Organizational Studies in Space: Stanislaw Lem and the Writing of Social Science Fiction

This paper seeks to introduce the oeuvre of the Polish science fiction author, Stanislaw Lem, whose work is argued to carry significance for students of organizational conduct. Singling out his most famous novel, Solaris, for particular attention, a critical interpretation is offered that selectively highlights Lem's epistemological and ontological pre-occupations concerning scientific inquiry and the human condition. These concerns are seen to resonate with contemporary issues in the field of organization studies. In particular, the rhetorical role of mimesis, viewed as a synthesis of rational and non-rational human motives, within Solaris is taken to inform a wide range of human conduct. The paper concludes by calling for a realist mode of organizational discourse that explores the dialectical relationship between what it characterizes as 'solar' and 'lunar' dimensions of human behaviour. A new challenge to organization studies will be not simply to learn from the substantive concerns of literary genres such as science fiction, but also to aspire after the narrative skills of their leading exponents

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance on murine studies, which have limited value in accurately predicting translational efficacy in larger animal models and humans. Here, we report the scale-up of a nanoimmunotherapy from mouse to large rabbit and porcine atherosclerosis models, with an emphasis on the solutions we implemented to overcome production and evaluation challenges. Specifically, we integrated translational imaging readouts within our workflow to both analyze the nanoimmunotherapeutic's in vivo behavior and assess treatment response in larger animals. We observed our nanoimmunotherapeutic's anti-inflammatory efficacy in mice, as well as rabbits and pigs. Nanoimmunotherapy-mediated reduction of inflammation in the large animal models halted plaque progression, supporting the approach's translatability and potential to acutely treat atherosclerosis

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species