LANDSAT survey of near-shore ice conditions along the Arctic coast of Alaska

The author has identified the following significant results. Winter and spring near-shore ice conditions were analyzed for the Beaufort Sea 1973-77, and the Chukchi Sea 1973-76. LANDSAT imagery was utilized to map major ice features related to regional ice morphology. Significant features from individual LANDSAT image maps were combined to yield regional maps of major ice ridge systems for each year of study and maps of flaw lead systems for representative seasons during each year. These regional maps were, in turn, used to prepare seasonal ice morphology maps. These maps showed, in terms of a zonal analysis, regions of statistically uniform ice behavior. The behavioral characteristics of each zone were described in terms of coastal processes and bathymetric configuration

Galaxy size trends as a consequence of cosmology

We show that recently documented trends in galaxy sizes with mass and redshift can be understood in terms of the influence of underlying cosmic evolution; a holistic view which is complimentary to interpretations involving the accumulation of discreet evolutionary processes acting on individual objects. Using standard cosmology theory, supported with results from the Millennium simulations, we derive expected size trends for collapsed cosmic structures, emphasising the important distinction between these trends and the assembly paths of individual regions. We then argue that the observed variation in the stellar mass content of these structures can be understood to first order in terms of natural limitations of cooling and feedback. But whilst these relative masses vary by orders of magnitude, galaxy and host radii have been found to correlate linearly. We explain how these two aspects will lead to galaxy sizes that closely follow observed trends and their evolution, comparing directly with the COSMOS and SDSS surveys. Thus we conclude that the observed minimum radius for galaxies, the evolving trend in size as a function of mass for intermediate systems, and the observed increase in the sizes of massive galaxies, may all be considered an emergent consequence of the cosmic expansion.Comment: 14 pages, 13 figures. Accepted by MNRA

Effects of Epigallocatechin-3-gallate Treatment on Cognitive Deficits in a Down Syndrome Mouse Model

poster abstractDown syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in a constellation of phenotypes that include intellectual disability (ID) and skeletal abnormalities. Ts65Dn mice, the most extensively studied model of DS, have three copies of approximately half the genes on Hsa21 and display many DS related phenotypes including skeletal and ID deficits. DYRK1A is found in three copies both in humans with DS and in Ts65Dn mice; DYRK1A has increased expression in humans with DS and is involved in a number of critical pathways including CNS development and osteoclastogenesis. Epigallcatechin-3-gallate (EGCG), the main polyphenolic compound found in green tea, inhibits Dyrk1a activity, and we have shown previously that a three-week treatment with EGCG during adolescence normalizes some skeletal abnormalities in Ts65Dn mice. The current study tested the hypothesis that a similar 3-week treatment with EGCG will also rescue cognitive deficits observed in Ts65Dn mice. Trisomic mice and euploid littermates were given EGCG or water (control) for three weeks during adolescence. Following termination of the treatment, the mice were tested sequentially (over 5 weeks) on locomotor activity (two daily 30-min sessions in an activity chamber), novel object recognition (NOR) memory, acquisition of delayed non-matching to place (DNMP) spatial working memory in a tmaze, or spatial learning and memory in the Morris water maze (MWM). Results to date indicate that Ts65Dn mice exhibit deficits in the learning and memory tasks compared to controls, but the 3-week EGCG treatment did not significantly improve their performance.We hypothesize that for EGCG to be effective for improving cognitive deficits of the Ts65Dn mice, it needs to be present in the brain during the behavioral testing period; our ongoing studies are testing this with continuous EGCG treatment throughout the behavioral testing process

A FAMILY OF CATION ATPASE-LIKE MOLECULES FROM PLASMODIUM-FALCIPARUM

Abstract. We report the nucleotide and derived amino acid sequence of the ATPase 1 gene from Plasmodium falciparum. The amino acid sequence shares homology with the family of "P-type cation transloeating ATPases in conserved regions important for nucleotide binding, conformational change, or phosphorylation. The gene, which is present on chromosome 5, has a product longer than any other reported for a P-type ATPase. Interstrain analysis from 12 parasite isolates by the polymerase chain reaction reveals that a 330-bp nucleotide sequence encoding three cytoplasmic regions conserved in cation ATPases (regions a-c) is of constant length. By contrast, another 360-bp sequence which is one of four regions we refer to as

Resting state connectivity and cognitive performance in adults with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Cognitive impairment is an inevitable feature of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), affecting executive function, attention and processing speed from an early stage. Impairment is associated with structural markers such as lacunes, but associations with functional connectivity have not yet been reported. Twenty-two adults with genetically-confirmed CADASIL (11 male; aged 49.8 ± 11.2 years) underwent functional magnetic resonance imaging at rest. Intrinsic attentional/executive networks were identified using group independent components analysis. A linear regression model tested voxel-wise associations between cognitive measures and component spatial maps, and Pearson correlations were performed with mean intra-component connectivity z-scores. Two frontoparietal components were associated with cognitive performance. Voxel-wise analyses showed an association between one component cluster and processing speed (left middle temporal gyrus; peak −48, −18, −14; ZE = 5.65, pFWEcorr = 0.001). Mean connectivity in both components correlated with processing speed (r = 0.45, p = 0.043; r = 0.56, p = 0.008). Mean connectivity in one component correlated with faster Trailmaking B minus A time (r = −0.77, p < 0.001) and better executive performance (r = 0.56, p = 0.011). This preliminary study provides evidence for associations between cognitive performance and attentional network connectivity in CADASIL. Functional connectivity may be a useful biomarker of cognitive performance in this population

Links between climate change mitigation, adaptation and development in land policy and ecosystem restoration projects: lessons from South Africa

Links between climate change adaptation, mitigation and development co-benefits in land policy and ecosystem restoration projects are hampered by limited understanding of how multi-faceted policy, institutions and projects interact. This paper explores perceptions of co-benefits produced by two community-level projects that pursue ecosystem restoration in South Africa. It develops a new analytical framework to assess the enabling and constraining factors in delivering triple wins for adaptation, mitigation and development. The aim is to investigate the potential for integrating community perspectives into policy and project development and implementation. Data collected through mixed-methods (policy analysis, semi-structured interviews, participatory site visits and focus groups) are analysed using thematic analysis. We find that while the projects investigated have potential to deliver triple wins, siloed approaches presently hinder effective implementation. In particular, project focus on job creation hampers the achievement of longer-term mitigation and adaptation benefits. Operational flexibility, long-term goals, multi-sectoral cooperation and enabling frameworks are imperative to the achievement of triple wins. Findings provide valuable lessons that can be applied across sub-Saharan Africa towards achieving triple wins in climate and development policy and practice, especially those developed with job creation and ecological restoration aims

Unpacking Brazil’s leadership in the global biofuels arena: Brazilian ethanol diplomacy in Africa

Biofuels represent an opportunity for Brazil to exert global leadership by substantially scaling up the production, consumption, and international trade of bioethanol. Africa represents an ideal venue in which to do this, given its suitable agro-climatic conditions and extensive land area. Brazil has consequently sought to establish bilateral partnerships with African countries, as well as North-South-South trilateral partnerships involving the EU and US. However, empirically grounded assessments of how Brazil’s leadership aspirations have unfolded in practice through these partnerships are limited. In this article, we examine Brazil’s potential to exert global political leadership, by analyzing its policy-based, structural, and instrumental qualities in making bilateral and trilateral inroads regarding bioethanol production in Africa. Interviews in Brazil, Africa, and Europe suggest that both the bilateral and trilateral avenues have produced meager results. Lack of domestic strategy and vision, economic recession, and a fragmented alliance network have reduced Brazil’s capacity to achieve its ethanol diplomacy objectives

Mock observations with the Millennium Simulation: cosmological downsizing and intermediate-redshift observations

Only by incorporating various forms of feedback can theories of galaxy formation reproduce the present-day luminosity function of galaxies. It has also been argued that such feedback processes might explain the counterintuitive behaviour of 'downsizing' witnessed since redshifts z ≃ 1–2. To examine this question, observations spanning 0.4 < z < 1.4 from the Deep Extragalactic Evolutionary Probe (DEEP)2/Palomar survey are compared with a suite of equivalent mock observations derived from the Millennium Simulation, populated with galaxies using the galform code. Although the model successfully reproduces the observed total mass function and the general trend of 'downsizing', it fails to accurately reproduce the colour distribution and type-dependent mass functions at all redshifts probed. This failure is shared by other semi-analytical models which collectively appear to 'over-quench' star formation in intermediate-mass systems. These mock lightcones are also a valuable tool for investigating the reliability of the observational results in terms of cosmic variance. Using variance estimates derived from the lightcones, we confirm the significance of the decline since z ∼ 1 in the observed number density of massive blue galaxies which, we argue, provides the bulk of the associated growth in the red sequence. We also assess the limitations arising from cosmic variance in terms of our ability to observe mass-dependent growth since z ∼ 1

Translocal imagination of Hong Kong connections: the shifting of Chow Yun-Fat's star image since 1997

Anyone who is interested in Hong Kong cinema must be familiar with one name: Chow Yun-fat (b. 1955). He rose to film stardom in the 1980s when Hong Kong cinema started to attract global attention beyond East Asia. During his early screen career, Chow established a star image as an urban citizen of modern Hong Kong through films such as A Better Tomorrow/Yingxiong bense (John Woo, 1986), City on Fire/Longhu fengyun (Ringo Lam, 1987), All About Ah-Long/A Lang de gushi (Johnnie To, 1989), God of Gamblers/Du shen (Wong Jing, 1989), and Hard Boiled/Lashou shentan (John Woo, 1992)