Technical assistance in Nigeria : developing geoscience skills for tomorrow

The World Bank funded Nigerian Geochemical Mapping Technical Assistance Project was started in 2008 within the Nigerian Ministry of Mines and Steel Development, and is now nearing completion. Staff from the Nigerian Geological Survey Agency (NGSA), the Nigerian academic community, British Geological Survey, and Geological Survey of Finland, have worked alongside one another in a comprehensive program of practical training and knowledge exchange. This program has enabled researchers from a range of backgrounds and experience in Africa and Europe to exchange knowledge and develop important geoscience skills. As part of this program key skills in many areas including; GIS, statistics, QC, data management, laboratory analysis, sampling methodologies, has developed the knowledge and skills base within the Nigerian geosciences community, and has maintained momentum for Nigeria’s national geochemical mapping program. An important objective of the Project is knowledge exchange during training of Nigerian geoscientists in conducting regional geochemical surveys as part of a long term mapping program across Nigeria. Practical training in methodologies for geochemical mapping formed the basis of a major field campaign in 2009, during which over 100 personnel were trained in geochemical mapping techniques. A similar number of personnel were involved in specialist training through a series of workshops and training courses in Nigeria and the UK. Two field areas were selected for the geochemical mapping training — one in central Nigeria (the ‘Minna Cell’) and one in south-western Nigeria (the ‘South-western Cell’) — covering a combined area of 52 000 km2. Key challenges involved the procurement of field equipment and consumables, and modernisation of sample preparation laboratories and archiving facilities at the National Geosciences Research Laboratory, Kaduna. New sample preparation and analytical equipment has been purchased and the laboratory staff have received training in the use of the new equipment. In the long-term it is envisaged that the analytical facilities will be developed further, and that all samples will be prepared, analysed and archived in Nigeria. A national geochemical mapping programme involving multi-element analysis of stream sediment samples is used as a primary dataset in the exploration for new economic mineral deposits. Establishing a geochemical baseline is necessary in order to monitor the effects of anthropogenic activities e.g. contamination caused by industrial waste and mining activities, for environmental investigations and medical geology studies both in rural and in urban areas, as well as studies within the agricultural and forestry sectors

On fundamental domains and volumes of hyperbolic Coxeter-Weyl groups

We present a simple method for determining the shape of fundamental domains of generalized modular groups related to Weyl groups of hyperbolic Kac-Moody algebras. These domains are given as subsets of certain generalized upper half planes, on which the Weyl groups act via generalized modular transformations. Our construction only requires the Cartan matrix of the underlying finite-dimensional Lie algebra and the associated Coxeter labels as input information. We present a simple formula for determining the volume of these fundamental domains. This allows us to re-produce in a simple manner the known values for these volumes previously obtained by other methods.Comment: v2: to be published in Lett Math Phys (reference added, typo corrected

Cerebrofaciothoracic dysplasia: four new patients with a recurrent TMCO1 pathogenic variant.

Biallelic loss of function variants in the TMCO1 gene have been previously demonstrated to result in cerebrofaciothoracic dysplasia (CFTD; MIM #213980). The phenotype of this condition includes severe intellectual disability, as well as distinctive craniofacial features, including brachycephaly, synophrys, arched eyebrows, "cupid's bow" upper lip, and microdontia. In addition, nonspecific skeletal anomalies are common, including bifid ribs, scoliosis, and spinal fusion. Only 19 molecularly confirmed patients have been previously described. Here, we present four patients with CFTD, including three brothers from a Pakistani background and an additional unrelated white Scottish patient. All share the characteristic craniofacial appearance, with severe intellectual disability and skeletal abnormalities. We further define the phenotype with comparison to the published literature, and present images to define the dysmorphic features in a previously unreported ethnic group. All of our patient series are homozygous for the same c.292_293del (p.Ser98*) TMCO1 pathogenic variant, which has been previously reported only in an isolated Amish population. Thus we provide evidence that CFTD may be more common than previously thought. The patients presented here further delineate the phenotypic spectrum of CFTD and provide evidence for a recurrent pathogenic variant in TMCO1

A Far-Ultraviolet View of Starburst Galaxies

Recent observational and theoretical results on starburst galaxies related to the wavelength regime below 1200 A are discussed. The review covers stars, dust, as well as hot and cold gas. This wavelength region follows trends similar to those seen at longer wavelengths, with several notable exceptions. Even the youngest stellar populations show a turn-over in their spectral energy distributions, and line-blanketing is much more pronounced. Furthermore, the O VI line allows one to probe gas at higher temperatures than possible with lines at longer wavelengths. Molecular hydrogen lines (if detected) provide a glimpse of the cold phase. I cover the crucial wavelength regime below 912 A and the implications of recent attempts to detect the escaping ionizing radiation.Comment: 8 pages, 3 figures, Invited Talk, Starbursts--From 30 Doradus to Lyman-Break Galaxies, ed. R. de Grijs & R. M. Gonzalez Delgado (Dordrecht: Kluwer

BRAIN Α-TOCOPHEROL CONCENTRATION IS INVERSELY ASSOCIATED WITH NEUROFIBRILLARY TANGLE COUNTS IN BRAIN REGIONS AFFECTED IN EARLIER BRAAK STAGES: A CROSS-SECTIONAL FINDING IN THE OLDEST OLD

Objectives: Higher vitamin E status has been associated with lower risk of Alzheimer’s disease (AD). However, evidence of the association of vitamin E concentration in neural tissue with AD pathologies is limited. Design: The cross-sectional relationship between the human brain concentrations of α- and γ-tocopherol and the severity of AD pathologies – neurofibrillary tangle (NFT) and neuritic plaque (NP) – was investigated. Setting & Participants: Brains from 43 centenarians (≥ 98 years at death) enrolled in the Phase III of the Georgia Centenarian Study were collected at autopsy. Measurements: Brain α- and γ-tocopherol concentrations (previously reported) were averaged from frontal, temporal, and occipital cortices. NP and NFT counts (previously reported) were assessed in frontal, temporal, parietal, entorhinal cortices, amygdala, hippocampus, and subiculum. NFT topological progression was assessed using Braak staging. Multiple linear regression was performed to assess the relationship between tocopherol concentrations and NP or NFT counts, with and without adjustment for covariates. Results: Brain α-tocopherol concentrations were inversely associated with NFT but not NP counts in amygdala (β = -2.67, 95% CI [-4.57, -0.79]), entorhinal cortex (β = -2.01, 95% CI [-3.72, -0.30]), hippocampus (β = -2.23, 95% CI [-3.82, -0.64]), and subiculum (β = -2.52, 95% CI [-4.42, -0.62]) where NFT present earlier in its topological progression, but not in neocortices. Subjects with Braak III-IV had lower α-tocopherol (median = 69,622 pmol/g, IQR = 54,389-72,155 pmol/g) than those with Braak I-II (median = 72,108 pmol/g, IQR = 64,056-82,430 pmol/g), but the difference was of borderline significance (p = 0.063). γ-Tocopherol concentrations were not associated with either NFT or NP counts in any brain regions assessed. Conclusions: Higher brain α-tocopherol level is specifically associated with lower NFT counts in brain structures affected in earlier Braak stages. Our findings emphasize the possible importance of α-tocopherol intervention timing in tauopathy progression and warrant future clinical trials

Measure for measure: new ways of looking at the long-term performance of firms

The need for sustainable long-term performance is an expectation driving the actions of those at the top of organisations. Yet there are few illusions about just how difficult that is to achieve – nor is it easy to determine precisely what should be measured and how

Mass and Magnetic Moments of the Heavy Flavored Baryons with J=3/2J=3/2 in Light Cone QCD Sum Rules

Inspired by the results of recent experimental discoveries for charm and bottom baryons, the masses and magnetic moments of the heavy baryons with $J^P=3/2^+$ containing a single heavy quark are studied within light cone QCD sum rules method. Our results on the masses of heavy baryons are in good agreement with predictions of other approaches, as well as with the existing experimental values. Our predictions on the masses of the states, which are not yet discovered in the experiments, can be tested in the future experiments. A comparison of our results on the magnetic moments of these baryons and the hyper central model predictions is presented.Comment: 33 Pages, 16 Figures and 3 Table