Mute Swan Observation at Gavins Point Dam Area, Cedar/Knox Co., Nebraska

The Nebraska Ornithologists’ Union Records Committee (NOURC) considers Mute Swan (Cygnus olor) to be Accidental in Nebraska (NOURC 2017) with only two accepted records. A review of Mute Swan status in the Midwest and Nebraska, how individual records in Nebraska are evaluated to determine wild provenance, and a review of Nebraska reports can be found in “The Mute Swan in Nebraska: History and Current Status” (Brogie et al. 2016). The following is an account of the third NOURC accepted record for Mute Swan in Nebraska. On 11 June 2021 we observed two sub-adult Mute Swans on Lake Yankton, Cedar County, Nebraska. Identification was straightforward: large, white, long-tailed swans with pale, slightly- knobbed bill with dark markings at the base. In flight the secondary coverts and the base of the primaries still retained some brown coloration, aging the birds as Basic II

The association of North Dakota skilled nursing facility characteristics with COVID-19 outbreak severity

Context: COVID-19 exerted severe challenges on skilled nursing facility (SNF) residents and staff. A combination of internal and external factors predisposed SNFs to an increased propensity of COVID-19 spread. Objective: The purpose of this paper is to examine which facility characteristics may have contributed to COVID-19 outbreaks within urban and rural North Dakota skilled nursing facilities. Methods: A 23-question survey regarding facility characteristics was developed and distributed to all 78 North Dakota skilled nursing facilities (SNF). Findings: Of the North Dakota SNF, 40 out of 78 total facilities (51.2%) participated in the survey. Of those participating, 38 of 40 (95%) were in counties with populations under 50,000, with the smallest county population being 1,876. A Spearman’s rank test suggested a relationship between the community spread of COVID-19 and the COVID-19 positivity of SNF residents. Spearman’s rank also suggested a positive association between the SNF resident COVID-19 positivity in relation to staff positivity (p-value 0.042) and county rates (p-value 0.045). Limitations: While this is a comprehensive survey with a very good response rate, two key limitations are identified. First, the survey relies on self-reported data from SNF staff. Second, it is not clear what data would have been received from non-responding SNFs. Implications: Substantial lessons have been learned, which may not only aid future pandemic preparedness but improve the quality of care for nursing home residents during a pandemic or other respiratory disease outbreaks. Proactively knowing susceptibilities and vulnerabilities ahead of time will allow local and state leaders to plan and allocate resources. Future state and local pandemic emergency plans need to be reviewed with the prioritization of skilled nursing facilities as front line facilities during a pandemic, rather than placing their “traditional” emphasis of emergency preparedness on hospitals

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.

Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal cord hemisections to adult rhesus monkeys and analyzed behavioral, electrophysiological and anatomical adaptations. We found marked spontaneous plasticity of corticospinal projections, with reconstitution of fully 60% of pre-lesion axon density arising from sprouting of spinal cord midline-crossing axons. This extensive anatomical recovery was associated with improvement in coordinated muscle recruitment, hand function and locomotion. These findings identify what may be the most extensive natural recovery of mammalian axonal projections after nervous system injury observed to date, highlighting an important role for primate models in translational disease research

The Association of North Dakota Skilled Nursing Facility Characteristics with COVID-19 Outbreak Severity

Context: COVID-19 exerted severe challenges on skilled nursing facility (SNF) residents and staff. A combination of internal and external factors predisposed SNFs to an increased propensity of COVID-19 spread. Objective: The purpose of this paper is to examine which facility characteristics may have contributed to COVID-19 outbreaks within urban and rural North Dakota skilled nursing facilities. Methods: A 23-question survey regarding facility characteristics was developed and distributed to all 78 North Dakota skilled nursing facilities (SNF). Findings: Of the North Dakota SNF, 40 out of 78 total facilities (51.2%) participated in the survey. Of those participating, 38 of 40 (95%) were in counties with populations under 50,000, with the smallest county population being 1,876. A Spearman’s rank test suggested a relationship between the community spread of COVID-19 and the COVID-19 positivity of SNF residents. Spearman’s rank also suggested a positive association between the SNF resident COVID-19 positivity in relation to staff positivity (p-value 0.042) and county rates (p-value 0.045). Limitations: While this is a comprehensive survey with a very good response rate, two key limitations are identified. First, the survey relies on self-reported data from SNF staff. Second, it is not clear what data would have been received from non-responding SNFs. Implications: Substantial lessons have been learned, which may not only aid future pandemic preparedness but improve the quality of care for nursing home residents during a pandemic or other respiratory disease outbreaks. Proactively knowing susceptibilities and vulnerabilities ahead of time will allow local and state leaders to plan and allocate resources. Future state and local pandemic emergency plans need to be reviewed with the prioritization of skilled nursing facilities as front line facilities during a pandemic, rather than placing their “traditional” emphasis of emergency preparedness on hospitals

Quantum Computation with Quantum Dots and Terahertz Cavity Quantum Electrodynamics

A quantum computer is proposed in which information is stored in the two lowest electronic states of doped quantum dots (QDs). Many QDs are located in a microcavity. A pair of gates controls the energy levels in each QD. A Controlled Not (CNOT) operation involving any pair of QDs can be effected by a sequence of gate-voltage pulses which tune the QD energy levels into resonance with frequencies of the cavity or a laser. The duration of a CNOT operation is estimated to be much shorter than the time for an electron to decohere by emitting an acoustic phonon.Comment: Revtex 6 pages, 3 postscript figures, minor typos correcte

Structure of the Mg-Chelatase Cofactor GUN4 Reveals a Novel Hand-Shaped Fold for Porphyrin Binding

In plants, the accumulation of the chlorophyll precursor Mg-protoporphyrin IX (Mg-Proto) in the plastid regulates the expression of a number of nuclear genes with functions related to photosynthesis. Analysis of the plastid-to-nucleus signaling activity of Mg-Proto in Arabidopsis thaliana led to the discovery of GUN4, a novel porphyrin-binding protein that also dramatically enhances the activity of Mg-chelatase, the enzyme that synthesizes Mg-Proto. GUN4 may also play a role in both photoprotection and the cellular shuttling of tetrapyrroles. Here we report a 1.78-Å resolution crystal structure of Synechocystis GUN4, in which the porphyrin-binding domain adopts a unique three dimensional fold with a “cupped hand” shape. Biophysical and biochemical analyses revealed the specific site of interaction between GUN4 and Mg-Proto and the energetic determinants for the GUN4 • Mg-Proto interaction. Our data support a novel protective function for GUN4 in tetrapyrrole trafficking. The combined structural and energetic analyses presented herein form the physical-chemical basis for understanding GUN4 biological activity, including its role in the stimulation of Mg-chelatase activity, as well as in Mg-Proto retrograde signaling

Incorporating Hydrologic Data and Ecohydrologic Relationships into Ecological Site Descriptions

The purpose of this paper is to recommend a framework and methodology for incorporating hydrologic data and ecohydrologic relationships in Ecological Site Descriptions (ESDs) and thereby enhance the utility of ESDs for assessing rangelands and guiding resilience-based management strategies. Resilience-based strategies assess and manage ecological state dynamics that affect state vulnerability and, therefore, provide opportunities to adapt management. Many rangelands are spatially heterogeneous or sparsely vegetated where the vegetation structure strongly influences infiltration and soil retention. Infiltration and soil retention further influence soil water recharge, nutrient availability, and overall plant productivity. These key ecohydrologic relationships govern the ecologic resilience of the various states and community phases on many rangeland ecological sites (ESs) and are strongly affected by management practices, land use, and disturbances. However, ecohydrologic data and relationships are often missing in ESDs and state-and-transition models (STMs). To address this void, we used literature to determine the data required for inclusion of key ecohydrologic feedbacks into ESDs, developed a framework and methodology for data integration within the current ESD structure, and applied the framework to a select ES for demonstrative purposes. We also evaluated the utility of the Rangeland Hydrology and Erosion Model (RHEM) for assessment and enhancement of ESDs based in part on hydrologic function. We present the framework as a broadly applicable methodology for integrating ecohydrologic relationships and feedbacks into ESDs and resilience-based management strategies. Our proposed framework increases the utility of ESDs to assess rangelands, target conservation and restoration practices, and predict ecosystem responses to management. The integration of RHEM technology and our suggested framework on ecohydrologic relations expands the ecological foundation of the overall ESD concept for rangeland management and is well aligned with resilience-based, adaptive management of US rangelands. The proposed enhancement of ESDs will improve communication between private land owners and resource managers and researchers across multiple disciplines in the field of rangeland management

Design and Implementation of an Underwater Sound Recording Device

To monitor the underwater sound and pressure waves generated by anthropogenic activities such as underwater blasting and pile driving, an autonomous system was designed to record underwater acoustic signals. The underwater sound recording device (USR) allows for connections of two hydrophones or other dynamic pressure sensors, filters high frequency noise out of the collected signals, has a gain that can be independently set for each sensor, and allows for 2 h of data collection. Two versions of the USR were created: a submersible model deployable to a maximum depth of 300 m, and a watertight but not fully submersible model. Tests were performed on the USR in the laboratory using a data acquisition system to send single-frequency sinusoidal voltages directly to each component. These tests verified that the device operates as designed and performs as well as larger commercially available data acquisition systems, which are not suited for field use. On average, the designed gain values differed from the actual measured gain values by about 0.35 dB. A prototype of the device was used in a case study to measure blast pressures while investigating the effect of underwater rock blasting on juvenile Chinook salmon and rainbow trout. In the case study, maximum positive pressure from the blast was found to be significantly correlated with frequency of injury for individual fish. The case study also demonstrated that the device withstood operation in harsh environments, making it a valuable tool for collecting field measurements

Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis

Rationale: Intravenous plasma-purified alpha-1 antitrypsin (IV-AAT) has been used as therapy for alpha-1 antitrypsin deficiency (AATD) since 1987. Previous trials (RAPID and RAPID-OLE) demonstrated efficacy in preserving computed tomography of lung density but no effect on FEV1. This observational study evaluated 615 people with severe AATD from three countries with socialized health care (Ireland, Switzerland, and Austria), where access to standard medical care was equal but access to IV-AAT was not. Objectives: To assess the real-world longitudinal effects of IV-AAT. Methods: Pulmonary function and mortality data were utilized to perform longitudinal analyses on registry participants with severe AATD. Measurements and Main Results: IV-AAT confers a survival benefit in severe AATD (P < 0.001). We uncovered two distinct AATD phenotypes based on an initial respiratory diagnosis: lung index and non-lung index. Lung indexes demonstrated a more rapid FEV1 decline between the ages of 20 and 50 and subsequently entered a plateau phase of minimal decline from 50 onward. Consequentially, IV-AAT had no effect on FEV1 decline, except in patients with a Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 2 lung index. Conclusions: This real-world study demonstrates a survival advantage from IV-AAT. This improved survival is largely decoupled from FEV1 decline. The observation that patients with severe AATD fall into two major phenotypes has implications for clinical trial design where FEV1 is a primary endpoint. Recruits into trials are typically older lung indexes entering the plateau phase and, therefore, unlikely to show spirometric benefits. IV-AAT attenuates spirometric decline in lung indexes in GOLD stage 2, a spirometric group commonly outside current IV-AAT commencement recommendations