682 research outputs found
Reconsidering translation and language in an international business context: beyond an instrumental approach.
International;
Developing language strategies for international companies: the contribution of translation studies.
This article introduces translation studies in order to theorize about the ways in which multiple languages in international companies can be combined. Its purpose is to develop different language strategies based on different theoretical perspectives within translation studies. Considering the historical developments in this discipline, we identify three perspectives each with a different conception of translation and language use. These conceptions are the theoretical basis on which we develop three language strategies: a mechanical, cultural and political language strategy. For each strategy, we discuss the selection of language(s), the role of translators and the validation method, and formulate proposition about the types of texts being produced. These propositions indicate that, through their international communication process, international companies become scripted as a particular type of multilingual organization, be it a uniform, a culturally sensitive or a hybrid text.Strategy; International; Companies; Studies; Selection; Validation; Text; Communication; Processes;
Cultuur en Human Resource Management: operationele en ethische principes.
Human resource management; Management; Resource management;
Bodyspace at the pub: sexual orientations and organizational space
In this article we argue that sexuality is not only an undercurrent of service environments, but is integral to the way that these workspaces are experienced and negotiated. Through drawing on Sara Ahmed’s (2006a) ‘orientation’ thesis, we develop a concept of ‘bodyspace’ to suggest that individuals understand, shape and make meaning of work spaces through complex sexually-orientated negotiations. Presenting analysis from a study of UK pubs, we explore bodyspace in the lived experience of workplace sexuality through three elements of orientation: background; bodily dwelling; and lines of directionality. Our findings show how organizational spaces afford or mitigate possibilities for particular bodies, which simultaneously shape expectations and experiences of sexuality at work. Bodyspace therefore provides one way of exposing the connection between sexual ‘orientation’ and the lived experience of service sector work
Reindeer carcasses provide foraging habitat for insectivorous birds of the alpine tundra
On August of 2016, almost an entire herd (n = 323) of wild tundra reindeer (Rangifer tarandus) was killed by lightning on Hardangervidda in southern Norway. While conducting fieldwork for another study in 2017, we opportunistically registered the occurrence and behaviour of birds on carcasses from this mass die-off. Several passerine species other than corvids were observed actively foraging on arthropods, such as blowfly (Calliphoridae sp.) adults and larvae, which are typically associated with carcass decomposition. We quantified observations of those birds, and described their foraging behaviour at the carcass site. In decreasing order of abundance, five passerine species were observed taking arthropods at the site: Meadow Pipit (Anthus pratensis), Northern Wheatear (Oenanthe oenanthe), Common Reed Bunting (Emberiza schoeniclus), Bluethroat (Luscinia svecica,), and Lapland Bunting (Calcarius lapponicus). Systematic surveys of passerines utilizing carcass sites would further our understanding of how such resources may affect behaviour and life history of various bird species
Synthesis of historical reservoir operations from 1980 to 2020 for the evaluation of reservoir representation in large-scale hydrologic models
All the major river systems in the contiguous United States (CONUS) (and many in the world) are impacted by dams, yet reservoir operations remain difficult to quantify and model due to a lack of data. Reservoir operation data are often inaccessible or distributed across many local operating agencies, making the acquisition and processing of data records quite time-consuming. As a result, large-scale models often rely on simple parameterizations for assumed reservoir operations and have a very limited ability to evaluate how well these approaches match actual historical operations. Here, we use the first national dataset of historical reservoir operations in the CONUS domain, ResOpsUS, to analyze reservoir storage trends and operations in more than 600 major reservoirs across the US. Our results show clear regional differences in reservoir operations. In the eastern US, which is dominated by flood control storage, we see storage peaks in the winter months with sharper decreases in the operational range (i.e., the difference between monthly maximum and minimum storage) in the summer. In the more arid western US where storage is predominantly for irrigation, we find that storage peaks during the spring and summer with increases in the operational range during the summer months. The Lower Colorado region is an outlier because its seasonal storage dynamics more closely mirrored those of flood control basins, yet the region is classified as arid, and most reservoirs have irrigation uses. Consistent with previous studies, we show that average annual reservoir storage has decreased over the past 40 years, although our analyses show a much smaller decrease than previous work. The reservoir operation characterizations presented here can be used directly for development or evaluation of reservoir operations and their derived parameters in large-scale models. We also evaluate how well historical operations match common assumptions that are often applied in large-scale reservoir parameterizations. For example, we find that 100 dams have maximum storage values greater than the reported reservoir capacity from the Global Reservoirs and Dams database (GRanD). Finally, we show that operational ranges have been increasing over time in more arid regions and decreasing in more humid regions, pointing to the need for operating policies which are not solely based on static values
Prediction of super-secondary structure in α-helical and β-barrel transmembrane proteins
International audienceA dynamic programming algorithm is proposed to predict the structure of different families of proteins and is tested with the b-barrel transmembrane proteins.Un algorithme est proposé qui permet, par programmation dynamique, de prédire la strucutre de différentes familles de protéines. Il est testé sur les proteeines transmembranaires (beta)
Structural and functional basis for RNA cleavage by Ire1
BACKGROUND: The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease (RNase) domain of Ire1 initiates a non-conventional mRNA splicing reaction, leading to the production of a transcription factor that controls UPR target genes. The mRNA splicing reaction is an obligatory step of Ire1 signaling, yet its mechanism has remained poorly understood due to the absence of substrate-bound crystal structures of Ire1, the lack of structural similarity between Ire1 and other RNases, and a scarcity of quantitative enzymological data. Here, we experimentally define the active site of Ire1 RNase and quantitatively evaluate the contribution of the key active site residues to catalysis.
RESULTS: This analysis and two new crystal structures suggest that Ire1 RNase uses histidine H1061 and tyrosine Y1043 as the general acid-general base pair contributing \u3e/=7.6 kcal/mol and 1.4 kcal/mol to transition state stabilization, respectively, and asparagine N1057 and arginine R1056 for coordination of the scissile phosphate. Investigation of the stem-loop recognition revealed that additionally to the stem-loops derived from the classic Ire1 substrates HAC1 and Xbp1 mRNA, Ire1 can site-specifically and rapidly cleave anticodon stem-loop (ASL) of unmodified tRNAPhe, extending known substrate specificity of Ire1 RNase.
CONCLUSIONS: Our data define the catalytic center of Ire1 RNase and suggest a mechanism of RNA cleavage: each RNase monomer apparently contains a separate catalytic apparatus for RNA cleavage, whereas two RNase subunits contribute to RNA stem-loop docking. Conservation of the key residues among Ire1 homologues suggests that the mechanism elucidated here for yeast Ire1 applies to Ire1 in metazoan cells, and to the only known Ire1 homologue RNase L
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