The association between sleep patterns and obesity in older adults.

BackgroundReduced sleep duration has been increasingly reported to predict obesity. However, timing and regularity of sleep may also be important. In this study, the cross-sectional association between objectively measured sleep patterns and obesity was assessed in two large cohorts of older individuals.MethodsWrist actigraphy was performed in 3053 men (mean age: 76.4 years) participating in the Osteoporotic Fractures in Men Study and 2985 women (mean age: 83.5 years) participating in the Study of Osteoporotic Fractures. Timing and regularity of sleep patterns were assessed across nights, as well as daytime napping.ResultsGreater night-to-night variability in sleep duration and daytime napping were associated with obesity independent of mean nocturnal sleep duration in both men and women. Each 1 h increase in the standard deviation of nocturnal sleep duration increased the odds of obesity 1.63-fold (95% confidence interval: 1.31-2.02) among men and 1.22-fold (95% confidence interval: 1.01-1.47) among women. Each 1 h increase in napping increased the odds of obesity 1.23-fold (95% confidence interval: 1.12-1.37) in men and 1.29-fold (95% confidence interval: 1.17-1.41) in women. In contrast, associations between later sleep timing and night-to-night variability in sleep timing with obesity were less consistent.ConclusionsIn both older men and women, variability in nightly sleep duration and daytime napping were associated with obesity, independent of mean sleep duration. These findings suggest that characteristics of sleep beyond mean sleep duration may have a role in weight homeostasis, highlighting the complex relationship between sleep and metabolism

On the dynamic response of an instrumented headform for alternative mounting stiffnesses when subjected to ballistic impacts

© 2017, © IMechE 2017. The current British Standard for head protectors for cricketers has been recently revised to include a projectile-based battery of tests, the intention being to ensure that a certified helmet will also prevent contact of the ball or grille with the specified headform facial region. The purpose of this study was to characterise the dynamic response of the headform to direct ballistic impacts for alternative headform mounting arrangements. On one hand, and in accordance with the relevant sections of the Standard, what might be described as a ‘Constrained’ setup was evaluated while, on the other hand, an arrangement with significantly reduced stiffness, in line with that previously reported for the passive human neck, was subject to equivalent appraisal. For each mounting scenario, an air cannon was used to project a cricket training ball at three speeds towards the instrumented headform at three locations with five repeats per speed/location combination. High-rate/resolution video and piezoelectric accelerometer data were collected and processed to determine the headform response. While differences between specific ball impact speed and location scenarios are set out in detail later in the article, overall observations are summarised as follows. From a ball/headform contact duration standpoint, video derived results showed ranges of 1.30–1.45 ms (Constrained) versus 1.26–1.41 ms. Maximum ball deformations, the timing of which enabling the event to be subdivided into ‘loading’ and ‘unloading’ phases, were found to be 82.5%–86.2% (Constrained) versus 82.8%–86.4% of original ball diameter; mean peak headform accelerations during loading were found to be 860–1615 m/s2 (Constrained) versus 967–1638 m/s2; and headform speeds at the end of the loading phase were found to be 0.5–0.92 m/s (Constrained) versus 0.54–0.93 m/s. Differences between headform response for the two mounting arrangements were observed to be more substantial during the loading rather than unloading phase

Semantic Sentiment Analysis of Twitter Data

Internet and the proliferation of smart mobile devices have changed the way information is created, shared, and spreads, e.g., microblogs such as Twitter, weblogs such as LiveJournal, social networks such as Facebook, and instant messengers such as Skype and WhatsApp are now commonly used to share thoughts and opinions about anything in the surrounding world. This has resulted in the proliferation of social media content, thus creating new opportunities to study public opinion at a scale that was never possible before. Naturally, this abundance of data has quickly attracted business and research interest from various fields including marketing, political science, and social studies, among many others, which are interested in questions like these: Do people like the new Apple Watch? Do Americans support ObamaCare? How do Scottish feel about the Brexit? Answering these questions requires studying the sentiment of opinions people express in social media, which has given rise to the fast growth of the field of sentiment analysis in social media, with Twitter being especially popular for research due to its scale, representativeness, variety of topics discussed, as well as ease of public access to its messages. Here we present an overview of work on sentiment analysis on Twitter.Comment: Microblog sentiment analysis; Twitter opinion mining; In the Encyclopedia on Social Network Analysis and Mining (ESNAM), Second edition. 201

Direct observation of incommensurate magnetism in Hubbard chains

The interplay between magnetism and doping is at the origin of exotic strongly correlated electronic phases and can lead to novel forms of magnetic ordering. One example is the emergence of incommensurate spin-density waves with a wave vector that does not match the reciprocal lattice. In one dimension this effect is a hallmark of Luttinger liquid theory, which also describes the low energy physics of the Hubbard model. Here we use a quantum simulator based on ultracold fermions in an optical lattice to directly observe such incommensurate spin correlations in doped and spin-imbalanced Hubbard chains using fully spin and density resolved quantum gas microscopy. Doping is found to induce a linear change of the spin-density wave vector in excellent agreement with Luttinger theory predictions. For non-zero polarization we observe a decrease of the wave vector with magnetization as expected from the Heisenberg model in a magnetic field. We trace the microscopic origin of these incommensurate correlations to holes, doublons and excess spins which act as delocalized domain walls for the antiferromagnetic order. Finally, when inducing interchain coupling we observe fundamentally different spin correlations around doublons indicating the formation of a magnetic polaron

Emerging technologies for sustainable irrigation: Selected papers from the 2015 ASABE and IA irrigation symposium

Citation: Lamm, F. R., Stone, K. C., Dukes, M. D., Howell, T. A., Sr., Robbins, J. W. D., Jr., & Mecham, B. Q. (2016). Emerging technologies for sustainable irrigation: Selected papers from the 2015 ASABE and IA irrigation symposium. Transactions of the Asabe, 59(1), 155-161. doi:10.13031/trans.59.11706This article is an introduction to the "Emerging Technologies in Sustainable Irrigation: A Tribute to the Career of Terry Howell, Sr." Special Collection in this issue of Transactions of the ASABE and the next issue of Applied Engineering in Agriculture, consisting of 16 articles selected from 62 papers and presentations at the joint irrigation symposium of ASABE and the Irrigation Association (IA), which was held in November 2015 in Long Beach, California. The joint cooperation on irrigation symposia between ASABE and IA can be traced back to 1970, and this time period roughly coincides with the career of Dr. Howell. The cooperative symposia have offered an important venue for discussion of emerging technologies that can lead to sustainable irrigation. This most recent symposium is another point on the continuum. The articles in this Special Collection address three major topic areas: evapotranspiration measurement and determination, irrigation systems and their associated technologies, and irrigation scheduling and water management. While these 16 articles are not inclusive of all the important advances in irrigation since 1970, they illustrate that continued progress occurs by combining a recognition of the current status with the postulation of new ideas to advance our understanding of irrigation engineering and science. The global food and water challenges will require continued progress from our portion of the scientific community. This article serves to introduce and provide a brief summary of the Special Collection. © 2016 American Society of Agricultural and Biological Engineers

Is a questionnaire and radiograph-based follow-up model for patients with primary hip and knee arthroplasty a viable alternative to traditional regular outpatient follow-up clinic?

Aims Increasing demand for total hip and knee arthroplasty (THA/TKA) and associated follow-up has placed huge demands on orthopaedic services. Feasible follow-up mechanisms are therefore essential. Methods We conducted an audit of clinical follow-up decision-making for THA/TKA based on questionnaire/radiograph review compared with local practice of Arthroplasty Care Practitioner (ACP)-led outpatient follow-up. In all 599 patients attending an ACP-led THA/TKA follow-up clinic had a pelvic/knee radiograph, completed a pain/function questionnaire and were reviewed by an ACP. An experienced orthopaedic surgeon reviewed the same radiographs and questionnaires, without patient contact or knowledge of the ACP’s decision. Each pathway classified patients into: urgent review, annual monitoring, routine follow-up or discharge. Results In total, 401 hip and 198 knee patients were included. There was substantial agreement between the ACP and surgeon for both hip (kappa = 0.69, 95% confidence interval (CI) 0.62 to 0.76) and knee (kappa = 0.81, 95% CI 0.74 to 0.88). Positive agreement was very high for discharge and routine follow-up; however the ACP was more likely to select annual monitoring and the surgeon urgent review. Discussion Review of the questionnaire/radiograph together identified all patients in need of increased surveillance, with good agreement for on-going patient management. However, review of the radiograph or questionnaire alone missed some patients with potential problems. A radiograph in conjunction with a questionnaire as a review may represent a cost effective THA/TKA follow-up mechanism. Take home message: A questionnaire and radiograph-based remote review may represent a cost-effective total joint arthroplasty follow-up mechanism; thereby reducing the considerable burden that follow-up currently places on the NHS. Cite this article: Bone Joint J 2016;98-B:201–8. </jats:sec

Soliton pair creation in classical wave scattering

We study classical production of soliton-antisoliton pairs from colliding wave packets in (1+1)-dimensional scalar field model. Wave packets represent multiparticle states in quantum theory; we characterize them by energy E and particle number N. Sampling stochastically over the forms of wave packets, we find the entire region in (E,N) plane which corresponds to classical creation of soliton pairs. Particle number is parametrically large within this region meaning that the probability of soliton-antisoliton pair production in few-particle collisions is exponentially suppressed.Comment: 16 pages, 8 figures, journal version; misprint correcte

Is platelet inhibition due to thienopyridines increased in elderly patients, in patients with previous stroke and patients with low body weight as a possible explanation of an increased bleeding risk?

Background The TRITON-TIMI 38 study has identified three subgroups of patients with a higher risk of bleeding during treatment with the thienopyridine prasugrel: patients with a history of stroke or transient ischaemic attack (TIA), patients ≥75 years and patients with a body weight <60 kg. However, the underlying pathobiology leading to this increased bleeding risk remains to be elucidated. The higher bleeding rate may be due to a stronger prasugrelinduced inhibition of platelet aggregation in these subgroups. The aim of the present study was to determine whether on-treatment platelet reactivity is lower in these risk subgroups as compared with other patients in a large cohort on the thienopyridine clopidogrel undergoing elective coronary stenting. Methods A total of 1069 consecutive patients were enrolled. On-clopidogrel platelet reactivity was measured in parallel by light transmittance aggregometry, the Verify- Now®P2Y12 assay and the PFA-100 collagen/ADP cartridge. Results Fourteen patients (1.5%) had a prior history of stroke or TIA, 138 patients (14.5%) were older than 75 years and 30 patients (3.2%) had a body weight <60 kg. Age ≥75 years and a history of stroke were independent predictors of a higher on-treatment platelet reactivity. In contrast, a body weight <60 kg was significantly associated with a lower on-treatment platelet reactivity. Conclusion In two high-risk subgroups for bleeding, patients ≥75 years and patients with previous stroke, onclopidogrel platelet reactivity is increased. In contrast, in patients with a low body weight, on-clopidogrel platelet reactivity is decreased, suggesting that a stronger response to a thienopyridine might only lead to more bleeds in patients with low body weight

Towards UK poSt Arthroplasty Follow-up rEcommendations (UK SAFE): protocol for an evaluation of the requirements for arthroplasty follow-up, and the production of consensus-based recommendations

Introduction: Hip and knee arthroplasties have revolutionised the management of degenerative joint diseases and, due to an ageing population, are becoming increasingly common. Follow-up of joint prostheses is to identify problems in symptomatic or asymptomatic patients due to infection, osteolysis, bone loss or potential peri-prosthetic fracture, enabling timely intervention to prevent catastrophic failure at a later date. Early revision is usually more straight-forward surgically and less traumatic for the patient. However, routine long-term follow-up is costly and requires considerable clinical time. Therefore, some centres in the UK have curtailed this aspect of primary hip and knee arthroplasty services, doing so without an evidence-base that such disinvestment is clinically- or cost-effective. Methods: Given the timeline from joint replacement to revision, conducting a randomised controlled trial (RCT) to determine potential consequences of disinvestment in hip and knee arthroplasty follow-up is not feasible. Furthermore the low revision rates of modern prostheses, less than 10% at 10 years, would necessitate thousands of patients to adequately power such a study. The huge variation in follow-up practice across the UK also limits the generalisability of an RCT. This study will therefore use a mixed-methods approach to examine the requirements for arthroplasty follow-up and produce evidence- and consensus-based recommendations as to how, when and on whom follow-up should be conducted. Four interconnected work packages will be completed: 1) a systematic literature review; 2a) analysis of routinely-collected NHS data from five national datasets to understand when and which patients present for revision surgery; 2b) prospective data regarding how patients currently present for revision surgery; 3) economic modelling to simulate long-term costs and quality-adjusted life years associated with different follow-up care models; 4) a Delphi-consensus process, involving all stakeholders, to develop a policy document which includes a stratification algorithm to determine appropriate follow-up care for an individual patient