Aerodynamic characteristics of a hypersonic research airplane concept having a 70 deg swept double-delta wing at Mach number 0.2

A wind-tunnel of the static longitudinal, lateral and directional stability characteristics of a hypersonic research airplane concept having a 70 deg swept double-delta wing was conducted in the Langley low-turbulence pressure tunnel. The configuration variables included wing planform, tip fins, center fin, and scramjet engine modules. A mach number of 0.2 was investigated over a Reynolds number (based on fuselage length) range of 2,200,000 to 19.75 x 1,000,000 (with a majority of tests at 10.0 x 1,000,000. Tests were conducted through an angle-of-attack range from about -2 deg to 34 deg at angles of sideslip of 0 deg to 5 deg, and at elevon deflection of 0 deg, -5 deg, -10 deg, -15 deg, and -20 deg. The drag coefficient of the integrated scramjet engine appears relatively constant with Reynolds number at the test Mach number of 0.2. Mild pitch-up was exhibited by the models equipped with tip fins. The forward delta, a highly swept forward portion of the wing, was destabilizing. The center fin model has a higher trimmed maximum lift-drag ratio and a wider trim lift and angle-of-attack range than the tip fin model. Both the tip fin models and center fin models exhibited positive dihedral effect and positive directional stability. Roll control was positive for the tip fin model, but yaw due to roll control was unfavorable

Temperature-(208-318 K) and pressure-(18-696Torr) dependent rate coefficients for the reaction between OH and HNO3

Abstract. Rate coefficients (k5) for the title reaction were ob- tained using pulsed laser photolytic generation of OH cou- pled to its detection by laser-induced fluorescence (PLP– LIF). More than 80 determinations of k5 were carried out in nitrogen or air bath gas at various temperatures and pres- sures. The accuracy of the rate coefficients obtained was en- hanced by in situ measurement of the concentrations of both HNO3 reactant and NO2 impurity. The rate coefficients show both temperature and pressure dependence with a rapid in- crease in k5 at low temperatures. The pressure dependence was weak at room temperature but increased significantly at low temperatures. The entire data set was combined with se- lected literature values of k5 and parameterised using a com- bination of pressure-dependent and -independent terms to give an expression that covers the relevant pressure and tem- perature range for the atmosphere. A global model, using the new parameterisation for k 5 rather than those presently ac- cepted, indicated small but significant latitude- and altitude- dependent changes in the HNO 3 / NO x ratio of between − 6 and + 6 %. Effective HNO 3 absorption cross sections (184.95 and 213.86 nm, units of cm 2 molecule − 1 ) were ob- tained as part of this work: σ 213 . 86 = 4.52 + 0 . 23 − 0 . 12 × 10 − 19 and σ 184 . 95 = 1.61 + 0 . 08 − 0 . 04 × 10 − 17

Kolmogorov Similarity Hypotheses for Scalar Fields: Sampling Intermittent Turbulent Mixing in the Ocean and Galaxy

Kolmogorov's three universal similarity hypotheses are extrapolated to describe scalar fields like temperature mixed by turbulence. By the analogous Kolmogorov third hypothesis for scalars, temperature dissipation rates chi averaged over lengths r > L_K should be lognormally distributed with intermittency factors I that increase with increasing turbulence energy length scales L_O as I_chi-r = m_T ln(L_O/r). Tests of Kolmogorovian velocity and scalar universal similarity hypotheses for very large ranges of turbulence length and time scales are provided by data from the ocean and the Galactic interstellar medium. The universal constant for turbulent mixing intermittency m_T is estimated from oceanic data to be 0.44+-0.01, which is remarkably close to estimates for Kolmogorov's turbulence intermittency constant m_u of 0.45+-0.05 from Galactic as well as atmospheric data. Extreme intermittency complicates the oceanic sampling problem, and may lead to quantitative and qualitative undersampling errors in estimates of mean oceanic dissipation rates and fluxes. Intermittency of turbulence and mixing in the interstellar medium may be a factor in the formation of stars.Comment: 23 pages original of Proc. Roy. Soc. article, 8 figures; in "Turbulence and Stochastic Processes: Kolmogorov's ideas 50 years on", London The Royal Society, 1991, J.C.R. Hunt, O.M. Phillips, D. Williams Eds., pages 1-240, vol. 434 (no. 1890) Proc. Roy. Soc. Lond. A, PDF fil

Development of tests for measurement of primary perceptual-motor performance

Tests for measuring primary perceptual-motor performance for assessing space environment effects on human performanc

Energetic and Environmental Constraints on the Community Structure of Benthic Microbial Mats in Lake Fryxell, Antarctica.

Ecological communities are regulated by the flow of energy through environments. Energy flow is typically limited by access to photosynthetically active radiation (PAR) and oxygen concentration (O2). The microbial mats growing on the bottom of Lake Fryxell, Antarctica, have well-defined environmental gradients in PAR and (O2). We analyzed the metagenomes of layers from these microbial mats to test the extent to which access to oxygen and light controls community structure. We found variation in the diversity and relative abundances of Archaea, Bacteria and Eukaryotes across three (O2) and PAR conditions: high (O2) and maximum PAR, variable (O2) with lower maximum PAR, and low (O2) and maximum PAR. We found distinct communities structured by the optimization of energy use on a millimeter-scale across these conditions. In mat layers where (O2) was saturated, PAR structured the community. In contrast, (O2) positively correlated with diversity and affected the distribution of dominant populations across the three habitats, suggesting that meter-scale diversity is structured by energy availability. Microbial communities changed across covarying gradients of PAR and (O2). The comprehensive metagenomic analysis suggests that the benthic microbial communities in Lake Fryxell are structured by energy flow across both meter- and millimeter-scales

Effects of cochlear implantation on binaural hearing in adults with unilateral hearing loss

A FDA clinical trial was carried out to evaluate the potential benefit of cochlear implant (CI) use for adults with unilateral moderate-to-profound sensorineural hearing loss. Subjects were 20 adults with moderate-to-profound unilateral sensorineural hearing loss and normal or near-normal hearing on the other side. A MED-EL standard electrode was implanted in the impaired ear. Outcome measures included: (a) sound localization on the horizontal plane (11 positions, −90° to 90°), (b) word recognition in quiet with the CI alone, and (c) masked sentence recognition with the target at 0° and the masker at −90°, 0°, or 90°. This battery was completed preoperatively and at 1, 3, 6, 9, and 12 months after CI activation. Normative data were also collected for 20 age-matched control subjects with normal or near-normal hearing bilaterally. The CI improved localization accuracy and reduced side bias. Word recognition with the CI alone was similar to performance of traditional CI recipients. The CI improved masked sentence recognition when the masker was presented from the front or from the side of normal or near-normal hearing. The binaural benefits observed with the CI increased between the 1- and 3-month intervals but appeared stable thereafter. In contrast to previous reports on localization and speech perception in patients with unilateral sensorineural hearing loss, CI benefits were consistently observed across individual subjects, and performance was at asymptote by the 3-month test interval. Cochlear implant settings, consistent CI use, and short duration of deafness could play a role in this result

Exclusion of the Locus for Autosomal Recessive Pseudohypoaldosteronism Type 1 from the Mineralocorticoid Receptor Gene Region on Human Chromosome 4q by Linkage Analysis.

Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids. Clinical expression of the disease varies from severely affected infants who may die to apparently asymptomatic individuals. Inheritance is Mendelian and may be either autosomal dominant or autosomal recessive. A defect in the mineralocorticoid receptor has been implicated as a likely cause of PHA1. The gene for human mineralocorticoid receptor (MLR) has been cloned and physically mapped to human chromosome 4q31.1-31.2. The etiological role of MLR in autosomal recessive PHA1 was investigated by performing linkage analysis between PHA1 and three simple sequence length polymorphisms (D4S192, D4S1548, and D4S413) on chromosome 4q in 10 consanguineous families. Linkage analysis was carried out assuming autosomal recessive inheritance with full penetrance and zero phenocopy rate using the MLINK program for two-point analysis and the HOMOZ program for multipoint analysis. Lod scores of less than -2 were obtained over the whole region from D4S192 to D4S413 encompassing MLR. This provdes evidence against MLR as the site of mutations causing PHA1 in the majority of autosomal recessive families

Entropy and the driving force for the filling of carbon nanotubes with water

The spontaneous filling of hydrophobic carbon nanotubes (CNTs) by water observed both experimentally and from simulations is counterintuitive because confinement is generally expected to decrease both entropy and bonding, and remains largely unexplained. Here we report the entropy, enthalpy, and free energy extracted from molecular dynamics simulations of water confined in CNTs from 0.8 to 2.7-nm diameters. We find for all sizes that water inside the CNTs is more stable than in the bulk, but the nature of the favorable confinement of water changes dramatically with CNT diameter. Thus we find (i) an entropy (both rotational and translational) stabilized, vapor-like phase of water for small CNTs (0.8–1.0 nm), (ii) an enthalpy stabilized, ice-like phase for medium-sized CNTs (1.1–1.2 nm), and (iii) a bulk-like liquid phase for tubes larger than 1.4 nm, stabilized by the increased translational entropy as the waters sample a larger configurational space. Simulations with structureless coarse-grained water models further reveal that the observed free energies and sequence of transitions arise from the tetrahedral structure of liquid water. These results offer a broad theoretical basis for understanding water transport through CNTs and other nanostructures important in nanofluidics, nanofiltrations, and desalination

MEMS practice, from the lab to the telescope

Micro-electro-mechanical systems (MEMS) technology can provide for deformable mirrors (DMs) with excellent performance within a favorable economy of scale. Large MEMS-based astronomical adaptive optics (AO) systems such as the Gemini Planet Imager are coming on-line soon. As MEMS DM end-users, we discuss our decade of practice with the micromirrors, from inspecting and characterizing devices to evaluating their performance in the lab. We also show MEMS wavefront correction on-sky with the "Villages" AO system on a 1-m telescope, including open-loop control and visible-light imaging. Our work demonstrates the maturity of MEMS technology for astronomical adaptive optics.Comment: 14 pages, 15 figures, Invited Paper, SPIE Photonics West 201

Influence of Age on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage

Objective We assessed the influence of age on warfarin dose, percentage time in target range (PTTR), and risk of major hemorrhage. Design Warfarin users recruited into a large prospective inception cohort study were categorized into three age groups: young (younger than 50 yrs), middle aged (50–70 yrs), and elderly (older than 70 yrs). The influence of age on warfarin dose and PTTR was assessed using regression analysis; risk of major hemorrhage was assessed using proportional hazards analysis. Models were adjusted for demographic, clinical, and genetic factors. Setting Two outpatient anticoagulation clinics. Participants A total of 1498 anticoagulated patients. Outcomes Warfarin dose (mg/day), PTTR, major hemorrhage. Results Of the 1498 patients, 22.8% were young, 44.1% were middle aged, and 33.1% were elderly. After accounting for clinical and genetic factors, compared with young warfarin users, warfarin dose requirements were 10.6% lower among the middle aged and an additional 10.6% lower for the elderly. Compared with young patients, middle-aged and elderly patients spent more time in target international normalized ratio (INR) range (p<0.0001), despite having fewer INR assessments (p<0.0001). Compared with young warfarin users, absolute risk of hemorrhage was marginally higher among the middle aged (p=0.08) and significantly higher among the elderly (p=0.016). Compared with young warfarin users, after adjustment, the relative risk of hemorrhage increased by 31% for each age category (p=0.026). Conclusions In a real-world setting, despite achieving better anticoagulation control, elderly patients had a higher risk of major hemorrhagic events. As the population ages and the candidacy for oral anticoagulation increases, strategies that mitigate the elevated risk of hemorrhage need to be identified