GENETIC CONTROL OF IMMUNE RESPONSES IN VITRO : V. STIMULATION OF SUPPRESSOR T CELLS IN NONRESPONDER MICE BY THE TERPOLYMERL-GLUTAMIC ACID60-L-ALANINE30-L-TYROSINE10 (GAT)

In recent studies we have found that GAT not only fails to elicit a GAT-specific response in nonresponder mice but also specifically decreases the ability of nonresponder mice to develop a GAT-specific PFC response to a subsequent challenge with GAT bound to the immunogenic carrier, MBSA. Studies presented in this paper demonstrate that B cells from nonresponder, DBA/1 mice rendered unresponsive by GAT in vivo can respond in vitro to GAT-MBSA if exogenous, carrier-primed T cells are added to the cultures. The unresponsiveness was shown to be the result of impaired carrier-specific helper T-cell function in the spleen cells of GAT-primed mice. Spleen cells from GAT-primed mice specifically suppressed the GAT-specific PFC response of spleen cells from normal DBA/1 mice incubated with GAT-MBSA. This suppression was prevented by pretreatment of GAT-primed spleen cells with anti-θ serum plus C or X irradiation. Identification of the suppressor cells as T cells was confirmed by the demonstration that suppressor cells were confined to the fraction of the column-purified lymphocytes which contained θ-positive cells and a few non-Ig-bearing cells. The significance of these data to our understanding of Ir-gene regulation of the immune response is discussed

Options for Managing Spent TRi-structural ISOtropic Nuclear Fuel

During the past few decades, there has been a renewed interest in advanced reactor concepts, especially the high-temperature gas-cooled and the molten salt-cooled technologies for energy production as well as hydrogen or process heat generation. Tri-structural isotropic fuel is intended to be used in some of these emerging reactor technologies. The fuel bearing TRISO particles are encapsulated in graphite, which acts in the capacity of a moderator. TRISO based fuels can be fabricated in the form of spherical pebbles or cylindrical compacts, the latter of which are then loaded into prismatic graphite blocks.Comment: Presented at the '2024 Waste Management Symposia

Effect of Relative Volume on Radio Transmitter Expulsion in Subadult Common Carp

Expulsion of surgically implanted radio transmitters is a problem in some fish telemetry studies. We conducted a 109-d experiment to test the hypothesis that variation in relative volume of transmitters surgically implanted in subadult common carp Cyprinus carpio would affect transmitter expulsion. We also necropsied fish at the end of the experiment to evaluate histological evidence for the mechanism of expulsion. Survival rate was high during our experiment; all control fish and 88% of the fish subjected to the implantation surgery survived. Expulsion rate was low; of the 23 fish that received transmitters and survived the experiment, only two (9%) expelled the transmitters. One of these expulsions occurred through a rupture of the incision and the other occurred via the intestine. Retained transmitters were all encapsulated by tissue, and most exhibited multiple adhesions to the intestine, gonads, and body wall. Adhesions were more numerous in fish that received larger transmitters

Major Histocompatibility Complex (MHC) Class II sequence polymorphism in long-finned pilot whale (Globicephala melas) from the North Atlantic

Funding Silvia S. Monteiro and Marisa Ferreira were supported by a Ph.D. grant from Fundação para a Ciência e Tecnologia (ref SFRH/BD/38735/2007 and SFRH/BD/30240/2006, respectively). Alfredo López was supported by a postdoctoral grant from Fundação para a Ciência e Tecnologia (ref SFRH/BPD/82407/2011). Catarina Eira is supported by CESAM (UID/AMB/50017), from FCT/MEC through national funds and FEDER (PT2020, Compete 2020). The work related with strandings and tissue collection in Portugal was partially supported by the SafeSea Project EEAGrants PT 0039 (supported by Iceland, Liechtenstein and Norway through the EEA Financial Mechanism), by the Project MarPro–Life09 NAT/PT/000038 (funded by the European Union–Program Life+) and by the project CetSenti FCT RECI/AAG-GLO/0470/2012; FCOMP-01-0124-FEDER-027472 (Funded by the Program COMPETE and Fundação para a Ciência e Tecnologia).Peer reviewedPostprin

SUSY GUTs with Yukawa unification: a go/no-go study using FCNC processes

We address the viability of exact Yukawa unification in the context of general SUSY GUTs with universal soft-breaking sfermion and gaugino mass terms at the GUT scale. We find that this possibility is challenged, unless the squark spectrum is pushed well above the limits allowed by naturalness. This conclusion is assessed through a global fit using electroweak observables and quark flavour-changing neutral current (FCNC) processes. The problem is mostly the impossibility of accommodating simultaneously the bottom mass and the BR(B --> Xs gamma), after the stringent CDF upper bound on the decay Bs --> mu^+ mu^- is taken into account, and under the basic assumption that the b --> s gamma amplitude have like sign with respect to the Standard Model one, as indicated by the B --> Xs l^+ l^- data. With the same strategy, we also consider the possibility of relaxing Yukawa unification to b - tau Yukawa unification. We find that with small departures from the condition tan beta ~= 50, holding when Yukawa unification is exact, the mentioned tension is substantially relieved. We emphasize that in the region where fits are successful the lightest part of the SUSY spectrum is basically fixed by the requirements of b - tau unification and the applied FCNC constraints. As such, it is easily falsifiable once the LHC turns on.Comment: 10 pages, 1 figure, 5 tables. v3: A few textual modifications. Conclusions unchanged. Matches journal versio

A practical review of energy saving technology for ageing populations

Fuel poverty is a critical issue for a globally ageing population. Longer heating/cooling requirements combine with declining incomes to create a problem in need of urgent attention. One solution is to deploy technology to help elderly users feel informed about their energy use, and empowered to take steps to make it more cost effective and efficient. This study subjects a broad cross section of energy monitoring and home automation products to a formal ergonomic analysis. A high level task analysis was used to guide a product walk through, and a toolkit approach was used thereafter to drive out further insights. The findings reveal a number of serious usability issues which prevent these products from successfully accessing an important target demographic and associated energy saving and fuel poverty outcomes. Design principles and examples are distilled from the research to enable practitioners to translate the underlying research into high quality design-engineering solutions

Long-finned pilot whale population diversity and structure in Atlantic waters assessed through biogeochemical and genetic markers

Acknowledgements. Cetacean samples were collected under the auspices of stranding monitoring programs run by the Sociedade Portuguesa de Vida Selvagem, the Coordinadora para o Estudio dos Mamíferos Mariños (supported by the regional government Xunta de Galicia), the UK Cetacean Strandings Investigation Programme and the Scottish Agriculture College Veterinary Science Division (jointly funded by Defra and the Devolved Governments of Scotland and Wales), the Marine Mammals Research Group of the Institute of Marine Research (Norway), the Museum of Natural History of the Faroe Islands and the International Fund for Animal Welfare Marine Mammal Rescue and Research Program (USA). The authors thank all the members of these institutions and organizations for their assistance with data and sample collection. S.S.M., P.M.F. and M.F. were supported by PhD grants from the Fundação para a Ciência e Tecnologia (POPH/FSE ref SFRH/BD/ 38735/ 2007, SFRH/BD/36766/2007 and SFRH/BD/30240/ 2006, respectively). A.L. was supported by a postdoctoral grant from the Fundação para a Ciência e Tecnologia (ref SFRH/BPD/82407/2011). The work related to strandings and tissue collection in Portugal was partially supported by the SafeSea project EEAGrants PT 0039 (supported by Iceland, Liechtenstein and Norway through the EEA Financial Mechanism), the MarPro project Life09 NAT/PT/000038 (funded by the European Union program LIFE+) and the project CetSenti FCT RECI/AAG-GLO/0470/2012 (FCOMP- 01-0124-FEDER-027472) (funded by the program COMPETE and the Fundação para a Ciência e Tecnologia). G.J.P. thanks the University of Aveiro and Caixa Geral de Depósitos (Portugal) for financial support. The authors acknowledge the assistance of the chemical analysts at Marine Scotland Science with the fatty acid analysis.Peer reviewedPostprintPublisher PD

The HIPASS Catalogue - II. Completeness, Reliability, and Parameter Accuracy

The HI Parkes All Sky Survey (HIPASS) is a blind extragalactic HI 21-cm emission line survey covering the whole southern sky from declination -90 to +25. The HIPASS catalogue (HICAT), containing 4315 HI-selected galaxies from the region south of declination +2, is presented in Meyer et al. (2004a, Paper I). This paper describes in detail the completeness and reliability of HICAT, which are calculated from the recovery rate of synthetic sources and follow-up observations, respectively. HICAT is found to be 99 per cent complete at a peak flux of 84 mJy and an integrated flux of 9.4 Jy km/s. The overall reliability is 95 per cent, but rises to 99 per cent for sources with peak fluxes >58 mJy or integrated flux > 8.2 Jy km/s. Expressions are derived for the uncertainties on the most important HICAT parameters: peak flux, integrated flux, velocity width, and recessional velocity. The errors on HICAT parameters are dominated by the noise in the HIPASS data, rather than by the parametrization procedure.Comment: Accepted for publication in MNRAS. 12 pages, 11 figures. Paper with higher resolution figures can be downloaded from http://hipass.aus-vo.or

Top Quark and Higgs Boson Masses: Interplay between Infrared and Ultraviolet Physics

We review recent efforts to explore the information on masses of heavy matter particles, notably of the top quark and the Higgs boson, as encoded at the quantum level in the renormalization group (RG) equations. The Standard Model (SM) and the Minimal Supersymmetric Standard Model (MSSM) are considered in parallel. First, the question is addressed to which extent the infrared (IR) physics of the ``top-down'' RG flow is independent of the ultraviolet (UV) physics. The central issues are i) IR attractive fixed point values for the top and the Higgs mass, the most outstanding one being m_t=O(190 GeV)sin(beta) in the MSSM, ii) IR attractive relations between parameters, the most prominent ones being an IR fixed top-Higgs mass relation in the SM, leading to m_H=O(156) GeV for the experimental top mass, and an IR fixed relation between the top mass and tan(beta) in the MSSM, and iii) an analytical assessment of their respective strengths of attraction. The triviality and vacuum stability bounds on the Higgs and top masses in the SM and the upper bound on the lightest Higgs boson mass in the MSSM are reviewed. The mathematical backbone, the rich structure of IR attractive fixed points, lines, surfaces,... in the multiparameter space, is made transparent. Interesting hierarchies emerge, most remarkably: IR attraction in the MSSM is systematically stronger than in the SM. Tau-bottom-(top) Yukawa coupling unification in supersymmetric grand unified theories and its power to focus the ``top-down'' RG flow into the IR top mass fixed point resp. onto the IR fixed line in the m_t-tan(beta) plane is reviewed. The program of reduction of parameters, a search for RG invariant relations between couplings, guided by the requirement of asymptotically free couplings in the UV limit,is summarized; its interrelations with the search forComment: review, 112 pages, 39 figures and 15 figures in a table; one LaTeX file, 50 postscript files; LaTeX uses style files epsfig.sty, rotating.sty, dina4p.sty; to be published in Progress in Particle and Nuclear Physics, Vol. 37, 1996, copyright Elsevier Science Lt

Perspectives on the scientific legacy of J. Philip Grime

Perhaps as much as any other scientist in the 20th century, J.P. Grime transformed the study of plant ecology and helped shepherd the field toward international prominence as a nexus of ideas related to global environmental change. Editors at the Journal of Ecology asked a group of senior plant ecologists to comment on Grime's scientific legacy. This commentary piece includes individual responses of 14 scientists from around the world attesting to Grime's foundational role in plant functional ecology, including his knack for sparking controversy, his unique approach to theory formulation involving clever experiments and standardized trait measurements of large numbers of species, and the continued impact of his work on ecological science and policy