396 research outputs found
Interacting Gears Synchronize Propulsive Leg Movements in a Jumping Insect
Joint Action
Many small insects are impressive jumpers, but large leaps and small bodies pose biomechanical challenges.
Burrows and Sutton
(p.
1254
) show that the nymphal planthopper
Issus
has interlocking gears on their hindleg trochanters that act together to cock the legs synchronously before triggering forward jumps. At the final molt, the gears are swapped for a high-performance friction-based mechanism because the risk of breaking a gear is high, the options for repair during molting are gone, and, moreover, the animal is bigger and stronger.
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Why do Large Animals Never Actuate Their Jumps with Latch-Mediated Springs? Because They can Jump Higher Without Them.
As animals get smaller, their ability to generate usable work from muscle contraction is decreased by the muscle's force-velocity properties, thereby reducing their effective jump height. Very small animals use a spring-actuated system, which prevents velocity effects from reducing available energy. Since force-velocity properties reduce the usable work in even larger animals, why don't larger animals use spring-actuated jumping systems as well? We will show that muscle length-tension properties limit spring-actuated systems to generating a maximum one-third of the possible work that a muscle could produce-greatly restricting the jumping height of spring-actuated jumpers. Thus a spring-actuated jumping animal has a jumping height that is one-third of the maximum possible jump height achievable were 100% of the possible muscle work available. Larger animals, which could theoretically use all of the available muscle energy, have a maximum jumping height that asymptotically approaches a value that is about three times higher than that of spring-actuated jumpers. Furthermore, a size related "crossover point" is evident for these two jumping mechanisms: animals smaller than this point can jump higher with a spring-actuated mechanism, while animals larger than this point can jump higher with a muscle-actuated mechanism. We demonstrate how this limit on energy storage is a consequence of the interaction between length-tension properties of muscles and spring stiffness. We indicate where this crossover point occurs based on modeling and then use jumping data from the literature to validate that larger jumping animals generate greater jump heights with muscle-actuated systems than spring-actuated systems
Successful Desensitization to Docetaxel after Severe Hypersensitivity Reactions in Two Patients
Purpose Two cases of successful desensitization to docetaxel after severe hypersensitivity reactions are reported. Summary Two patients with gynecological malignancies (uterine leiomyosarcoma and ovarian adenocarcinoma) experienced severe hypersensitivity reactions with docetaxel, including flushing, numbness, sharp radiating pain, severe nausea and vomiting, apnea, and unresponsiveness. Both patients received ondansetron before docetaxel. One patient received dexamethasone, diphenhydramine, and famotidine premedication before docetaxel, as she had previously reacted to paclitaxel. Docetaxel infusions were stopped, and the reactions were treated with diphenhydramine and dexamethasone (one patient also received famotidine). After resolution of symptoms, the docetaxel was not reinitiated due to the nature of the reactions. For the next cycle, both patients received a graded drug challenge or desensitization. Both were pre-medicated with dexamethasone, diphenhydramine, and famotidine. The docetaxel was given as infusions of 0.1%, 1%, and 10% of the dose, with each infusion given over one hour. After this, the remainder of the dose was infused over one hour. Both patients tolerated this desensitization well and completed a total of three and four cycles each. The first patient to receive the desensitization did complain of chest pain during the first desensitization, and the infusion rate was decreased to administer the drug over two hours. After she tolerated two cycles of two-hour infusions, the infusion rate was increased to administer each docetaxel infusion over one hour. Conclusion Two patients who had severe hypersensitivity reactions to docetaxel successfully received further docetaxel doses via a desensitization procedure that involved the sequential administration of solutions containing increasing concentrations of the drug
Mantises exchange angular momentum between three rotating body parts to jump precisely to targets.
Flightless animals have evolved diverse mechanisms to control their movements in air, whether falling with gravity or propelling against it. Many insects jump as a primary mode of locomotion and must therefore precisely control the large torques generated during takeoff. For example, to minimize spin (angular momentum of the body) at takeoff, plant-sucking bugs apply large equal and opposite torques from two propulsive legs [1]. Interacting gear wheels have evolved in some to give precise synchronization of these legs [2, 3]. Once airborne, as a result of either jumping or falling, further adjustments may be needed to control trajectory and orient the body for landing. Tails are used by geckos to control pitch [4, 5] and by Anolis lizards to alter direction [6, 7]. When falling, cats rotate their body [8], while aphids [9] and ants [10, 11] manipulate wind resistance against their legs and thorax. Falling is always downward, but targeted jumping must achieve many possible desired trajectories. We show that when making targeted jumps, juvenile wingless mantises first rotated their abdomen about the thorax to adjust the center of mass and thus regulate spin at takeoff. Once airborne, they then smoothly and sequentially transferred angular momentum in four stages between the jointed abdomen, the two raptorial front legs, and the two propulsive hind legs to produce a controlled jump with a precise landing. Experimentally impairing abdominal movements reduced the overall rotation so that the mantis either failed to grasp the target or crashed into it head first.GPS was supported by HFSP grant LT00422/2006-C. DAC was funded by a Leverhulme
Trust grant F/09 364/K to S.R. Ott, University of Leicester, whom we thank for his support.This is the accepted manuscript. The final version is available at http://www.cell.com/current-biology/abstract/S0960-9822%2815%2900086-X
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Resilin and chitinous cuticle form a composite structure for energy storage in jumping by froghopper insects.
BACKGROUND: Many insects jump by storing and releasing energy in elastic structures within their bodies. This allows them to release large amounts of energy in a very short time to jump at very high speeds. The fastest of the insect jumpers, the froghopper, uses a catapult-like elastic mechanism to achieve their jumping prowess in which energy, generated by the slow contraction of muscles, is released suddenly to power rapid and synchronous movements of the hind legs. How is this energy stored? RESULTS: The hind coxae of the froghopper are linked to the hinges of the ipsilateral hind wings by pleural arches, complex bow-shaped internal skeletal structures. They are built of chitinous cuticle and the rubber-like protein, resilin, which fluoresces bright blue when illuminated with ultra-violet light. The ventral and posterior end of this fluorescent region forms the thoracic part of the pivot with a hind coxa. No other structures in the thorax or hind legs show this blue fluorescence and it is not found in larvae which do not jump. Stimulating one trochanteral depressor muscle in a pattern that simulates its normal action, results in a distortion and forward movement of the posterior part of a pleural arch by 40 microm, but in natural jumping, the movement is at least 100 microm. CONCLUSION: Calculations showed that the resilin itself could only store 1% to 2% of the energy required for jumping. The stiffer cuticular parts of the pleural arches could, however, easily meet all the energy storage needs. The composite structure therefore, combines the stiffness of the chitinous cuticle with the elasticity of resilin. Muscle contractions bend the chitinous cuticle with little deformation and therefore, store the energy needed for jumping, while the resilin rapidly returns its stored energy and thus restores the body to its original shape after a jump and allows repeated jumping.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are
Jumping without slipping: leafhoppers (Hemiptera: Cicadellidae) possess special tarsal structures for jumping from smooth surfaces.
Many hemipteran bugs can jump explosively from plant substrates, which can be very smooth. We therefore analysed the jumping performance of froghoppers (Philaenus spumarius, Aphrophoridae) and leafhoppers (Aphrodes bicinctus/makarovi, Cicadellidae) taking off from smooth (glass) and rough (sandpaper, 30 µm asperity size) surfaces. On glass, the propulsive hind legs of Philaenus froghoppers slipped, resulting in uncontrolled jumps with a fast forward spin, a steeper angle and only a quarter of the velocity compared with jumps from rough surfaces. By contrast, Aphrodes leafhoppers took off without their propulsive hind legs slipping, and reached low take-off angles and high velocities on both substrates. This difference in jumping ability from smooth surfaces can be explained not only by the lower acceleration of the long-legged leafhoppers, but also by the presence of 2-9 soft pad-like structures (platellae) on their hind tarsi, which are absent in froghoppers. High-speed videos of jumping showed that platellae contact the surface briefly (approx. 3 ms) during the acceleration phase. Friction force measurements on individual hind tarsi on glass revealed that at low sliding speeds, both pushing and pulling forces were small, and insufficient to explain the recorded jumps. Only when the tarsi were pushed with higher velocities did the contact area of the platellae increase markedly, and high friction forces were produced, consistent with the observed jumps. Our findings show that leafhoppers have special adhesive footpads for jumping from smooth surfaces, which achieve firm grip and rapid control of attachment/detachment by combining anisotropic friction with velocity dependence
Targeted search for continuous gravitational waves: Bayesian versus maximum-likelihood statistics
We investigate the Bayesian framework for detection of continuous
gravitational waves (GWs) in the context of targeted searches, where the phase
evolution of the GW signal is assumed to be known, while the four amplitude
parameters are unknown. We show that the orthodox maximum-likelihood statistic
(known as F-statistic) can be rediscovered as a Bayes factor with an unphysical
prior in amplitude parameter space. We introduce an alternative detection
statistic ("B-statistic") using the Bayes factor with a more natural amplitude
prior, namely an isotropic probability distribution for the orientation of GW
sources. Monte-Carlo simulations of targeted searches show that the resulting
Bayesian B-statistic is more powerful in the Neyman-Pearson sense (i.e. has a
higher expected detection probability at equal false-alarm probability) than
the frequentist F-statistic.Comment: 12 pages, presented at GWDAW13, to appear in CQ
The Royal Society Climate Updates: What have we learnt since the IPCC 5th Assessment Report?
Climate has a huge influence on the way we live. For example, it affects the crops we can grow and the diseases we might encounter in particular locations. It also determines the physical infrastructure we need to build to survive comfortably in the face of extremes of heat, cold, drought and flood.
Human emissions of carbon dioxide and other greenhouse gases have changed the composition of the atmosphere over the last two centuries. This is expected to take Earth’s climate out of the relatively stable range that has characterised the last few thousand years, during which human society has emerged. Measurements of ice cores and sea-floor sediments show that the current concentration of carbon dioxide, at just over 400 parts per million, has not been experienced for at least three million years. This causes more of the heat from the Sun to be retained on Earth, warming the atmosphere and ocean. The global average of atmospheric temperature has so far risen by about 1˚C compared to the late 19th century, with further increases expected dependent on the trajectory of carbon dioxide emissions in the next few decades.
In 2013 and 2014 the Intergovernmental Panel on Climate Change (IPCC) published its fifth assessment report (AR5) assessing the evidence about climate change and its impacts. This assessment considered data from observations and records of the past. It then assessed future changes and impacts based on various scenarios for emissions of greenhouse gases and other anthropogenic factors. In 2015, almost every nation in
the world agreed (in the so-called Paris Agreement) to the challenging goal of keeping global average warming to well below 2°C above pre-industrial temperatures while pursuing efforts to limit it to 1.5°C. With the next assessment report (AR6) not due until 2022, it is timely to consider how evidence presented since the publication of AR5 affects the assessments made then.
The Earth’s climate is a complex system. To understand it, and the impact that climate change will have, requires many different kinds of study. Climate science consists of theory, observation and modelling. Theory begins with well-established scientific principles, seeks to understand processes occurring over a range of spatial and temporal scales and provides the basis for models. Observation includes long time series of careful measurements, recent data from satellites, and studies of past climate using archives such as tree rings, ice cores and marine sediments. It also encompasses laboratory and field experiments designed to test and enhance understanding of processes. Computer models of the Earth climate system use theory, calibrated and validated by the observations, to calculate the result of future changes. There are nevertheless uncertainties in estimating future climate. Firstly the course of climate change is dependent on what socioeconomic, political and energy paths society takes. Secondly there remain inevitable uncertainties induced for example by variability in the interactions between different parts of the Earth system and by processes, such as cloud formation, that occur at too small a scale to incorporate precisely in global models.
Assessments such as those of the IPCC describe the state of knowledge at a particular time, and also highlight areas where more research is needed. We are still exploring and improving our understanding of many of the processes within the climate system, but, on the whole, new research confirms the main ideas underpinning climate research, while refining knowledge, so as to reduce the uncertainty in the magnitude and extent of crucial impacts
Bayesian detection of unmodeled bursts of gravitational waves
The data analysis problem of coherently searching for unmodeled
gravitational-wave bursts in the data generated by a global network of
gravitational-wave observatories has been at the center of research for almost
two decades. As data from these detectors is starting to be analyzed, a renewed
interest in this problem has been sparked. A Bayesian approach to the problem
of coherently searching for gravitational wave bursts with a network of
ground-based interferometers is here presented. We demonstrate how to
systematically incorporate prior information on the burst signal and its source
into the analysis. This information may range from the very minimal, such as
best-guess durations, bandwidths, or polarization content, to complete prior
knowledge of the signal waveforms and the distribution of sources through
spacetime. We show that this comprehensive Bayesian formulation contains
several previously proposed detection statistics as special limiting cases, and
demonstrate that it outperforms them.Comment: 18 pages, 3 figures, revisions based on referee comment
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