM). The development of internal meaning attached to the team and external actions such as searching for team-related information and promoting the team to others is examined, and the influence of media on attitude formation is commented on. A review of previous literature on the topic is also provided

A comparison of compacting and caking behavior of carbonate-based washing powders

Two types of sodium carbonate powder produced by spray drying (SD) and dry neutralization (DN) were studied for their compaction properties using a uniaxial compression tester. A comparison was also made with Persil washing powder. Dry neutralized sodium carbonate showed greater resistance to compression and also produced a weaker compact when compressed to 100 kPa. Spray-dried sodium carbonate had an absence of fine particles but compacted easily. Differential scanning calorimetry (DSC) showed that both types of powder were predominantly amorphous in nature. Moisture sorption measurements showed that both powders behaved in a similar way below 50% relative humidity (RH). However, dry neutralized sodium carbonate had a high moisture affinity above this RH. Particle structures were also examined using scanning electron microscopy, showing the heterogeneous interior of the spray-dried particles

Multiplicative renormalizability of gluon and ghost propagators in QCD

We reformulate the coupled set of continuum equations for the renormalized gluon and ghost propagators in QCD, such that the multiplicative renormalizability of the solutions is manifest, independently of the specific form of full vertices and renormalization constants. In the Landau gauge, the equations are free of renormalization constants, and the renormalization point dependence enters only through the renormalized coupling and the renormalized propagator functions. The structure of the equations enables us to devise novel truncations with solutions that are multiplicatively renormalizable and agree with the leading order perturbative results. We show that, for infrared power law behaved propagators, the leading infrared behavior of the gluon equation is not solely determined by the ghost loop, as concluded in previous studies, but that the gluon loop, the three-gluon loop, the four-gluon loop, and even massless quarks also contribute to the infrared analysis. In our new Landau gauge truncation, the combination of gluon and ghost loop contributions seems to reject infrared power law solutions, but massless quark loops illustrate how additional contributions to the gluon vacuum polarization could reinstate these solutions. Moreover, a schematic study of the three-gluon and four-gluon loops shows that they too need to be considered in more detail before a definite conclusion about the existence of infrared power behaved gluon and ghost propagators can be reached.Comment: 13 pages, 1 figure, submitted to Phys. Rev.

Cardinal characteristics at in a small u (κ) model

We provide a model where u(κ)<2κu(κ)<2κ for a supercompact cardinal κ. [10] provides a sketch of how to obtain such a model by modifying the construction in [6]. We provide here a complete proof using a different modification of [6] and further study the values of other natural generalizations of classical cardinal characteristics in our model. For this purpose we generalize some standard facts that hold in the countable case as well as some classical forcing notions and their properties

Changes in the trajectory of the radio jet in 0735+178?

We present multi-epoch 8.4 and 43 GHz Very Long Baseline Array images of the BL Lac object 0735+178. The images confirm the presence of a twisted jet with two sharp apparent bends of 90$^{\circ}$ within two milliarcseconds of the core, resembling a helix in projection. The observed twisted geometry could be the result of precession of the jet inlet, but is more likely produced by pressure gradients in the external medium through which the jet propagates. Quasi-stationary components are observed at the locations of the 90$^{\circ}$ bends, possibly produced by differential Doppler boosting. Identification of components across epochs, since the earliest VLBI observations of this source in 1979.2, proves difficult due to the sometimes large time gaps between observations. One possible identification suggests the existence of superluminal components following non--ballistic trajectories with velocities up to $11.6\pm 0.6 h_{65}^{-1} c$. However, in images obtained after mid-1995, components show a remarkable tendency to cluster near several jet positions, suggesting a different scenario in which components have remained nearly stationary in time at least since mid-1995. Comparison with the earlier published data, covering more than 19 years of observations, suggests a striking qualitative change in the jet trajectory sometime between mid-1992 and mid-1995, with the twisted jet structure with stationary components becoming apparent only at the later epochs. This would require a re-evaluation of the physical parameters estimated for 0735+178, such as the observing viewing angle, the plasma bulk Lorentz factor, and those deduced from these.Comment: 18 pages, 5 figures, accepted for publication in MNRA

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)

SummaryObjectiveTo evaluate the clinical effectiveness of intraarticular IL-1 receptor antagonist (IL-1Ra) for anterior cruciate ligament (ACL) tear.MethodsEleven patients with acute ACL tear confirmed by magnetic resonance imaging (MRI) were randomized to receive a single intraarticular injection of IL-1Ra (anakinra 150 mg, n = 6) or equal volume of saline placebo (1 ml, n = 5). The double-blinded treatment was administered a mean 2 weeks after injury. Synovial fluid (SF) (n = 9 patients) and sera (all patients) were available at baseline (prior to injection) and immediately prior to surgery (mean 35 days later) and analyzed for SF IL-1α, IL-1β, IL-1Ra and serum hyaluronan (HA), an indicator of synovial inflammation. The primary outcome, standardized Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire, was obtained at 0 (baseline), 4, and 14 days after injection.ResultsCompared with placebo, the IL-1Ra group had substantially greater improvement in key outcomes over 14 days (KOOS pain P = 0.001; activities of daily living P = 0.0015; KOOS sports function P = 0.0026; KOOS quality of life (QOL) P = 0.0048; and total KOOS P < 0.0001). There were no adverse reactions in either group. SF IL-1α (P = 0.05) and serum HA (P = 0.03), but not IL-1β, or IL-1Ra, decreased significantly in the IL-1Ra but not the placebo treated patients. Compared with placebo, IL-1α was borderline significantly different in the IL-1Ra treated group (P = 0.06).ConclusionsAdministered within the first month following severe knee injury, IL-1Ra reduced knee pain and improved function over a 2-week interval. This promising proof of concept study provides a new paradigm for studies of acute joint injury and suggests that a larger follow-up study is warranted

Precision Timing Measurements of PSR J1012+5307

We present results and applications of high precision timing measurements of the millisecond pulsar J1012+5307. Combining our radio observations with results based on optical observations, we derive complete 3-D velocity information for this system. Correcting for Doppler effects, we derive the intrinsic spin parameters of this pulsar and a characteristic age of 8.6 +/- 1.9 Gyr. Our upper limit for the orbital eccentricity of only 8 * 10^-7 (68% C.L.) is the smallest ever measured for a binary system. We demonstrate that this makes the pulsar an ideal laboratory to test certain aspects of alternative theories of gravitation. Our precise measurements suggest deviations from a simple pulsar spin-down timing model, which are consistent with timing noise and the extrapolation of the known behaviour of slowly rotating pulsars.Comment: 9 pages, 6 figure