Intención de abandono y abandono durante el primer curso de Formación Profesional de Grado Medio: un análisis tomando como referencia el concepto de implicación del estudiante ("student engagement")

This article analyzes dropout intention and the effective dropout rate amongst fi rst year students enrolled in Intermediate Vocational Education & Training (IVET) using seven factors related to student engagement (SE). The data analyzed come from a questionnaire based in SE concept applied to a sample of 1,030 students enrolled in the fi rst year of IVET. Regarding dropout intention, professional perspectives were the factor with the greatest predictive weight. Regarding the dropout during the fi rst course, the factors with the greatest weight were involvement in the school/educational tasks and relationship with teachers. Results suggest that professional perspectives are very important to engage IVET students with the program in which they are enrolled, but these must later be complemented with student involvement in the school/educational tasks and good relationships with the teaching staff. The importance of this article lies in the scarcity of empirical works focusing on dropout from IVET programs and its applicability in interventions aimed at reducing the dropout rate.Este artículo analiza la intención de abandono y el abandono durante el primer curso de Formación Profesional de Grado Medio (FPGM) en función de siete factores relacionados con el concepto de implicación del estudiante (IE) o student engagement (SE). Los datos analizados provienen de un cuestionario basado en el concepto de IE aplicado a una muestra de 1.030 estudiantes matriculados en el primer curso FPGM. Respecto a la intención de abandono, las perspectivas profesionales fueron el factor con mayor peso predictivo. Respecto al abandono durante el primer curso, los factores con mayor peso fueron las relaciones con el profesorado y la implicación en el trabajo escolar. Los resultados sugieren que las perspectivas profesionales son muy importantes para vincular al estudiante con la profesión estudiada, pero es necesario que éstas se complementen con implicación en las tareas escolares y buenas relaciones con el profesorado para reducir el riesgo de abandono. La importancia del artículo reside en la escasez de trabajos empíricos focalizados en el abandono que se produce en FPGM y en su utilidad para fundamentar intervenciones dirigidas a reducir el abandono

Isabel de Josa : una insòlita dona catalana del segle XVI

Aquesta restitució biogràfica descobreix Isabel de Josa, dona trencadora dels estereotips femenins, religiosos i morals de la primera meitat del cinc-cents. Partint d'una recerca documental exhaustiva per tal de diferenciar els aspectes verídics dels llegendaris pels quals va ser inclosa en els gineceum de virtuoses i literates en la querella de les dones, citada en els estudis sobre Ignasi de Loyola i objecte de confusió bibliogràfica, desvelem la irrupció d'una figura de identitat polièdrica amb gran projecció dins la societat catalana i italiana en l'exercici d'una religiositat pràctica instrumentalitzada a través de la prèdica pública, missió assistencial i obra fundacional

Seguiment de les infeccions urinàries en Pediatria : control de qualitat

An internal medical audit has been carried out with 36 urinary infection patients who were admitted in Paediatrics Service of the Hospital of Mataró. That system for evaluation of quality, has been used comparing the facts recorded in the clinical record, with the protocol of urinary infection established by the paediatric service. The performance of the audit has been useful to remake on the importance of a complete and oriented clinical record, and to plan the need of practising pielography and cistography in the presence of an urinary infection in children.Se realizó una auditoría médica interna sobre 36 pacientes diagnosticados de infección urinaria, ingresados en el Servicio de Pediatría del Hospital de Mataró. Se utilizó este método de evaluación sobre la calidad asistencial, comparando los datos que existían en las historias clínicas con los protocolos de infección urinaria establecidos por el servicio. La realización de esta auditoría ha sido útil para recalcar la importancia de una historia clínica completa y orientada, así como plantearse en un futuro la necesidad de practicar pielografía y cistografía ante toda infección urinaria en los niños

Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients

Altres ajuts: This work was partially supported by[...] , CIBERONC-CB16/12/00233, and "Una manera de hacer Europa" (Innocampus; CEI-2010-1-0010)". M.G.-A., I.P.-C., and C.J. are supported by the Fundación Española de Hematología y Hemoterapia (FEHH, co-funded by Fundación Cris in the latter case), A.M. by the European Social Fund and the Spanish Education Council through the University of Salamanca, [...]. All Spanish funding is co-sponsored by the European Union FEDER program.Multiple myeloma is a heterogeneous disease whose pathogenesis has not been completely elucidated. Although B-cell receptors play a crucial role in myeloma pathogenesis, the impact of clonal immunoglobulin heavy-chain features in the outcome has not been extensively explored. Here we present the characterization of complete heavy-chain gene rearrangements in 413 myeloma patients treated in Spanish trials, including 113 patients characterized by next-generation sequencing. Compared to the normal B-cell repertoire, gene selection was biased in myeloma, with significant overrepresentation of IGHV3, IGHD2 and IGHD3, as well as IGHJ4 gene groups. Hypermutation was high in our patients (median: 8.8%). Interestingly, regarding patients who are not candidates for transplantation, a high hypermutation rate (≥7%) and the use of IGHD2 and IGHD3 groups were associated with improved prognostic features and longer survival rates in the univariate analyses. Multivariate analysis revealed prolonged progression-free survival rates for patients using IGHD2/IGHD3 groups (HR: 0.552, 95% CI: 0.361−0.845, p = 0.006), as well as prolonged overall survival rates for patients with hypermutation ≥7% (HR: 0.291, 95% CI: 0.137−0.618, p = 0.001). Our results provide new insights into the molecular characterization of multiple myeloma, highlighting the need to evaluate some of these clonal rearrangement characteristics as new potential prognostic markers

Estrategias de estudio y trabajo en estudiantes universitarios de la UIB

El estudio se centra en el conocimiento de los procesos de aprendizaje que se desarrollan en la enseñanza superior, siendo su objetivo principal la evaluación de las estrategias de aprendizaje utilizadas por estudiantes universitarios a lo largo de su formación inicial. Responde a un diseño descriptivo-exploratorio, dirigido a las estrategias de estudio y trabajo de la población universitaria de la Universidad de las Islas Baleares (UIB). Para ello, se procedió a la elaboración de un cuestionario como instrumento de recogida de datos1 sobre estrategias de estudio y trabajo, categorizado en cuatro grupos de estrategias (disposicionales y de apoyo; de búsqueda, recogida y selección de información; de procesamiento y uso de información; metacognitivas, de regulación y control) y sus correspondientes subcategorías. Se trabajó con una muestra de 949 estudiantes de la UIB, clasificados por ámbitos disciplinares y estudios, agrupados en grandes dimensiones (sexo; estudios de ciclo corto y de ciclo largo; rama de estudios; dedicación al estudio y actividad laboral), aportando, para cada una de ellas los datos estadísticos en los que se constata una diferencia significativa.L’estudi està centrat en el coneixement dels processos d’aprenentatge que es desenvolupen a l’ensenyament superior, i el l’objectiu principal és l’avaluació de les estratègies d’aprenentatge utilitzades per estudiants universitaris al llarg de la seva formació inicial. Respon a un disseny descriptiu-exploratori, dirigit a les estratègies d’estudi i treball de la població universitària de la Universitat de les Illes Balears (UIB). En aquest sentit, es va confeccionar un qüestionari com a instrument de recollida de dades sobre estratègies d’estudi i treball, categoritzat en quatre grups d’estratègies (disposicionals i de suport; de cerca, recollida i selecció d’informació; de processament i ús d’informació; metacognitives, de regulació i control) i les subcategories corresponents. Es va treballar amb una mostra de 949 estudiants de la UIB, classificats per àmbits disciplinaris i estudis, agrupats en grans dimensions (sexe; estudis de cicle curt i de cicle llarg; branca d’estudis; dedicació a l’estudi i activitat laboral), que varen aportar, per a cadascuna, dades estadístiques en els quals es constata una diferència significativa.The study is focused on the knowledge of learning processes developed in Higher Education and the main objective is to assess the learning strategies of university students along their initial training. This is a response to a descriptive-exploratory design addressed to the learning and working strategies among the students of the University of the Balearic Islands (UIB). Regarding to this, a question paper was designed as a tool for the collection of data on the studying and working strategies sorted by four strategy groups (dispositional and backup groups; research, collection and selection of information; processing and use of information; metacognitive, regulation and control groups) with their respective subcategories. We took a sample of 949 students from the UIB, sorted by study and disciplinary areas, and we gathered them in larger-dimension groups (gender, shorter and longer degrees, field of study and commitment to studies and work). These groups provided, for each of the samples, statistical information in which an important difference is stated

Risk factors and outcome of COVID-19 in patients with hematological malignancies

Background: Prognostic factors of poor outcome in patients with hematological malignancies and COVID-19 are poorly defned. Patients and methods: This was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confrmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020. Results: We included 367 pediatric and adult patients with hematological malignancies, including recipients of autologous (ASCT) (n=58) or allogeneic stem cell transplantation (allo-SCT) (n=65) from 41 hospitals in Spain. Median age of patients was 64 years (range 1-93.8). Recipients of ASCT and allo-SCT showed lower mortality rates (17% and 18%, respectively) compared to non-SCT patients (31%) (p=0.02). Prognostic factors identifed for day 45 overall mortality (OM) by logistic regression multivariate analysis included age>70 years [odds ratio (OR) 2.1, 95% con‑ fdence interval (CI) 1.2-3.8, p=0.011]; uncontrolled hematological malignancy (OR 2.9, 95% CI 1.6-5.2, p20 mg/dL (OR 3.3, 95% CI 1.7-6.4, p<0.0001). In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids was associated with lower OM (OR 0.42, 95% CI 0.2-0.89 and OR 0.31, 95% CI 0.11-0.87, respectively, p=0.02) whereas the use of hidroxycloroquine did not show signifcant improvement in OM (OR 0.64, 95% CI 0.37-1.1, P=0.1). Conclusions: In most patients with hematological malignancies COVID-19 mortality was directly driven by older age, disease status, performance status, as well as by immune (neutropenia) parameters and level of infammation (high CRP). Use of azithromycin and low dose corticosteroids may be of value in very severe COVID-19

SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

BACKGROUND: COVID-19 sequelae can affect about 15% of patients with cancer who survive the acute phase of SARS-CoV-2 infection and can substantially impair their survival and continuity of oncological care. We aimed to investigate whether previous immunisation affects long-term sequelae in the context of evolving variants of concern of SARS-CoV-2. METHODS: OnCovid is an active registry that includes patients aged 18 years or older from 37 institutions across Belgium, France, Germany, Italy, Spain, and the UK with a laboratory-confirmed diagnosis of COVID-19 and a history of solid or haematological malignancy, either active or in remission, followed up from COVID-19 diagnosis until death. We evaluated the prevalence of COVID-19 sequelae in patients who survived COVID-19 and underwent a formal clinical reassessment, categorising infection according to the date of diagnosis as the omicron (B.1.1.529) phase from Dec 15, 2021, to Jan 31, 2022; the alpha (B.1.1.7)-delta (B.1.617.2) phase from Dec 1, 2020, to Dec 14, 2021; and the pre-vaccination phase from Feb 27 to Nov 30, 2020. The prevalence of overall COVID-19 sequelae was compared according to SARS-CoV-2 immunisation status and in relation to post-COVID-19 survival and resumption of systemic anticancer therapy. This study is registered with ClinicalTrials.gov, NCT04393974. FINDINGS: At the follow-up update on June 20, 2022, 1909 eligible patients, evaluated after a median of 39 days (IQR 24-68) from COVID-19 diagnosis, were included (964 [50·7%] of 1902 patients with sex data were female and 938 [49·3%] were male). Overall, 317 (16·6%; 95% CI 14·8-18·5) of 1909 patients had at least one sequela from COVID-19 at the first oncological reassessment. The prevalence of COVID-19 sequelae was highest in the pre-vaccination phase (191 [19·1%; 95% CI 16·4-22·0] of 1000 patients). The prevalence was similar in the alpha-delta phase (110 [16·8%; 13·8-20·3] of 653 patients, p=0·24), but significantly lower in the omicron phase (16 [6·2%; 3·5-10·2] of 256 patients, p<0·0001). In the alpha-delta phase, 84 (18·3%; 95% CI 14·6-22·7) of 458 unvaccinated patients and three (9·4%; 1·9-27·3) of 32 unvaccinated patients in the omicron phase had sequelae. Patients who received a booster and those who received two vaccine doses had a significantly lower prevalence of overall COVID-19 sequelae than unvaccinated or partially vaccinated patients (ten [7·4%; 95% CI 3·5-13·5] of 136 boosted patients, 18 [9·8%; 5·8-15·5] of 183 patients who had two vaccine doses vs 277 [18·5%; 16·5-20·9] of 1489 unvaccinated patients, p=0·0001), respiratory sequelae (six [4·4%; 1·6-9·6], 11 [6·0%; 3·0-10·7] vs 148 [9·9%; 8·4-11·6], p=0·030), and prolonged fatigue (three [2·2%; 0·1-6·4], ten [5·4%; 2·6-10·0] vs 115 [7·7%; 6·3-9·3], p=0·037). INTERPRETATION: Unvaccinated patients with cancer remain highly vulnerable to COVID-19 sequelae irrespective of viral strain. This study confirms the role of previous SARS-CoV-2 immunisation as an effective measure to protect patients from COVID-19 sequelae, disruption of therapy, and ensuing mortality. FUNDING: UK National Institute for Health and Care Research Imperial Biomedical Research Centre and the Cancer Treatment and Research Trust

Determinants of enhanced vulnerability to COVID-19 in UK cancer patients: a European Study

Background: Despite high contagiousness and rapid spread, SARS-CoV-2 has led to heterogeneous outcomes across affected nations. Within Europe, the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100.000 as of January 2021. We aimed to compare the national impact of COVID-19 on the risk of death in UK cancer patients versus those in continental Europe (EU). / Methods: We performed a retrospective analysis of the OnCovid study database, a European registry of cancer patients consecutively diagnosed with COVID-19 in 27 centres from February 27 to September 10, 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline, including oncological and COVID-19 specific therapy across UK and EU cohorts and evaluated the association of these factors with the risk adverse outcome in multivariable Cox regression models. / Findings: Compared to EU (n=924), UK patients (n=468) were characterised by higher case fatality rates (40.38% versus 26.5%, p<0.0001), higher risk of death at 30 days (hazard ratio, HR 1.64 [95%CI 1.36-1.99]) and 6 months after COVID-19 diagnosis (47.64% versus 33.33%, p<0.0001, HR 1.59 [95%CI 1.33-1.88]). UK patients were more often males, of older age and more co-morbid than EU counterparts (p<0.01). Receipt of anticancer therapy was lower in UK versus EU patients (p<0.001). Despite equal proportions of complicated COVID-19, rates of intensive care admission and use of mechanical ventilation, UK cancer patients were less likely to receive anti-COVID-19 therapies including corticosteroids, anti-virals and interleukin-6 antagonists (p<0.0001). Multivariable analyses adjusted for imbalanced prognostic factors confirmed the UK cohort to be characterised by worse risk of death at 30 days and 6 months, independent of patient’s age, gender, tumour stage and status, number of co-morbidities, COVID-19 severity, receipt of anticancer and anti-COVID-19 therapy. Rates of permanent cessation of anticancer therapy post COVID-19 were similar in UK versus EU. / Interpretation: UK cancer patients have been more severely impacted by the unfolding of the COVID-19 pandemic despite societal risk mitigation factors and rapid deferral of anticancer therapy. The increased frailty of UK cancer patients highlights high-risk groups that should be prioritised for anti-SARS-CoV-2 vaccination. Continued evaluation of long-term outcomes is warranted

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research