Evaluation of Treatment Integrity Errors on Mand Acquisition

Manding (requesting) is a vital component of successful language development and allows children to access reinforcers in their environment. When training mands, caregivers may not implement the training program as designed ( treatment integrity failures ). The purpose of the current study was to evaluate the effects of incorrect-item delivery (Experiment 1) and response-independent item delivery (Experiment 2) across four levels of treatment integrity (0%, 40%, 70%, and 100%) on mand acquisition. A total of six children (three in each experiment), who communicated vocally using full sentences and engaged in some independent manding participated in the study. During Experiment 1, two of the three participants acquired the mand fastest during 100% integrity. Delivery of the incorrect item was detrimental to mand acquisition, but the effects were idiosyncratic across the two participants. The third participant did not acquire any mands. During Experiment 2, all three participants acquired the mand fastest during the 100% integrity condition. All participants acquired the mand trained with 70% integrity. None of the participants acquired the mands trained with 40% and 0% integrity, suggesting that delivery of the item independent of responding was detrimental to acquisition. For mand training to be most effective, caregivers must implement mand training with high levels of integrity

Driven Rydberg atoms reveal quartic level repulsion

The dynamics of Rydberg states of a hydrogen atom subject simultaneously to uniform static electric field and two microwave fields with commensurate frequencies is considered in the range of small fields amplitudes. In the certain range of the parameters of the system the classical secular motion of the electronic ellipse reveals chaotic behavior. Quantum mechanically, when the fine structure of the atom is taken into account, the energy level statistics obey predictions appropriate for the symplectic Gaussian random matrix ensemble.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev. Let

Non-resonant driving of H atom with broken time-reversal symmetry

The dynamics of atomic hydrogen placed in a static electric field and illuminated by elliptically polarized microwaves is studied in the range of small field amplitudes where perturbation calculations are applicable. For a general configuration of the fields any generalized time-reversal symmetry is broken and, as the classical dynamics is chaotic, the level statistics obeys the random matrices prediction of Gaussian unitary ensemble.Comment: 4 pages, 2 figures, accepted for publication in J. Phys.

Insensitivity of flavoured leptogenesis to low energy CP violation

If the baryon asymmetry of the Universe is produced by leptogenesis, CP violation is required in the lepton sector. In the seesaw extension of the Standard Model with three hierarchical right-handed neutrinos, we show that the baryon asymmetry is insensitive to the PMNS phases: thermal leptogenesis can work for any value of the observable phases. This result was well-known when there are no flavour effects in leptogenesis; we show that it remains true when flavour effects are included.Comment: 4 pages, 1 figure; version accepted for publication, added explanations, notation clarifie

Phase space structures and ionization dynamics of hydrogen atom in elliptically polarized microwaves

The multiphoton ionization of hydrogen atoms in a strong elliptically polarized microwave field exhibits complex features that are not observed for ionization in circular and linear polarized fields. Experimental data reveal high sensitivity of ionization dynamics to the small changes of the field polarization. The multidimensional nature of the problem makes widely used diagnostics of dynamics, such as Poincar\'{e} surfaces of section, impractical. We analyze the phase space dynamics using finite time stability analysis rendered by the fast Lyapunov Indicators technique. The concept of zero--velocity surface is used to initialize the calculations and visualize the dynamics. Our analysis provides stability maps calculated for the initial energy at the maximum and below the saddle of the zero-velocity surface. We estimate qualitatively the dependence of ionization thresholds on the parameters of the applied field, such as polarization and scaled amplitude

‘Building Space: Developing Reflection for Wellbeing’ Can a chaplain help healthcare professionals develop reflective practice for wellbeing for themselves and their team?

In this thesis I develop a new, wider and richer understanding of wellbeing, through developing a process of reflective practice, with healthcare professionals within their challenging work culture. As a healthcare chaplain, having witnessed poor staff morale, I conducted a critical examination of NHS wellbeing reports and strategies, which revealed an understanding of staff wellbeing that ironically follows simply a health model. Challenging this, I argue for a broader interpretation of wellbeing that, in addition to focusing on health, is more holistic, relational and contextual. I develop reflective practice to nurture this, the use of which extends in healthcare beyond education and professional development. In my action research, knowledge was generated through ethnographic participation and observation, over a year, reflecting as chaplain with eight teams of healthcare professionals. This used my simple and memorable HELP Wellbeing Reflection Cycle (building on Kolb’s (1984) model of experiential learning) that combines reflection on work and personal development. My project also responds to Rolfe’s call (2014) for greater use in healthcare of Schön’s (1980) “reflection-in-action”. Building on these works, I develop reflection for healthcare professionals to nurture their wellbeing. My encouragement of the participants to self-facilitate their own reflective groups, when familiar with this method of reflection, is also a contribution to reflective practice, healthcare and the chaplain’s role. Thematic data analysis emerged from the reflexive field notes of our shared experience as co-reflective practitioners. The themes include healthcare professionals making the human connection between themselves and with their patients. They also value the space to reflect together, realising their desire for team support and a shared goal, as well as job satisfaction in this demanding culture. These themes, I argue, are consistent with the broader definitions of wellbeing, giving them the opportunity to be both a healthcare professional and human. Further data analysis also reveals consistency with wider wellbeing interpretations (including personal wellbeing measurements and data from the Office for National Statistics (2014, 2015)). I develop the role of chaplain as the healthcare professionals’ co-reflector, sharing their reflective space as a pastoral encounter and a source for learning. This combines the images of “empty handed” (Swift, 2009) “welcoming guest” and “mutual hospitality” (Walton, M., 2012). I offer to national healthcare the wider understanding of wellbeing, and the value of creating provision for reflective space to nurture it, in the care of healthcare professionals. This research offers the potential for exciting further developments in a wider constituency both in and beyond healthcare

MINOMICS:visualizing prokaryote transcriptomics and proteomics data in a genomic context

We have developed MINOMICS, a tool that allows facile and in-depth visualization of prokaryotic transcriptomic and proteomic data in conjunction with genomics data. MINOMICS generates interactive linear genome maps in which multiple experimental datasets are displayed together with operon, regulatory motif, transcriptional promoter and transcriptional terminator information

Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.

Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of cations on functional states of the adenosine A2A GPCR. While Na+ reinforces an inactive ensemble and a partial-agonist stabilized state, Ca2+ and Mg2+ shift the equilibrium toward active states. Positive allosteric effects of divalent cations are more pronounced with agonist and a G-protein-derived peptide. In cell membranes, divalent cations enhance both the affinity and fraction of the high affinity agonist-bound state. Molecular dynamics simulations suggest high concentrations of divalent cations bridge specific extracellular acidic residues, bringing TM5 and TM6 together at the extracellular surface and allosterically driving open the G-protein-binding cleft as shown by rigidity-transmission allostery theory. An understanding of cation allostery should enable the design of allosteric agents and enhance our understanding of GPCR regulation in the cellular milieu