Large-scale radio continuum properties of 19 Virgo cluster galaxies The influence of tidal interactions, ram pressure stripping, and accreting gas envelopes

Deep scaled array VLA 20 and 6cm observations including polarization of 19 Virgo spirals are presented. This sample contains 6 galaxies with a global minimum of 20cm polarized emission at the receding side of the galactic disk and quadrupolar type large-scale magnetic fields. In the new sample no additional case of a ram-pressure stripped spiral galaxy with an asymmetric ridge of polarized radio continuum emission was found. In the absence of a close companion, a truncated HI disk, together with a ridge of polarized radio continuum emission at the outer edge of the HI disk, is a signpost of ram pressure stripping. 6 out of the 19 observed galaxies display asymmetric 6cm polarized emission distributions. Three galaxies belong to tidally interacting pairs, two galaxies host huge accreting HI envelopes, and one galaxy had a recent minor merger. Tidal interactions and accreting gas envelopes can lead to compression and shear motions which enhance the polarized radio continuum emission. In addition, galaxies with low average star formation rate per unit area have a low average degree of polarization. Shear or compression motions can enhance the degree of polarization. The average degree of polarization of tidally interacting galaxies is generally lower than expected for a given rotation velocity and star formation activity. This low average degree of polarization is at least partly due to the absence of polarized emission from the thin disk. Ram pressure stripping can decrease whereas tidal interactions most frequently decreases the average degree of polarization of Virgo spiral galaxies. We found that moderate active ram pressure stripping has no influence on the spectral index, but enhances the global radio continuum emission with respect to the FIR emission, while an accreting gas envelope can but not necessarily enhances the radio continuum emission with respect to the FIR emission.Comment: 37 pages, 26 figures, accepted for publication in A&

17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors

Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle. Although estrogens can enhance drug-seeking behavior, they do not directly induce reinstatement on their own. To model this phenomenon, we tested whether an estrogen could augment drug-seeking behavior in response to an ordinarily subthreshold reinstatement trigger. Following cocaine self-administration and extinction, female rats were ovariectomized to isolate estrogen effects on reinstatement. Although neither peak proestrus levels of the primary estrogen 17β-estradiol (E2; 10 μg/kg, i.p., 1-h pretreatment) nor a subthreshold cocaine dose (1.25 mg/kg, i.p.) alone were sufficient to reinstate drug-seeking behavior, pretreatment with E2 potentiated reinstatement to the ordinarily subthreshold cocaine dose. Furthermore, E2 microinfusions revealed that E2 (5 μg/0.3 μl, 15-min pretreatment) acts directly within the prelimbic prefrontal cortex (PrL-PFC) to potentiate reinstatement. As E2 has been implicated in endocannabinoid mobilization, which can disinhibit PrL-PFC projection neurons, we investigated whether cannabinoid type-1 receptor (CB1R) activation is necessary for E2 to potentiate reinstatement. The CB1R antagonist AM251 (1 or 3 mg/kg, i.p., 30-min pretreatment) administered prior to E2 and cocaine suppressed reinstatement in a dose-dependent manner. Finally, PrL-PFC AM251 microinfusions (300 ng/side, 15-min pretreatment) also suppressed E2-potentiated reinstatement. Together, these results suggest that E2 can augment reactivity to an ordinarily subthreshold relapse trigger in a PrL-PFC CB1R activation-dependent manner

The magnetic fields of large Virgo cluster spirals: Paper II

The Virgo cluster of galaxies provides excellent conditions for studying interactions of galaxies with the cluster environment. Both the high-velocity tidal interactions and effects of ram pressure stripping by the intracluster gas can be investigated in detail. We extend our systematic search for possible anomalies in the magnetic field structures of Virgo cluster spirals in order to characterize a variety of effects and attribute them to different disturbing agents. Six angularly large Virgo cluster spiral galaxies (NGC4192, NGC4302, NGC4303, NGC4321, NGC4388, and NGC4535) were targets of a sensitive total power and polarization study using the 100-m radio telescope in Effelsberg at 4.85GHz and 8.35GHz (except for NGC4388 observed only at 4.85GHz, and NGC4535 observed only at 8.35GHz). Magnetic field structures distorted to various extent are found in all galaxies. Three galaxies (NGC4302, NGC4303, and NGC4321) show some signs of possible tidal interactions, while NGC4388 and NGC4535 have very likely experienced strong ram-pressure and shearing effects, respectively, visible as distortions and asymmetries of polarized intensity distributions. As in our previous study, even strongly perturbed galaxies closely follow the radio-far-infrared correlation. In NGC4303 and NGC4321, we observe symmetric spiral patterns of the magnetic field and in NGC4535 an asymmetric pattern. Magnetic fields allow us to trace even weak interactions that are difficult to detect with other observations. Our results show that the degree of distortions of a galaxy is not a simple function of the distance to the cluster center but reflects also the history of its interactions. The angle between the velocity vector and the rotation vector of a galaxy may be a general parameter that describes the level of distortions of galactic magnetic fields.Comment: 12 pages, 18 figures, 2 tables. Accepted for publication in Astronomy and Astrophysic

Antibacterial Activity of Gentamicin-bonded Gelatin-sealed Polyethylene Terephthalate Vascular Prostheses

AbstractObjectivesTo create an antibiotic-modified vascular prosthesis with a prolonged bactericidal activity, susceptible to endothelialisation.MethodsWe used a covalent method of gentamicin sulphate immobilisation to polyethylene terephthalate prosthesis sealed with gelatin. Antibacterial activity was assayed in Luria-Bertani medium against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains. Prosthesis endothelialisation was performed using bovine aorta endothelial cells (BAEC).ResultsGentamicin was bound to vascular prostheses in the amount of 12g per kg of prosthesis. Ninety-seven percent of antibiotic bound in covalent way and remained on the biomaterial for at least 30 days during shaking in PBS solution. Gentamicin-modified prostheses exerted bactericidal or bacteriostatic effect on growth of clinical and reference bacterial strains, prevented biofilm formation and were highly susceptible to endothelialisation. BAEC viability exceeded 90%, which indicated that gentamicin-vascular prostheses were not toxic for these cells.ConclusionsCovalent gentamicin immobilisation resulted in effective antibacterial protection of vascular prostheses against clinical and reference strains of S. aureus, E. coli and P. aeruginosa and allowed for a strong adherence of endothelial cells to antibiotic-modified prostheses

Large-scale magnetized outflows from the Virgo Cluster spiral NGC4569

Using the Effelsberg radio telescope at 4.85GHz and 8.35 GHz we discovered large symmetric lobes of polarized radio emission around the strongly HI deficient Virgo cluster spiral galaxy NGC4569. These lobes extend up to 24 kpc from the galactic disk. Our observations were complemented by 1.4 GHz continuum emission from existing HI observations. This is the first time that such huge radio continuum lobes are observed in a cluster spiral galaxy. The eastern lobe seems detached and has a flat spectrum typical for in-situ cosmic ray electron acceleration. The western lobe is diffuse and possesses vertical magnetic fields over its whole volume. The lobes are not powered by an AGN, but probably by a nuclear starburst producing >10^5 supernovae which occurred ~30 Myr ago. Since the radio lobes are symmetric, they resist ram pressure due to the galaxy's rapid motion within the intracluster medium.Comment: Accepted for publication in A&A, 8 pages, 6 figure

Surface of underdoped YBa2Cu3O7- δ as revealed by STM/STS

We performed scanning tunneling microscopy and spectroscopy on untwinned crystals of underdoped YBa2Cu3O7- δ at δ = 0.4. A comprehensive statistical analysis of our topographic data indicates a doping dependent cleaving behavior of this material. We find in particular that at δ = 0.4 the material primarily cleaves in multiples of one unit cell along the c-axis with a high corrugation of the topmost layer. Our data suggest that the low temperature cleaving mainly results in a disruption of the CuO chain layers involving a redistribution of the layer atoms onto the two cleaving planes. In a few instances, fractional step heights (in terms of the c-axis lattice constant) are observed as well. Scanning tunneling spectroscopy reveals that such fractional steps connect surfaces which differ significantly in their tunneling conductance

Ozone-based eye drops activity on ocular epithelial cells and potential pathogens infecting the front of the eye

Confirmation of the biological effectiveness of new ophthalmic preparations introduced in the market is an important element in maintaining the safety of using this type of medications. This study aimed to investigate the activity of Ozodrop® on human corneal and conjunctival epithelial cells, as well as its antibacterial and antifungal activity. Cytotoxicity analyses of ocular surface epithelial cells were performed in vitro by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) and Neutral Red uptake assays. The level of nitric oxide released by the cells was assessed by the Griess method. The reduction of the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical by the tested formulation was analyzed. Microbiological tests were also performed. It was found that the Ozodrop® preparation exhibited biological activity, but was less active than the reference antibiotics and the anti-yeast agent. The cytotoxic activity of the Ozodrop® formulation was dependent on the time of cell exposure to it. No toxic effect was observed in the short-term, for up to 3 h. It appeared after 24 h of exposure of the cells to the preparation. The drops showed antioxidant activity in the specified concentration range. They also stimulated the release of nitric oxide, mainly by corneal epithelial cells. The Ozodrop® formulation exhibits biological activity that can be considered useful in the treatment of infections in the front part of the eye

Tidal interaction vs. ram pressure stripping effects as seen in X-rays. Hot gas in group and cluster galaxies

The hot intracluster/intragroup medium (ICM/IGM) and a high galaxy density can lead to perturbations of the galactic interstellar medium (ISM) due to ram pressure and/or tidal interaction effects. In radio polarimetry observations, both phenomena may manifest similar features. X-ray data can help to determine the real origin of the perturbation. We analyse the distribution and physical properties of the hot gas in the Virgo cluster spiral galaxies NGC 4254 and NGC 4569, which indicate that the cluster environment has had a significant influence on their properties. By performing both spatial and spectral analyses of X-ray data, we try to distinguish between two major phenomena: tidal and ram pressure interactions. We compare our findings with the case of NGC 2276, in which a shock was reported, by analysing XMM-Newton X-ray data for this galaxy. We use archival XMM-Newton observations of NGC 4254, NGC 4569, and NGC 2276. Maps of the soft diffuse emission in the energy band 0.2 - 1 keV are obtained. For the three galaxies, especially at the position of magnetic field enhancements we perform a spectral analysis to derive gas temperatures and thus to look for shock signatures. A shock is a signature of ram pressure resulting from supersonic velocities; weak tidal interactions are not expected to influence the temperature of the ionized gas. In NGC 4254, we do not observe any temperature increase. This suggests tidal interactions rather than ram pressure stripping. In NGC 4569 the radio polarized ridge shows a higher temperature, which may indicate ram-pressure effects. For NGC 2276, we do not find clear indications of a shock. The main driver of the observed distortions is most likely tidal interaction. Determining gas temperatures via sensitive X-ray observations seems to be a good method for distinguishing between ram pressure and tidal interaction effects acting upon a galaxy.Comment: 13 pages, 13 figures, 8 tables, Accepted for publication in Astronomy and Astrophysic

The Nature of Composite LINER/HII Galaxies, As Revealed from High-Resolution VLA Observations

A sample of 37 nearby galaxies displaying composite LINER/HII and pure HII spectra was observed with the VLA in an investigation of the nature of their weak radio emission. The resulting radio contour maps overlaid on optical galaxy images are presented here, together with an extensive literature list and discussion of the individual galaxies. Radio morphological data permit assessment of the ``classical AGN'' contribution to the global activity observed in these ``transition'' LINER galaxies. One in five of the latter objects display clear AGN characteristics: these occur exclusively in bulge-dominated hosts.Comment: 31 pages, 27 figures, accepted by ApJ