Cell Phone-Induced Perceptual Impairments During Simulated Driving

Our research assessed the effects of cellular phone conversations on driving performance. When subjects were deeply involved in cellular phone conversations using either a hand-held or hands-free device, they were more than twice as likely to miss simulated traffic signals presented at the center of fixation than when they were not distracted by the cell phone conversation. By contrast, performance was not disrupted by listening to radio broadcasts or listening to a book on tape. One might argue that when subjects were conversing on a cell phone that they detected the simulated traffic signals, but that the responses to them were suppressed. To assess this, we examined the implicit perceptual memory for items that were presented at fixation but called for no response. Implicit perceptual memory was strong when subjects were not engaged in a cellphone conversation but impaired when they were so engaged. We suggest that active participation in a cell phone conversation disrupts performance by diverting attention to an engaging cognitive context other than the one immediately associated with driving

Production of Methane and Water from Crew Plastic Waste

Recycling is a technology that will be key to creating a self sustaining lunar outpost. The plastics used for food packaging provide a source of material that could be recycled to produce water and methane. The recycling of these plastics will require some additional resources that will affect the initial estimate of starting materials that will have to be transported from earth, mainly oxygen, energy and mass. These requirements will vary depending on the recycling conditions. The degredation products of these plastics will vary under different atmospheric conditions. An estimate of the the production rate of methane and water using typical ISRU processes along with the plastic recycling will be presented

Reconciliation of the carbon budget in the ocean’s twilight zone

Photosynthesis in the surface ocean produces approximately 100 gigatonnes of organic carbon per year, of which 5 to 15 per cent is exported to the deep ocean1, 2. The rate at which the sinking carbon is converted into carbon dioxide by heterotrophic organisms at depth is important in controlling oceanic carbon storage3. It remains uncertain, however, to what extent surface ocean carbon supply meets the demand of water-column biota; the discrepancy between known carbon sources and sinks is as much as two orders of magnitude4, 5, 6, 7, 8. Here we present field measurements, respiration rate estimates and a steady-state model that allow us to balance carbon sources and sinks to within observational uncertainties at the Porcupine Abyssal Plain site in the eastern North Atlantic Ocean. We find that prokaryotes are responsible for 70 to 92 per cent of the estimated remineralization in the twilight zone (depths of 50 to 1,000 metres) despite the fact that much of the organic carbon is exported in the form of large, fast-sinking particles accessible to larger zooplankton. We suggest that this occurs because zooplankton fragment and ingest half of the fast-sinking particles, of which more than 30 per cent may be released as suspended and slowly sinking matter, stimulating the deep-ocean microbial loop. The synergy between microbes and zooplankton in the twilight zone is important to our understanding of the processes controlling the oceanic carbon sink

The National Early Warning Score and its subcomponents recorded within ±24 hours of emergency medical admission are poor predictors of hospital-acquired acute kidney injury

YesBackground: Hospital-acquired Acute Kidney Injury (H-AKI) is a common cause of avoidable morbidity and mortality. Aim: To determine if the patients’ vital signs data as defined by a National Early Warning Score (NEWS), can predict H-AKI following emergency admission to hospital. Methods: Analyses of emergency admissions to York hospital over 24-months with NEWS data. We report the area under the curve (AUC) for logistic regression models that used the index NEWS (model A0), plus age and sex (A1), plus subcomponents of NEWS (A2) and two-way interactions (A3). Likewise for maximum NEWS (models B0,B1,B2,B3). Results: 4.05% (1361/33608) of emergency admissions had H-AKI. Models using the index NEWS had the lower AUCs (0.59 to 0.68) than models using the maximum NEWS AUCs (0.75 to 0.77). The maximum NEWS model (B3) was more sensitivity than the index NEWS model (A0) (67.60% vs 19.84%) but identified twice as many cases as being at risk of H-AKI (9581 vs 4099) at a NEWS of 5. Conclusions: The index NEWS is a poor predictor of H-AKI. The maximum NEWS is a better predictor but seems unfeasible because it is only knowable in retrospect and is associated with a substantial increase in workload albeit with improved sensitivity.The Health Foundatio

CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL EFFECTS OF AMPLIGEN, A MISMATCHED DOUBLE-STRANDED RNA, IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

10 patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC), or lymphadenopathy syndrome (LAS) were given 200-250 mg ampligen, a mismatched double-stranded (ds) RNA with in-vitro antiviral activity against human immunodeficiency virus (HIV), twice a week for up to 18 weeks, without side-effects or toxicity. In all 9 patients who were positive for HIV RNA in peripheral blood mononuclear cells before therapy, levels became undetectable between days 10 and 40 of the start of therapy. 6 of the 7 patients with ARC or LAS also showed a progressive reduction in HIV load as measured by co-culture assays. All 10 patients had augmentation of delayed-type hypersensitivity skin reactions. Other changes noted during ampligen therapy included an increase in or maintenance of numbers of helper-inducer T lymphocytes, improvements in HIV-related symptoms, rises in titre of neutralising antibodies against HIV, and restoration of proper functioning of the natural lymphocyte antiviral dsRNA-dependent (2\u27-5\u27 oligoadenylate/RNA-ase L) pathway. Thus, in the short term, ampligen seems to have the dual ability to restore immunological function and to control HIV replication. © 1987

The SPINDLE Disruption-Tolerant Networking System ∗

program is developing technologies that enable access to information when stable end-to-end paths do not exist and network infrastructure access cannot be assured. DTN technology makes use of persistence within network nodes, along with the opportunistic use of mobility, to overcome disruptions to connectivity. In this paper, we describe the SPINDLE Disruption-Tolerant Networking system and related technology being developed at BBN under the DTN program. Using an open-source, standardsbased core with a plugin architecture and well-specified interfaces, we enable independent development and insertion of innovative DoD-relevant technology while allowing the core system to be refined and engineered within a COTS context. SPINDLE technology innovations include: (i) routing algorithms that work efficiently across a wide range of network disruption, (ii) a name-management architecture for DTNs that supports progressive resolution of intentional name attributes within the network (not at the source), including support for “queries as names ” and name-scheme translation, (iii) distributed caching, indexing, and retrieval approaches for disruptiontolerant content-based (rather than locator-based) access to information, and (iv) a declarative knowledge-based approach that integrates routing, intentional naming, policy-based resource management, and content-based access to information. We present preliminary results that show that the DTN approach outperforms traditional end-to-end approaches across a wide range of network disruption. I