Designing a Compensated–Kidney Donation System

Osteochondral lesions of the talus (OLTs) are the third most common type of osteochondral lesion and can cause pain and instability of the ankle joint. Episurf Medical AB is a medical technology company that develops individualized implants for patients who are suffering from focal cartilage lesions. Episurf have recently started a project that aims to implement their implantation technique in the treatment of OLTs. This master thesis was a part of Episurf’s talus project and the main goal of the thesis was to find the optimal implantation angle of the Episurf implant when treating OLTs. The optimal implantation angle was defined as the angle that minimized the maximum equivalent (von Mises) strain acting on the implant shaft during the stance phase of a normal gait cycle. It is desirable to minimize the strain acting on the implant shaft, since a reduction of the strain can improve the longevity of the implant. To find the optimal implantation angle a finite element model of an ankle joint treated with the Episurf implant was developed. In the model an implant with a diameter of 12 millimeters was placed in the middle part of the medial side of the talar dome. An optimization algorithm was designed to find the implantation angle, which minimized the maximum equivalent strain acting on the implant shaft. The optimal implantation angle was found to be a sagittal angle of 12.5 degrees and a coronal angle of 0 degrees. Both the magnitude and the direction of the force applied to the ankle joint in the simulated stance phase seemed to influence the maximum equivalent strain acting on the implant shaft. A number of simplifications have been done in the simulation of this project, which might affect the accuracy of the results. Therefore it is recommended that further, more detailed, simulations based on this project are performed in order to improve the result accuracy.Fokala broskskador på talusbenet är den tredje vanligaste typen av fokala broskskador och kan ge upphov till smärta och instabilitet av fotleden. Episurf Medical AB är ett medicintekniskt företag som utvecklar individanpassade implantat för patienter med fokala broskskador. Episurf har nyligen påbörjat ett projekt där deras teknik ska användas i behandlingen av fokala broskskador på talusbenet. Den här masteruppsatsen var en del i Episurfs talusprojekt och dess huvudmål var att finna den optimala implantationsvinkeln av Episurfs implantat i behandlingen av fokala broskskador på talusbenet. Den optimala implanteringsvinkeln definierades som den vinkel som minimerade den effektiva von Mises-töjningen som verkade på implantatskaftet under stance-fasen i en normal gångcykel. Det är eftersträvansvärt att minimera belastningen på implantatskaftet eftersom en reducering av belastningen kan förbättra implantatets livslängd. En finita element-modell av en fotled behandlad med Episurfs implantat utvecklades för att för att finna den optimala implantationsvinkeln. I modellen placerades ett implantat med en diameter på 12 millimeter på mittendelen av talus mediala sida. En optimeringsalgoritm utformades för att finna implantationsvinkeln som minimerade den effektiva von Mises-töjningen på implantatskaftet. Den funna optimala implantationsvinkeln bestod av en vinkel på 12.5 grader i sagittalplan och en vinkel på 0 grader i koronalplan. Både storleken och riktningen på kraften som applicerats på fotleden under den simulerade stance-fasen av gångcykeln verkade påverka belastningen på implantatskaftet. Ett antal förenklingar har gjorts i projektets simuleringar, vilket kan påverka noggrannheten i resultatet. Därför rekommenderas att ytterligare, mer detaljerade simuleringar baserade på det här projektet görs för att förbättra resultatets noggrannhet

Drop rebound in clouds and precipitation

The possibility of rebound for colliding cloud drops was measured by determining the collection efficiency. The collection efficiency for 17 size pairs of relatively uncharged drops in over 500 experimental runs was measured using two techniques. The collection efficiencies fall in a narrow range of 0.60 to 0.70 even though the collection drop was varied between 63 and 326 microns and the size ratio from 0.05 to 0.33. In addition the measured values of collection efficiencies (Epsilon) were below the computed values of collision efficiencies (E) for rigid spheres. Therefore it was concluded that rebound was occurring for these sizes since inferred coalescence (epsilon = Epsilon/E) efficiencies are about 0.6 yo 0.8. At a very small size ratio (r/R = p = 0.05, R = 326 microns) the coalescence efficiency inferred is in good agreement with the experimental findings for a supported collector drop. At somewhat large size ratios the inferred values of epsilon are well above results of supported drop experiments, but show a slight correspondence in collected drop size dependency to two models of drop rebound. At a large size ratio (p = 0.73, R = 275) the inferred coalescence efficiency is significantly different from all previous results

Pretender punishment induced by chemical signalling in a queenless ant

Animal societies are stages for both conflict and cooperation. Reproduction is often monopolized by one or a few individuals who behave aggressively to prevent subordinates from reproducing (for example, naked mole-rats, wasps and ants). Here we report an unusual mechanism by which the dominant individual maintains reproductive control. In the queenless ant Dinoponera quadriceps, only the alpha female reproduces. If the alpha is challenged by another female she chemically marks the pretender who is then punished by low-ranking females. This cooperation between alpha and low-rankers allows the alpha to inflict punishment indirectly, thereby maintaining her reproductive primacy without having to figh

Function and dysfunction of fatty acid mobilization: a review

Western populations have a growing obesity epidemic due in part to excessive nutrient intake from high-fat diets, which are increasingly common. Overindulgence of nutrients is associated with a greater incidence of metabolic dysfunction and a greater risk for obesity, diabetes, hypertension, and other metabolic disorders that lower quality of life. Research in humans and animal models has improved our understanding of how excess circulating free fatty acids negatively impact the ability of muscle and other tissues to regulate nutrient uptake and utilization. It is generally accepted by the scientific community that excess circulating fatty acids lead to insulin resistance, but there is little clarity regarding the underlying mechanisms. In the present review, we will outline the current understanding of the characteristics associated with fatty acid mobilization and fatty acid utilization within specific tissues. We will also discuss the potential mechanistic role of hyperlipidemia on metabolic dysfunction associated with type 2 diabetes

UA3/1/7/2 Henry Cherry Campaign Letter

Form letter sent to supporters of Henry Cherry\u27s gubernatorial campaign

Clear air turbulence

Research on forecasting, detection, and incidents of clear air turbulenc

A Time-Series Analysis of U.S. Kidney Transplantation and the Waiting List: Donor Substitution Effects and "Dirty Altruism"

This paper provides an econometric analysis of the relationship between live and deceased (cadaveric) kidney donations for the United States for the period 1992:IV through 2006:II. Statistical analysis shows that increases in deceased donor transplants reduce future live donor grafts, controlling for both waiting list effects and exogenous trends. This result has important, and potentially dire, implications for efforts to reduce the organ shortage by increasing use of cadaver donors.Kidney Transplantations; Donor Substitution Effects; Dirty Altruism; Cointegration

Large collection of astrophysical S-factors and its compact representation

Numerous nuclear reactions in the crust of accreting neutron stars are strongly affected by dense plasma environment. Simulations of superbursts, deep crustal heating and other nuclear burning phenomena in neutron stars require astrophysical S-factors for these reactions (as a function of center-of-mass energy E of colliding nuclei). A large database of S-factors is created for about 5000 non-resonant fusion reactions involving stable and unstable isotopes of Be, B, C, N, O, F, Ne, Na, Mg, and Si. It extends the previous database of about 1000 reactions involving isotopes of C, O, Ne, and Mg. The calculations are performed using the Sao Paulo potential and the barrier penetration formalism. All calculated S-data are parameterized by an analytic model for S(E) proposed before [Phys. Rev. C 82, 044609 (2010)] and further elaborated here. For a given reaction, the present S(E)-model contains three parameters. These parameters are easily interpolated along reactions involving isotopes of the same elements with only seven input parameters, giving an ultracompact, accurate, simple, and uniform database. The S(E) approximation can also be used to estimate theoretical uncertainties of S(E) and nuclear reaction rates in dense matter, as illustrated for the case of the 34Ne+34Ne reaction in the inner crust of an accreting neutron star.Comment: 13 pages, 2 figures, Phys. Rev. C, accepte