68 research outputs found
A multicopy suppressor screening approach as a means to identify antibiotic resistance determinant candidates in Yersinia pestis
Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides
The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this class of compounds include fermentation and natural products chemistry, precursor-directed biosynthesis, mutasynthesis, semi-synthesis, and total synthesis. The end products range from biochemical tools for probing mechanism of action to clinical trials materials; in turn, the considerable efforts to produce the target molecules have expanded the technologies used to generate them. Here, the full complement of methods is reviewed, reflecting remarkable contributions from scientists of various disciplines over a period of 7 years since the first publication of the structure of 1
Ohpikiihaakan-ohpihmeh (Raised Somewhere Else): A 60s Scoop Adoptee’s Story of Coming Home (Colleen Cardinal)
Pipelined Full-Precision Bit-Serial Multiplication
Coordinated Science Laboratory was formerly known as Control Systems LaboratoryU of I OnlyRestricted to UIUC communit
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