1,044 research outputs found
Numerical comparison of pipe-column-separation models
Results comparing six column-separation numerical models for simulating localized vapor cavities and distributed vaporous cavitation in pipelines are presented. The discrete vapor-cavity model (DVCM) is shown to be quite sensitive to selected input parameters. For short pipeline systems, the maximum pressure rise following column separation can vary markedly for small changes in wave speed, friction factor, diameter, initial velocity, length of pipe, or pipe slope. Of the six numerical models, three perform consistently over a broad number of reaches. One of them, the discrete gas-cavity model, is recommended for general use as it is least sensitive to input parameters or to the selected discretization of the pipeline. Three models provide inconsistent estimates of the maximum pressure rise as the number of reaches is increased; however, these models do give consistent results provided the ratio of maximum cavity size to reach volume is kept below 10%.Angus R. Simpson and Anton Bergan
Pilot, Rollout and Monte Carlo Tree Search Methods for Job Shop Scheduling
Greedy heuristics may be attuned by looking ahead for each possible choice,
in an approach called the rollout or Pilot method. These methods may be seen as
meta-heuristics that can enhance (any) heuristic solution, by repetitively
modifying a master solution: similarly to what is done in game tree search,
better choices are identified using lookahead, based on solutions obtained by
repeatedly using a greedy heuristic. This paper first illustrates how the Pilot
method improves upon some simple well known dispatch heuristics for the
job-shop scheduling problem. The Pilot method is then shown to be a special
case of the more recent Monte Carlo Tree Search (MCTS) methods: Unlike the
Pilot method, MCTS methods use random completion of partial solutions to
identify promising branches of the tree. The Pilot method and a simple version
of MCTS, using the -greedy exploration paradigms, are then
compared within the same framework, consisting of 300 scheduling problems of
varying sizes with fixed-budget of rollouts. Results demonstrate that MCTS
reaches better or same results as the Pilot methods in this context.Comment: Learning and Intelligent OptimizatioN (LION'6) 7219 (2012
Discovering Valuable Items from Massive Data
Suppose there is a large collection of items, each with an associated cost
and an inherent utility that is revealed only once we commit to selecting it.
Given a budget on the cumulative cost of the selected items, how can we pick a
subset of maximal value? This task generalizes several important problems such
as multi-arm bandits, active search and the knapsack problem. We present an
algorithm, GP-Select, which utilizes prior knowledge about similarity be- tween
items, expressed as a kernel function. GP-Select uses Gaussian process
prediction to balance exploration (estimating the unknown value of items) and
exploitation (selecting items of high value). We extend GP-Select to be able to
discover sets that simultaneously have high utility and are diverse. Our
preference for diversity can be specified as an arbitrary monotone submodular
function that quantifies the diminishing returns obtained when selecting
similar items. Furthermore, we exploit the structure of the model updates to
achieve an order of magnitude (up to 40X) speedup in our experiments without
resorting to approximations. We provide strong guarantees on the performance of
GP-Select and apply it to three real-world case studies of industrial
relevance: (1) Refreshing a repository of prices in a Global Distribution
System for the travel industry, (2) Identifying diverse, binding-affine
peptides in a vaccine de- sign task and (3) Maximizing clicks in a web-scale
recommender system by recommending items to users
Breath Practices for Survivor and Caregiver Stress, Depression, and Post- traumatic Stress Disorder: Connection, Co-regulation, Compassion
Does compassion itself benefit the healing process or does the activation of neurophysiological processes, from which the experience of compassion arises, trigger a cascade of physical and psychological changes that support health and well-being? Exploration of the neurological substrates of compassion reveals multiple healing pathways that can be activated by mind-body practices. Furthermore, these pathways affect physical health, emotion regulation, and how we perceive and relate to others.
Physiological states affect the capacity for empathy, compassion and understanding. A state of calm alertness based on sympatho-vagal balance may support such high-level prosocial functions. Evidence suggests that polyvagal-informed mind-body practices, particularly Voluntarily Regulated Breathing Practices (VRBPs), efficiently induce such physiological states and that these same states can reduce inflammation and oxidative stress, while improving cardiovascular function, respiratory efficiency, and physical health.
Mind-body practices, such as Coherent or Resonant Breathing can balance, strengthen, and increase the adaptive flexibility of stress response systems, potentially counteracting the detrimental effects of excess stress, neglect, and trauma on emotion regulation, physical health, and the ability to experience love and compassion. Research is needed to support integration of mind-body practices into healthcare systems. The methods being used to study mind-body techniques may be further refined by considering the target symptoms, population being studied, specific parameters of each practice, and methods of teaching subjects.
The current state of global health calls for treatments that can be delivered to large populations by small numbers of healthcare providers under conditions where resources are limited. Slow gentle Coherent or Resonant Breathing and related mind-body practices are low cost, low risk, easily taught, rapidly effective, scalable, non-stigmatizing, and sustainable. At the convergence of neurophysiological research with contemplative and other mind-body practices, we marvel at the possibilities for relieving emotional and physical suffering as well as improving how we relate to one another
A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes.
Effects of Yoga on Thalamic Gamma-Aminobutyric Acid, Mood and Depression: Analysis of Two Randomized Controlled Trials
Objective: The Vagal-Gamma-Aminobutyric Acid (GABA) theory proposes that some yoga postures and breathing practices exert their effects through stimulation of vagal nerves (parasympathetic system) with associated brain GABA increases. To evaluate this theory, we compared results from a 12-week randomized controlled trial (RCT) of yoga in participants with Major Depressive Disorder (MDD) with those of a similar RCT in healthy control participants (HC).
Methods: In an RCT, magnetic resonance spectroscopy (MRS) and mood measures were acquired in subjects with MDD (n=15) prior to and following a 12-week yoga intervention. The same measures were obtained in the HC (n=17) group. In both studies, thalamic GABA/Creatine was obtained using MEGAPRESS at 4 Telsa at baseline (Scan-1), post-intervention (Scan-2), and immediately following a yoga session (Scan-3). Clinical scales were completed prior to each scan.
Results: The MDD-group had significantly lower GABA compared to the HC at baseline (Scan-1, p=0.001), but not after 12 weeks of yoga, either before (Scan-2, p=0.12) or after a yoga session (Scan-3, p=0.20). Depressive symptoms decreased significantly in the MDD-group (p=0.0001), and anxiety improved in both groups.
Conclusion: After a 12-week yoga intervention, MDD-group mood and anxiety measures improved with scores equivalent to those of non-depressed individuals. This study provides the first evidence of brain GABA increases associated with specific yoga postures and breathing practices in MDD. These results suggest potential benefits of specific yoga postures and breathing practices as monotherapy or augmentation to other treatments to reduce anxiety and depression in MDD
Randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support for inactive adults with chronic health conditions: the e-coachER trial.
OBJECTIVE: To determine whether adding web-based support (e-coachER) to an exercise referral scheme (ERS) increases objectively assessed physical activity (PA). DESIGN: Multicentre trial with participants randomised to usual ERS alone (control) or usual ERS plus e-coachER (intervention). SETTING: Primary care and ERS in three UK sites from 2015 to 2018. PARTICIPANTS: 450 inactive ERS referees with chronic health conditions. INTERVENTIONS: Participants received a pedometer, PA recording sheets and a user guide for the web-based support. e-coachER interactively encouraged the use of the ERS and other PA options. MAIN OUTCOME MEASURES: Primary and key secondary outcomes were: objective moderate-to-vigorous PA (MVPA) minutes (in â„10âmin bouts and without bouts), respectively, after 12 months. Secondary outcomes were: other accelerometer-derived and self-reported PA measures, ERS attendance, EQ-5D-5L, Hospital Anxiety and Depression Scale and beliefs about PA. All outcomes were collected at baseline, 4 and 12 months. Primary analysis was an intention to treat comparison between intervention and control arms at 12-month follow-up. RESULTS: There was no significant effect of the intervention on weekly MVPA at 12 months between the groups recorded in â„10âmin bouts (mean difference 11.8âmin of MVPA, 95%âCI: -2.1 to 26.0; p=0.10) or without bouts (mean difference 13.7âmin of MVPA, 95%âCI: -26.8 to 54.2; p=0.51) for 232 participants with usable data. There was no difference in the primary or secondary PA outcomes at 4 or 12 months. CONCLUSION: Augmenting ERS referrals with web-based behavioural support had only a weak, non-significant effect on MVPA. TRIAL REGISTRATION NUMBER: ISRCTN15644451
Oblique Confinement and Phase Transitions in Chern-Simons Gauge Theories
We investigate non-perturbative features of a planar Chern-Simons gauge
theory modeling the long distance physics of quantum Hall systems, including a
finite gap M for excitations. By formulating the model on a lattice, we
identify the relevant topological configurations and their interactions. For M
bigger than a critical value, the model exhibits an oblique confinement phase,
which we identify with Lauglin's incompressible quantum fluid. For M smaller
than the critical value, we obtain a phase transition to a Coulomb phase or a
confinement phase, depending on the value of the electromagnetic coupling.Comment: 8 pages, harvmac, DFUPG 91/94 and MPI-PhT/94-9
Laser-driven electron source suitable for single-shot Gy-scale irradiation of biological cells at dose-rates exceeding Gy/s
We report on the first systematic characterisation of a tuneable laser-driven
electron source capable of delivering Gy-scale doses in a duration of 10 - 20
ps, thus reaching unprecedented dose rates in the range of
Gy/s. Detailed characterisation of the source indicates, in agreement with
Monte-Carlo simulations, single-shot delivery of multi-Gy doses per pulse over
cm-scale areas, with a high degree of spatial uniformity. The results reported
here confirm that a laser-driven source of this kind can be used for systematic
studies of the response of biological cells to picosecond-scale radiation at
ultra-high dose rates.Comment: submitted for publicatio
The FLASHForward Facility at DESY
The FLASHForward project at DESY is a pioneering plasma-wakefield
acceleration experiment that aims to produce, in a few centimetres of ionised
hydrogen, beams with energy of order GeV that are of quality sufficient to be
used in a free-electron laser. The plasma wave will be driven by high-current
density electron beams from the FLASH linear accelerator and will explore both
external and internal witness-beam injection techniques. The plasma is created
by ionising a gas in a gas cell with a multi-TW laser system, which can also be
used to provide optical diagnostics of the plasma and electron beams due to the
<30 fs synchronisation between the laser and the driving electron beam. The
operation parameters of the experiment are discussed, as well as the scientific
program.Comment: 19 pages, 9 figure
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