Modeling and Implementing RFID Enabled Operating Environment for Patient Safety Enhancement

Patient safety has become a growing concern in health care. The U.S. Institute of Medicine (IOM) report “To Err Is Human: Building a Safer Health System” in 1999 included estimations that medical error is the eighth leading cause of death in the United States and results in up to 100,000 deaths annually. However, many adverse events and errors occur in surgical practice. Within all kinds of surgical adverse events, wrong-side/wrong-site, wrong-procedure, and wrong- patient adverse events are the most devastating, unacceptable, and often result in litigation. Much literature claims that systems must be put in place to render it essentially impossible or at least extremely difficult for human error to cause harm to patients. Hence, this research aims to develop a prototype system based on active RFID that detects and prevents errors in the OR. To fully comprehend the operating room (OR) process, multiple rounds of on site discussions were conducted. IDEF0 models were subsequently constructed for identifying the opportunity of improvement and performing before-after analysis. Based on the analysis, the architecture of the proposed RFID-based OR system was developed. An on-site survey conducted subsequently for better understanding the hardware requirement will then be illustrated. Finally, an RFID-enhanced system based on both the proposed architecture and test results was developed for gaining better control and improving the safety level of the surgical operations

Simultaneous Horizontal and Vertical Oscillation of a Quiescent Filament observed by CHASE and SDO

In this paper, we present the imaging and spectroscopic observations of the simultaneous horizontal and vertical large-amplitude oscillation of a quiescent filament triggered by an EUV wave on 2022 October 02. Particularly, the filament oscillation involved winking phenomenon in Ha images and horizontal motions in EUV images. Originally, a filament and its overlying loops across AR 13110 and 13113 erupted with a highly inclined direction, resulting in an X1.0 flare and a non-radial CME. The fast lateral expansion of loops excited an EUV wave and the corresponding Moreton wave propagating northward. Once the EUV wavefront arrived at the quiescent filament, the filament began to oscillate coherently along the horizontal direction and the winking filament appeared concurrently in Ha images. The horizontal oscillation involved an initial amplitude of 10.2 Mm and a velocity amplitude of 46.5 km/s, lasting for 3 cycles with a period of 18.2 minutes and a damping time of 31.1 minutes. The maximum Doppler velocities of the oscillating filament are 18 km/s (redshift) and 24 km/s (blueshift), which was derived from the spectroscopic data provided by CHASE/HIS. The three-dimensional velocity of the oscillation is determined to be 50 km/s at an angle of 50 to the local photosphere plane. Based on the wave-filament interaction, the minimum energy of the EUV wave is estimated to be 2.7 10 20 J. Furthermore, this event provides evidence that Moreton wavesshould be excited by the highly inclined eruptions

miR-182-5p Promotes Growth in Oral Squamous Cell Carcinoma by Inhibiting CAMK2N1

Background/Aims: Emerging evidence suggests that the propagation of oral squamous cell carcinoma (OSCC) is influenced by the abnormal expression of microRNAs (miRNAs). This study aimed to characterize the involvement of miR-182-5p in OSCC by targeting the calcium/ calmodulin-dependent protein kinase II inhibitor CAMK2N1. Methods: miR-182-5p expression was quantified in OSCC tissues and cell lines with reverse transcription polymerase chain reaction (RT-PCR). Cell colony formation, Cell Counting Kit-8 (CCK-8), Ki-67, and nude mouse xenograft assays were used to characterize the role of miR-182-5p in the proliferation of OSCC. A miR-182-5p target gene was identified with western blotting, RT-PCR, and luciferase activity assays. OSCC patient survival based on CAMK2N1 expression was also analyzed. Results: miR-182-5p was up-regulated in in vitro cell lines and in vivo clinical OSCC samples. CCK-8, colony formation, and Ki-67 assays revealed that miR-182-5p promoted the growth and proliferation of OSCC cells. miR-182-5p directly targeted CAMK2N1, as evidenced by luciferase assays and target prediction algorithms. CAMK2N1 operated as a tumor suppressor gene in patients with OSCC. Down-regulating miR-182-5p expression in the CAL-27 cell line restored CAMK2N1-mediated OSCC cell proliferation. miR-182-5p expression inhibited the activation of AKT, ERK1/2, and NF-κB. Mice injected with CAL-27 cells transfected with miR-182-5p-inhibitor demonstrated a significant increase in tumor size and weight and increased CAMK2N1 mRNA and protein expression compared with the miR-negative control group. Conclusion: The miR-182-5p-CAMK2N1 pathway can be potentially targeted to regulate the proliferation of OSCC cells

MHV Vertices and Fermionic Scattering Amplitudes in Gauge Theory with Quarks and Gluinos

The Cachazo-Svrcek-Witten approach to perturbative gauge theory is extended to gauge theories with quarks and gluinos. All googly amplitudes with quark-antiquark pairs and gluinos are computed and shown to agree with the previously known results. The computations of the non-MHV or non-googly amplitudes are also briefly discussed, in particular the purely fermionic amplitude with 3 quark-antiquark pairs.Comment: 41 pages, 21 figures; v2, minor changes, references added;v3, 2 important additions, references adde

Advances in Molecular Quantum Chemistry Contained in the Q-Chem 4 Program Package

A summary of the technical advances that are incorporated in the fourth major release of the Q-Chem quantum chemistry program is provided, covering approximately the last seven years. These include developments in density functional theory methods and algorithms, nuclear magnetic resonance (NMR) property evaluation, coupled cluster and perturbation theories, methods for electronically excited and open-shell species, tools for treating extended environments, algorithms for walking on potential surfaces, analysis tools, energy and electron transfer modelling, parallel computing capabilities, and graphical user interfaces. In addition, a selection of example case studies that illustrate these capabilities is given. These include extensive benchmarks of the comparative accuracy of modern density functionals for bonded and non-bonded interactions, tests of attenuated second order Møller–Plesset (MP2) methods for intermolecular interactions, a variety of parallel performance benchmarks, and tests of the accuracy of implicit solvation models. Some specific chemical examples include calculations on the strongly correlated Cr2 dimer, exploring zeolite-catalysed ethane dehydrogenation, energy decomposition analysis of a charged ter-molecular complex arising from glycerol photoionisation, and natural transition orbitals for a Frenkel exciton state in a nine-unit model of a self-assembling nanotube