Results of tests OA26 and IA16 in the NASA/ARC 3.5-foot hypersonic wind tunnel on an 0.015-scale model (36-OTS) of the space shuttle configuration 140A/B to obtain pressures for venting analysis

Tests were conducted, from November 15 to December 4, 1973, to obtain surface pressure data on an 0.015-scale replica of the Space Shuttle Vehicle 4. Data were obtained at Mach numbers of 5.3, 7.4, and 10.3, to support the venting analysis for both launch and entry conditions. These tests were the final tests in a series covering a Mach number range from 0.6 to 10.3. The model was instrumented with pressure orifices in the vicinity of the cargo bay door hinge and parting lines, and on the side of the fuselage at the crew compartment, and below the orbital maneuvering system pods at the aft compartment. The model was tested at angles of attack and sideslip consistent with expected divergencies from the nominal trajectory

A search for X-rays from UV Ceti flare stars

A search of MIT/OSO-7 data was made for evidence of X-ray emission from flares of UV Ceti flare stars. Observations from McDonald Observatory were used to identify the times of optical flares. The only instance of coincident coverage occurred on 1974 January 21 UT at 03:43:26 GMT for delta m(u)=0.86 flare of YZ CMi. No radio coverage of this particular event was obtained. Upper limits (3 sigma) of 0.8, 1.0, and 0.7 photons/sq cm-sec on the observed X-ray flux were set for the energy ranges greater than or approximately equal to 15, greater than or approximately equal to 3, and 1-10 keV, respectively

Imprints of magnetic power and helicity spectra on radio polarimetry statistics

Statistical properties of turbulent magnetic fields in radio-synchrotron sources should imprint on the statistics of polarimetric observables. In search of these imprints, we calculate correlation and cross-correlation functions from a set of observables containing the total intensity I, the polarized intensity P and the Faraday depth phi. The correlation functions are evaluated for all combinations of observables up to fourth order in the magnetic field B. We derive these as far as possible analytically and from first principles only using some basic assumptions such as Gaussian statistics of the underlying magnetic field in the observed region and statistical homogeneity. We further assume some simplifications to reduce the complexity of the calculations, as for a start we were interested in a proof of concept. Using this statistical approach, we show that it is in principle possible to gain information about the helical part of the magnetic power spectrum, namely via the correlation functions and . Using this insight, we construct an easy-to-use test for helicity, called LITMUS (Local Inference Test for Magnetic fields which Uncovers heliceS). For now, all calculations are given in a Faraday-free case, but set up in a way so that Faraday rotational effects could be included later on.Comment: 24 pages, 4 figures; typos corrected; additional explanations in section 1 and 2; revised and extended derivation in section 5, results unchange

Faraday caustics: Singularities in the Faraday spectrum and their utility as probes of magnetic field properties

We describe singularities in the distribution of polarized intensity as a function of Faraday depth (i.e. the Faraday spectrum) caused by line-of-sight (LOS) magnetic field reversals. We call these features Faraday caustics because of their similarity to optical caustics. They appear as sharply peaked and asymmetric profiles in the Faraday spectrum, that have a tail that extends to one side. The direction in which the tail extends depends on the way in which the LOS magnetic field reversal occurs (either changing from oncoming to retreating or vice versa). We describe how Faraday caustics will form three-dimensional surfaces that relate to boundaries between regions where the LOS magnetic field has opposite polarity. We present examples from simulations of the predicted polarized synchrotron emission from the Milky Way. We derive either the probability or luminosity distribution of Faraday caustics produced in a Gaussian magnetic field distribution as a function of their strength, F, and find that for strong Faraday caustics P(F)\proptoF^{-3} . If fully resolved, this distribution is also shown to depend on the Taylor microscale, which relates to the largest scale over which dissipation is important in a turbulent flow.Comment: 14 pages, 9 figures, Accepted for publication in Astronomy & Astrophysic

Therapist Dreams about Clients

Little empirical research has been conducted on therapist dreams about clients. The purpose of the current study was to learn more about this phenomenon, with a focus on four specific areas: (1) themes that occur in such dreams, (2) the meaning therapists make of the dreams, (3) what methods therapists use for gaining understanding of these dreams, and (4) what uses therapists make of their understanding. The consensual qualitative research method was used to analyze transcripts of interviews with 8 experienced therapists. Results indicated that the dreams typically had primarily negative interpersonal patterns, deepened therapist awareness of a known issue; therapists used multiple methods to work with the dreams; and therapists used their understanding of the dream in deciding how to proceed with the case. Specific meaning of the dreams included signals of unmanaged countertransference and indications to make fundamental changes in the therapeutic relationship or the therapist's life

Mass spectrometers and atomic oxygen

The likely role of atmospheric atomic oxygen in the recession of spacecraft surfaces and in the shuttle glow has revived interest in the accurate measurement of atomic oxygen densities in the upper atmosphere. The Air Force Geophysics Laboratory is supplying a quadrupole mass spectrometer for a materials interactions flight experiment being planned by the Johnson Space Center. The mass spectrometer will measure the flux of oxygen on test materials and will also identify the products of surface reactions. The instrument will be calibrated at a new facility for producing high energy beams of atomic oxygen at the Los Alamos National Laboratory. The plans for these calibration experiments are summarized

Triepitopic Antibody Fusions Inhibit Cetuximab-Resistant BRAF and KRAS Mutant Tumors via EGFR Signal Repression

Dysregulation of epidermal growth factor receptor (EGFR) is a hallmark of many epithelial cancers, rendering this receptor an attractive target for cancer therapy. Much effort has been focused on the development of EGFR-directed antibody-based therapeutics, culminating in the clinical approval of the drugs cetuximab and panitumumab. Unfortunately, the clinical efficacy of these drugs has been disappointingly low, and a particular challenge to targeting EGFR with antibody therapeutics has been resistance, resulting from mutations in the downstream raf and ras effector proteins. Recent work demonstrating antibody cocktail-induced synergistic downregulation of EGFR motivated our design of cetuximab-based antibody–fibronectin domain fusion proteins that exploit downregulation-based EGFR inhibition by simultaneously targeting multiple receptor epitopes. We establish that, among our engineered multiepitopic formats, trans-triepitopic antibody fusions demonstrate optimal efficacy, inducing rapid EGFR clustering and internalization and consequently ablating downstream signaling. The combined effects of EGFR downregulation, ligand competition, and immune effector function conspire to inhibit tumor growth in xenograft models of cetuximab-resistant BRAF and KRAS mutant cancers. Our designed triepitopic constructs have the potential to enhance the efficacy and expand the scope of EGFR-directed therapies, and our multiepitopic may be readily applied to other receptor targets to formulate a new class of antibody-based therapeutics.National Institutes of Health (U.S.) (Grant CA96504)American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowshi

Simplified, standardized methods to assess the accuracy of clinical cancer staging

Background. Hospitals lack intuitive methods to monitor their accuracy of clinical cancer staging, which is critical to treatment planning, prognosis, refinements, and registering quality data. Methods. We introduce a tabulation framework to compare clinical staging with the reference-standard pathological staging, and quantify systematic errors. As an example, we analyzed 9,644 2016 U.S. National Cancer Institute SEER surgically-treated non-small cell lung cancer (NSCLC) cases, and computed concordance with different denominators to compare with incompatible past results. Results. The concordance for clinical versus pathological lymph node N-stage is very good, 83.4 ± 1.0%, but the tumor length-location T-stage is only 58.1 ± 0.9%. There are intuitive insights to the causes of discordance. Approximately 29% of the cases are pathological T-stage greater than clinical T-stage, and 12% lower than the clinical T-stage, which is due partly to the fact that surgically-treated NSCLC are typically lower-stage cancer cases, which results in a bounded higher probability for pathological upstaging. Individual T-stage categories Tis, T1a, T1b, T2a, T2b, T3, T4 invariant percent-concordances are 85.2 ± 9.7 + 10.3%; 72.7 ± 1.6 + 11.3%; 46.6 ± 1.8 + 10.9%; 54.6 ± 1.6 – 20.5%; 41.6 ± 3.3 – 0.1%; 54.7 ± 2.8 – 24.1%; 55.2 ± 4.7 + 2.6%, respectively. Each percent-concordance is referenced to an averaged number of pathological and clinical cases. The first error number quantifies statistical fluctuations; the second quantifies clinical and pathological staging biases. Lastly, comparison of over and under staging versus clinical characteristics provides further insights. Conclusions. Clinical NSCLC staging accuracy and concordance with pathological values can improve. As a first step, the framework enables standardizing comparing staging results and detecting possible problem areas. Cancer hospitals and registries can implement the efficient framework to monitor staging accuracy

Probing magnetic turbulence by synchrotron polarimetry: statistics and structure of magnetic fields from Stokes correlators

We describe a technique for probing the statistical properties of cosmic magnetic fields based on radio polarimetry data. Second-order magnetic field statistics like the power spectrum cannot always distinguish between magnetic fields with essentially different spatial structure. Synchrotron polarimetry naturally allows certain 4th-order magnetic field statistics to be inferred from observational data, which lifts this degeneracy and can thereby help us gain a better picture of the structure of the cosmic fields and test theoretical scenarios describing magnetic turbulence. In this work we show that a 4th-order correlator of physical interest, the tension-force spectrum, can be recovered from the polarized synchrotron emission data. We develop an estimator for this quantity based on polarized-emission observations in the Faraday-rotation-free frequency regime. We consider two cases: a statistically isotropic field distribution, and a statistically isotropic field superimposed on a weak mean field. In both cases the tension force power spectrum is measurable; in the latter case, the magnetic power spectrum may also be obtainable. The method is exact in the idealized case of a homogeneous relativistic-electron distribution that has a power-law energy spectrum with a spectral index p=3, and assumes statistical isotropy of the turbulent field. We carry out tests of our method using synthetic data generated from numerically simulated magnetic fields. We show that the method is valid, that it is not prohibitively sensitive to the value of the electron spectral index, and that the observed tension-force spectrum allows one to distinguish between, e.g., a randomly tangled magnetic field (a default assumption in many studies) and a field organized in folded flux sheets or filaments.Comment: Published on MNRAS 200