Ferramentas de gestão e de apoio à tomada de decisão das unidades de agricultura familiar

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico, Programa de Pós-Graduação em Administração, Florianópolis, 201

Sexual dimorphism in tuberculosis incidence: children cases compared to adult cases in Tuscany from 1997 to 2011.

BackgroundIn most countries, men seem to be more susceptible to tuberculosis (TB) than women, but only few studies have investigated the reasons of this gender incidence difference. The effect of sexual hormones on immunity is possible.MethodsData from children and adults, living in Tuscany, hospitalized for TB in all the thirty-one regional hospitals from January 1st 1997 to December 31st 2011, were analyzed using the International Classification of Disease, 9th Revision, Clinical Modification.ResultsDuring the study period, 10,744 patients were hospitalized with TB diagnosis, precisely 279 (2.6%) children [0-14 years], 205 (1.9%) adolescents [15-18 years] and 10,260 (95.5%) adults [≥ 18 years]. The male population ranged from 249 patients (51.4%) in children and adolescents, to 6,253 (60.9%) in adults. Pulmonary TB was the most common form both in children and adults. Men were more likely than women to have pulmonary TB after puberty, while no significant differences were found between males and females in the hospitalized children. The male gender also resulted the most affected for the extra-pulmonary disease sites, excluding the lymphatic system, during the reproductive age.ConclusionsOur findings suggest a possible role of sexual hormones in the development of TB. No significant male-female difference was found in TB incidence among children, while a sex ratio significantly different from 1:1 emerged among reproductive age classes. An increased incidence difference also persisted in older men, suggesting that male-biased risk factors could influence TB progression. Some limitations of the study are the sample size, the method of discharge diagnosis which could be deficient in accuracy in some cases, the increasing number of immigrants and the lack of possible individual risk factors (smoke and alcohol). Further studies are needed to investigate the possible hormone-driven immune mechanisms determining the sexual dimorphism in TB

Analisando processos de formação de tutoria em questões de gênero e diversidade na escola nos cursos “Gênero e Diversidade na Escola” da UFSC

A Universidade Federal de Santa Catarina (UFSC) realizou práticas de ação afirmativas ao ter ofertado cursos de formação que trabalharam temáticas de gênero e diversidade étnico-racial com o objetivo de formar profissionais da educação em temáticas de gênero, diversidades, sexualidades, orientação sexual, relações étnico-raciais, preconceitos e deficiências – iniciativa que também buscou realizar inclusão de estudantes e profissionais ao mesmo tempo em que procurava reduzir questões relacionadas ao preconceito e às desigualdades sociais no âmbito do universo acadêmico. Este artigo analisa a implementação de algumas dessas práticas adotadas pela universidade, centrando-se na análise de características da construção de saberes e na trajetória de formação acadêmica e profissional das equipes de tutoria envolvidas nas ofertas do curso Gênero e Diversidade na Escola (GDE) entre 2009 e 2016. O objetivo geral deste estudo é investigar como os processos de formação de tutoria e as práticas desenvolvidas ao longo do GDE foram sendo desenvolvidos nas equipes envolvidas em suas três edições realizadas na UFSC, contribuindo para a formação de futuros/as professores/as capazes de dialogar com as transformações que os estudos feministas, queer e das questões étnico-raciais no país buscam fomentar

Inventário de Dicksonia sellowiana Hook. em Santa Catarina.

(Inventário de Dicksonia sellowiana Hook. em Santa Catarina). A intensa exploração comercial de Dicksonia sellowiana a deixaram na categoria de ameaçada de extinção, sendo incluída na lista brasileira de espécies da flora ameaçada de extinção. Por isso, o presente trabalho visa apresentar o estudo da distribuição das populações de D. sellowiana para apontar os locais de maior ocorrência da espécie em Santa Catarina, e avaliar a relação da densidade populacional com fatores ambientais, como altitude e clima. Foram instaladas 225 unidades amostrais, com 4.000 m2 nas regiões do planalto e oeste catarinense, baseadas na grade de 10 km x 10 km conforme procedimento do Inventário Florístico Florestal de Santa Catarina. Nestas 225 unidades amostrais, D. sellowiana foi encontrada em 94, com variação de um a 391 indivíduos. A grande densidade da espécie em áreas mais elevadas (superiores a 1.000 m) está relacionada com os dados climáticos que influenciam a população diretamente, apontados pelo Critério de Informação de Akaike corrigido, ou seja, a altitude e a variação de temperatura que ela provoca. Observou-se também, que a espécie apresenta maior concentração da população nos menores intervalos de altura e diâmetro, chegando a elevadas densidades com até 977 indivíduos/ha em algumas áreas. As informações obtidas pelo inventário sobre esta espécie possibilitam indicar medidas de conservação para a espécie, como área a serem conservadas e apoio a produtores rurais

The use of artificial intelligence to create a virtual patient for oral and maxillofacial surgical planning

The advancement of digital image acquisition technologies in dentistry has facilitated the creation of virtual patients through the integration of two- and three-dimensional (2D and 3D) images within digital platforms. These images, sourced from technologies such as Cone Beam Computed Tomography (CBCT), intraoral scanners (IOS), and 3D facial scanners, can be aligned and merged to comprehensively assess the bone structure, gingival and soft tissues, and the dentition. Additionally, 2D clinical photographs are incorporated into the digital project, enhancing aesthetic analysis and planning. Artificial intelligence (AI) algorithms can also be used to enhance and facilitate 3D image alignment. However, detailed information on digital workflows to work with virtual patients for dental and maxillofacial treatment planning is lacking in the literature. The purpose of this article is to describe a technique to create a virtual patient to assess the relationship between the patient’s soft and hard tissues with the optional use of AI to enhance the quality of 3D-reconstructed models from CBCT. Within the limitations of this study, the technique described herein is suggested to be useful for prosthetically-driven treatment planning of surgical procedures such as crown lengthening, bone grafts and dental implant placement.peer-reviewe

Fatores de competitividade organizacional

The objective of this article is to identify in the business administration literature the elements considered most important to improve business performance, based on content analysis of academic articles on subjects related to competitiveness, productivity, efficiency and performance. The data come from periodicals available from sources listed at the CAPES portal in the period from 2000 to 2009. From the analysis of 486 articles, we identified 15 organizational competitiveness factors: strategic alliances, human capital, reliability, knowledge, cost, cultural factors, flexibility, innovation, quality, speed, customer relations, social responsibility, control systems, production techniques, and information and communication technologies. These factors have the potential to contribute to the establishment of organizational priorities and can be considered as guides for the construction of management instruments and the implementation of actions to improve competitiveness.Este artigo tem por objetivo identificar, na produção bibliográfica da área de administração de empresas, quais são os elementos considerados como capazes de prover melhores condições de desempenho no âmbito empresarial. O trabalho desenvolveu-se a partir da análise de conteúdo de artigos científicos, que tratam sobre assuntos relacionados à competitividade, à produtividade, à eficiência, ao desempenho e à performance organizacional, no Portal de Periódicos da CAPES, no período de 2000 a 2009. A partir da análise de 486 artigos científicos, identificaram-se 15 fatores de competitividade organizacional: Alianças Estratégicas, Capital Humano, Confiabilidade, Conhecimento, Custo, Fatores Culturais, Flexibilidade, Inovação, Qualidade, Rapidez, Relacionamento com Clientes, Responsabilidade Social, Sistemas de Controle, Técnicas de Produção, Tecnologias de Informação e Comunicação. fatores apresentam potencial para contribuir ao estabelecimento de prioridades organizacionais, e podem ser considerados como orientadores na construção de instrumentos de gestão e na implementação de ações de melhoria da competitividade

Cdc42 localized in the CatSper signaling complex regulates cAMP‐dependent pathways in mouse sperm

Sperm acquire the ability to fertilize in a process called capacitation and undergo hyperactivation, a change in the motility pattern, which depends on Ca2+ transport by CatSper channels. CatSper is essential for fertilization and it is subjected to a complex regulation that is not fully understood. Here, we report that similar to CatSper, Cdc42 distribution in the principal piece is confined to four linear domains and this localization is disrupted in CatSper1-null sperm. Cdc42 inhibition impaired CatSper activity and other Ca2+-dependent downstream events resulting in a severe compromise of the sperm fertilizing potential. We also demonstrate that Cdc42 is essential for CatSper function by modulating cAMP production by soluble adenylate cyclase (sAC), providing a new regulatory mechanism for the stimulation of CatSper by the cAMP-dependent pathway. These results reveal a broad mechanistic insight into the regulation of Ca2+ in mammalian sperm, a matter of critical importance in male infertility as well as in contraception.Fil: Luque, Guillermina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Xu, Xinran. State University of Colorado - Fort Collins; Estados UnidosFil: Romarowski, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. State University of Colorado - Fort Collins; Estados UnidosFil: Gervasi, María G.. University of Massachussets; Estados UnidosFil: Orta, Gerardo. Universidad Autonoma de México. Instituto de Biotecnología; MéxicoFil: De la Vega Beltrán, José L.. Universidad Autonoma de México. Instituto de Biotecnología; MéxicoFil: Stival, Cintia Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Gilio, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Visconti, Pablo E.. University of Massachussets; Estados UnidosFil: Krapf, Diego. State University of Colorado - Fort Collins; Estados UnidosFil: Darszon, Alberto. Universidad Autonoma de México. Instituto de Biotecnología; MéxicoFil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Electronic cigarette use in 12 European countries. Results from the TackSHS survey.

BACKGROUND: Limited data on electronic cigarette prevalence, patterns and settings of use are available from several European countries. METHODS: Within the TackSHS project, a face-to-face survey was conducted in 2017-2018 in 12 European countries (Bulgaria, England, France, Germany, Greece, Ireland, Italy, Latvia, Poland, Portugal, Romania and Spain). Overall, 11,876 participants, representative of the population aged ≥15 years in each country, provided information on electronic cigarette. RESULTS: 2.4% (95% confidence interval, CI: 2.2-2.7) of the subjects (2.5% among men and 2.4% among women; 0.4% among never, 4.4% among current- and 6.5% among ex-smokers) reported current use of electronic cigarette, ranging from 0.6% in Spain to 7.2% in England. Of the 272 electronic cigarette users, 52.6% were dual users (i.e., users of both electronic and conventional cigarettes) and 58.8% used liquids with nicotine. In all, 65.1% reported using electronic cigarette in at least one indoor setting where smoking is forbidden, in particular in workplaces (34.9%), and bars and restaurants (41.5%). Multivariable logistic regression analysis showed that electronic cigarette use was lower among older individuals (p for trend <0.001) and higher among individuals with high level of education (p for trend 0.040). Participants from countries with higher tobacco cigarette prices more frequently reported electronic cigarette use (odds ratio 3.62; 95% CI: 1.80-7.30). CONCLUSIONS: Considering the whole adult population of these 12 European countries, more than 8.3 million people use electronic cigarettes. The majority of users also smoked conventional cigarettes, used electronic cigarettes with nicotine and consumed electronic cigarettes in smoke-free indoor areas

Pediatric Intensive Care Unit admission criteria for haemato-oncological patients: a basis for clinical guidelines implementation

Recent advances in supportive care and progress in the development and use of chemotherapy have considerably improved the prognosis of many children with malignancy, thus the need for intensive care admission and management is increasing, reaching about 40% of patients throughout the disease course. Cancer remains a major death cause in children, though outcomes have considerably improved over the past decades. Prediction of outcome for children with cancer in Pediatric Intensive Care Unit (PICU) obviously requires clinical guidelines, and these are not well defined, as well as admission criteria. Major determinants of negative outcomes remain severe sepsis/septic shock association and respiratory failure, deserving specific approach in children with cancer, particularly those receiving a bone marrow transplantation. A nationwide consensus should be achieved among pediatric intensivists and oncologists regarding the threshold clinical conditions requiring Intensive Care Unit (ICU) admission as well as specific critical care protocols. As demonstrated for the critically ill non-oncologic child, it appears unreasonable that pediatric patients with malignancy can be admitted to an adult Intensive Care Unit ICU. On a national basis a pool of refecence institutions should be identified and early referral to an oncologic PICU is warranted