35 research outputs found
ARCTIC: Durvalumab + tremelimumab and durvalumab monotherapy vs SoC in â„ 3L advanced NSCLC treatment
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Idling Magnetic White Dwarf in the Synchronizing Polar BY Cam. The Noah-2 Project
Results of a multi-color study of the variability of the magnetic cataclysmic
variable BY Cam are presented. The observations were obtained at the Korean
1.8m and Ukrainian 2.6m, 1.2m and 38-cm telescopes in 2003-2005, 56
observational runs cover 189 hours. The variations of the mean brightness in
different colors are correlated with a slope dR/dV=1.29(4), where the number in
brackets denotes the error estimates in the last digits. For individual runs,
this slope is much smaller ranging from 0.98(3) to 1.24(3), with a mean value
of 1.11(1). Near the maximum, the slope becomes smaller for some nights,
indicating more blue spectral energy distribution, whereas the night-to-night
variability has an infrared character. For the simultaneous UBVRI photometry,
the slopes increase with wavelength from dU/dR=0.23(1) to dI/dR=1.18(1). Such
wavelength dependence is opposite to that observed in non-magnetic cataclysmic
variables, in an agreement to the model of cyclotron emission. The principal
component analysis shows two (with a third at the limit of detection)
components of variablitity with different spectral energy distribution, which
possibly correspond to different regions of emission. The scalegram analysis
shows a highest peak corresponding to the 200-min spin variability, its quarter
and to the 30-min and 8-min QPOs. The amplitudes of all these components are
dependent on wavelength and luminosity state. The light curves were fitted by a
statistically optimal trigonometrical polynomial (up to 4-th order) to take
into account a 4-hump structure. The dependences of these parameters on the
phase of the beat period and on mean brightness are discussed. The amplitude of
spin variations increases with an increasing wavelength and with decreasing
brightnessComment: 30pages, 11figures, accepted in Cent.Eur.J.Phy
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Corey-Chaykovsky Reaction of Chiral Sulfinyl Imines: A Convenient Procedure for the Formation of Chiral Aziridines
Combining two-directional synthesis and tandem reactions: desymmetrisation by intramolecular cycloaddition/triazoline fragmentation
Game Tree Algorithms and Solution Trees
. In this paper a theory of game tree algorithms is presented, entirely based upon the concept of a solution tree. Two types of solution trees are distinguished: max and min trees. Every game tree algorithm tries to prune as many nodes as possible from the game tree. A cut-o# criterion in terms of solution trees will be formulated, which can be used to eliminate nodes from the search without a#ecting the result. Further, we show that any algorithm actually constructs a superposition of a max and a min solution tree. Finally, we will see how solution trees and the related cuto# criterion are applied in major game tree algorithms like alphabeta and MTD. Keywords: Game tree search, Minimax search, Solution trees, Alphabeta, SSS*, MTD. 1 Introduction A game tree models the behavior of a two-player game. Each node n in such a tree represents a position in a game. An example of a game tree with game values is found in Figure 1. The players are called Max and Min. Max is moving from the squ..