Challenges and Opportunities for Ecosystem-Based Management and Marine Spatial Planning in the Irish Sea

Ecosystem-Based Management (EBM) integrates the connections between land, air, water and all living things including human beings and their institutions. The location of the Irish Sea, between major historical industrial centres, its history of use and exploitation, combined with its hydrographic characteristics, have led to the current patterns of use. EBM efforts have been ongoing for over a decade but political boundaries have led to fragmented governance. The forthcoming UK exit from the European Union (EU) may pose further challenges. This chapter examines articulations between political boundaries, spatial scales of Marine Spatial Planning and nested social-ecological systems including the gyre in the western Irish Sea, and Dublin Bay. Examples of emerging best practices are provided and the challenges of data availability for ecosystem services are considered

YOUTH EMPLOYMENT IN AFRICA: NEW EVIDENCE AND POLICIES FROM SWAZILAND

Drawing on the 2007 and 2010 Swaziland Labor Force Surveys, this paper provides first systematic evidence on recent youth employment challenges in Swaziland, a small, land-locked, middle-income country with one of the highest youth unemployment rates in Africa. The paper first documents the various labor market disadvantages faced by the Swazi youth, such as high unemployment and discouragement, and how they changed from 2007 to 2010. A multinomial logit regression analysis is then carried out to analyze the socio-economic drivers of the unfavorable youth labor market outcomes on the supply side. Since many of the factors that can unlock the employment potential of the Swazi youth are on the demand side of the labor market, the paper examines the barriers to job creation and youth entrepreneurship. It concludes with experiences of other countries that could inform design of more effective interventions for youth employment in Swaziland.http://deepblue.lib.umich.edu/bitstream/2027.42/133071/1/wp1052.pd

Accounting Transparency of Non-Governmental Organizations: A Bibliometric Analysis

As non-governmental organizations (NGOs) become increasingly i nvolved in international affairs, they face a growing deficit of confidence d ue to opacity of information environment. This opacity not only affects NG O financing, but also decreases public confidence in NGOs, affecting negati vely their sustainability. Due to the crucial role of transparency in NGOs, t he present study performs a bibliometric analysis of the research on accoun ting transparency.2019-2

Alpha shapes: Determining 3D shape complexity across morphologically diverse structures

Background. Following recent advances in bioimaging, high-resolution 3D models of biological structures are now generated rapidly and at low-cost. To utilise this data to address evolutionary and ecological questions, an array of tools has been developed to conduct 3D shape analysis and quantify topographic complexity. Here we focus particularly on shape techniques applied to irregular-shaped objects lacking clear homologous landmarks, and propose the new ‘alpha-shapes’ method for quantifying 3D shape complexity. Methods. We apply alpha-shapes to quantify shape complexity in the mammalian baculum as an example of a morphologically disparate structure. Micro- computed-tomography (μCT) scans of bacula were conducted. Bacula were binarised and converted into point clouds. Following application of a scaling factor to account for absolute differences in size, a suite of alpha-shapes was fitted to each specimen. An alpha shape is a formed from a subcomplex of the Delaunay triangulation of a given set of points, and ranges in refinement from a very coarse mesh (approximating convex hulls) to a very fine fit. ‘Optimal’ alpha was defined as the degree of refinement necessary in order for alpha-shape volume to equal CT voxel volume, and was taken as a metric of overall shape ‘complexity’. Results Our results show that alpha-shapes can be used to quantify interspecific variation in shape ‘complexity’ within biological structures of disparate geometry. The ‘stepped’ nature of alpha curves is informative with regards to the contribution of specific morphological features to overall shape ‘complexity’. Alpha-shapes agrees with other measures of topographic complexity (dissection index, Dirichlet normal energy) in identifying ursid bacula as having low shape complexity. However, alpha-shapes estimates mustelid bacula as possessing the highest topographic complexity, contrasting with other shape metrics. 3D fractal dimension is found to be an inappropriate metric of complexity when applied to bacula. Conclusions. The alpha-shapes methodology can be used to calculate ‘optimal’ alpha refinement as a proxy for shape ‘complexity’ without identifying landmarks. The implementation of alpha-shapes is straightforward, and is automated to process large datasets quickly. Beyond genital shape, we consider the alpha-shapes technique to hold considerable promise for new applications across evolutionary, ecological and palaeoecological disciplines

Food consumption and diet quality choices of Roma in Romania: a counterfactual analysis

This paper analyses the diet quality aspect of food security of Roma in Romania. We employed a modified Blinder-Oaxaca decomposition technique using Household Budget Survey data for the period 2004–2011. The estimates suggest that Roma have inferior diet diversity compared to the non-Roma. Around one-third of the diet diversity gap is explained by the differences in observed socio-economic factors, whereas the remaining part of the gap is attributed to unobserved factors. We argue that the unexplained component of the diet diversity gap is caused by the discrimination of the Roma on the labour market and by their specific informal institutions

Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1

Background: In human breast cancer, the growth factor receptor HER2 is associated with disease progression and resistance to endocrine treatment. Growth factor induced mitogen activated protein kinase activity can phosphorylate not only the oestrogen receptor, but also its coactivator proteins AIB1 and SRC-1. Aim: To determine whether insensitivity to endocrine treatment in HER2 positive patients is associated with enhanced expression of coactivator proteins, expression of the HER2 transcriptional regulator, PEA3, and coregulatory proteins, AIB1 and SRC-1, was assessed in a cohort of patients with breast cancer of known HER2 status. Methods: PEA3, AIB1, and SRC-1 protein expression in 70 primary breast tumours of known HER2 status (HER2 positive, n = 35) and six reduction mammoplasties was assessed using immunohistochemistry. Colocalisation of PEA3 with AIB1 and SRC-1 was determined using immunofluorescence. Expression of PEA3, AIB1, and SRC-1 was correlated with clinicopathological parameters. Results: In primary breast tumours expression of PEA3, AIB1, and SRC-1 was associated with HER2 status (p = 0.0486, p = 0.0444, and p = 0.0012, respectively). In the HER2 positive population, PEA3 expression was associated with SRC-1 (p = 0.0354), and both PEA3 and SRC-1 were significantly associated with recurrence on univariate analysis (p = 0.0345; p<0.0001). On multivariate analysis, SRC-1 was significantly associated with disease recurrence in HER2 positive patients (p = 0.0066). Conclusion: Patients with high expression of HER2 in combination with SRC-1 have a greater probability of recurrence on endocrine treatment compared with those who are HER2 positive but SRC-1 negative. SRC-1 may be an important predictive indicator and therapeutic target in breast cancer