Metamaterials Application in Sensing

Metamaterials are artificial media structured on a size scale smaller than wavelength of external stimuli, and they can exhibit a strong localization and enhancement of fields, which may provide novel tools to significantly enhance the sensitivity and resolution of sensors, and open new degrees of freedom in sensing design aspect. This paper mainly presents the recent progress concerning metamaterials-based sensing, and detailedly reviews the principle, detecting process and sensitivity of three distinct types of sensors based on metamaterials, as well as their challenges and prospects. Moreover, the design guidelines for each sensor and its performance are compared and summarized

Thyroid function analysis after roxadustat or erythropoietin treatment in patients with renal anemia: a cohort study

AbstractPurpose This cohort study was designed to explore whether roxadustat or erythropoietin could affect thyroid function in patients with renal anemia.Methods The study involved 110 patients with renal anemia. Thyroid profile and baseline investigations were carried out for each patient. The patients were divided into two groups: 60 patients taking erythropoietin served as the control group (rHuEPO group) and 50 patients using roxadustat served as the experimental group (roxadustat group).Results The results indicated that there were no significant differences in serum total thyroxine (TT4), total triiodothyronine (TT3), free triiodothyronine (FT3), free thyroxine (FT4) or thyroid stimulating hormone (TSH) between the two groups at baseline. After treatment, TSH, FT3, and FT4 were significantly lower in the roxadustat group than in the rHuEPO group (p < 0.05). After adjusting for age, sex, dialysis modality, thyroid nodules and causes of kidney disease, Cox regression showed that roxadustat was an independent influencing factor on thyroid dysfunction (HR 3.37; 95% CI 1.94–5.87; p < 0.001). After 12 months of follow-up, the incidence of thyroid dysfunction was higher in the roxadustat group than in the rHuEPO group (log-rank p < 0.001).Conclusion Roxadustat may lead to a higher risk of thyroid dysfunction, including low TSH, FT3 and FT4, than rHuEPO in patients with renal anemia

Forecast of Current and Future Distributions of <i>Corythucha marmorata</i> (Uhler) under Climate Change in China

Corythucha marmorata (Uhler) emerged as an invasive pest in China around 2010, posing a significant threat to plants within the Asteraceae family. Employing the MaxEnt model, this study endeavors to anticipate the potential geographic distribution of Corythucha marmorata amid present and forthcoming climatic conditions, utilizing a dataset of 60 distributional occurrences alongside environmental parameters. The results revealed that presently, suitable regions span from 18–47° N to 103–128° E, with pronounced suitability concentrated notably in Jiangsu, Shanghai, Anhui, Hubei, Jiangxi, Hunan, Guangdong, Guangxi, Chongqing, and Sichuan. Projections suggested a general expansion of suitable habitats, albeit with exceptions noted in SSP1–2.6 and SSP2–4.5 scenarios in the 2050s and SSP5–8.5 in the 2070s. The potential suitability of areas for Corythucha marmorata was influenced by major factors such as precipitation in the warmest quarter (bio18), mean temperature in the warmest quarter (bio10), mean temperature in the wettest quarter (bio8), and annual precipitation (bio12). Notably, temperature and precipitation emerge as primary determinants affecting both current and future ranges. In comparison with the current distributional area, there was a trend towards increasing the potentially suitable areas in the future. Moreover, there was a greater risk of spreading to the north of China in the future. This study serves as a pivotal resource for guiding future endeavors in monitoring, early detection, and preventative management strategies targeting Corythucha marmorata

Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhanced Proangiogenic Potential of Cardiac Fibroblasts via Angiopoietin-Like 4

Background and Objectives. After myocardial hypoxic injury, it is important to enhance vascular formation and restore blood supply for injury repair. Previous studies have suggested that cardiac fibroblasts (CFs) play a crucial role in angiogenesis after myocardial injury. Small extracellular vesicles (sEVs) derived from human umbilical cord mesenchymal stem cells (hucMSCs) promote fibroblast-to-myofibroblast differentiation in inflammatory environment and have cardioprotective effects. It remains unknown whether sEVs regulate cardiac fibroblasts to promote angiogenesis after myocardial injury. Methods and Results. We isolated primary CFs from Sprague-Dawley rats (1–3 days old) and treated them with lipopolysaccharide (LPS) and LPS+sEVs. RNA sequencing analysis revealed that angiopoietin-like 4 (Angptl4) was increased in the LPS+sEVs group more than in the LPS group. After inhibition of Angptl4 expression in sEVs and CFs, cell proliferation, Transwell migration, and tube formation assays were used to detect the angiogenic activity of human umbilical vein endothelial cells. β-Catenin expression in CFs was detected by western blotting. The β-catenin inhibitor ICG001 was used to examine whether β-catenin was involved in the proangiogenic potential of CFs promoted by sEVs. sEVs enhanced the proangiogenic potential of CFs under inflammatory conditions, which was associated with β-catenin signaling. The proangiogenic potential of CFs was decreased when Angptl4 was knocked down in CFs and in hucMSCs. Conclusions. The sEVs regulated CFs to promote angiogenesis via Angptl4 in an inflammatory environment. This may provide a research basis for treating myocardial injury with sEVs

Thyroid function analysis after roxadustat or erythropoietin treatment in patients with renal anemia: a cohort study

This cohort study was designed to explore whether roxadustat or erythropoietin could affect thyroid function in patients with renal anemia. The study involved 110 patients with renal anemia. Thyroid profile and baseline investigations were carried out for each patient. The patients were divided into two groups: 60 patients taking erythropoietin served as the control group (rHuEPO group) and 50 patients using roxadustat served as the experimental group (roxadustat group). The results indicated that there were no significant differences in serum total thyroxine (TT4), total triiodothyronine (TT3), free triiodothyronine (FT3), free thyroxine (FT4) or thyroid stimulating hormone (TSH) between the two groups at baseline. After treatment, TSH, FT3, and FT4 were significantly lower in the roxadustat group than in the rHuEPO group (p p p  Roxadustat may lead to a higher risk of thyroid dysfunction, including low TSH, FT3 and FT4, than rHuEPO in patients with renal anemia.</p

Path Analysis of Quantitative Characters for Mactra veneriformis with Different Ages in Geligang

Mactra veneriformis is a common economic benthic shellfish with high nutritional value and is widely distributed in the Shandong and Liaoning provinces. Geligang is located in the northern part of Liaodong Bay. It is formed by the water impact of Shuangtaizi and Liaohe River. It has an area of approximately 10 000 hm2 with a fertile substrate. It is an important habitat of beach shellfish, such as M. veneriformis. Studies on the influencing factors of wild population quality traits and their correlation with morphological traits are helpful for developing genetic breeding of marine shellfish. To analyze the effects of morphological traits on quality traits of M. veneriformis at different ages in Geligang, the shell length (SL), shell width (SW), shell height (SH), body weight (BW), and soft tissue wet weight (RW) of 1–3 years old M. veneriformis were analyzed using correlation analysis, path analysis, and multiple regression analysis. The M. veneriformis used in the experiment was obtained from the Geliang in Liaodong Bay in September 2022. A total of 80 1-year-old, 104 2-year-old, and 168 3-year-old M. veneriformis were obtained. The results showed that the morphological traits of M. veneriformis at different growth stages had different contributions to quality traits, and there were significant differences (P 0.05) and was eliminated. The optimal regression equation of quantitative traits to qualitative traits of 1–3 year-old M. veneriformis was established. The results showed that when BW was the target trait, SW was the main selection trait and SL was the auxiliary selection trait for 1–3 year-old M. veneriformis. When RW was the target trait, SW should be the main selection trait for 1-year-old M. veneriformis, supplemented by SL. The SL should be the main selection trait for both 2- and 3-year-old M. veneriformis, but the SW was the auxiliary selection trait for 2-year-old M. veneriformis, while the SH was for 3-year-old M. veneriformis. In this study, correlation analysis, path analysis, and multiple regression analysis were performed on the morphological traits and quality traits of 1–3 years old M. veneriformis to determine the key morphological traits affecting the quality traits of M. veneriformis at different ages. In this study, the R2 values of the morphological traits of 1- and 2-year-old M. veneriformis (0.898 and 0.859, respectively) were greater than 0.850, indicating that the main factors affecting the body weight of living M. veneriformis were found. However, the R2 value of the morphological traits of 3-year-old M. veneriformis (0.815) was below 0.850, indicating that there may be other influencing traits in addition to the traits analyzed in this study. The reason may be that with the growth of M. veneriformis, the thickness of the shell and the effect on the weight of the living body gradually increase. In this study, the R2 values of morphological traits of 1–3 years old M. veneriformis (0.738, 0.648, and 0.538, respectively) on the wet weight of soft tissue were all below 0.850, indicating that there were other key factors affecting the wet weight of soft tissue. The age of sexual maturity of the M. veneriformis is at 1 year. The development of the gonad in the soft part may be closely related to the size of the wet weight of the soft tissue. The sampling period is mainly in the proliferation to depletion period of the gonad development of M. veneriformis. The gonad development is simultaneously affected by the environment. These results can provide reference for breeding M. veneriformis and the selection of parent shellfish

Copper(I)-Catalyzed Sulfonylation of 8‑Aminoquinoline Amides with Sulfonyl Chlorides in Air

A simple and mild protocol for copper­(I)-mediated sulfonylation of 8-aminoquinoline amides with sulfonyl chlorides was developed, affording desired products in moderate to good yields. This reaction proceeds in air and features excellent substrate tolerance, especially for aliphatic sulfonyl chlorides

Copper(I)-Catalyzed Sulfonylation of 8‑Aminoquinoline Amides with Sulfonyl Chlorides in Air

A simple and mild protocol for copper­(I)-mediated sulfonylation of 8-aminoquinoline amides with sulfonyl chlorides was developed, affording desired products in moderate to good yields. This reaction proceeds in air and features excellent substrate tolerance, especially for aliphatic sulfonyl chlorides

Silver(I)-Catalyzed C4–H Amination of 1‑Naphthylamine Derivatives with Azodicarboxylates

A simple and efficient protocol for silver­(I)-catalyzed picolinamide directed C4–H amination of 1-naphthylamine derivatives with readily available azodicarboxylates has been developed, demonstrating a new approach to 1,4-naphthalenediamine derivatives in high yields. Note that this reaction system could proceed under external-oxidant- and additive-free conditions (only requires 5 mol % of AgOAc as the catalyst in acetone)