Ecological Surveys of Welsh Lakes 2016

This project set out to collect, process and supply to NRW ecological and environmental data from a network of 14 lake sites across Wales, in support of NRW’s integrated monitoring programme for protected sites (SACs and SSSIs), the Water Framework Directive, Nitrates Directive, Biodiversity Action Plans and other legislative and policy drivers. In particular the surveys are aimed at informing management and restoration of protected sites and facilitating delivery of River Basin Management Plans. Using standard methods, lakes were surveyed to assess the species and abundance of aquatic plants growing within and directly around the lake and to measure water clarity, dissolved oxygen and temperature within the lakes. · The aquatic plant species are listed within the report and the complete survey results supplied to NRW as MS Excel spreadsheets. · Calculations are presented for the onward use of determining the ecological status of the lakes with respect to the Water Framework Directive (LEAFPACS). The results of the aquatic plant surveys are suitable for the purposes of assessing site condition for Habitats Directive standing water features and SSSI status. The lake metrics are applicable for the production of ecological quality ratios from which the lakes may be classified in accordance with the requirements of Water Framework Directive (2000/60/EC) Ecological Surveys of Welsh Lakes 2016 (NRW Evidence Report No. 204). Available from: https://www.researchgate.net/publication/318135626_Ecological_Surveys_of_Welsh_Lakes_2016_NRW_Evidence_Report_No_204 [accessed Sep 29, 2017]

The ESO-Spitzer Imaging extragalactic Survey (ESIS) I: WFI B,V,R deep observations of ELAIS-S1 and comparison to Spitzer and GALEX data

The ESO-Spitzer extragalactic Imaging Survey (ESIS) is the optical follow up of the Spitzer Wide-Area InfraRed Extragalactic (SWIRE) survey in the ELAIS-S1 area. This paper presents B, V, R Wide Field Imager observations of the first 1.5 square degree of the ESIS survey. Data reduction is described including astrometric calibration, illumination and color corrections, completeness and photometric accuracy estimates. Number counts and color distributions are compared to literature observational and theoretical data, including non-evolutionary, PLE, evolutionary and semi-analytic Lambda-CDM galaxy models, as well as Milky Way stellar predictions. ESIS data are in good agreement with previous works and are best reproduced by evolutionary and hierarchical Lambda-CDM scenarios. The ELAIS-S1 area benefits from extensive follow-up from X-ray to radio frequencies: some potential uses of the multi-wavelength observations are illustrated. Optical-Spitzer color-color plots promise to be very powerful tools to disentangle different classes of sources (e.g. AGNs, starbursts, quiescent galaxies). Ultraviolet GALEX data are matched to optical and Spitzer samples, leading to a discussion of galaxy properties in the UV-to-24 microns color space. The spectral energy distribution of a few objects, from the X-rays to the far-IR are presented as examples of the multi-wavelength study of galaxy emission components in different spectral domains.Comment: Accepted for publication in A&A. 24 pages, quality of some figures have been degrade

Ultraluminous Infrared Galaxies

Ever since their discovery in the 1970's, UltraLuminous InfraRed Galaxies (ULIRGs; classically Lir>10^12Lsun) have fascinated astronomers with their immense luminosities, and frustrated them due to their singularly opaque nature, almost in equal measure. Over the last decade, however, comprehensive observations from the X-ray through to the radio have produced a consensus picture of local ULIRGs, showing that they are mergers between gas rich galaxies, where the interaction triggers some combination of dust-enshrouded starburst and AGN activity, with the starburst usually dominating. Very recent results have thrown ULIRGs even further to the fore. Originally they were thought of as little more than a local oddity, but the latest IR surveys have shown that ULIRGs are vastly more numerous at high redshift, and tantalizing suggestions of physical differences between high and low redshift ULIRGs hint at differences in their formation modes and local environment. In this review we look at recent progress on understanding the physics and evolution of local ULIRGs, the contribution of high redshift ULIRGs to the cosmic infrared background and the global history of star formation, and the role of ULIRGs as diagnostics of the formation of massive galaxies and large-scale structures.Comment: Review article, published in "Astrophysics Update 2 - topical and timely reviews on astronomy and astrophysics". Ed. John W. Mason. Springer/Praxis books. ISBN: 3-540-30312-X. 53 pages, 5 figures. Higher quality figures available on reques

The Early Royal Society and Visual Culture

Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artefacts –manufactured objects worth commissioning, collecting and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades”. Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records.AH/M001938/1 (AHRC

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

The Gene Ontology resource: enriching a GOld mine

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease