Safe Concurrency Introduction through Slicing

Traditional refactoring is about modifying the structure of existing code without changing its behaviour, but with the aim of making code easier to understand, modify, or reuse. In this paper, we introduce three novel refactorings for retrofitting concurrency to Erlang applications, and demonstrate how the use of program slicing makes the automation of these refactorings possible

Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms

Peer reviewedPublisher PD

Deferiprone (DFP) targets cancer stem cell (CSC) propagation by inhibiting mitochondrial metabolism and inducing ROS production

Deferiprone (DFP), also known as Ferriprox, is an FDA-approved, orally active, iron chelator that is currently used clinically for the treatment of iron-overload, especially in thalassaemia major. As iron is a critical factor in Fe-S cluster assembly that is absolutely required for the metabolic function of mitochondria, we hypothesized that DFP treatment could be used to selectively target mitochondria in cancer stem cells (CSCs). For this purpose, we used two ER(+) human breast cancer cell lines, namely MCF7 and T47D cells, as model systems. More specifically, a 3D tumorsphere assay was employed as a functional readout of CSC activity which measures anchorage-independent growth under low attachment conditions. Here, we show that DFP dose dependently inhibited the propagation of CSCs, with an IC-50 of ~100 nM for MCF7 and an IC-50 of ~0.5 to 1 μM for T47D cells, making DFP one the most potent FDA-approved drugs that we and others have thus far identified for targeting CSCs. Mechanistically, we show that high concentrations of DFP metabolically targeted both mitochondrial oxygen consumption (OCR) and glycolysis (extracellular acidification rates (ECAR)) in MCF7 and T47D cell monolayers. Most importantly, we demonstrate that DFP also induced a generalized increase in reactive oxygen species (ROS) and mitochondrial superoxide production, and its effects reverted in the presence of N-acetyl-cysteine (NAC). Therefore, we propose that DFP is a new candidate therapeutic for drug repurposing and for Phase II clinical trials aimed at eradicating CSCs

Traits in Lepidoptera assemblages are differently influenced by local and landscape scale factors in farmland habitat islands

Semi-natural grassland islands have a key role in slowing down biodiversity decline in intensively cultivated agricultural landscapes. Assemblages in such habitat patches are not only limited by local habitat quality, but are also influenced by the suitability and distribution of different habitat types in the surrounding landscape. If we want to preserve a functionally diverse Lepidoptera fauna, both local and landscape scale environmental effects, including land use and management, should be considered. In the present study, we describe trait-based characteristics of noctuid dominated macro-moth assemblages (MMAs) in grassland remnants of an intensively cultivated agricultural area. By gathering environmental data from local to landscape scales, we aimed to identify the most influential scales, possible interactions between scales and the role of integrated arable fields in shaping MMAs. We conducted abundance weighted trait-based multivariate analysis of the assemblages based on six trait groups. Both local and landscape scale variables had important influence, acting on different traits of the assemblages. By variance partitioning, we could identify variables that exerted maximal effect at 50 m and 250 m radii circles. Variables describing local vegetation and identity of neighbouring crop were responsible for species richness and rarity status, while the area of arable and wooded habitats within 250 m were responsible for total catch and pest status related traits. There was significant interaction between principal components axes representing local and landscape variables. Rarity, more than other traits, was influenced by the interaction. Integrated fields had no effect on MMAs. The present study highlights the contributions of both local and landscape scales to the shaping of MMAs and suggests that the preservation of both local habitat quality and landscape heterogeneity are important if we would like to maintain species rich and functionally diverse Lepidoptera fauna

Characterisation of moulds from apple fruit in Hungary

The surface microbial contamination is of great interest in case of fruit because of the threat of postharvest spoilage. Apple is a valuable product from growing, commercial, as well as from nutritional points of view. Apple diseases during the growing season can be satisfactorily controlled by different plant protection technologies, but postharvest decay of apples caused by the so called storage moulds cannot be completely avoided. Cold storage — alone, or in combination with other methods — is the main technology used to successfully prolong the shelf life of apples. The origin of the moulds causing the decay of apples during storage is not well understood. In this work the surface mycobiota of apple fruit grown in Soroksár, in the orchard of the Corvinus University of Budapest was investigated

Detection of multipartite entanglement with two-body correlations

We show how to detect entanglement with criteria built from simple two-body correlation terms. Since many natural Hamiltonians are sums of such correlation terms, our ideas can be used to detect entanglement by energy measurement. Our criteria can straightforwardly be applied for detecting different forms of multipartite entanglement in familiar spin models in thermal equilibrium.Comment: 5 pages including 2 figures, LaTeX; for the proceedings of the DPG spring meeting, Berlin, March 200

Rossby Wave Instability and three-dimensional vortices in accretion disks

Context. The formation of vortices in accretion disks is of high interest in various astrophysical contexts, in particular for planet formation or in the disks of compact objects. But despite numerous attempts it has thus far not been possible to produce strong vortices in fully three-dimensional simulations of disks. Aims. The aim of this paper is to present the first 3D simulation of a strong vortex, established across the vertically stratified structure of a disk by the Rossby Wave Instability. Methods. Using the Versatile Advection Code (VAC), we set up a fully 3D cylindrical stratified disk potentially prone to the Rossby Wave Instability. Results. The simulation confirms the basic expectations obtained from previous 2D analytic and numerical works. The simulation exhibits a strong vortex that grows rapidly and saturates at a finite amplitude. On the other hand the third dimension shows unexpected additional behaviours that could be of strong importance in the astrophysical roles that such vortices can play.Comment: Accepted by Astronomy and Astrophysic