Fit-in GFRP Liner for Retrofitting Corroded Metal Culverts

Corrugated metal pipes (CMPs) have been used as culverts in North America since the 1950s. Today, corrosion of CMPs is a major problem that requires an urgent and efficient solution to retrofit thousands of corroded CMPs across the country. One potential solution gaining wide acceptance is to use a fit-in Glass Fiber Reinforced Polymer (GFRP) liner inside the old CMPs and to connect them using polymer grout. In this paper, a methodology to retrofit corrugated metal culvert using a fit-in GFRP profile liner was developed and implemented. First, material characterization of the GFRP material and the epoxy grout were carried out for proper design of the retrofit system. Second, full-scale CMP-GFRP composite section was tested under three-point bending configuration to observe the retrofitted culvert behavior to failure. The new CMP-GFRP section develops full composite action and shows failure capacity of 75 kip with a deflection of 3.52 in at the end of the test. Post failure of the polymeric grout, GFRP pipe failure was observed at mid-span location starting on the tension side. A finite element model was developed to understand the behavior of the CMP-GFRP composite pipe and to allow for the efficient design of the proposed retrofitting system

Predictors and Impact of Intensification of Antihyperglycemic Therapy in Type 2 Diabetes: Translating Research into Action for Diabetes (TRIAD)

ObjectiveThe purpose of this study was to examine the predictors of intensification of antihyperglycemic therapy in patients with type 2 diabetes; its impact on A1C, body weight, symptoms of anxiety/depression, and health status; and patient characteristics associated with improvement in A1C.Research design and methodsWe analyzed survey, medical record, and health plan administrative data collected in Translating Research into Action for Diabetes (TRIAD). We examined patients who were using diet/exercise or oral antihyperglycemic medications at baseline, had A1C >7.2%, and stayed with the same therapy or intensified therapy (initiated or increased the number of classes of oral antihyperglycemic medications or began insulin) over 18 months.ResultsOf 1,093 patients, 520 intensified therapy with oral medications or insulin. Patients intensifying therapy were aged 58 +/- 12 years, had diabetes duration of 11 +/- 9 years, and had A1C of 9.1 +/- 1.5%. Younger age and higher A1C were associated with therapy intensification. Compared with patients who did not intensify therapy, those who intensified therapy experienced a 0.49% reduction in A1C (P < 0.0001), a 3-pound increase in weight (P = 0.003), and no change in anxiety/depression (P = 0.5) or health status (P = 0.2). Among those who intensified therapy, improvement in A1C was associated with higher baseline A1C, older age, black race/ethnicity, lower income, and more physician visits.ConclusionsTreatment intensification improved glycemic control with no worsening of anxiety/depression or health status, especially in elderly, lower-income, and minority patients with type 2 diabetes. Interventions are needed to overcome clinical inertia when patients might benefit from treatment intensification and improved glycemic control

Late Effects in Hematopoietic Cell Transplant Recipients with Acquired Severe Aplastic Anemia: A Report from the Late Effects Working Committee of the Center for International Blood and Marrow Transplant Research

With improvements in hematopoietic cell transplant (HCT) outcomes for severe aplastic anemia (SAA), there is a growing population of SAA survivors after HCT. However, there is a paucity of information regarding late effects that occur after HCT in SAA survivors. This study describes the malignant and nonmalignant late effects in survivors with SAA after HCT. A descriptive analysis was conducted of 1718 patients post-HCT for acquired SAA between 1995 and 2006 reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). the prevalence and cumulative incidence estimates of late effects are reported for 1-year HCT survivors with SAA. of the HCT recipients, 1176 (68.5%) and 542 (31.5%) patients underwent a matched sibling donor (MSD) or unrelated donor (URD) HCT, respectively. the median age at the time of HCT was 20 years. the median interval from diagnosis to transplantation was 3 months for MSD HCT and 14 months for URD HCT. the median follow-up was 70 months and 67 months for MSD and URD HCT survivors, respectively. Overall survival at I year, 2 years, and 5 years for the entire cohort was 76% (95% confidence interval [CI]: 74-78), 73% (95% CI: 71-75), and 70% (95% CI: 68-72). Among 1-year survivors of MSD HCT, 6% had 1 late effect and 1% had multiple late effects. for 1-year survivors of URD HCT, 13% had 1 late effect and 2% had multiple late effects. Among survivors of MSD HCT, the cumulative incidence estimates of developing late effects were all <3% and did not increase over time. in contrast, for recipients of URD HCT, the cumulative incidence of developing several late effects exceeded 3% by 5 years: gonadal dysfunction 10.5% (95% CI: 7.3-14.3), growth disturbance 7.2% (95% CI: 4.4-10.7), avascular necrosis 6.3% (95% CI: 3.6-9.7), hypothyroidism 5.5% (95% CI: 2.8-9.0), and cataracts 5.1% (95% CI: 2.9-8.0). Our results indicated that all patients undergoing HCT for SAA remain at risk for late effects, must be counseled about, and should be monitored for late effects for the remainder of their lives.Public Health Service Grant from the National Cancer InstituteNational Heart, Lung, and Blood InstituteNational Institute of Allergy and Infectious DiseasesNational Cancer InstituteHealth Resources and Services Administration/Department of Health and Human ServicesOffice of Naval ResearchAllosAmgenAngioblastChildrens Hosp Orange Cty, Dept Hematol, Orange, CA 92668 USACIBMTR Med Coll Wisconsin, Dept Biostat, Milwaukee, WI USAMed Coll Wisconsin, CIBMTR Stat Ctr, Milwaukee, WI 53226 USAKing Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh 11211, Saudi ArabiaNew York Med Coll, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Valhalla, NY 10595 USAStemcyte, Covina, CA USADana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USAUniv Florida, Dept Hematol Oncol, Gainesville, FL USAPrincess Margaret Hosp, Dept Med, Toronto, ON M4X 1K9, CanadaUniv S Florida, All Childrens Hosp, Dept Pediat Hematol & Oncol, St Petersburg, FL 33701 USAUniv Basel Hosp, Dept Hematol, CH-4031 Basel, SwitzerlandOregon Hlth & Sci Univ, Dept Hematol & Oncol, Portland, OR 97201 USAChildrens Natl Med Ctr, Dept Blood & Marrow Transplantat, Washington, DC 20010 USABaylor Coll Med, Ctr Cell Therapy, Dept Hematol & Oncol, Houston, TX 77030 USAUniv N Carolina Hosp, Dept Pediat, Chapel Hill, NC USAUniv Hosp Case, Med Ctr, Dept Med, Cleveland, OH USAUniv Arkansas Med Sci, Dept Hematol & Oncol, Little Rock, AR 72205 USACincinnati Childrens Hosp Med Ctr, Dept Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH USATufts Med Ctr, Dept Med & Pediat, Boston, MA USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Hematol & Oncol, Tampa, FL 33612 USAFlorida Ctr Cellular Therapy, Dept Med, Orlando, FL USAUniv Fed Parana, Dept Bone Marrow Transplantat, BR-80060000 Curitiba, Parana, BrazilVanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USAInst Oncol Pediat, Dept Pediat, São Paulo, BrazilFred Hutchinson Canc Res Ctr, Dept Clin Res & Transplantat, Seattle, WA 98104 USAMt Sinai Med Ctr, Dept Bone Marrow & Stem Cell Transplantat, New York, NY 10029 USAUniv N Carolina Hosp, Dept Hematol & Oncol, Chapel Hill, NC USAUniv Manitoba, CancerCare Manitoba, Dept Manitoba Blood & Marrow Transplant Program, Winnipeg, MB, CanadaKarolinska Univ Hosp, Ctr Allogene Stem Cell Transplantat, Dept Pediat, Stockholm, SwedenLouisiana State Univ, Hlth Sci Ctr, Childrens Hosp, Dept Pediat, New Orleans, LA USADept Natl Marrow Donor Program, Minneapolis, MN USAPublic Health Service Grant from the National Cancer Institute: U24-CA76518National Heart, Lung, and Blood Institute: 5U01HL069294Office of Naval Research: N00014-06-1-0704Office of Naval Research: N00014-08-1-0058HHSH234200637015CWeb of Scienc

Late effects in hematopoietic cell transplant recipients with acquired severe aplastic anemia: a report from the late effects working committee of the center for international blood and marrow transplant research (CIBMTR)

CHOC Children’s Hospital - UC Irvine, Orange, CAMedical College of Wisconsin, Milwaukee, WIMedical College of Wisconsin, Milwaukee, WIKing Faisal Specialist Hospital and Research Center, Riyadh, TX, Saudi ArabiaNew York Medical College, Valhalla, NYStemcyte, Covina, CADana Farber Cancer Institute, Boston, MAUniversity of Florida, Gainesville, FLPrincess Margaret Hospital, Toronto, ON, CanadaAll Children’s Hospital, St. Petersburg, FLUniversity Hospital Basel, Basel, SwitzerlandOregon Health and Science University, Portland, ORChildren’s National Medical Center, Washington, DCBaylor College of Medicine Center for Cell Therapy, Houston, TXUniversity of North Carolina Hospitals, Chapel Hill, NCUniversity Hospitals Case Medical Center, Cleveland, OHUniversity of Arkansas for Medical Sciences, Little Rock, ARCincinnati Children’s Hospital Medical Center, Cincinnati, OHTufts Medical Center, Boston, MAH Lee Moffitt Cancer Center and Research Institute, Tampa, FLFlorida Center for Cellular Therapy, Orlando, FLUniversidade Federal de Parana, Curitiba, BrazilVanderbilt University Medical Center, Nashville, TNInstituto de Oncologia Pediatrica, Sao Paulo, BrazilFred Hutchinson Cancer Research Center, Seattle, WAMount Sinai Medical Center, New York, NYUniversity of North Carolina, Chapel Hill, NCCancerCare Manitoba, University of Manitoba, Winnipeg, CanadaKarolinska University Hospital, Center for Allogeneic Stem Cell Transplantation, Stockholm, SwedenChildrens Hospital LSU Health Sciences Center, New Orleans, LANational Marrow Donor Program, Minneapolis, MNWeb of Scienc

Differences in HDL Cholesterol Levels between Postmenopausal Women Who Take Hormone Replacement Therapy and Exercise and Postmenopausal Women Who Take Hormone Replacement Therapy and Who Do Not Exercise

The purpose of this study was to examine differences in the HDL cholesterol levels of two groups of postmenopausal women. HDL cholesterol levels are thought to be the cardioprotective lipoprotein component of total cholesterol levels. The study was based on findings that state exercise directly increases HDL cholesterol levels, thus lowering the risk for cardiovascular disease. All participants in the study had been on hormone replacement therapy for a minimum of one year. One group of women participated in a regular sustained program of exercise, and the second group did not participate in a regular sustained program of exercise. A questionnaire designed by the researcher was used to assess demographic data, as well as the participant\u27s medical history, and dietary and exercise patterns. Chart reviews were conducted to ensure accuracy of data. Sixty-five women responded and met criteria for participation in the study. Analysis of variance found no significant differences between the HDL cholesterol levels of the 2 groups. There was no significance found between the amount of time in minutes the participants exercised and HDL cholesterol levels, but a weak non-significant relationship was found in the frequency of exercise levels and HDL cholesterol levels. Although further research is needed, this study determined that it is the frequency rather than the length of time exercise is performed that impacts HDL cholesterol levels

Cost-Effective Methods to Retrofit Metal Culverts Using Composites

One of the current pressing problems for all DOTs is the corrosion-oriented deterioration of existing metal culverts. These metal culverts typically are designed for a life of 50 years. However, corrosion is making them last no longer than 30 years. A Glass Fiber Reinforced Polymers (GFRP) pipe section has been evaluated as a fit-in GFRP profile liner for complete repair and rehabilitation of the corroded metal culvert with an expected life of 75 years. This is mainly because of the corrosion free nature of the GFRP material. A comprehensive rehabilitation methodology and laboratory scale three-point bending test was conducted to test the composite action of the steel-GFRP section. A finite element model was developed to provide inference on the mechanics of the GFRP-CMP section and the effect of corrosion on the mechanics of the retrofitted pipe. The FE model was verified with experimental observations and will be used to design GFRP section for retrofitting an existing culvert in the field. A Life Cycle Cost Analysis model was developed to conduct a cost-benefit analysis of the proposed retrofitting technique and compare it with other existing technologies

Study of the relationship between procurement duration and project performance in Design-Build projects: Comparison between Water/Wastewater and Transportation Sectors

Previous studies on building, industrial, and transportation projects found that projects delivered using design-build tend to perform better than projects delivered with the traditional design-bid-build method. However, performance of design-build projects is affected by various factors, with procurement-related factors being among the most influential. Whereas other aspects of procurement have been largely investigated, the effect of procurement duration on project performance has been studied only for design-build transportation projects. In addition, few studies have focused specifically on the delivery of water/wastewater projects. This paper includes the results of a study on the relationship between procurement duration and performance of water/wastewater design-build projects. The study methodology was based on regression analysis of data from a sample of water/wastewater design-build projects. The results show that unlike the transportation sector, procurement duration has little effect on either schedule or cost performance in the water/wastewater sector. Likely reasons for this difference were then explored through a content analysis of procurement documents

Fit-in GFRP Liner for Retrofitting Corroded Metal Culverts

Corrugated metal pipes (CMPs) have been used as culverts in North America since the 1950s. Today, corrosion of CMPs is a major problem that requires an urgent and efficient solution to retrofit thousands of corroded CMPs across the country. One potential solution gaining wide acceptance is to use a fit-in Glass Fiber Reinforced Polymer (GFRP) liner inside the old CMPs and to connect them using polymer grout. In this paper, a methodology to retrofit corrugated metal culvert using a fit-in GFRP profile liner was developed and implemented. First, material characterization of the GFRP material and the epoxy grout were carried out for proper design of the retrofit system. Second, full-scale CMP-GFRP composite section was tested under three-point bending configuration to observe the retrofitted culvert behavior to failure. The new CMP-GFRP section develops full composite action and shows failure capacity of 75 kip with a deflection of 3.52 in at the end of the test. Post failure of the polymeric grout, GFRP pipe failure was observed at mid-span location starting on the tension side. A finite element model was developed to understand the behavior of the CMP-GFRP composite pipe and to allow for the efficient design of the proposed retrofitting system