Upscaling A Challenge-Based And Modular Education Concept (CMODE-UP)

In 2019, a course at a Dutch University of Technology was redesigned towards challenge-based and modular education. The course was received positively by students and their learning outcomes (grades and engagement) increased compared to previous years. This redesign was quite intensive, and case-specific. It did not deliver a specific set of design principles that can easily be used to redesign other courses within the university or even other universities. Therefore, a follow-up project was started, that aims to deliver a framework to scale-up the course redesign tested in the previous study (CMODE; Challenge-based Modular On-demand Digital Education). This framework will be designed using practical principles and will be evidence-informed. The project consists of three stages: (1) informal interviews with key actors at our university, experienced in studying and/or designing modular instruction, a systematic literature review on challenge-based education and modular instruction; (2) a test of the design principles that were developed using the interviews and literature review; and (3) a test of the CMODE-up framework that was built on the results from the second stage, using think-out-loud protocols. In the current study we specifically focus on the first stage. A first look at the already existing literature around challenge-based education and modular instruction shows us that both concepts have been around for a long time in higher engineering education. Since education has become more and more digitized (and the development of MOOCs), it appears that the concepts have taken a quick increase in relevance. However, both concepts have only been studied minimally in relation to each other. We deem it thus highly relevant to first build a clear and proper view on both concepts, the strengths and weaknesses, and where both (can) meet. So that anyone who has intentions like ours - to implement both in higher education - can do this in an evidence-informed manner.</p

The Halo Beaming Model for Gamma-Ray Bursts

We consider a model for gamma-ray bursts (GRBs) from high-velocity neutron stars in the galactic halo. In this model, bursters are born in the galactic disk with large recoil velocities V_r, and GRBs are beamed to within emission cones of half-angle \phi centered on V_r. We describe scenarios for magnetically -channeled GRBs that have such beaming characteristics. We then make detailed comparisons of this halo beaming model (HBM) to BATSE and PVO data for GRB intensity & angular position distributions. Acceptable fits to observations of over 1000 bursts are obtained for \phi = 15 - 30 degrees and for a BATSE sampling depth ~ 180 kpc. Present data favor a truly isotropic (cosmological) model over the HBM, but not by a statistically compelling margin. Bursters born in nearby external galaxies, such as M31, are almost entirely undetectable in the HBM because of misdirected beaming. We analyze several refinements of the basic HBM: gamma-ray intensities that vary with angle from the beam axis; non-standard-candle GRB luminosity functions; and models including a subset of bursters that do not escape from the galaxy. We also discuss the energy budgets for the bursters, the origins of their recoils, and the physics of burst beaming and alignment. One possible physical model is based on the magnetar model of soft gamma repeaters (SGRs). Empirical bounds on the rate of formation and peculiar velocities of SGRs imply that there exist ~ 10^4 to ~ 10^7 aged SGRs in the galactic halo within a distance of 100 kpc. The HBM gives an acceptable fit to observations only if it satisfies certain conditions (e.g. \phi ~ 20 deg) which are possible, but for which there exist no clear & compelling theoretical justifications. The cosmological burster hypothesis is more generic and thus more attractive in this sense. (Abbreviated Abstract).Comment: ApJ accepted, 9 figures, AASTE

A systematic review of high-fibre dietary therapy in diverticular disease

The exact pathogenesis of diverticular disease of the sigmoid colon is not well established. However, the hypothesis that a low-fibre diet may result in diverticulosis and a high-fibre diet will prevent symptoms or complications of diverticular disease is widely accepted. The aim of this review is to assess whether a high-fibre diet can improve symptoms and/or prevent complications of diverticular disease of the sigmoid colon and/or prevent recurrent diverticulitis after a primary episode. Clinical studies were eligible for inclusion if they assessed the treatment of diverticular disease or the prevention of recurrent diverticulitis with a high-fibre diet. The following exclusion criteria were used for study selection: studies without comparison of the patient group with a control group. No studies concerning prevention of recurrent diverticulitis with a high-fibre diet met our inclusion criteria. Three randomised controlled trials (RCT) and one case-control study were included in this systematic review. One RCT of moderate quality showed no difference in the primary endpoints. A second RCT of moderate quality and the case-control study found a significant difference in favour of a high-fibre diet in the treatment of symptomatic diverticular disease. The third RCT of moderate quality found a significant difference in favour of methylcellulose (fibre supplement). This study also showed a placebo effect. High-quality evidence for a high-fibre diet in the treatment of diverticular disease is lacking, and most recommendations are based on inconsistent level 2 and mostly level 3 evidence. Nevertheless, high-fibre diet is still recommended in several guideline

Inert coupling of IRDye800CW to monoclonal antibodies for clinical optical imaging of tumor targets

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Molecular imaging of angiogenesis with SPECT

Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine. SPECT imaging is more widely available than PET imaging and the radionuclides used for SPECT are easier to prepare and usually have a longer half-life than those used for PET. In addition, SPECT is a less expensive technique than PET. Commonly used gamma emitters are: 99mTc (Emax 141 keV, T1/2 6.02 h), 123I (Emax 529 keV, T1/2 13.0 h) and 111In (Emax 245 keV, T1/2 67.2 h). Compared to clinical SPECT, PET has a higher spatial resolution and the possibility to more accurately estimate the in vivo concentration of a tracer. In preclinical imaging, the situation is quite different. The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm). In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed

Robotic injection of zebrafish embryos for high-throughput screening in disease models

The increasing use of zebrafish larvae for biomedical research applications is resulting in versatile models for a variety of human diseases. These models exploit the optical transparency of zebrafish larvae and the availability of a large genetic tool box. Here we present detailed protocols for the robotic injection of zebrafish embryos at very high accuracy with a speed of up to 2000 embryos per hour. These protocols are benchmarked for several applications: (1) the injection of DNA for obtaining transgenic animals, (2) the injection of antisense morpholinos that can be used for gene knock-down, (3) the injection of microbes for studying infectious disease, and (4) the injection of human cancer cells as a model for tumor progression. We show examples of how the injected embryos can be screened at high-throughput level using fluorescence analysis. Our methods open up new avenues for the use of zebrafish larvae for large compound screens in the search for new medicines

A multicenter randomized clinical trial investigating the cost-effectiveness of treatment strategies with or without antibiotics for uncomplicated acute diverticulitis (DIABOLO trial)

Background. Conservative treatment of uncomplicated or mild diverticulitis usually includes antibiotic therapy. It is, however, uncertain whether patients with acute diverticulitis indeed benefit from antibiotics. In most guidelines issued by professional organizations antibiotics are considered mandatory in the treatment of mild diverticulitis. This advice lacks evidence and is merely based on experts' opinion. Adverse effects of the use of antibiotics are well known, including allergic reactions, development of bacterial resistance to antibiotics and other side-effects. Methods. A randomized multicenter pragmatic clinical trial comparin