Root Canal Retreatment Menggunakan Kombinasi Kalsium Hidroksida Dan Chlorhexidine Sebagai Medikamen Intra Kanal Insisivus Sentral Kiri Maksila

Enterococcus faecalis adalah bakteri yang paling banyak terdapat pada infeksi saluran akar yang telah dirawat endodontik. Chlorhexidine mempunyai daya anti bakteri spektrum luas dan telah digunakan dalam endodontik sebagai bahan irigasi maupun medikasi intrakanal. Chlorhexidine mempunyai efek bakterisidal dan fungisidal karena chlorhexidine diserap ke dalam permukaan sel bakteri dan menyebabkan rusaknya integritas sel membran. Kalsium hidroksida digunakan karena mempunyai keuntungan seperti biokompatibel, bahan antimikroba dengan efek pH yang tinggi dan stimulasi jaringan keras. Campuran kalsium hidroksida dan chlorhexidine digunakan untuk alternatif melawan bakteri Enterococcus faecalis. Tujuan dari laporan kasus ini adalah untuk melaporkan kesuksesan perawatan saluran akar ulang pada gigi incisivus sentral kiri maksila dengan periodontitis periapikal akut menggunakan kombinasi kalsium hidroksida dan chlorhexidine sebagai medikamen intrakanal. Seorang pasien wanita 24 tahun datang dengan keluhan gigi insisivus sentral kiri atas yang terasa sakit sejak 4 tahun yang lalu. Gigi terasa sakit saat diperkusi, namun palpasi dan mobilitas normal. Gigi tersebut mengalami trauma dan patah 6 tahun yang lalu dan telah dilakukan perawatan endodontik. Pemeriksaan radiografi menunjukkan obturasi gigi 21 yang tidak hermetis dengan radiolusensi di periapikal dengan batas difus, pelebaran ligamen periodontal dan terputusnya lamina dura. Perawatan berupa perawatan saluran akar ulang menggunakan kombinasi kalsium hidroksida dan chlorhexidine sebagai medikamen intrakanal. Root canalretreatment dengan cleaning dan shaping ulang yang baik dengan menggunakan medikasi intrakanal berupa kombinasi kalsium hidroksida dan chlorhexidine 2% diharapkan mempunyai efek antimikroba yang sinergis untuk mencapai kesuksesan root canal retreatment. Root Canal Retreatment Using Calcium Hydroxide as Intra Canal Medicament On The Maxillary Left Incisor. Enterococcus faecalis bacteria is most abundant in the root canal infection treated endodontically. Chlorhexidine has a broad antibacterial spectrum and has been used as an endodontic irrigant and intracanal medication. Chlorhexidine has a bactericidal and fungicidal effect as chlorhexidine absorbed into the bacterial cell surface and cause damage to the integrity of the cell membrane. Calcium hydroxide is a biocompatible, antimicrobial agents with high pH effects and stimulates hard tissue formation. A mixture of calcium hydroxide and chlorhexidine is used to control bacteria Enterococcus faecalis alternative. The purpose of this case report is to report on the success of root canal treatment in the left maxillary central incisor with acute periapical periodontitis using a combination of calcium hydroxide and chlorhexidine as intracanal A 24 years old female patient presents with left upper central incisor tooth ache since 4 years ago. The tooth was hurt to percussion, but normal to pulpation as well as the mobility. The tooth has a history of previous trauma and broken 6 years ago and has performed endodontic treatment. Radiographic examination showed obturation teeth 21 are not hermetic with periapical radiolucency in diffuse boundaries, widening of the periodontal ligament and the dissolution of the lamina dura. Root canal re-treatment using a combination of calcium hydroxide and chlorhexidine as intracanal medicaments were performed. In conclussion, the root canal cleaning and shaping retreatment can be performed using a combination of calcium hydroxide and chlorhexidine as intracanal medication

The Implementation of Outdoor Learning Strategy Focusing on Outdoor Project to Enhance Students' Ability in Writing Descriptive Text

ABSTRACT Writing is the process of expressing and developing ideas in written form. Students face some difficulties in writing descriptive text, to solve this problem the researcher tried to enhance students writing ability in descriptive text by using Outdoor Learning Strategy. Outdoor learning strategy is a strategy that use natural or environment as a place to learn and it purpose to help students can understand the material. Therefore, this study aimed to know the students improvement after got treatment of outdoor learning strategy. This research used a descriptive quantitative method, with pre – experimental design with the type one group pre – test post – test design. Population of this study is all students of class X IPA SMA Negeri 1 Suwawa and sample of this research were the students class X IPA 3. The data were collected by doing test and scoring with rubric. This research were analyzing by using t test. The result of this research shows that the mean score of pre – test is 6.84 and post – test is 14.4. Moreover, the result of hypothesis verification, it is found that T count = 74.8 at the level of significance (a = 0.05) and degree of freedom (df) = 25 – 1= 24. Then, it is found that T table= 2.064. It can be concluded that Outdoor Learning strategy can enhance students ability in writing descriptive text, because based on the criteria above shows that t count is more than t table 74.8 ≥ 2.064. Thus, it can be concluded that Outdoor Learning strategy can enhance students’ ability in writing descriptive text. Keywords: writing, descriptive text, outdoor learning strateg

РАЗМЫШЛЕНИЯ О ТРАНСГЕНЕРАЦИОННОМ СООБЩЕСТВЕ. ГРАНИЦЫ И СВЯЗИ МЕЖДУ ПОКОЛЕНИЯМИ

Should we be considered responsible (and if so, why) towards the species we belong to, in addition of being responsible for ourselves? Typically, the answers that are offered to this and similar questions, make reference to arguments based, alternatively, on the idea that things we have to care of are valuable for us, people like us, or per se. This talks develops a different perspective, based on the idea that in a lot of cases the responsibility is an obligation due not to the kind of value certain thing are supposed to have, but rather to the type of actions that social people and institutions generally perform. After discussing the metaphysical model of these actions, which I call ―transgenerationals‖, I will show the reason why transgenerational actions necessarily imply responsibility of one generation to the other. In a word, they require responsibility between generations and hence a particular sensitivity to the future. I also plan to show that transgenerationality is something that unites generations along with such a human ability as the memoryОсновной вопрос, на который я пытаюсь ответить в своей статье: «Должны ли мы считаться ответственными (и если да, то почему) по отношению к нашему биологическому виду, в дополнение к ―ответственности за себя‖»? Как правило, ответы на этот и подобные вопросы опираются на аргументы, основанные на идее о том, что предмет нашей заботы, имеет ценность для таких же, как мы, или сами по себе. Такой дискурс открывает различные перспективы, связанные с представлениями о том, что во многих случаях ответственность является обязанностью, накладываемой не только из-за ее предполагаемой ценности, а, скорее, посредством типа действия, обычно происходящего от социальных групп или институций. После обсуждения метафизической модели действий, которые я называю «трансгенерационными» (межпоколенческими), я покажу причину, по которой такие действия обязательно подразумевают ответственность одного поколения перед другим. В статье утверждается, что они требуют доверия между поколениями и, следовательно, особой чувствительности к будущему. Также показывается, что трансгенерациональность – это нечто, объединяющее поколения, наряду с такой человеческой способностью как память

Analisis Stabilitas Dinding Penahan Tanah dengan Metode Numerik

Salah satu upaya untuk melindungi bangunan-bangunan yang ada adalah dengan pembuatan dinding penahan tanah (retaining wall) di sekitar PLTG. Dalam perencanaan dinding penahan tanah, besarnya angka keamanan yang diperoleh harus di atas batas yang telah ditentukan. Penelitian ini menganalisis stabilitas dinding penahan tanah tipe gravitasi. Analisis yang dilakukan dengan menggunakan software PLAXIS dan perhitungan manual (metode Rankine). Analisis stabilitas tanah ditinjau dari segi pergeseran, penggulingan serta penurunan daya dukung tanah. Stabilitas terhadap penggeseran berdasarkan metode numeris (program PLAXIS) untuk dinding penahan tanah tipe 1 dan 2 besarnya di atas standar kriteria minimum (SF > 1,55). Faktor keamanan dinding penahan tanah tipe 1 sebesar 2,7 dan dinding penahan tanah tipe 2 sebesar 2,5 yang artinya aman terhadap penggeseran. Perhitungan manual untuk dinding penahan tanah tipe 1 (SF = 1,59) dan tipe 2 (SF = 1,81) juga besarnya di atas standar kriteria minimum yang ditetapkan. Stabilitas terhadap penggulingan berdasarkan perhitungan manual untuk dinding penahan tanah tipe 1 (SF = 2,47) dan dinding penahan tipe 2 (SF = 2,01) besarnya di atas standar kriteria minimum (SF > 2,00)

Microcalcifications Detection using PFCM and ANN

This work presents a method to detect Microcalcifications in Regions of Interest from digitized mammograms. The method is based mainly on the combination of Image Processing, Pattern Recognition and Artificial Intelligence. The Top-Hat transform is a technique based on mathematical morphology operations that, in this work is used to perform contrast enhancement of microcalcifications in the region of interest. In order to find more or less homogeneous regions in the image, we apply a novel image sub-segmentation technique based on Possibilistic Fuzzy c-Means clustering algorithm. From the original region of interest we extract two window-based features, Mean and Deviation Standard, which will be used in a classifier based on a Artificial Neural Network in order to identify microcalcifications. Our results show that the proposed method is a good alternative in the stage of microcalcifications detection, because this stage is an important part of the early Breast Cancer detectio

АКТУАЛЬНОСТЬ ЭСТЕТИКИ Б. КРОЧЕ

The fundamental thesis of Benedetto Croce’s Aesthetic consists of two main points: (i) intuitive knowledge is independent of logical knowledge, (ii) intuitive knowledge is given in art, while logical knowledge in philosophy.After illustrating some theoretical elements that make Croce’s aesthetic a focal point in contemporary aesthetics, in the present article I will show how, given the validity of the first part of Croce’s thesis (i), the second part of his thesis (ii) is not defensible in the terms pro- posed by him. Finally, on the basis on the previous analyses, I shall offer some arguments in favour of maintaining the disciplinary distinction between aesthetics and philosophy of art.Основные положения эстетики Кроче включают два пункта: 1) интуитивное знание не зависит от логического; 2) интуитивное знание дано в искусстве, а логическое – в философии.В данной статье я сначала приведу некоторые доводы в пользу значимости некоторых элементов теории Кроче для современной эстетики, а затем покажу, что, несмотря на справедливость его первого утверждения (1), второе (2) нельзя обосновать в рамках его теории. И, наконец, на основе предыдущих умозаключений, я представлю обоснование различия между эстетикой и философией искусства

Improvement for detection of microcalcifications through clustering algorithms and artificial neural networks

A new method for detecting microcalcifications in regions of interest (ROIs) extracted from digitized mammograms is proposed. The top-hat transform is a technique based on mathematical morphology operations and, in this paper, is used to perform contrast enhancement of the mi-crocalcifications. To improve microcalcification detection, a novel image sub-segmentation approach based on the possibilistic fuzzy c-means algorithm is used. From the original ROIs, window-based features, such as the mean and standard deviation, were extracted; these features were used as an input vector in a classifier. The classifier is based on an artificial neural network to identify patterns belonging to microcalcifications and healthy tissue. Our results show that the proposed method is a good alternative for automatically detecting microcalcifications, because this stage is an important part of early breast cancer detectio

LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity.

Inflammasomes are cytosolic innate immune sensors of pathogen infection and cellular damage that induce caspase-1-mediated inflammation upon activation. Although inflammation is protective, uncontrolled excessive inflammation can cause inflammatory diseases and can be detrimental, such as in coronavirus disease (COVID-19). However, the underlying mechanisms that control inflammasome activation are incompletely understood. Here we report that the leucine-rich repeat (LRR) protein ribonuclease inhibitor (RNH1), which shares homology with LRRs of NLRP (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing) proteins, attenuates inflammasome activation. Deletion of RNH1 in macrophages increases interleukin (IL)-1β production and caspase-1 activation in response to inflammasome stimulation. Mechanistically, RNH1 decreases pro-IL-1β expression and induces proteasome-mediated caspase-1 degradation. Corroborating this, mouse models of monosodium urate (MSU)-induced peritonitis and lipopolysaccharide (LPS)-induced endotoxemia, which are dependent on caspase-1, respectively, show increased neutrophil infiltration and lethality in Rnh1 <sup>-/-</sup> mice compared with wild-type mice. Furthermore, RNH1 protein levels were negatively related with disease severity and inflammation in hospitalized COVID-19 patients. We propose that RNH1 is a new inflammasome regulator with relevance to COVID-19 severity

Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription

The IPC-81 cell line is derived from the transplantable BNML model of acute myelogenic leukemia (AML), known to be a reliable predictor of the clinical efficiency of antileukemic agents, like the first-line AML anthracycline drug daunorubicin (DNR). We show here that cAMP acted synergistically with DNR to induce IPC cell death. The DNR-induced death differed from that induced by cAMP by (1) not involving Bim induction, (2) being abrogated by GSK3β inhibitors, (3) by being promoted by the HSP90/p23 antagonist geldanamycin and truncated p23 and (4) by being insensitive to the CRE binding protein (CREB) antagonist ICER and to cyclin-dependent protein kinase (CDK) inhibitors. In contrast, the apoptosis induced by cAMP correlated tightly with Bim protein expression. It was abrogated by Bim (BCL2L11) downregulation, whether achieved by the CREB antagonist ICER, by CDK inhibitors, by Bim-directed RNAi, or by protein synthesis inhibitor. The forced expression of BimL killed IPC-81WT cells rapidly, Bcl2-overexpressing cells being partially resistant. The pivotal role of CREB and CDK activity for Bim transcription is unprecedented. It is also noteworthy that newly developed cAMP analogs specifically activating PKA isozyme I (PKA-I) were able to induce IPC cell apoptosis. Our findings support the notion that AML cells may possess targetable death pathways not exploited by common anti-cancer agents